천연염료에 의한 직물염색

변수진 全南大學校 藝術硏究所 2005 藝術論集 Vol.6 No.-

The current using materials for natural dye are used to dyeing of textile or medicines for a long time. The dyeing with natural material is interested at the intention to health and environment-friendly dyeing process. It has the function of antimicrobial activity, hygiene, insect proofing etc.. at the same time without saying that the aesthetic value. In spite of this advantage, the natural dyeing did not developed for several reason, which was low colorfastness, repeatability burdensomeness, difficult dyeing process, difficulty of material storage, extraction of colorants and treatment with mordant and so on... The natural dye is very complicated because it is mixed by several colorant ingredients. The natural dye classifies according th the tone of color or the dyeing properties, chemical structure of colorants. etc... The very important condition for colorants extraction is the temperature for extraction and time. Most of the natural dye is dyeing in boiled water. Of course the temperature of dyeing liquid is different according to colorant ingredients of natural dye and fabrics. A mordant is the material that was directly processed to fabrics for displaying color matter to be colored certainly on the fabric. The purpose of this study is the use extension and practical use of natural dyeing by the more systematically arrangement about kind and properties of natural dye, extraction method of colorants, process and condition of dyeing, treatment method of mordant and the effect of mordants etc..

허혈성 심질환에서 염증지표에 관한 연구

번정득,권영주,박상호,한대희,이상철,강진환,김명구,심규혁,최병조,온영근,현민수,김성구 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background : Atherosclerosis is the chief underlying cause of ischemic heart disease and there is increasing evidence that inflammation is an important determinant of the development of atherosclerosis. We assessed the levels of inflammatory markers in patients with ischemic heart disease and normal group who has normal coronary angiograms. Materials and Methods : Coronary angiography was performed in 142 patients. 107 patients of ischemic heart disease(stable angina pectoris 58, unstable angina pectoris 30, Acute myocardial infarction 19) and 38 normal control subjects. We assessed the level of inflammatory markers, such as CRP, ESR, fibrinogen and leukocyte. Results : CRP, ESR and fibrinogen values of the patients with stable angina pectoris and unstable angina pectoris were higher than that of normal control group, but there were no statistical significance. Leukocyte value of the patients with unstable angina pectoris(9003.3±701.5/mm^(3)) was significantly higher than that of the patients with stable angina pectoris(6685.5±245.8/mm^(3)) and normal control subjects(6394.3±235.1/mm^(3)). CRP, ESR and fibrinogen values of the patients with acute myocardial infarction were also higher than that of normal control subjects. CRP was 3.88±2.05 mg/dL in acute mocardial infarction group, and 0.29±0.15 mg/dL in normal control subject group(p<0.05). Fibrinogen was 541.6±45.1 mg/dL in acute myocardial infarction group, 321.4±25.6 mg/dL in normal control subject group(p<0.05). Leukocyte was 10942.1±737.6/mm^(3) in acute myocardial infarction group, 6394.3±235.1/mm^(3) in normal control subject group(p<0.05). Conclusions : This study demonstrate that CRP, fibrinogen and leukocyte values of acute myocardial infarction group were significantly higher than that of control group and stable, unstable argina pectoris group. Leucokyte values were significantly elevated in unstable angina group, but CRP values were not in unstable angina group.

