Molecular-resolution micro-resonant biosensor with adjustable natural frequency

Xiaorui Fu,Ming Zhang,Dezhi Hou,Chong Li 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.10

Modern sensors are becoming increasingly small in size while their sensitivity requirements remain relatively strict, to the point that the processing technology and test technology are highly difficult and costly. This paper proposes a micro-resonant biosensor with adjustable natural frequency. A positive feedback signal with a phase difference of 180 degrees is used to reduce the equivalent mass of the resonator, yielding an ultrahigh resonant frequency. The biosensor is formed by a coating bovine blood solution on the surface of the resonator of a cantilever sensor. The instantaneous frequency equation of the biosensor is established using a coupling dynamic calculation. The changes in instantaneous frequency during hemoglobin oxygen absorption and deoxygenation, are then measured. The proposed millimeter micro-resonant biosensor system measures the molecular weight of a single oxygen molecule quality at 5.7619×10 -23 g, only deviating by 8.306 % from the theoretical value. Finally, the potential of the micron scale sensor is deeply taped.

Nonlinear primary resonance and bifurcation analyses of a micro-resonant pressure sensor

Xiaorui Fu,Chong Li 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.2

The micro-resonant pressure sensor outputs frequency signals for which distortion does not take place over long-distance transmission. As the dimensions of the sensor decrease, the nonlinear coupling effects caused by the van der Waals force, electrostatic force, and air damping force should be considered. Here, based on the nonlinear dynamic equation, the amplitude-frequency characteristics near resonance and the equation on the displacement response far away from resonance are obtained. Using these equations, changes in the sensor’s amplitude-frequency characteristics and the vibration amplitude far away from resonance, along with the system parameters, are investigated. The variations of the chaotic vibration characteristics of the sensor with the thickness of the resonator are studied by the numerical method. The results show that the relevant parameters of the resonator have a great influence on the primary resonance and bifurcation of the sensor. The sensor changes from periodic vibration to chaotic vibration through period-doubling bifurcation in a certain range of parameters. These results can be used to determine the measurements of the resonators to ensure sensor performance.

Effect of six sugars on the longevity, oviposition performance and nutrition accumulation in an endoparasitoid, Meteorus pulchricornis (Hymenoptera: Braconidae)

Sheng Sheng,Xiaorui Zhang,Yu Zheng,Jiao Wang,Yu Zhou,Chengwu Liao,Jun Wang,Fu-an Wu 한국응용곤충학회 2019 Journal of Asia-Pacific Entomology Vol.22 No.1

The effects of six sugar resources (fructose, glucose, sucrose, trehalose, raffinose and honey) on the longevity, oviposition performance and nutrition levels of Meteorus pulchricornis, a thelytokous larval endoparasitoid of the common cutworm Spodoptera litura were examined under laboratory conditions. Female adults of M. pulchricornis fed 1 M fructose, glucose, trehalose or sucrose solutions survived longer than those fed on other sugar solutions or water. When provided with honey or sucrose solutions, the female parasitoids laid more offspring than those fed other sugar diets or the control. The body size of offspring driven from honey-, fructose-, sucrose-, and glucose-fed females, along with water-fed group, were larger than the trehalose- and raffinose-fed females. However, the emergence rates of all offspring generated from different sugars- and water-fed females were similar. When separately given honey, sucrose or fructose, M. pulchricornis females accumulated fructose at a higher level than the other groups. Parasitoid wasps fed trehalose solution accumulated the highest level of total sugar. Glycogen levels and lipid content were highest at emergence and then decreased across all diets. In addition, females fed on trehalose had the highest level of glycogen compared to other sugar diets and water control regardless of emergency level. Females fed trehalsoe, fructose, and glucose solutions had a higher level of lipid than those fed other sugar solutions and water at life end. The outcome of this study can benefit both laboratory rearing and management interventions that improve sugar sources for the parasitoid in the field.

