Efficient adsorptive elimination of organic pollutants from aqueous solutions on ZIF-8/MWCNTs-COOH nanoadsorbents: Adsorption kinetics, isotherms, and thermodynamic study

Xinling Zhang,Ning Yuan,Shuo Xu,Yi Li,Qibao Wang 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.111 No.-

The removal of organic pollutants was examined by new zeolitic imidazolate framework-8/carboxyl-functionalized multi-walled carbon nanotubes (ZIF-8/MWCNTs-COOH) nanoadsorbents, which were preparedvia controlling the reaction sequence of MWCNTs-COOH with the precursors of ZIF-8. Structuralmorphology and chemical composition characterizations confirmed the successful preparation of ZIF-8/MWCNTs-COOH nanoadsorbents. The obtained samples manifested a preferable adsorption capacityfor Congo red with the maximum adsorption capacity of 1185.58 mg g1 with an adsorption removal rateof 97.93% at equilibrium adsorption. Further analyses indicated that the adsorption process conformed tothe pseudo-second-order kinetic model and Langmuir adsorption isotherm. The thermodynamic analyseswere depicted as endothermic, entropy-increasing, and spontaneous. The effects of pH value, interferingions, and dosage on the adsorption properties were systematically explored. The nanoadsorbent can beexpediently reused for eight cycles without a prominent reduction in adsorption activity. The improvedperformance and high reusability can be ascribed to the increasing specific surface, the presence of electrostaticinteraction, hydrogen bonding, and p–p interaction between ZIF-8/MWCNTs-COOH and organicmolecules. In addition, the prepared composites also showed a better adsorption performance for tetracyclinewith the equilibrium adsorption capacity of 471.22 mg g1 compared to pure ZIF-8 and MWCNTs-COOH.

MicroRNA-375 is a therapeutic target for castration-resistant prostate cancer through the PTPN4/STAT3 axis

Gan Junqing,Liu Shan,Zhang Yu,He Liangzi,Bai Lu,Liao Ran,Zhao Juan,Guo Madi,Jiang Wei,Li Jiade,Li Qi,Mu Guannan,Wu Yangjiazi,Wang Xinling,Zhang Xingli,Zhou Dan,Lv Huimin,Wang Zhengfeng,Zhang Yanqiao,Q 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-

The functional role of microRNA-375 (miR-375) in the development of prostate cancer (PCa) remains controversial. Previously, we found that plasma exosomal miR-375 is significantly elevated in castration-resistant PCa (CRPC) patients compared with castration-sensitive PCa patients. Here, we aimed to determine how miR-375 modulates CRPC progression and thereafter to evaluate the therapeutic potential of human umbilical cord mesenchymal stem cell (hucMSC)-derived exosomes loaded with miR-375 antisense oligonucleotides (e-375i). We used miRNA in situ hybridization technique to evaluate miR-375 expression in PCa tissues, gain- and loss-of-function experiments to determine miR-375 function, and bioinformatic methods, dual-luciferase reporter assay, qPCR, IHC and western blotting to determine and validate the target as well as the effects of miR-375 at the molecular level. Then, e-375i complexes were assessed for their antagonizing effects against miR-375. We found that the expression of miR-375 was elevated in PCa tissues and cancer exosomes, correlating with the Gleason score. Forced expression of miR-375 enhanced the expression of EMT markers and AR but suppressed apoptosis markers, leading to enhanced proliferation, migration, invasion, and enzalutamide resistance and decreased apoptosis of PCa cells. These effects could be reversed by miR-375 silencing. Mechanistically, miR-375 directly interfered with the expression of phosphatase nonreceptor type 4 (PTPN4), which in turn stabilized phosphorylated STAT3. Application of e-375i could inhibit miR-375, upregulate PTPN4 and downregulate p-STAT3, eventually repressing the growth of PCa. Collectively, we identified a novel miR-375 target, PTPN4, that functions upstream of STAT3, and targeting miR-375 may be an alternative therapeutic for PCa, especially for CRPC with high AR levels.

