鹿茸 藥針 製劑가 힌쥐 腎臟 組織의 抗酸化 作用에 미치는 影響

윤철호,정지천,신억섭 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

Cervus elaphus for herb-acupuncture solution (CEHAS) was tested for the effects of free radical generating enzyme and lipid peroxidation in rat's kidney. In vitro, levels of lipid peroxide in tissues of kidney were proportionally decreased to concentration of extracts prepared from CEHAS. They were much more decreased, when lipid perocidation was inducesd with ferrous iron(Fe II). Also, enzyme activities of xanthine oxidase were decreased. The ratio of type conversion of zanthine oxidase was lowered, too. But, it was not seen changes on enzyme activities of aldehyde oxidase. These results suggest that CEHAS decrease the activities of free radical generating enzymes such as xanthine oxidase which form lipid peroxide.

全蝎 抽出物의 抗癲癎效果에 關한 硏究

신현철,윤철호,김종대,정지천,신억섭,허근 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

In convulsion state by PTZ in rat, anticonvulsive effect and some γ-aminobutyric acid (GABA)-related mechanisms of Bythus extract in brain was experimented. It was ingibited GABA-T activity, lipid peroxide generation and xanthine oxidase activity as scheduled administration in vitro and vivo. And the content of brain gutathione was increased as scheduled administration in rat. In convulsion state by PTZ of previously managed rat by Buthus extract, onset eime and duration were non-specific changes but recovery time and severity was remarkably reduced. In conclusion speculated that Buthus extract inhibits convulsion by control of GABA content in brain.

동종골수이식 환자에서 발생한 지역사회발생 Parainfluenza virus 3형 폐렴 1예

신종욱,조요한,강철인,김성한,이상윤,김의석,오명돈,이환종,박선양,김병국,최강원 대한감염학회 2002 감염 Vol.34 No.5

다중이용시설내 공기중 바이오에오로졸 농도분포 특성에 관한 연구

이철민,김윤신,이태형,박원석,홍승철 한국환경과학회 2004 한국환경과학회지 Vol.13 No.3

This study was conducted to evaluate the characterization of airborne bioaerosol in public facilities in Seoul. A total of 17 public facilities were investigated from December, 2002 to February, 2003. As results of the survey, the mean concentrations of bacteria and fungi in indoor air of public facilities were 378.08±296.33 CFU/m³ by RCS and 106.38±171.63 CFU/m³ and 347.46 ± 335.32 CFU/m³ and 95.23±62.61 CFU/m³, by Six-stage cascade air sampler respectively. The mean concentrations of bacteria in indoor air (by ventilation method) were 517.14± 343.93 CFU/m³ of natural ventilation and 215,83±100.71 CFU/m³ of mechanical ventilation. The mean concentrations of fungi in indoor air (by ventilation method) were 83.14±79.16 CFU/m³ of natural ventilation and 133.50±248.07 CFU/m³ of mechanical ventilation. The mean concentrations of bacteria in indoor air were 449.44 CFU/m³ for the ground and 217.50±103.68 CFU/m³ for the underground. The mean concentrations of fungi in indoor air were 63.89±77.66 CFU/m³ for the ground and 202.00±290.08 CFU/m³ for the underground.

도시근린공원의 이미지와 이용만족도에 관한 연구

하영철,정수일,곽윤근,신현익,하헌정,김익환,김석만 金烏工科大學校 1999 論文集 Vol.20 No.-

This paper presents the future direction of the development and maintenance of the urban park of the Kumi city. The direction was obtained by analyzing the evaluation results on the satisfaction level of park use and the park image of the park users. The analysis results are as follows. 1) It turns out that the rest and accommodation facilities are the major facilities that uplifts the total image of the park. 2) Among the park images, the image on the pleasantness was the major image, related with the satisfaction on the park equipments. 3) The social class, who gave a bad score on the above equipments and images, is a low-aged class, who is a white class with high income as well. Therefore, it is suggested that the park maintenance plan, with emphasis on the class, is an important task.

대기오염지역과 청청지역의 초등학생 폐기능 검사에 관한 연구

김윤신,이철민,조용성,최원욱 한양대학교 환경및산업의학연구소 2000 環境과 産業醫學 Vol.9 No.1

During July 1996, Junejuly 1997, a pilot study to investigate effects of air pollution on school children's health was undertaken in polluted areas and a clean area, Korea. To examine the pulmonaly function of 790 boys and girls from selected four elelmentary schools in Yechon, Ulsan, and Sokcho, respectively, a standard respiratory questionnaire was administered and pulmonary function tests were performed. There was a significant difference in the level and criteria of impediment-scale of pulmonafy function(FEV1.0 and FVC) between exposed groups to polluted area and clean area. The surveyed prevalence of major diseases and past histoly of major diseases was shown higher response rate in polluted area than non-polluted area. The additional longitudinal study that carefully monitors air pollutants and health data should be conducted to confirm these results. Key Words : Health effect, Air pollution, Pulmonary function test(PFT)

서울시 일부 대기 중 라돈농도의 분포에 관한 연구

김윤신,이철민,김현탁,이홍석,박태술 한양대학교 환경및산업의학연구소 2000 環境과 産業醫學 Vol.9 No.1

A study of atmospheric radon concentrations survey in Korea, Seoul was carried out with ERM(Electrostatic Radon Monitor) from October 1998 to September 1999. The mean of atmospheric radon concentrations 4.79Bq/㎥ at Seoul. Radon concentration were distributed 3.65-8.71Bq/㎥. The seasonal pattern seems to be relatively higher during the autumn and relatively low during the spring. The result from correlation analysis was significant obtained between atmospheric radon concentrations and meteorological factor.