Preparation and Characterization of Platinum Nanoparticles Supported by Non-woven Fabric for Formaldehyde Decomposition

Gaodan Luo,Qian Yu,Lin Yu,Xiaorui Wang,Xiuqing Hao,Jing Fu 한국섬유공학회 2019 Fibers and polymers Vol.20 No.10

Vacuum adsorption was employed to synthesize platinum/polyethylene terephthalate (PET) samples with greatpotential for indoor air quality improvement application. Pt nanoparticles (PNPS) were loaded onto surface of non-wovenfabric composed of polyethylene terephthalate (PET) and with high air permeability. High activity was sought for the Pt/PETcatalyst by investigating the effects of hexadecyl trimethyl ammonium bromide (CTAB) on PNP sizes and PET fibersurfaces. The prepared samples were characterized by XRD, SEM, TEM, TG, FTIR and XPS analysis. The results indicatedthat Pt/PET samples were successfully fabricated, and a formaldehyde conversation of 70.8 % was obtained within 150 minat 35 oC using Pt/PET with 0.6 wt% Pt loading. This research provided a facile method for depositing Pt onto PET fibers(non-woven fabric), and the catalytic activities of the resulting composite Pt/PET materials indicated them to be promisingfor applications to indoor air remediation.

Output characteristics and experiments of a novel low frequency rotary piezoelectric motor

Kang Liang,Chong Li,Yujian Tong,Jiwen Fang,Wei Zhong,Xiaorui Fu 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.3

In order to improve the output performance of a piezoelectric motor under low driving frequency, a novel rotary piezoelectric motor driven by two piezoelectric actuators is proposed that is actuated based on harmonic and friction driving mechanism. The motor uses two piezoelectric actuators to drive two amplifying mechanisms with π/2 phase difference to produce harmonic motion, and then drives the rotor to rotate through friction force. Based on the driving principle, the electromechanical coupling equations of the motor are established. And a test platform is built to test the output characteristics of the motor. The results show that fluctuation of harmonic force and output torque occurs when the motor operates at different positions. Under the driving voltage and frequency of 150 V and 5 Hz, the actual average output torque of the prototype is 3.08 Nmm. Moreover, fluctuation of harmonic force and output torque occurs when the motor operates at different positions.

Baseline Total Metabolic Tumor Volume and Total Lesion Glycolysis Measured on 18F-FDG PET-CT Predict Outcomes in T-Cell Lymphoblastic Lymphoma

Xiaoyan Feng,Xin Wen,Ling Li,Zhenchang Sun,Xin Li,Lei Zhang,Jingjing Wu,Xiaorui Fu,Xinhua Wang,Hui Yu,Xinran Ma,Xudong Zhang,Xinli Xie,Xingmin Han,Mingzhi Zhang 대한암학회 2021 Cancer Research and Treatment Vol.53 No.3

Purpose There is no optimal prognostic model for T-cell lymphoblastic lymphoma (T-LBL). Here, we discussed the predictive value of total metabolic tumor volume (TMTV) and total lesion glycolysis (TLG) measured on 18F-fluorodeoxyglucose positron emission tomography–computed tomography (PET-CT) in T-LBL.Materials and Methods Thirty-seven treatment naïve T-LBL patients with PET-CT scans were enrolled. TMTV was obtained using the 41% maximum standardized uptake value (SUVmax) threshold method, and TLG was measured as metabolic tumor volume multiplied by the mean SUV. Progression-free survival (PFS) and overall survival (OS) were analyzed by Kaplan-Meier curves and compared by the log-rank test.Results The optimal cutoff values for SUVmax, TMTV, and TLG were 12.7, 302 cm3, and 890, respectively. A high SUVmax, TMTV, and TLG indicated a shorten PFS and OS. On multivariable analysis, TMTV ≥ 302 cm3, and central nervous system (CNS) involvement predicted inferior PFS, while high SUVmax, TLG and CNS involvement were associated with worse OS. Subsequently, we generated a risk model comprising high SUVmax, TMTV or TLG and CNS involvement, which stratified the population into three risk groups, which had significantly different median PFS of not reached, 14 months, and 7 months for low-risk group, mediate-risk group, and high-risk group, respectively (p < 0.001). Median OS were not reached, 27 months, and 13 months, respectively (p < 0.001).Conclusion Baseline SUVmax, TMTV, and TLG measured on PET-CT are strong predictors of worse outcome in T-LBL. A risk model integrating these three parameters with CNS involvement identifies patients at high risk of disease progression.