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김경애,정유진,안나리,장혁기 서울여자대학교 자연과학연구소 2013 자연과학연구논문집 Vol.25 No.-
We reviewed literatures on human brain activity on exercise. It was proved that exercise activate brain function through various equipments. Among methods to evaluate brain activation, there are Electroencephalography (EEG), Magnetoencephalography (MEG), transcranial doppler sonography (TCD), Magnetic resonance imaging (MRI), Near Infrared Spectroscopy (NIRS) methods. There were different characteries in each measurement methods to demonstrate exercise effects. NIRS is a spectroscopic method that uses the near infrared region of the electromagnetic spectrum. According to using brain scanning equipments involved NIRS, moderate exercise increased frontal lobe (specially prefrontal cortex) and improves cognitive performance. This review will be discussed about brain activation and cognitive functions.
정신분열병의 인지적 표지자와 Catechol-O-Methyltransferase Val158Met 유전자 다형성의 연합연구
박해정,박동연,조은영,김나라,전현옥,이유상,이동수,홍경수 대한신경정신의학회 2008 신경정신의학 Vol.47 No.2
Objectives : Catechol-O-methyltransferase (COMT) gene has been identified as a positional and functional candidate gene of schizophrenia. Although specific mechanism of increasing schizophrenia susceptibility by this gene has not been well described yet, recent studies suggest that the valine allele of COMT Val158Met polymorphism may contribute to cognitive decline in schizophrenia. The present study investigated the association between this polymorphism of COMT gene and cognitive markers related to schizophrenia in both schizophrenia patients and normal controls. Methods : The subjects were 78 patients with schizophrenia diagnosed by DSM-IV and 97 normal controls. Comprehensive neurocognitive tests for which performance deficits have been reported in schizophrenia were administered. Genotyping for COMT Val158Met polymorphism was done with SNapShot method. Association analyses between genotype and cognitive functions were performed using ANCOVA and MANCOVA. Results : In the comparison of allele frequencies between patient and control groups, no significant association between the polymorphism and schizophrenia was observed. Significant differences of cognitive performance among genotype groups were not identified in control group. This trend was also observed in the patient group. In the combined analysis of both patient and control groups, there was no significant genotype or genotype-by group effect on any cognitive function measure. Conclusion : These findings do not support a major role of COMT gene in the regulation of the cognitive processes of schizophrenia.
남성화 암쥐의 모리스 수중 미로 수행력 : 성에 따른 공간기억력과 테스토르테론 효과의 차이
신성현,박제민,정우영,박문일,서유나,김성곤,강철중 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.5
Objectives : It is widely accepted that gonadal steroids are involved in organization and activation of sexual dimorphism in the brain areas related with spatial leaming. This study aimed to test the following hypothesis : 1) spatial memory is affected by sex, 2) this difference is related with brain differentiation by exposure to testosterone in the neonatal period, and/or 3) the sexual difference of spatial memory is the result of the interaction between organization of sexual dimorphism in the brain and the circulating testosterone after growing up. Methods : Testosterone enanthate 100 ㎍, ('androgenized') orvehicle ('control') was randomly administered to 28 female and 25 male rat pups within 24 hour of birth. The escape latencies (EL) in Morris water maze were measured in 15 and 16 week of age with vehicle ('baseline') and with 10 μmol/kg of testosterone ('with testosterone'), respectively. Each session Consis-ted of 10 trials, and means of the last 5 trials were analyzed. Results : The baseline EL of the males were significantly shorter than females regardless ofneonatal exposure to testosterone. With testosterone, EL of the androgenized females were significantly shorter than control females and comparable to those of males. Conclusion : Neonatal exposure to testosterone in female rats may develop a tesosterone-dependent male-like spatial leaming system.
