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Masahiro Takeuchi,Takefumi Katsuki,Kumiko Yoshida,Kumiko Yoshida,Michinori Iwamura,Toshihiro Inokuchi,Akira Furutani,Tomoe Katoh,Kazuaki Kawano,Keiji Hirata 한국유방암학회 2021 Journal of breast cancer Vol.24 No.5
Locally advanced breast cancer (tumor > 5 cm, widespread infiltration of the skin and muscle, or metastases to lymph nodes) is difficult to resect by surgery, and even when it is resectable, there is a high probability of local recurrence and distant metastasis. Therefore, systemic therapy should be administered first. However, as cutaneous infiltration progresses, the patient's quality of life is impaired by pain, bleeding, presence of exudates, and a foulsmelling odor. Treatment with Mohs paste with systemic therapy can control symptoms associated with skin infiltration and can also be expected to decrease tumor volume. Herein, we report a case in which a tumor was resected following Mohs paste and systemic chemotherapy administration, and the skin defect was reconstructed with a latissimus dorsi myocutaneous flap. We also review the literature for previously reported cases of breast cancer involving Mohs paste.
Recent topics on the engineering for solid-state peak-power lasers in repetitive operation
Masahiro Nakatsuka,Hidetsugu Yoshida,Hisanori Fujita,Kana Fujioka,Yasushi Fujimoto,Yasushi Fujimoto 한국물리학회 2003 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.43 No.42
Solid-state lasers have been developed for peak-power operation in the terawatt to petawatt regions by using chirped pulse amplication (CPA) and optical parametric (OPCPA) technology. Also thermal distortion-free, 10-nsec repetitive peak-power lasers have been developed. Broadband amplication of a solid-state laser is a key issue for the pre-amplication stage of CPA system, and the OPA scheme gives a high gain with a very low pre-pulse level while keeping a 5-nm bandwidth. On the other hand, nonlinear optical technology using stimulated Brillouin scattering (SBS) is promising as a way to compensate for thermal diculties caused in strongly pumped laser materials. SBS is well known for the phase conjugation mirror (PCM) used for an average power output with a high re ectivity of over 95 %. A liquid uorocarbon with a special treatment can be used to achieve a 10-ns duration, 50-Hz repetition laser delivering 0.4-GW peak power, with a 200-W average power. A liquid ow system in an SBS cell can be used to realize PCM behavior up to the kW range. The last theme in this paper is a short review of new ceramic materials for a scalable solid-state laser. In past ten years, Japanese researchers have investigated new transparent ceramic YAG materials for industrial application. The ceramics have many advantages for an average power laser, such as high doping rate, co-doping potential, large-size fabrication, and composite structure.
YOSHIDA, Hidetsugu,NAGASAWA, Muneyuki,OKADA, Hajime,FUJITA, Hisanori,NAKATSUKA, Masahiro,PARKS, Hyunmin レーザー學會 2008 レーザー硏究 Vol.36 No.9
Heavy fluorocarbons and perfluoropolyether liquids are ideal media for high power stimulated Brillouin scat-tering experiments from ultraviolet to infrared laser. Stimulated Brillouin scattering (SBS) reflectivity and threshold of new SBS liquids were measured systematically at four wavelengths (1064, 532, 355 and 266 nm). Fluorinert FC-72, -75, -77 and Galden HT 70, -135 exhibits high reflectivity of over 90 % and excellent fidel-ity in phase conjugation for over 100 mJ, 10 ns optical pulse at 1064, 532, and 355 run. Among them, FC-77 and HT 70 were found to be good candidates to replace FC-72, -75 liquids which previously were known to be a good SBS media up to now. Heavy fluorocarbons and perfluoropolyether liquids are most promising as a phase conjugate SBS mirror for all solid-state high-energy lasers because of its high damage threshold and low absorbance.
