국내산 중하(Metapenaeus joyneri) 내 주알레르겐 규명 : 가열 및 소화액에 의한 변화

윤성호,김현아,김현미,최정희,서창희,남동호,김윤근,민경업,박해심 대한알레르기학회 2004 천식 및 알레르기 Vol.24 No.2

출산에 따른 그레이브스병의 재발 및 관련이자

임창훈,최현아,한승석,김해성,이창욱,정호연,한기옥,장학철,박원근,윤현구,한인권 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.2

Background: Pregnancy affects the course of Graves' Disease (GD), and patients who initially maintain euthyroid function into their middle trimester with minimum doses of antithyroid drugs become exacerbated after delivery. Even patients who are completely cured, requiring no treatment during pregnancy, can relapse after delivery. In this study, we examined the postpartum changes in the thyroid functions of patients with GD, and attempted to determine the factors contributing to these changes. Methods: The study subjects were recruited from pregnant women visiting our outpatient clinic for routine prenatal evaluations. 45 women previously diagnosed with GD, who had been treated and cured with hyperthyroidism, and were no longer taking any thyroid medications, were evaluated for 1 year post delivery. Results: Among 45 patients, 20 (44.4%) developed thyroid disorders following delivery. Postpartum thyroiditis (PPT) developed in 8 patients (17.8%), and GD developed in 12 (26.0%). The onset of the PPT disease 3.1 ± 1.4 months following delivery, which was significantly earlier than the 6.7 ± 2.7 months required for the post delivery onset of GD (p=0.003). The TBII values, measured during the thyrotoxic state in each womaen, were negative in women with PPT and positive in 71.4% of women with GD (p=0.030). The duration of treatment for hyperthyroidism prior or pregnancy, the number of recurrences, and the time interval without treatment, were not associated with the development of postpartum thyroid disorders. Whereas, the mean number of past pregnancies for women who developed PPT was 3.9 ± 2.1, and was significantly higher than the 2.2 ± 1.7 for women developing no thyroid dysfunctions (p=0.044). In 13 women their initial onset of GD occurred within one year postpartum, 7 (53.8%) having had a recurrence, which was significantly higher than in women whose disease onset occurred unrelated to delivery (5 of 32 women: 15.6%). Conclusion: Women with GD developed postpartum thyroid dysfunctions in 44.4% of cases. Women whose initial disease onset occurred within one year postpartum had higher recurrences of GD, and women who developed PPT had a history of higher gravidity compared to the euthyroid women postpartum. Therefore, if women with GD develop postpartum thyroid dysfunctions, the diagnosis should be made, and a treatment modality planned, following careful considerations of the patients' past obstetric history, changes in clinical manifestations and the TBII values

Determination of Diversity, Distribution and Host Specificity of Korean Laccaria Using Four Approaches

( Hae Jin Cho ),( Ki Hyeong Park ),( Myung Soo Park ),( Yoonhee Cho ),( Ji Seon Kim ),( Chang Wan Seo ),( Seung-yoon Oh ),( Young Woon Lim ) 한국균학회 2021 Mycobiology Vol.49 No.5

The genus Laccaria (Hydnangiaceae, Agaricales) plays an important role in forest ecosystems as an ectomycorrhizal fungus, contributing to nutrient cycles through symbiosis with many types of trees. Though understanding Laccaria diversity and distribution patterns, as well as its association with host plants, is fundamental to constructing a balanced plant diversity and conducting effective forest management, previous studies have not been effective in accurately investigating, as they relied heavily on specimen collection alone. To investigate the true diversity and distribution pattern of Laccaria species and determine their host types, we used four different approaches: specimen-based analysis, open database search (ODS), NGS analysis, and species-specific PCR (SSP). As a result, 14 Laccaria species have been confirmed in Korea. Results regarding the species distribution pattern were different between specimen-based analysis and SSP. However, when both were integrated, the exact distribution pattern of each Laccaria species was determined. In addition, the SSP revealed that many Laccaria species have a wide range of host types. This study shows that using these four different approaches is useful in determining the diversity, distribution, and host of ECM fungi. Furthermore, results obtained for Laccaria will serve as a baseline to help understand the role of ECM fungi in forest management in response to climate change.