관상동맥질환 환자에서 스텐트 시술 후 재협착에 관한 연구

강진환,권영주,박상호,한대희,이상철,김명구,변정득,최병조,심규혁,온영근,현민수,김성구 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background and aims : In the coronary artery disease, a rate of restenosis was much decreased by placement of coronary stent than when percutaneous transluminal coronary angioplasty has been applied, but there are still important clinical problems of restenosis. There has been many progressive studies about various factors contributed to this restenosis. So, we studied a relation between restenosis after placement of coronary stent in the coronary artery disease and many clinical factors, characteristics of stenotic lesion and procedural factors, and also assessed the restenosis rate of various coronary stents. Methods : Total 58 lesions(46 cases of patients ; man 30, woman 16) were evaluated, which has been performed a follow-up coronary angiography after 6 months (mean 188 days) since coronary stent had been placed. Various stents were implanted and assessed a relation between restenosis and many factors. Results : Of 58 lesions were target stenotic studies, there were 22 of restenotic lesions(37.9%), and the restenosis rate wes statistically significant difference in the relation with diabetes mellitus(p<0.05), group of acute myocardial infarction(p<0.05) among clinical diagnosis of ischemic heart disease(stable angina, unstable angina and acute myocardial infarction) in clinical factors and with high dilation pressure of stent(p<0.05) in procedural factors. When the rate of restenosis was evaluated among implanted stents, it was lowest in the Multilink^(®) stent and highest in the Nir Royal^(®) stent(60%). Conclusion : In this study of restenosis and various factors after placement of stents in the coronary artety disease, factors such as diabetes mellitus, group of acute myocardial infarction and a dilation pressure of stent were significant related with restenosis and the restenosis rate of Multilink^(®) stent was lowest and the highest restenosis rate was of Nir Royal^(®) stent.

5G 대역을 이용한 생체이식용 안테나 설계

김해진(Kim Hae Jin),변경수(Byun Gyung Su) 한국통신학회 2022 한국통신학회 학술대회논문집 Vol.2022 No.2

본 논문은 5G 대역을 이용한 생체이식용 안테나를 제안한다. 제안된 안테나는 생체 이식을 위하여 인체에 무해한 물질인 SU-8을 사용하여 설계되었다. 제안된 안테나는 사각 패치 구조로 20GHz에서 동작하고 -15dB의 반사손실과 -0.07dBi의 안테나 이득 특성을 가진다. 제안된 소형 폼 팩터 패치 안테나는 기존 의료분야의 사용 주파수에 비하여 높은 주파수 대역을 사용하여 더 작은 크기를 차지하지만 더 높은 방사 이득의 장점을 가져 향후 생체의학 응용 분야에 적합하다.

고콜레스테롤 혈증 환자에서 Cerivastatin(LIPOBAY, 의과학연구소)의 임상효과 및 안전성에 관한 연구

박성훈,김미연,정수진,이영숙,박창한,변은경,전성희 梨花女子大學校 醫科大學 醫科學硏究所 2001 EMJ (Ewha medical journal) Vol.24 No.3

목적 : Cerivastatin(LIPOBAY)은 최근에 개발되어 사용되기 시작한 HMG-CoA 환원효소 억제제로서 저용량으로 탁월한 콜레스테롤 강하효과를 보이는 약물이다. 저자들은 Cerivatatin(LIPOBAY)의 혈중 콜레스테롤 강하효과를 평가하고 약물의 안전성을 평가하기 위하여 본 연구를 시행하였다. 방법 : 고콜레스테롤혈증 환자 37명(남자 13명, 여자 24명)을 대상으로 하였다. 대상환자는 2주간의 저콜레스테롤 식이 후에도 혈청 콜레스테롤이 240㎎/㎗이상이거나, 관상동맥질환이 있는 환자는 혈청콜레스테롤이 220㎎/㎗이상인 경우 cerivastatin 0.4㎎을 8주간 복용하도록 하였다. 임상적 관찰과 검사실 검사(간기능검사, 일반혈액검사, 혈청지질검사)는 투약개시 후 4주 및 8주 후에 시행하였다. 결과 : Cerivastatin 0.4㎎을 4주간 투여한 후 측정한 LDL 콜레스테롤, 총콜레스테롤, triglyceride, 및 HDL 콜레스테롤은 각각 38%, 28.8%, 11.6% 및 7.8% 감소하였다. 총콜레스테롤/HDL 콜레스테롤 비 및 LDL/HDL비는 각각 20.8% 및 31.1% 감소하였다. 투약 8주후에 측정한 검사소견은 4주후에 비해 유의한 변화를 보이지 않았다. 한명의 환자(2.7%)에서 간기능 검사상 AST, 및 ALT의 지속적인 상승으로 투약을 중지하였다. 결론 : Cerivastatin 0.4㎎/day는 혈청콜레스테롤을 효과적으로 감소시켰으며 심각한 부작용은 볼 수 없었다. 따라서 적극적으로 LDL콜레스테롤을 낮출 필요가 있는 고콜레스테롤혈증 환자에서 cerivastatin은 효과적이고 안전한 약물이라고 생각된다. Objectives : Cerivastain(LIPOBAY) is recently developed HMG-CoA reductase inhibitor which is effective in lowering serum cholesterol levels at microgram does. We evaluated the clinical efficacy and safety of cerivastatin(LIPOBAY) in patients with hypercholesterolemia. Method : Thirty-seven patients(male : 13, female : 24) with hypercholesteolemia defined as baseline serum total cholesterol ≥240㎎/㎗, or ≥220㎎/㎗ in patients with known coronary artery disease were included for this study. After 2 weeks of low cholesterol diet, if the serum total choesterol level meet the criteria, cerivastain 0.4㎎/day was prescribed for 8 weeks. Clinical follow-up and laboratory tests were performed 4 weeks and 8 weeks after medication. Results : After 4 weeks of cerivastain 0.4㎎/day treatment, low density lipoprotein(LDL) cholesterol decreased 38% and total cholesterol decreased 28.8% from baseline. Triglyceride decreased 11.6%, and high density lipoprotein(HDL) cholesterol decreased 7.8% from baseline. Total cholesterol/HDL ratio decreased 20.8% and LDL/HDL ratio decreased 31.1% from baseline. After 8 weeks of treatment, no further significant changes were noted compared with the values at 4 weeks. Cervastatin was discontinued in one patient(2.7%) due to continuous liver enzyme elevation. Conclusion : Cerivastatin 0.4㎎/day is effective in lowering serum cholesterol levels without significant adverse reactions. Cerivastatin is effective and safe for patients with hypercholesterolemia who needs aggressive LDL cholesterol lowering.