LINC00657 knockdown suppresses hepatocellular carcinoma progression by sponging miR-424 to regulate PD-L1 expression

Xinling Cao,Guanping Zhang,Tao Li,Chengming Zhou,Lei Bai,Jinming Zhao,Turgunjan Tursun 한국유전학회 2020 Genes & Genomics Vol.42 No.11

Background Hepatocellular carcinoma (HCC) is the sixth most commonly diagnosed malignant tumor and the fourth leadingcause of cancer-related deaths worldwide. As a novel non-coding RNA, LINC00657 was firstly identified as an oncogenicrole in breast cancer. However, few research focus on the effect of LINC00657 on the progression of HCC. Objectives The purpose of this study was to investigate the effect of LINC00657 on HCC tissues and cells, and furtherexplore the potential mechanism. Methods We first measured the expression of LINC00657 in HCC tissues and cell lines using qRT-PCR. Next we establishedLINC00657 knockdown in HCC cells. CCK-8 assay, cell invasion assay, flow cytometry analysis, qRT-PCR and westernblotting were applied to assess the role of LINC00657 knockdown in the biological behavior of HCC cells. The bioinformaticsanalysis and the rescue experiment were devoted to the underlying mechanism. Results LINC00657 was remarkably overexpressed in HCC tissues and cell lines, associated with poor prognosis. LINC00657knockdown repressed cell proliferation and invasion, promoted cell apoptosis of HCC cell lines. The bioinformatics analysisshowed LINC00657 sponged miR-424 as a ceRNA. Besides, PD-L1 mimic rescued the suppression of si-LINC00657 inthe biological behavior of HCC cells. Conclusion In a word, we observed LINC00657 regulated PD-L1 expression by sponging miR-424, thus affecting the developmentsof hepatocellular carcinoma. These findings LINC00657 may provide new evidence for therapeutic application inhepatocellular carcinoma.

Aminated cassava residue-based magnetic microspheres for Pb(II) adsorption from wastewater

Xinling Xie,Jie Huang,Youquan Zhang,Zhangfa Tong,Anping Liao,Xingkui Guo,Zuzeng Qin,Zhanhu Guo 한국화학공학회 2019 Korean Journal of Chemical Engineering Vol.36 No.2

Aminated cassava residue magnetic microspheres (ACRPM) were synthesized via an inverse emulsion method by using chemically modified cassava residue as a crude material, and acrylic acid (AA), acrylamide (AM), and methyl methacrylate (MMA) as monomers and a polyethylene glycol/methanol system (PEG/MeOH) as the porogen. Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), N2 adsorption-desorption and vibrating sample magnetometry (VSM) were used to characterize the ACRPM. The results indicated that amino groups were grafted to the cassava residue magnetic microspheres, and the Fe3O4 nanoparticles were encapsulated in the microspheres. After porogen was added, the particle size of the ACRPM decreased from 16.5 μm to 150 nm with a pore volume of 0.05510m3/g, and the specific surface area of the ACRPM increased from 3.02 to 12.34m2/g. The ACRPM were superparamagnetic, and the saturation magnetization was 9.8 emu/g. The maximum adsorption capacity of Pb(II) on the ACRPM was 390mg/g. The ACRPM exhibited a large specific surface area and provided many adsorption sites for metal ion adsorption, which favored a high adsorption capacity. Additionally, the Pb(II) adsorption process was fitted to pseudo-second-order kinetic and Langmuir isothermal adsorption models. This suggests that the Pb(II) adsorption process was dominated by a chemical reaction process and that chemisorption was the rate-controlling step during the Pb(II) removal process. In addition, the adsorbent exhibited good stability after six consecutive reuses.

The Application of Clove Extract Protects Chinesestyle Sausages against Oxidation and Quality Deterioration

Huiyun Zhang,Xinyan Peng,Xinling Li,Jingjuan Wu,Xinyu Guo 한국축산식품학회 2017 한국축산식품학회지 Vol.37 No.1

This study was conducted to evaluate the effects of clove extract (CE) (0.25%, 0.5%, 1%, and 2%) on the oxidative stability and quality deterioration of Chinese-style sausage stored for 21 d at 4°C. The addition of clove extract to sausages significantly retarded increases in Thiobarbituric Reactive Substances (TBARS) values (p<0.05), while also controlling the production of protein carbonyls (p<0.05). However, the addition of clove extract promoted reduced thiol group content in sausages (p<0.05). Sausages amended with clove extract also had decreased L* values (p<0.05) and increased a* values (p<0.05) when compared with the control. Similarly, texture deterioration was retarded in sausage containing added clove extract when compared with the control during refrigerated storage. Moreover, the addition of clove extract had no negative effects on the sensory properties of sausages. These results suggested that clove extract was effective at protecting sausages from oxidation and quality deterioration during refrigerated storage for 21 d.