Hymecromone 복합제제(Pasmital^�)의 만성담낭염과 Oddi 괄약근 이완 효과에 대한 연구

윤완희,박혜덕,장일성 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.1

Experience at the Cleveland Clinic is that approximately 65 to 70% of patients with symptomatic gallstones are diagnosed as having chronic cholecystitis. Of the group of patients with chronic cholecystitis, approximately 20% have mild, vague symptoms. If the episodes of cholecystitis are not severe, recurrent, and progressive in their intensity or they have poor operative risk, medical treatment include antispasmodic medication is often tried. The purpose of this study was to investigate the effect go hymecromoe combination product(Pasmital^??) given orally in chronic cholecystitis as a medical treatment and to evaluate the pressure changes in the bile duct in postoperative patients received Pasmital^??. 1. Satisfactory symptomatic improvement (Visick grades Ⅰor Ⅱ) was achieved 75.0% after 1 week Pasmital^?? administration and 87.5% after 3 weeks Pasmital^?? administration. 2. There was a mean reduction of bile duct pressure of 31.2% in basal pressure and 36.7% in opening pressure following Pasmital^?? administration. 3. No side effects or abnormal laboratory values attributable to the Pasmital^?? were observed.

U-rantac^ⓡ의 위산 분비억제 효과에 대한 연구

윤완희,장일성,박혜덕 충남대학교 의과대학 지역사회의학연구소 1987 충남의대잡지 Vol.14 No.1

Ranitidine HC1(U-rantac^ⓡ) is a highly effective, rapidly acting histamine H2-receptor antagonist. It inhibit basal and stimulated secretion of gastric acid, reducing both the volume, and the acid pepsin content of the secretion. Now, It has been widely used for treatment of the peptic ulcer. We has investigated the effect of Ranitidine HC1 in the peptic ulcer and stomach cancer in 62 patients who had been admitted to the Department of General Surgery, Chungnam National Universtity Hospital from Jan. 1987 to Apr. 1987. The following results were obtained: 1. The prevalent age in duodenal ulcer was fourth decade, gastric ulcer, fifth decade, and stomach cancer, sixth decade, respectively. 2. The male to female ratio in duodenal ulcer was 2. 8 : 1, gastric ulcer, 2 : 1, and stomach cancer, 1:1. 3. After intramuscular injection of Ranitidine HCl in duodenal ulcer, volume of gastric secretion was decreased in 31ml/hr (36%) in male and 20m1/hr (33%) in female, and gastric acidity was decreased in 3. 5mEq/hr (54. 4%) and 2. OmEq/hr (48.8%), respectively. In gastric ulcer, the volume of gastric secretion was decreased in 14ml/hr (21. 9%) in male and 4m1/hr (7. 7%) in female, and the gastric acidity was decreased in 0. 9mEq/hr (39.0%) and 0. 6mq/hr(23. 1%), respectivly. In stomach cancer, the volume of the gastric secretion was decreased in 17ml/hr (28. 8%) in male and 15ml/hr (25.9%) in female, and the gastric acidity was decreased in 0.5mEq/hr (15.6%) and 0.6mEq,/hr (19.4%), respectively.

Midazolam의 백서 기관평활근 이완효과와 Flumazenil의 길항작용

윤석화,신용섭,손수창,이원형,김혜자,최세진 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2

Midazolam have been used widely as adjuvants in both regional and general anesthesia and in high risk patients in the intensive care unit. In the present study we evaluated the effect of midazolam and antagonistic effect of flumazenil on isolated rat tracheal preparations mounted for recording isometric contractile force. Trachea smooth muscle were contracted with acetylcholine (10^-5M, Ach) and potassium chloride (40mM KC1). Midazolam 5x10 exp (-6)M and 5x10 exp (-5)M produced dose-dependent relaxation and flumazenil (3.2 x 10 exp (-7)M), central antagonist of benzodiazepine, pretreatment had no significant change midazolaminduced relaxation. Midazolam probably did not relax airway smooth muscle by activatong central benzodiazepine receptors, as flumazenil did not block the concentration-related relaxation of midazolam. Our study suggests that flumazenil may be used satety for asthmatic patients who have been with midazolam, as flumazenil did not antagonize airway relaxation elicited by midazolam.

방사선조사와 Paclitaxel의 병합요법에 의한 신내막 과증식억제

장기육,승기배,강동헌,임상현,정해억,임효영,김태균,김연실,채장성,김재형,홍순조,윤세철,최규보 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.6