정신분열병 환자에서의 한국어판 사회적응 척도의 개발 : 신뢰도 및 타당도 연구

김철권,서지민,김상수,조진석,하준선,김정옥,변원탄 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6

연구목적: 정신분열병 환자의 사회적응 정도를 측정하는데 사용되는 사회적응 척도의 한국어판을 개발하기 위함이다. 방 법: 사회적응 척도를 번역한 후 정신분열병 환자 67명과 정상인 78명을 대상으로 신뢰도와 타당도를 검증하였다. 결 과: 자료분석 결과 검사-재검사 신뢰도는 0.85, 검사자간 신뢰도는 0.89, 내적 일치도는 0.87로 높은 수치였다. 변별 타당도를 검증하기 위하여 정신분열병 환자군과 정상 대조군을 비교한 결과 정신분열병 환자군에서 사회적응 정도가 유의하게 낮았다. 구성 타당도를 알아보기 위하여 10개 영역간의 상관관계를 측정한 결과 성적적응 영역을 제외한 모든 영역들에서 유의한 상관관계를 보였다. 본 척도의 전반적 평가 영역 결과와 GAF 결과간의 상관성을 통해 간접적으로 검증한 공존 타당도 역시 유의하였다. 결 론: 한국판 사회적응 척도는 우수한 신뢰도와 타당도가 입증되었고 나아가 정신분열병 환자의 사회적응 정도를 평가하는데 유용하게 사용되어질 수 있을 것이다. Objectives: The purpose of this study was to develop the Korean version of the Social Adjustment Scale Ⅱ-Revised Version(KSAS Ⅱ-RV) in the schizophrenics. Methods: KSAS Ⅱ-RV was administered to 67 schizophrenic patients and 78 matched normal controls for examining the reliability and validity. Results: Data analysis showed statistically significant reliabilities and validities of KSAS Ⅱ-RV. The test-retest reliability, inter-rater reliability, and internal consistency for total scores of KSAS Ⅱ-RV were 0.85, 0.89. and 0.87, respectively. Evidence for discriminant validity of KSAS Ⅱ-RV comes from the results that the mean scores of schizophrenic patients were significantly high than those of normal controls. Construct validity was assessed by calculating the 10 inter-subareas correlations of the KSAS Ⅱ-RV, and all except the sexual adjustment area were statistically significant. Significant correlations between the global area scores of KSAS Ⅱ-RV and those of Global Assessment of Functioning Scale lend support for the concurrent validity of this instrument indirectly. Conclusions: KSAS Ⅱ-RV was found to be a valid and reliable instrument which can be used to evaluate the degree of social adjustment in the schizophrenic patients.