Surface durability of WC/C-coated case-hardened steel gear
Masahiro Fujii,Masanori Seki,Akira Yoshida 대한기계학회 2010 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.24 No.1
The purpose of this study is to investigate the influence of tungsten carbide/carbon (WC/C) coating on the surface durability of casehardened steel gear. Two kinds of WC/C coatings were deposited on the ground gear pair made of chromium molybdenum steel with carburizing and quenching. One is the conventional WC/C coating, and the other is WC/C coating with about 1 μm CrN interlayer. Here,the WC/C-coated test pinion and the WC/C-coated one with CrN interlayer are represented by WT and ST, respectively. Non-coated test pinion is represented by NT. The surface roughness along the tooth profile direction of WT and ST was almost the same as that of NT. A spur gear test was carried out with an IAE power circulating type gear test rig under EP gear oil lubricating condition. The fatal failure mode of the test pinions was pitting due to surface cracking. The fatigue life of WT was longer than that of NT under a maximum Hertzian stress pmax=1700 MPa. On the other hand, under pmax=1900 MPa, that of WT was as long as that of NT due to the peeling occurrence of the coated layer. Under the comparatively low load condition without peeling occurrence, the surface roughness of WT decreased with the increasing number of cycles, and their fatigue life became longer than that of NT. On the contrary, in the case of ST, the peeling of the coated layer occurred at a comparatively early stage of the gear test, and the dedendum was worn by tens of micrometers. Therefore, in the case of ST, the effect of the WC/C coating disappeared at a comparatively small number of cycles.
Yoshida-Ohuchi, Hiroko,Kanagami, Takashi,Naitoh, Yutaka,Kameyama, Mizuki,Hosoda, Masahiro The Korean Association for Radiation Protection 2017 방사선방어학회지 Vol.42 No.1
Background: One of the most urgent issues following the accident at the Fukushima Daiichi nuclear power plant (FDNPP) was the remediation of the land, in particular, for residential area contaminated by the radioactive materials discharged. In this study, the effect of decontamination on reduction of ambient dose equivalent outdoors and indoors was evaluated. The latter is essential for residents as most individuals spend a large portion of their time indoors. Materials and Methods: From December 2012 to November 2014, thirty-seven Japanese single-family detached wooden houses were investigated before and after decontamination in evacuation zones. Outdoor and indoor dose measurements (n = 84 and 114, respectively) were collected based on in situ measurements using the NaI (Tl) scintillation surveymeter. Results and Discussion: The outdoor ambient dose equivalents [$H^*(10)_{out}$] ranged from 0.61 to $3.71{\mu}Sv\;h^{-1}$ and from 0.23 to $1.32{\mu}Sv\;h^{-1}$ before and after decontamination, respectively. The indoor ambient dose equivalents [$H^*(10)_{in}$] ranged from 0.29 to $2.53{\mu}Sv\;h^{-1}$ and from 0.16 to $1.22{\mu}Sv\;h^{-1}$ before and after decontamination, respectively. The values of reduction efficiency (RE), defined as the ratio by which the radiation dose has been reduced via decontamination, were evaluated as $0.47{\pm}0.13$, $0.51{\pm}0.13$, and $0.58{\pm}0.08$ ($average{\pm}{\sigma}$) when $H^*(10)_{out}$ < $1.0{\mu}Sv\;h^{-1}$, $1.0{\mu}Sv\;h^{-1}$ < $H^*(10)_{out}$ < $2.0{\mu}Sv\;h^{-1}$, and $2.0{\mu}Sv\;h^{-1}$ < $H^*(10)_{out}$, respectively, indicating the values of RE increased as $H^*(10)_{out}$ increased. It was found that the values of RE were $0.53{\pm}0.12$ outdoors and $0.41{\pm}0.09$ indoors, respectively, indicating RE was larger outdoors than indoors. Conclusion: Indoor dose is essential as most individuals spend a large portion of their time indoors. The difference between outdoors and indoors should be considered carefully in order to estimate residents' exposure dose before their returning home.