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Yozo Sato,Shigeru Matsushima,Yoshitaka Inaba,Tsuyoshi Sano,Hidekazu Yamaura,Mina Kato,Yasuhiro Shimizu,Yoshiki Senda,Tsuneo Ishiguchi 대한영상의학회 2015 Korean Journal of Radiology Vol.16 No.3
To retrospectively evaluate relative enhancement (RE) in the hepatobiliary phase of gadoxetic acid disodium-enhanced magnetic resonance (MR) imaging as a preoperative estimation of future remnant liver (FRL) function in a patients who underwent portal vein embolization (PVE). In 53 patients, the correlation between the indocyanine green clearance (ICG-K) and RE imaging was analyzed before hepatectomy (first analysis). Twenty-three of the 53 patients underwent PVE followed by a repeat RE imaging and ICG test before an extended hepatectomy and their results were further analyzed (second analysis). Whole liver function and FRL function were calculated on the MR imaging as follows: RE x total liver volume (RE Index) and FRL-RE x FRL volume (Rem RE Index), respectively. Regarding clinical outcome, posthepatectomy liver failure (PHLF) was evaluated in patients undergoing PVE. Indocyanine green clearance correlated with the RE Index (r = 0.365, p = 0.007), and ICG-K of FRL (ICG-Krem) strongly correlated with the Rem RE Index (r = 0.738, p < 0.001) in the first analysis. Both the ICG-Krem and the Rem RE Index were significantly correlated after PVE (r = 0.508, p = 0.013) at the second analysis. The rate of improvement of the Rem RE Index from before PVE to after PVE was significantly higher than that of ICG-Krem (p = 0.014). Patients with PHLF had a significantly lower Rem RE Index than patients without PHLF (p = 0.023). Relative enhancement imaging can be used to estimate FRL function after PVE.
Tomonori Tetsunaga,Toru Sato,Naofumi Shiota,Tomoko Tetsunaga,Masahiro Yoshida,Yoshiki Okazaki,Kazuki Yamada 대한정형외과학회 2015 Clinics in Orthopedic Surgery Vol.7 No.2
Postoperative pain relief can be achieved with various modalities. However, there are only few reports that have analyzed postoperative analgesic techniques in total hip arthroplasty patients. The aim of this retrospective study was to compare the postoperative outcomes of three different analgesic techniques after total hip arthroplasty. Methods: We retrospectively reviewed the influence of three analgesic techniques on postoperative rehabilitation after total hip arthroplasty in 90 patients divided into three groups (n = 30 patients per group). Postoperative analgesia consisted of continuous epidural analgesia (Epi group), patient-controlled analgesia with morphine (PCA group), or a continuous femoral nerve block (CFNB group). We measured the following parameters relating to postoperative outcome: visual analog scale scores, the use of supplemental analgesia, side effects, length of the hospital stay, plasma D-dimer levels, and the Harris hip score. Results: Each group had low pain scores with no significant differences between the groups. The PCA group had a lower frequency of supplemental analgesia use compared to the Epi and CFNB groups. Side effects (nausea/vomiting, inappetence) and day 7 D-dimer levels were significantly lower in the CFNB group (p < 0.05). There were no significant differences between the groups in terms of the length of the hospital stay or the Harris hip score. Conclusions: Although there were no clinically significant differences in outcomes between the three groups, the CFNB provided good pain relief which was equal to that of the other analgesics with fewer side effects and lower D-dimer levels in hospitalized patients following total hip arthroplasty.