상악동 아래벽과 상악 대구치 치근사이 위치관계에 관한 방사선학적 연구

박창서,윤혜림 大韓口腔顎顔面 放射線學會 1998 Imaging Science in Dentistry Vol.28 No.1

In this study, radiographic evaluation was made using panoramic radiography and cross-sectional tomography of ?? in male and female adults in their 20's on the relationship between the maxillary sinus floor and the apex of the maxillary molar, to test the accuracy and effectiveness of the cross-sectional tomography, and to use this information in the assessment of preop. and postop. root canal treatment, apical surgery, extraction and implantology. Forty-one adults with an average age of 24.4 years were studied using panoramic radiography and cross-sectional tomography. In panoramic view and cross-sectional view, the position of the apices of maxillary molars were classified as separated, contacted, or protruded type; the general shape of the maxillary sinus floor was evaluated horizontally and vertically from cross-sectional tomography. The accuracy of each radiography was tested using maxilla from 5 fresh cadavers from the Anatomy Lab at Yonsei University Dental College, and panoramic view and cross-sectional tomography were taken in the same condition as with the patients. The results were as follows: 1. Panoramic view and cross-sectional view were taken in the maxilla specimen, and the actual distance between the maxillary sinus floor and the tooth apices were measured in the specimen: the median values of the distance from the tooth apices to the maxillary sinus floor in the panoramic view, cross-sectional view and in the actual maxilla specimen were 2.83mm. 4.51mm, and 4.15mm, respectively. In the cross-sectional view ,the measured distance was close to the actual distance but in the panoramic view, the measured distance was far from the actual distance. 2. When the results of thee panoramic view and cross-sectional view were compared, 40.5% of the results agreed with each other in the two radiographic. Methods and buccal roots of the 2nd molar were the closest to the maxillary sinus floor in the cross-sectional tomography. 3. In cross-sectional view, when the vertical relationship of the maxillary sinus floor and maxillary roots was assessed, in 1st molars type Ⅱ(the sinus floor that extends down to the buccolingual furcation area) was predominant, while in 2nd molars, type I (the sinus floor located above the level connecting the buccal and lingual apices) was predominant. In the horizontal relationship, in 1st molars, type Ⅱ (the lowest floor of the maxillary sinus located in between the buccal and lingual roots) was predominant; in 2nd molars, type I (the lowest floor of the maxillary sinus located on the buccal side of the buccal roots) and type Ⅱ appeared in similar frequency. In conclusion, the ?? cross-sectional tomography was more effective than the frequently used panoramic view, in that the relationship of the maxillary molars and maxillary sinus floor can be evaluated more accurately and the buccolingual cross-sectional view can also be observed. And maxillary sinus floor that was close to maxillary 2nd molar had tendency to be located on buccal side than that close to 1st molar. Therefore, cross-sectional tomography is and effective and accurate method to evaluate the position of the teeth in relation to the sinus floor preoperative and can be easily used to diagnose localized periapical lesions. Also, the image quality obtained was quite satisfactory.

악골에 발생한 석회화 치성낭의 임상 및 방사선학적 고찰

박창서,김기덕,윤혜림 大韓口腔顎顔面放射線學會 1996 Imaging Science in Dentistry Vol.26 No.2

Nine cases presented with a calcifying odontogenic cyst to the Dental Hospital of the College of Dentistry, Yonsei University, from January 1987 to September June, 1996, Clinical or histopathological findings were observed according to each radiologic criteria. The results obtained are as follows: 1. The male to female ratio was 2:1 with a mean age of 25 years. 2. The radiographic appearences of nine cases were well-defined radiolucent lesions in which eight cases were shown unilocular lesions and only one lesion was seen multilocular lesion. 3. Radiologically, three of nine cases were pure radiolucent lesions and others, six cases were radiolucent contained a variable amount of radiopaque material. 4. Histologically, two cases were classified simple cyst, five were cyst associated odonoma, two were neoplastic type. 5. Histlolgical findings according to the radiological classification, two of three radiolucenct lesions were simple cysts; another was a cyst associated with odontoma. While, four of six radiologic mixed lesions turned out to be a cyst associated with odontoma, two was the neoplastic type.

0.5% Bupivacaine을 이용한 척수마취시 마취제의 비중이 마취효과에 미치는 영향

김창열,윤석화,김혜자,최세진 충남대학교 의과대학 지역사회의학연구소 1992 충남의대잡지 Vol.19 No.1

Effects of solutions of 0.5% bupivacaine, containing different concentrations of dextrose (0%, 0.5%, 0.8%, 1%, 3%, 5%, 8%) were studied after intrathecal injection in seven (Group A-Group G) groups of 15 patients. The results are summarized as follows: 1. The mean specific gravity of solutions was 1.0065, 1.0087, 1.0092, 1.0094, 1.0152, 1.0198 and 1.0314 (Group A-Group G). These values are isobaric (Group A, B), hyperbaric (Group E, F, G), and slightly hyperbaric (Group C, D) compared to cerebrospinal fluid at 25℃. 2. The mean maximum level of sensory block was increased according to the increment of specific gravity of the solutions. But no significant differences between Group A and B, Group C and D, Group E, F, and G. 3. The mean time of sensory block to T11 was decreased according to the increment of specific gravity of the solutions. 4. The mean time to the expected level (T4) of sensory block at given dosage of each solution was 25.7, 18.4, 9.7 minutes(Group E, F, G, respectively). 5. Complete motor block of the legs was rapid according to the increment of specific gravity of the solutions.