정신분열병 외래환자에서 사회기능, 정신병리, 그리고 주의력 결손간의 관계

김철권,정순민,김진원,김상수,변원탄 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.1

본 연구의 목적은 증상이 안정된 83명의 정신분열병 외래 환자들을 대상으로 증상, 사회적응, 그리고 주의력간의 연관성을 알아보기 위한 것이다. 정상 대조군은 정신분열병 환자군과 교육수준, 나이, 성별등이 비슷한 60명으로 하였다. 증상은 양성 및 음성증상 증후군 척도(PANSS)를 이용하여 평가하였고, 사회적응은 한국판 사회적응 척도를 이용하였다. 그리고 주의력은 지속수행 검사(Continuous Performance Test)와 정보 감지능력검사(Span of Apprehension Task)를 사용하였다. 그 결과는 다음과 같다. 1) 정신분열병 환자군이 정상 대조군에 비해 지속수행 검사와 정보 감지능력 검사 모두에서 유의한 결손을 보였다. 또 사회적용 척도의 총 점수와 10개 소영역의 점수에서도 정신분열병 환자군이 정상 대조군에 비해 유의하게 낮았다. 2) 사회기능과 증상군의 연관성에서는 양성증상, 음상증상, 일반증상 모두 사회기능의 총 점수와 연관성이 없었다. 그러나 사회적 여가활동 소영역에서는 음성증상과 유의한 상관성이 있었다. 3) 사회적응 척도의 총 점수와 지속수행 검사에서 가장 중요한 변인인 민감도와의 상관관계에서는 유의한 상관성을 보였다. 그러나 사회적응 척도의 총 점수와 정보 감지능력 검사에서 가장 중요한 변인인 정답반응 횟수간에는 유의한 상관성을 보이지 않았다. 사회적응 척도중 도구적 역할 소영역은 민감도 및 정답반응 횟수와 상관성이 있었다.그리고 친구관계 소영역은 민감도와 유의한 상관성을 보였다. 4) 증상과 주의력과의 상관관계에서는 지속수행 검사의 민감도와 음성증상간에 유의한 상관성을 보였다. 이러한 결과는 증상이 안정된 정신분열병 외래환자에서 지속적 주의력이 전반적인 사회 기능을 예측하는 한 인자가 될 수 있음을 시사한다. In order to study the relations between attentional deficits and social functioning of the schizophrenia, 83 stable outpatients with DSM-Ⅳ schizophrenia and matched 60 normal controls were examined for their sustained attention, sensory register, and social functioning by means of Continuous performance test(CPT), Span apprehension task(SPAN), and Korean version of Social Adjustment Scale Ⅱ-Revised Version(KSAS Ⅱ-RV) respectively. Psychopathology was assessed using the Positive and Negative Syndrome Scale(PANSS). The results were as follows. 1) Schizophrenic patients showed a significant deficit in the sustained attention and sensory register as manifested in the data of CPT and SPAN, compared with the matched normal controls. Schizophrenic patients also showed a significantly poor social functioning in measure of KSAS Ⅱ-RV compared with the matched normal controls. 2) There was no correlation between three type of symptoms(positive/negative/general) and total scores of social functioning. But negative symptoms was correlated with the social leisure subarea of KSASⅡ-RV. 3) CPT was correlated with total scores of social functioning including the instrumental role and friend relation subareas of KSASⅡ-RV, whereas SPAN was only correlated with instrumental role subarea of social functioning. 4) In the relations between attention and symptoms, CPT was correlated with negative symptoms. These results suggest that the deficit of the sustained attention may be a predictive factor of social functioning in the schizophrenic outpatients.

