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Jin-Won Bak,Yeong-Shin Ham,So-Young Shin,Kwon-Jin Park,Chun-Yeol You,Dae-Yong Jeong,Nam-Hee Cho 대한금속·재료학회 2023 ELECTRONIC MATERIALS LETTERS Vol.19 No.5
Variations in the multiferroic properties of BiFeO 3 (BFO) powders were investigated with respect to the crystallite size and Gd-doping. Nanoscale BFO powders with an average particle size range of ~ 30–80 nm were synthesized by a solid-state reaction using microwave-assisted heat treatment with Bi(NO 3 ) 3 ·5H 2 0, FeC 2 O 4 ·2H 2 O and Gd(NO 3 ) 3 ·6H 2 O as source precursors supplying Bi, Fe, and Gd, respectively. These were heat-treated at temperatures ranging from 200 to 700 °C. The reaction led to the formation of crystallite powders with a particle size of a few tens of nanometers. It was confi rmed that these samples had multiferroic properties at room temperature, and the value of M s varied signifi cantly from ferromagnetic to antiferromagnetic and vice versa with the size of the powders. In particular, ferromagnetic and ferroelectric features were observed when the size of the BFO powder was < ~ 30 nm (half of the spin-canted cycle). As the crystallite size was reduced to that corresponding to half of the spin canted cycle, the value of Ms increased by 8.8 times from 1.41 to 12.46 memu/g. Compared to pure BFO, when Gd was doped, Ms values increased by ~ 60% and 240% in ~ 30 nm and ~ 60 nm particle-sized powders.
Wnt/β-catenin signaling activator restores hair regeneration suppressed by diabetes mellitus
( Yeong Chan Ryu ),( You-rin Kim ),( Jiyeon Park ),( Sehee Choi ),( Geon-uk Kim ),( Eunhwan Kim ),( Yumi Hwang ),( Heejene Kim ),( Soon Sun Bak ),( Jin Eun Lee ),( Young Kwan Sung ),( Gyoonhee Han ),( 생화학분자생물학회 2022 BMB Reports Vol.55 No.11
Diabetes mellitus is one of the most prevalent diseases in modern society. Many complicationssuch as hepatic cirrhosis, neuropathy, cardiac infarction, and so on are associated with diabetes. Although a relationship between diabetes and hair loss has been recently reported, the treatment of diabetic hair loss by Wnt/β-catenin activators has not been achieved yet. In this study, we found that the depilation-induced anagen phase was delayed in both db/db mice and high-fat diet (HFD) and streptozotocin (STZ)-induced diabetic mice. In diabetic mice, both hair regrowth and wound-induced hair follicle neogenesis (WIHN) were reduced because of suppression of Wnt/β- catenin signaling and decreased proliferation of hair follicle cells. We identified that KY19382, a small molecule that activates Wnt/β-catenin signaling, restored the capabilities of regrowth and WIHN in diabetic mice. The Wnt/β-catenin signaling activator also increased the length of the human hair follicle which was decreased under high glucose culture conditions. Overall, the diabetic condition reduced both hair regrowth and regeneration with suppression of the Wnt/β-catenin signaling pathway. Consequently, the usage of Wnt/β-catenin signaling activators could be a potential strategy to treat diabetes-induced alopecia patients. [BMB Reports 2022; 55(11): 559-564]
Yeong-Seon Won,Seung-Jae Lee,Hyung-Jin Lim,Jaehoon Bae,Seon Gyeong Bak,Nisansala Chandimali,Eun Hyun Park,Sang-Ik Park,Hirofumi Tachibana 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.10
The discovery of limocitrin in Sedum sarmentosum Bunge, a compound known for its potent antitumor activity, hassparked interest in understanding its molecular mechanisms and bioactive effects. Breast cancer, particularly triple-negative breastcancer (TNBC), presents a challenging prognosis with a higher likelihood of recurrence, metastasis, and lower survival ratescompared tomost other cancer types. This study aimed to explore the anticancer potential of limocitrin on two different human breastcancer cell lines. The results of the study revealed that limocitrin effectively reduced the viability of breast cancer cells, with IC50values of 29.33 – 0.010 and 28.70 – 0.030 lM for MDA-MB-231 and MCF-7 cells, respectively. Further investigations demonstratedthat limocitrin induced apoptotic cell death, characterized by an increase in the population of apoptotic cells and the formationof apoptotic bodies. Limocitrin induced the upregulation of apoptosis-related protein expressions such as apoptosis-inducing factor,Bax, endonuclease G, and cleaved-poly ADP-ribose polymerase, while downregulating the expression of proteins associated withcell survival, including Akt, Bcl-2, Bid,mTOR, PI3K, procaspases, and p70 S6 kinase.Notably, the response to limocitrin treatmentvaried between the two types of breast cancer cells, indicating a differential effect of limocitrin on the intracellular signalingpathways related to cell survival in breast cancer.These findings open up avenues for further research and exploration of limocitrin asa potential therapeutic agent for breast cancer treatment, especially for challenging subtypes like TNBC.