성인 급성 백혈병의 치료에 관한 연구

김종완,장준,신승훈,윤일국,박철신,김삼용 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2

19 adult ALL patients were treated with follwing regimens; VP regimen to 5 patients, VPA regimen to 4 patients, multi-drug combined intensive therapy of Hoelzer regimen to 10 patients. The results of therapy are as follows: 1. Complete remission occured in 3 patients on VP regimen(60%), 4 patients on VPA regimen (100%), 8 patients on Hoelzer regimen (80%), respectively, and overall complete remission rate was 78.9%. 2. Mean survival time of total patients was 13.8 months, and in complete remission group, it was 16.2 month, but in non-complete remission group, it was 1.8 month. 3. Factors favorable for complete remission were absence of organomegaly(P<0.05) and initial leukocyte count under 30,000/㎟(P<0.01), factors favorable for the survival duration were initial leukocyte count under 30,000/㎟(P<0.05) and remission within 4 weeks of treatment.(P<0.01). 4. Recurrence rate were 40% in VP regimen, 50% in VPA regimen, and 20% in Hoelzer regimen. 5. During the remission induction period, common side effects of chemotherapy were alopecia, nausea, vomiting, mucositis, and general weakness and it was severe in VPA regimen and Hoelzer reimen than in VP regimen. But no significant difference was noted between VPA regimen and Hoelzer regimen. From the above results, we could confirm the importance of multiple drug combined intensive chemotherapy of remission regimen and periodic reinduction chemotherapy.

공기청정기의 일부 실내공기 오염물질 제거효율에 관한 연구

이태형,김윤신,홍승철,이철민,김종철,전형진,김중호 한국환경과학회 2005 한국환경과학회지 Vol.14 No.5

In this study, we investigated PM_(10), NO₂, and 1-hydroxypyrene(1-OHP) in urine at indoor environments which are 35 houses and 20 hospitals for using air cleaner and non-using air cleaner in Seoul metropolitan area and Kyoung-gi province from April, 2003 to February, 2004. Moreover, we examined effect of improvement for indoor air quality and health effect by concentration of 1-OHP also we investigated removal efficiency by air cleaner for PM_(10), NO₂, and 1-OHP that were 28.5%, 27.4%, and 42.1% respectively. Concentration of PM_(10), NO₂, and 1-OHP were 19.02±18.14μg/m³, 8.66±3.06ppb, and 0.19±0.18μg/g creatinine when air cleaner was no worked. The concentration for PM_(10), NO₂ and 1-OHP were 13.60+10.79μg/m³, 6.29±2.71ppb, and 0.11±0.10μg/g creatinine, respectively. It was significant statistically. Therefore, it is considered using the air cleaner to remove the partial pollutants in indoor environment and is positive effect for health.

서울시 도로변 오존 측정농도에 관한 분석

박원석,김윤신,이종태,홍승철,이철민 한국보건통계학회 2003 보건정보통계학회지 Vol.28 No.2

The purpose of this study is to analyze the change of the concentration of ozone in Seoul in accordance with the automobile traffic by using the daily highest concentration of O₃, CO, and the daily average concentration of NO₂ among the data stemmed from the automatic air pollution measurement network in the streets of Seoul. The data used in this study were measured in the streets of heavy traffic in Seoul between the period of 1998 and 2000. In particular, the concentration data of O₃, CO and NO₂ were used among the measured data. The used data were divided into the days of the week, lead to compare the concentration of O₃, NO₂ and CO between Friday, the most heavy traffic day, and Sunday, the most light traffic day of the week. In this study, the concentration of NO₂ and CO on Friday were higher than that of Sunday due to the influence by the automobile traffic in Seoul, while the concentration level of O₃ was higher on Sunday than on Friday. It's probably because Seoul, which contain the characteristics of the polluted city area, satisfied the VOC-limited condition that the O₃ concentration had not been lowered, despite the lowered concentration of NO₂ and CO due to the reduced automobile traffic on Sunday, comparing to Friday. It is my understanding that Seoul area where this study has been implemented has more possibility of having the VOC-limited condition and accordingly it is believed to be more effective to control the VOC sources than reducing the exhausting amount of NO_(x). Based on the result of this study, the concentration of O₃ in Seoul is not stemmed from the automobile traffic. since this study utilized data measured on the streets of Seoul, it is urgently required to implement studies more broadly and variously based on this study, paving the way toward reducing the maximum ozone concentration.