Takayama, Yuki,Taketa-Sato, Midori,Komori, Hirofumi,Morita, Kumiko,Kang, Su-Jin,Higuchi, Yoshiki,Akutsu, Hideo The Chemical Society of Japan 2011 Bulletin of the Chemical Society of Japan Vol.84 No.10
<P>Cytochrome <I>c</I><SUB>3</SUB> possesses four hemes in a compact configuration and exhibits extremely low reduction potentials. Besides the well-characterized factors contributing to the reduction potentials, the aromatic rings have been suggested to be involved. To elucidate its mechanism, the effect of mutations at conserved and noncoordinated aromatic residues on the reduction/oxidation properties of heme irons was investigated on the basis of crystal structures, NMR spectra of coordinated His, and reduction potentials. Phe20 parallel to heme 1 is the most conserved residue. On its mutation, the change in each coordination structure was subtle in the crystal structures despite of significant changes in the NMR spectra and reduction potentials. Significant increases in the reduction potentials of heme 1 led to the conclusion that the aromatic ring of Phe20 stabilizes the polarization of the π-electron density induced by the oxidized iron in the same heme. Furthermore, the reduction potential of heme 2 was also affected by the mutation at Phe20, revealing that the electrostatic interaction between the π-electron system of the porphyrin and a distant iron contributes to the iron reduction potential. This kind of interaction provides new insight into the role of the heme architecture in regulation of the reduction potentials.</P>
Physical Properties of a New Ternary Compound RP₃Al<SUB>5</SUB> (R = rare earth)
Hiroto Fukuda,Takatsugu Koizumi,Yoshiki J. Sato,Yusei Shimizu,Ai Nakamura,Dexin Li,Yoshiya Homma,Atsushi Miyake,Dai Aoki,Masashi Tokunaga,Ryoma Kato,Masanobu Shiga,Tatsuya Kawae,Fuminori Honda 한국물리학회 2023 새물리 Vol.73 No.12
Electronic properties of a new ternary f-electron system RP ₃Al<SUB>5</SUB> (R: rare earth elements) have been investigated. RPt ₃Al<SUB>5</SUB> crystalizes in the CePt ₃Al<SUB>5</SUB>-type orthorhombic structure where R atoms form 1-dimensional chains along the b-axis. LaPt ₃Al<SUB>5</SUB> shows superconductivity below 0.4 K, while others show magnetic ordering. CePt ₃Al<SUB>5</SUB> orders antiferromagnetically below T<SUB>N</SUB> = 1.2 K with spontaneous moment and shows successive magnetic transition at T<SUB>m</SUB> = 0.9 K. The nearly divalent antiferromagnet EuPt ₃Al<SUB>5</SUB> indicates an unusual valence cross-over behavior into the nearly trivalent state under high pressure of 9 GPa. It is also found that most of RPt ₃Al<SUB>5</SUB> orders antiferromagnetically and, in some cases, shows characteristic features in magnetic suscep- tibility, where the broad maximum appears slightly above T<SUB>N</SUB>, reecting the low-dimensional nature.
Ultrasonic Investigation of the Eu-based Intermetallic System EuZn₂Ge₂
Shinya Kudo,Kazuki Saito,Takuto Sato,Mitsuteru Nakamura,Masahito Yoshizawa,Kazuhei Wakiya,Yoshiki Nakanishi,Hikaru Hirabayashi,Shinji Michimura,Masashi Kosaka 한국물리학회 2023 새물리 Vol.73 No.12
In this study, an elastic property of EuZn₂Ge₂ with the tetragonal ThCr₂Si₂-type structure has been investigated by ultrasonic measurements. Elastic constants C<SUB>33</SUB> and C<SUB>44</SUB> were measured as a function of temperature and magnetic _eld applied along the [001] direction. A previous study reported that EuZn₂Ge₂ exhibited three magnetic phase transitions at T<SUB>N1</SUB> = 14.9 K, T<SUB>N2</SUB> = 8.4 K, and T<SUB>t</SUB> = 5 K. We found that an elastic anomaly appeared in the temperature dependence of both of C<SUB>33</SUB> and C<SUB>44</SUB> at T<SUB>N2</SUB>. On the other hand, the corresponding anomaly was hardly visible at T<SUB>N1</SUB> and T<SUB>t</SUB>. These results suggest that a magneto-elastic coupling at T<SUB>N2</SUB> may be relatively large compared with those at T<SUB>N1</SUB> and T<SUB>t</SUB>.
Susumu Yoshino,Riyo Awa,Yasuo Miyake,Ikuo Fukuhara,Hisao Sato,Yoshiki Endo,Shinpei Tomita,Hiroshige Kuwahara 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.11
This study's aim was to evaluate the safety of daily consumption of Kaempferia parviflora extract (KPE) using a randomized double-blind placebo-controlled study with 52 recruited healthy Japanese subjects. Each subject received five KPE tablets (containing 150 mg of KPFORCE™/tablet) or placebo daily for 4 weeks. There were no adverse events related to KPE intake or any abnormalities compared with placebo group in anthropometric, cardiovascular, blood, and urine parameters during the course of the study. Thus, daily KPE ingestion was found to be safe in healthy Japanese men and women.