녹동균 세포외막 단백질 백신 CFC-1-101의 안정성 및 면역원성 검토 : 임상 제 Ⅰ/Ⅱa상 시험
장인진,김익상,유경상,임동석,김형기,신상구,장우현,박완제,이나경,정상보,안동호,조양제,안보영,이윤하,김영지,남성우,김현수 대한감염학회 1998 감염 Vol.30 No.3
목적 : 제일제당에서는 녹농균의 세포외막 단밸질을 유효성분으로 하는 백신인 CFC-101을 개발하였으며, 동물시험에서 이 백신의 안전성과 유효성을 입증하였다. 본 연구에서는 이 녹농균 백신의 인체에 대한 안전성과 면역원성을 평가하는 동시에 인체 접종시의 최적 투여 용량을 결정하기 위하여 제 I/Ⅱa상 임상시험을 수행하였다. 방법 : 건강한 성인 남자를 피험자로 선별하여 각 용량군에 백신투여자 6명, 위약투여자 2명을 배정하였다. 백신 투여군은 0.25mg, 0.5mg 또는 1.0mg 용량의 녹농균 백신을 7일 간격으로 3회에 걸쳐 근육주사 하였으며, 위약 투여군에게는 세포외막 단백질을 제외한 동일한 성분을 투여하였다. 백신접종 후 국소적 또는 전신적인 반응의 발생여부를 관찰하고, 혈액시료를 체취하여 백신의 역가와 유효성을 검정하였다. 결과 : 녹농균 백신 CFC-101은 모든 접종자에서 양호한 내약성을 보였다. 또한 0.5mg 과 1.0mg 백신 투여군에서는 100%의 항체양전율을 나타내었다. 생성된 항체는 녹농균 세포외막단백질에 특이성을 보였고, 녹농균 감염에 대해 방어효능이 있었다. 결론 : 이와같은 결과로부터 이 녹농균 백신은 인체에 안전하게 투여할 수 있으며, 높은 항체 생성능으로 감염방어 효능을 보이고 0.5mg과 1.0mg이 최적용량인 것으로 판단되었다. Background : We developed a Pseudomonas aeruginosa outer membrane protein(OMP) vaccine CFC-101, and the prophylactic efficacy of which has been demonstrated in animal models. In order to evaluate the safety and immunogenicity of the P. aeruginosa vaccine, we carried out a phase I/Ⅱa clinical trial in healthy male volunteers. Methods : Groups of eight volunteers, including two placebo subjects, were vaccinated intramuscularly with three doses of 0.25, 0.5 or 1.0 mg of the vaccine at one week intervals. Sings of systemic and local reactions observed after vaccination were recorded for each vaccinee for 5 days. Physical examinations were performed on days 0, 1, 7, 8, 14, 15, 21, and 42, and clinical laboratory tests were done on days 0, 3, and 21. Blood samples for assay of serum antibody levels were obtained up to 42 days after the first vaccination. Results : The vaccine was generally well tolerated by all vaccinees, showing no significant side effects. In the three dosage groups, all vaccinees, except one receiving the 0.25 mg dose, showed significant elevation in serum IgG antibody titers against the vaccine proteins, indicating 100% seroconversion in 0.5 and 1.0 mg groups. The human antibodies induced by the vaccine were specific for P. aeruginosa OMPs, as confirmed by western blot analysis and immunoprecipitation assays. The capacity of the human antisera to enhance opsonophagocytic killing activity by polymorphonuclear leukocytes and to confer protection against P. aeruginosa infections indicates that the antibodies elicited by the vaccine have protective efficacy. Conclusion : We conclude that the P. aeruginosa OMP vaccine is safe and effective for human use and its optimal dose to be 0.5 or 1.0 mg.
P279 : The effects of freeze dried extract of dangyuja (citrus grandis osbeck) on melanogenesis
( Yu Na Lee ),( Hae Jeong Youn ),( Min Jung Kim ),( Soo Young Kim ),( Nam Kyung Roh ),( Ho Jung Jung ),( Yu Ri Kim ),( Jae Wook Jung ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Although previous studies have identified that both the fruit and leaf of dangyuja (Citrus grandis Osbeck) exhibits anticancer, antioxdant and anti-inflammatory effect, the inhibitory effect of melanogenesis have not been reported. Objectives: In this study, freeze dried extract of dangyuja was evaluated for their potential to inhibit melanogenesis. Methods: Cytotoxicity and melanin content in mouse B16F10 melanoma cells were assayed after treatment with the freeze dried extracts of dangyuja. Results: Freeze dried extracts of dangyuja strongly decreased the tyrosinase activity for catalysis of L-dihydroxyphenylalanine (L-DOPA) oxidation in a dose- dependent manner. The results demonstrate that extracts possessed low cytotoxic activity and that melanin content was reduced. Conclusion: Freeze dried extracts of dangyuja is a safe natural materials that show an effective inhibition of melanogenesis. These results suggest that freeze dried extracts of dangyuja can be considered as an effective skin whitening reagent for application in cosmetics.
