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정문용(Yong, Yeong-Mun),이무식(Lee, Moo-Sik),나백주(Na, Bak-Ju),김철웅(Kim, Chul-Woung),김광환(Kim, Kwang-Hwan),유인숙(Yoo, In-Sook) 한국산학기술학회 2009 한국산학기술학회 학술대회 Vol.- No.-
요 약 신종 및 재출현 전염병이 지속적으로 유행하고 해외 전염병의 국내유입가능성이 증대됨에 따라 국립검역소의 검역관리 사업의 효율성 평가는 매우 중요하다. 연구는 평가 구성요소 사이의 상대적 중요도, 즉 가중치(weight) 부여에 있어서 과학적 타당성을 인정받고 있는계층분석절차(Analytical Hierarchy Process; AHP) 기법에 의한 이원비교방법을 사용하여 설정하였다. AHP기법은 복잡한 다기준 의사결정문제(multi-criteria decision making problem)를 계층화하여 단순화․체계화시킴으로써 그 영향도를 계량화하는데 탁월한 기법이라는 평가를 받고 있다. 실제 측정에 있어서는 본 모형을 이용하여 얻어졌다. 대영역(기관평가영역, 서비스 및 프로그램평가 영역), 중영역(투입, 과정, 결과, 검역업무, 검사업무, 위생관리업무, 병원체조사감시업무, 전염병예방홍보․교육업무)으로 구분하여 최종적으로 평가지표로 선정된 지표는 실제 국립검역소 사업에 적용하였으며, 이에 대한 최소한의 평가지표를 최종 선정하여 향후 국립검역소사업 평가체계를 보다 체계화 하였다.
Collimated Low Fluence Q-switched Nd: YAG 레이저를 이용한 새로운 기미 치료법
정세영 ( Se Yeong Jeong ),장성은 ( Sung Eun Chang ),박하나 ( Ha Na Bak ),최지호 ( Jee Ho Choi ),김일환 ( Il Hwan Kim ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.9
Background: Laser treatment in melasma has previously failed because of the resulting inflammation and consequent pigmentation and excessive thermal damage caused by the use of high fluence. Objective: This study is aimed at establishing the concept of the collimated low fluence Q-switched Nd: YAG laser as a treatment for melasma by investigating its therapeutic effects clinically as well as histopathologically. Methods: 27 patients were treated weekly with Q-switched Nd: YAG laser (1,064 nm wavelength, 7 mm spot size, 1.6~2.5 J/cm2 fluence) for 8 weeks. The results were evaluated based on standardized clinical images that used Robo skin analyzer, spectrophotometer, MASI score and general severity. Results: 17 (58.8%) patients showed GOOD (50~75% improvement) and no case of full recurrence was examined and partial recurrence was detected in 12/17 patients. Common adverse effects include pain, erythema, and temporary edema. Rarely partial hypopigmented macules and diffuse hyperpigmentation appeared. Additional studies, such as immunohistochemical examination and electron microscopic examination, are also currently in progress. Conclusion: The collimated low fluence Q-switched Nd: YAG Laser is effective in melasma treatment. This treatment method is a new concept that can be described as selective photothermolysis with minimal thermal damage and inflammation reaction to affected tissues by pigmentation. We consider this treatment method should be regarded as Minimized Selective Photothermolysis (MSP) that will provide a new effective treatment for melasma. (Korean J Dermatol 2008;46(9):1163~1170)
Pathogenesis of Korean Sapelovirus A in piglets and chicks
Kim, Deok-Song,Kang, Mun-Il,Son, Kyu-Yeol,Bak, Geon-Yong,Park, Jun-Gyu,Hosmillo, Myra,Seo, Ja-Young,Kim, Ji-Yun,Alfajaro, Mia Madel,Soliman, Mahmoud,Baek, Yeong-Bin,Cho, Eun-Hyo,Lee, Ju-Hwan,Kwon, Jos Microbiology Society 2016 The Journal of general virology Vol.97 No.-
Studies on the Apoptosis-Inducing Effect of Ulmi Pumilae Cortex on Human Leukemia HL-60 Cells
Rhyu Jun Ki,Yu Bong Seon,Jeong Jae Eun,Bak Jin Yeong,Son In Hwan,Lee Ju Seok,Jeon Byeong Hun,Mun Byung Soon The Physiological Society of Korean Medicine and T 2004 동의생리병리학회지 Vol.18 No.3
The antiproliferative effect of the water extract of the branch and root bark of Ulmi Pumilae Cortex(WEUPC) was investigated on the p53-negative human leukemia cell line (HL-60). A dose- and time-dependent inhibition of cell growth was observed; this effect appears to be due to induction of apoptosis. Involvement of oxidative stress is indicated by a dose-dependent increase in intracellular reactive oxygen species levels. In addition. anti-apoptic effect was observed in the cells simultaneously treated with WEUPC and the anti-oxidant N-acetylcysteine. WEUPC did not affect the anti-apoptotic Bcl-2 and the pro-apoptotic Bax, whereas p21/sup WAF1/CIPl/ was enhanced in a dose- and time-dependent fashion; this effect was partially inhibited by N-acetylcysteine. The increase in p21/sup WAF1/CIPl/ was accompanied by a parallel accumulation of cells in the G1 phase of the cycle. These results suggest that the p53-independent induction of p21/sup WAF1/CIP/ and the induction of apoptosis may mediate the anti proliferative effect of WEUPC at least in this study; on the basis of this observation, WEUPC could be proposed as an useful adjunct to the treatment of p53-deficient tumors, which are often refractory to standard chemotherapy.
박승연(Seung Yeon Park),이정남(Jung Nam Lee),정민(Min Chung),이운기(Un Gi Lee),이영돈(Yeong Don Lee),오재환(Jae Hwan Oho),백정흠(Jung Hum Bak),박연호(Yeon Ho Park),김현영(Hyeon Yeong Kim),김건국(Keon Kuk Kim),최상태(Sang Tae Choi) 대한외과학회 2007 Annals of Surgical Treatment and Research(ASRT) Vol.72 No.2
Appendiceal mucocele is a cystic dilatation of the appendiceal lumen with mucus, which may be caused by either benign or malignant diseases. In this report, five cases of appendiceal mucocele are reported, three of which had a preoperative diagnosis of mucocele, whereas the others were found incidentally during the operation under the diagnosis of intussusception and periappendiceal abscess. All five patients underwent surgical resections, including one ileocecal resection and four right hemicolectomies. Histopathology revealed a mucinous cystadenoma in four cases, and a mucinous cystadenocarcinoma in one. There was no disease-related death during 18 months of follow-up.