만성 심부전환자의 혈액에서 측정한 Tumor necrosis factor-α 및 Interleukin-6의 임상적 의의

김명구,김성구,박상호,한대희,강진환,변정득,심규혁,최병조,방덕원,온영근,현민수,권영주 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background and objectives: Many conditions are responsible for the pathophysiology and progressive mechanisms of congestive heart failure. More recently, it has also become evidence that another class of biologycally activated molecules generically reffered to as cytokine these are also over expressed in congestive heart failure. Therefore, the purpose of this study was to measure concentrations of tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) in mild to severe symptoms of heart failure and compare their values with those found in normal control and analysed correlation relationship between cytokine level, clinical findings and hemodynamic indicies. Subjects and Methodology: Levels of TNF-α and IL-6 were measured on pulmonary artery during cardiac catheterization in heart failure patients(n=32) and normal subjects(n=8) as well as physical examination and echocardiogram. Cytokines assay were performed on plasma using commercially available ELISA(Enazyme-Linked Immunosorbent Assay) kits. Results: Although the levels of TNF-α and IL-6 tend to increase in congestive heart failure group, the cytokines level was not made significantly statistical difference between congestive heart failure group and controls. When analyzing the correlation between the levels of PCWP(pulmonary capillary wedge pressure) and cytokines(TNF-α, IL-6), respectively, there were statistically significant correlation coefficient 0.32,(p<0.05), 0.39(p<0.01). The cytokine IL-6 and pressure of pulmonary artery were significant correlation.(correlation coefficient 0.36, p<0.02) More significantly, there was correlated with TNF-α and IL-6.(correlation coefficient 0.57, p<0.001) Conclusions: There was tended toward high concentration of TNF-α & IL-6 in congestive heart failure and significant difference for PCWP between TNF-α & IL-6, thus may be correlated with development and progression in congestive heart failure.

Production of Gamma-Amminobutyric Acid by Fed-Batch Culture of Lactobacillus plantarum KFCC 11556P Isolated from Kimchi

Su-Jin Byun,Woo-Tae Song,Min-A Kim,Sang-Hyun Lee 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

Gamma aminobutyric acid (GABA), catalyzed by the decarboxylation of L-glutamic acid from glutamate decaboxylase (GAD), is one of the useful component of rice bran as exciting an inhibitory neurotransmitter, which is a kind of non-protein amino acid widely distributed in the natural world the biosynthesis. In this study, Lactobacillus plantarum KFCC 11556P (LW) isolated from water kimchi was used as a fermentation strain, and the optimal conditions for producing GABA in a fed-batch condition were investigated. As a result of adding 0.5, 1, and 3% glutamate to the rice bran medium to improve GABA production capacity, GABA production was the highest at 60.4 mM when 3% glutamate was added. However, a significant amount of glutamate residue was still left in the rice bran fermentation process. To solve this, the amount of glutamate added was reduced to 0.5% and fermented for 10 days with 5% LW. Thereafter, a new rice bran medium containing 2.5% glutamate was added weekly for 3 weeks. After 31 days of fed-batch fermentation, the highest GABA content was found to be 145.2 mM and glutamate was exhausted.

A rare case of abnormal vaginal bleeding caused by vulva venous hemangioma: a case report

( Jin Ok Park ),( Jung Mi Byun ),( Hwa Jin Cho ),( Dae Hoon Jeong ),( Do Hwa Im ),( Byung Jin Min ),( Hye Rim Park ),( Young Nam Kim ),( Kyung Bok Lee ),( Moon Su Sung ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-

Haemangioma is a benign formation originating from vascular tissue which usually occurs in childhood. A hemangioma can occur anywhere on the body but, vulva venous hemangiomas are extremely rare in nulliparous women. A 25-year-old woman with abnormal vaginal bleeding with genital ulcerative lesion for six months presented to the hospital. Vaginal examination revealed a 1.5X1 cm papillary mass with ulcerated surface on the vaginal fourchette. Speculum examination revealed a cervix with an apparently normal epithelium and external os with no pathological discharge. The mass was visually suspected to be a precancerous lesion or malignancy. The mass was successfully removed by complete excision and biopsy showed ulcerative lesion with chronic active inflammation and granulation tissue and compatible with squamous papilloma. One month later, the same lesion with bleeding was growing on vaginal fourchette and, excision was performed. The pathologic finding was vulva hemangioma. The review of primary vulva lesion was diagnosed with hemangioma and, the second lesion was recurred hemangioma. Vulva hemangiomas with ulcerative lesion are very rare and only small number of cases are reported in literature. It is necessary to carry out differential diagnosis of premalignant or malignant lesions.