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말초성 신경아세포종 : 두개골 발생 증례 보고 Involving Skull
박양화,권익승,류연석,신미경,최문배,홍승관,문명선 대한신경외과학회 1988 Journal of Korean neurosurgical society Vol.17 No.4
The peripheral neuroblastomas are malignant neoplasms that originate from the adrenal gland and sympathetic nervous tissues. They usually occur in childhood. They exhibit such malignant features that they metastasize early to lung, liver, bone, rarely skull and other structures. The patients with peripheral neuroblastoma have short duration of symptom and short survival period. They reveal the characteristic light microscopic features that resemble other small cell carcinomas. The establishment of final diagnosis of peripheral neuroblastoma needs various special stainings for small cell carcinomas, and the electron microscopic findings are the most reliable. The authers recently experienced a case of peripheral neuroblastoma in a 26-year old man which involved right frontoparietal skull vault. The only chief complaint was a local non-tender mass at right frontoparietal scalp. Neither headache nor any neurological deficits was detected. Simple skull X-ary revealed a punched out rediolucency at right frontoparietal bone and brain CT showed a superficial elliptical high density mass that enhanced strongly. The mass was totally removed by wide craniectomy. The tumor invaded and penetrated the dura but the arachnoid membrane. at the tumor bed was not invaded by the tumor. The tumor was confirmed as peripheral neuroblastoma by various special stainings for small cell carcinomas. Following surgical resection of the mass, post-operative radiotherpy was offered(4800 rads for about 5 weeks). The patient aggrevated progressively and showed numerous metastases to such bones as lumbar vertebrae, pelvis and humerus to became paraplegic. 8 months after the operation, the patient died.
Shin, Yeun-Kyung,Li, Yang,Liu, Qiang,Anderson, Deborah H.,Babiuk, Lorne A.,Zhou, Yan American Society for Microbiology 2007 Journal of virology Vol.81 No.23
<B>ABSTRACT</B><P>Recent studies have demonstrated that influenza A virus infection activates the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway by binding of influenza NS1 protein to the p85 regulatory subunit of PI3K. Our previous study proposed that two polyproline motifs in NS1 (amino acids 164 to 167 [PXXP], SH3 binding motif 1, and amino acids 213 to 216 [PPXXP], SH3 binding motif 2) may mediate binding to the p85 subunit of PI3K. Here we performed individual mutational analyses on these two motifs and demonstrated that SH3 binding motif 1 contributes to the interactions of NS1 with p85β, whereas SH3 binding motif 2 is not required for this process. Mutant viruses carrying NS1 with mutations in SH3 binding motif 1 failed to interact with p85β and induce the subsequent activation of PI3K/Akt pathway. Mutant virus bearing mutations in SH3 binding motif 2 exhibited similar phenotype as the wild-type (WT) virus. Furthermore, viruses with mutations in SH3 binding motif 1 induced more severe apoptosis than did the WT virus. Our data suggest that SH3 binding motif 1 in NS1 protein is required for NS1-p85β interaction and PI3K/Akt activation. Activation of PI3K/Akt pathway is beneficial for virus replication by inhibiting virus induced apoptosis through phosphorylation of caspase-9.</P>
Monitoring of Five Bovine Arboviral Diseases Transmitted by Arthropod Vectors in Korea
Shin, Yeun-Kyung,Oem, Jae-Ku,Yoon, So-Ra,Hyun, Bang-Hoon,Cho, In-Soo,Yoon, Soon-Seek,Song, Jae-Young The Korean Society for Microbiology 2009 Journal of Bacteriology and Virology Vol.39 No.4
A survey was performed in Korea to monitor the prevalence of five bovine arboviruses [Akabane virus, Aino virus, Chuzan virus, bovine ephemeral fever (BEF) virus, and Ibaraki virus] in arthropod vectors, such as Culicoides species. To determine the possible applications of survey data in annual monitoring and warning systems in Korea, we examined the prevalence of bovine arboviruses in arthropod vectors using RT-PCR. To compare the sensitivity and specificity of virus detection, nested PCR was also performed in parallel for all five viruses. Using the RT-PCR, the detection limits were at least up to $10^{1.5}$, $10^{2.8}$, $10^{2.0}$, $10^{1.8}$, and $10^{4.0}$ $TCID_{50}/ml$ for Akabane virus, Aino virus, Chuzan virus, BEF virus, and Ibaraki virus, respectively. When nested PCR was performed using $1{\mu}l$ of PCR product, the detection limits were increased, to $10^{0.05}$, $10^{1.8}$, $10^{1.0}$, $10^{0.008}$, and $10^{2.0}\;TCID_{50}/ml$ for Akabane virus, Aino virus, Chuzan virus, BEF virus, and Ibaraki virus, respectively. Thus, nested PCR increased the sensitivity of the virus detection limit by 1~2 log. We pooled 30~40 mosquitoes in one sample. We collected 113 samples in 2006, 135 samples in 2007, and 100 samples in 2008. Among these samples, Chuzan virus and BEF virus genes were detected at a range between 0.82% and 1.19%, and Akabane virus, Aino virus, and Ibaraki virus genes were detected at less than 0.20%. These data may provide some insight into future epidemiological studies of bovine arboviral diseases in Korea.
Inhibition of DNA Topoisomerases Ⅰ and Ⅱ and Cytotoxicity by Lignans from Saururus chinensis
Yeun-Kyung Lee,Chang-Seob Seo,이종순,Kyong-Seon Lee,Shin-Jung Kang,Yurngdong Jahng,Hyun Wook Chang,Jong-Keun Son 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.10
Thirteen lignans, erythro-austrobailignan-6 (1), meso-dihydroguaiaretic acid (2), sauchinone (3), 1'-epi-sauchinone (4), saucerneol D (5), manassantin B (6), manassantin A (7), nectandrin B (8), machilin D (9), saucerneol F (10), saucerneol G (11), saucerneol H (12) and saucerneol I (13), were isolated from the ethyl acetate extract of the roots of Saururus chinensis. Among these compounds, 5 showed potent inhibitory activities against DNA topoisomerase I and II, and 5, 6, 7 and 10 showed mild cytotoxicities against HT-29 (IC50 values; 13, 12, 11, and 10μM, respectively) and HepG2 cell lines (IC50 values; 16, 11, 12, and 11 μM, respectively).
A positron emission tomography microdosing study with sertraline in healthy volunteers.
Shin, Kwang-Hee,Kim, Kyu-Pyo,Lim, Kyoung Soo,Kim, Ji Who,Lee, Yun-Sang,Yang, Bo Yeun,Lee, Jae Sung,Jung, Jae-Min,Yoon, Seo-Hyun,Jang, In-Jin,Yu, Kyung-Sang Dustri-Verlag Dr. Karl Feistle 2012 International journal of clinical pharmacology and Vol.50 No.3
<P>This study explored microdosing methods for evaluating the distribution and pharmacokinetics (PK) of a central nervous system (CNS) drug candidate.</P>