Jin Young Lee,Jean Kyung Bak,Mina Kim,Ho-Gyun Shin,Kyun-Ik Park,Seung-Pyo Lee,Hee-Sun Lee,Ju-Yeun Lee,Kwang-il Kim,Si-Hyuck Kang,Jang Hoon Lee,Se Yong Jang,Ju-Hee Lee,Kye Hun Kim,Jae Yeong Cho,Jae-Hye 대한내과학회 2023 The Korean Journal of Internal Medicine Vol.38 No.1
Background/Aims: This study evaluated the long-term cardiovascular complications among Korean patients with hypertension and compared them with that of controls without hypertension. Methods: The Korean Hypertension Cohort (KHC) enrolled 11,043 patients with hypertension and followed them for more than 10 years. Age- and sex-matched controls without hypertension were enrolled at a 1:10 ratio. We compared the incidence of cardiovascular events and death among patients and controls without hypertension. Results: The mean age was 59 years, and 34.8% and 16.5% of the patients belonged to the high and moderate cardiovascular risk groups, respectively. During the 10-year follow-up, 1,591 cardiovascular events (14.4%) with 588 deaths (5.3%) occurred among patients with hypertension and 7,635 cardiovascular events (6.9%) with 4,826 deaths (4.4%) occurred among controls. Even the low-risk population with hypertension showed a higher cardiovascular event rate than the population without hypertension. Although blood pressure measurements in the clinic showed remarkable inaccuracy compared with those measured in the national health examinations, systolic blood pressure (SBP) ≥ 150 mmHg was significantly associated with a higher risk of cardiovascular events. Conclusions: This long-term follow-up study confirmed the cardiovascular event rates among Korean hypertensive patients were substantial, reaching 15% in 10 years. SBP levels ≥ 150 mmHg were highly associated with occurrence of cardiovascular event rates.
Hyung Jin Lim,Seon Gyeong Bak,Yeong-Seon Won,Seung-Jae Lee 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Chronic and excessive inflammation could destroy host organs and cause inflammatory diseases. In this study, we investigated the anti-inflammatory effects of Alpinia katsumadai seed-derived 2,3,5,22,23-pentahydroxy-2,6,10,15, 19,23-hexamethyl-tetracosa-6,10,14,18-tetraene (PHT) using LPS-stimulated J774 cells and a formalin-induced chronic paw inflammation mouse model. The in vitro results showed that PHT exhibited no cytotoxicity and decreased LPS-induced NO secretion. Additionally, PHT inhibited LPS-induced inducible NO synthase (iNOS) and cyclooxygenase2 (COX2) expression. The PCR results showed that PHT downregulated the gene expression of the pro-inflammatory cytokines interleukin-1β (IL-1β) and interleukin-6 (IL-6) but not tumor necrosis factor α (TNF-α). PHT inhibited the LPS-induced phosphorylation of extracellular signal-regulated kinase (ERK) and nuclear factor kappa light chain enhancer of activated B cells (NF-κB). In a mouse model, oral administration of 50 mg/kg PHT significantly alleviated both mouse paw thickness and volume. These results indicate that PHT has potential anti-inflammatory effects and should be considered a possible functional material.