New-onset of palmoplantar pustulosis while on adalimumab treatment for ankylosing spondylitis
( Yu Na Lee ),( Ho Jung Jung ),( Yu Ri Kim ),( Jae Wook Jung ),( Hyun Jung Park ),( Hyung Jin Hahn ),( Young Ji Hwang ),( Ji Young Kim ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2012 대한피부과학회 학술발표대회집 Vol.64 No.1
P135 : Analysis of the safety and efficacy of three natural extracts in cosmetics
( Yu Na Lee ),( Hae Jeong Youn ),( Min Jung Kim ),( Soo Young Kim ),( Nam Kyung Roh ),( Ho Jung Jung ),( Yu Ri Kim ),( Jae Wook Jung ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: The function of sebum in human is reducing water loss from the skin``s surface and protecting the skin from infection by microorganism. However, when there is excessive secretion of sebum, it will cause black heads and expansion of the pores so that waste will be accumulated. Objectives: To develop cosmetics for sebum removal and pore improvement that can improve limitations of the existing products. The ingredients include Diospyros kaki (D. kaki ), Castanea crenata (C. crenata), and Polygonum cuspidatum (P. cuspidatum) and to verify the safety and human efficacy evaluation. Methods: Bacteria microbial limit test and patch test performed with 31 participants. Also, with 23 participants who have oily skin, efficacy evaluation was performed. Changes in the amount of sebum, moisture, dead skin condition, blackhead, skin roughness between before and after the test were compared for control group. Results: As a result of safety assessment, there was no pathogenic microorganism for microbial limit test and, there was no skin reactions for patch test. For changes in the amount of sebum and black head from efficacy evaluation,there was temporary improvement for the experimental group. For the amount of moisture, dead skin, and skin roughness of the experimental group showed improvement. Conclusion: When being complemented with body application test for long-term usage, they can be used as natural ingredients when cosmetic manufacturers or sellers are developing new products.
( Ho Jung Jung ),( Nam Kyung Roh ),( Soo Young Kim ),( Yu Ri Kim ),( Yu Na Lee ),( Jae Wook Jung ),( Hyung Jin Hahn ),( Hyun Jung Park ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: T.rubrum is most common fungal pathogens that causes tinea pedis and onychomycosis. Due to limitation of current treatment options, alternative therapies are desirable. We investigated inhibitory effect of UVC, terbinafine liquid and Natural Extracted Anti-fungal Material on T. rumbrum in vitro. Objectives: Total 25 plate was cultured for 10 days on mycosel agar plate; 5 strains of T. rubrum and 5 copies for each strain. They are divided into 5 groups for control, UVC irradiation, terbinafine spray, Biocleanact spray(natural extracted anti-fungal material), UVC and Biocleanact spray group. Methods: The cultured media were irradiated for 1 hour daily for 3 weeks in the germicidal lamp emitting 253.7 nm(UVC) and power of 11mW/cm2 at 10cm distance. Terbinafine liquids and Biocleanact was sprayed respectively twice on the surface to fully cover the colony area. We measured the median diameter of each colony every other day for 3 weeks. And analyzed the change of colony diameter and growth rate. Results: The UVC had barely no effect to restrain the growth of T. rubrum, similar with growth of the control group. However, both the terbinafine spray and Biocleanact slowed down the growth rate remarkably and showed similar effect. Conclusion: We could only figure out the fungistatic effect, but not the fungicidal effect in vitro. UVC irradiation settings in this study totally not effective. In the further study, more variable wavelength and fluences of UVC irradiation should be investigated.