The Model of Regional Tourism Cooperation in the Region of Beijing, Tianjun and Hebei

Zoy, Tongqian,Zhang, Xinling,Cong, Chaohua 동북아관광학회 2007 동북아관광연구 Vol.3 No.1

The Application of Cartilage Tissue Engineering with Cell-Laden Hydrogel in Plastic Surgery: A Systematic Review

Wang Guanhuier,Zhang Xinling,Bu Xi,An Yang,Bi Hongsen,Zhao Zhenmin 한국조직공학과 재생의학회 2022 조직공학과 재생의학 Vol.19 No.1

BACKGROUND: As a contour-supporting material, the cartilage has a significant application value in plastic surgery. Since the development of hydrogel scaffolds with sufficient biomechanical strength and high biocompatibility, cell-laden hydrogels have been widely studied for application in cartilage bioengineering. This systematic review summarizes the latest research on engineered cartilage constructed using cell-laden hydrogel scaffolds in plastic surgery. METHODS: A systematic review was performed by searching the PubMed and Web of Science databases using selected keywords and Medical Subject Headings search terms. RESULTS: Forty-two studies were identified based on the search criteria. After full-text screening for inclusion and exclusion criteria, 18 studies were included. Data collected from each study included culturing form, seed cell types and sources, concentration of cells and gels, scaffold materials and bio-printing structures, and biomechanical properties of cartilage constructs. These cell-laden hydrogel scaffolds were reported to show some feasibility of cartilage engineering, including better cell proliferation, enhanced deposition of glycosaminoglycans and collagen type II in the extracellular matrix, and better biomechanical properties close to the natural state. CONCLUSION: Cell-laden hydrogels have been widely used in cartilage bioengineering research. Through 3-dimensional (3D) printing, the cell-laden hydrogel can form a bionic contour structure. Extracellular matrix expression was observed in vivo and in vitro, and the elastic modulus was reported to be similar to that of natural cartilage. The future direction of cartilage tissue engineering in plastic surgery involves the use of novel hydrogel materials and more advanced 3D printing technology combined with biochemistry and biomechanical stimulation.

1-methylcyclopropene treatment improves postharvest quality and antioxidant activity of Prunus domestica L. cv. Ximei fruit

Ma Yanyan,Zhang Weida,CHENGSHAOBO,Yang Wanting,Liu Yuxing,Yang Shengyu,Zhang Xinling,Guo Minrui,Chen Guogang 한국원예학회 2022 Horticulture, Environment, and Biotechnology Vol.63 No.6

Prunus domestica L. cv. Ximei fruit perishes quickly due to intense metabolic activity after being harvested. To prolong shelf life and maintain fruit quality, the eff ects of 1-methylcyclopropene (1-MCP) treatment on P. domestica fruit during storage at 4 ± 1 °C were investigated. The results showed that the soluble solid content (SSC), respiratory rate (29.8%), ethylene production (27.2%), anthocyanin content, malonaldehyde content (MDA), hydrogen peroxide content (H 2O2), and superoxide anion activity (O 2·−) of P. domestica fruit were all signifi cantly reduced by 1-MCP treatment (1.0 μL L −1), while the content of ascorbic acid and total phenol, and the activity of SUPEROXIDE DISMUTASE (SOD, 61.3%), CATALASE (CAT, 39.0%), ASCORBATE PEROXIDASE (APX, 23.7%), and PEROXIDASE (POD, 38.0%) increased compared to untreated fruit after 35 days of cold storage. Overall, 1-MCP treatment could maintain high postharvest quality and anti- oxidant activity in P. domestica fruit

Low Carbon Concrete Prepared with Scattering-Filling Coarse Aggregate Process

Weiguo Shen,Chuan Zhang,Xinling Li,Hua Shi,Guiming Wang,Xiaowu Tian 한국콘크리트학회 2014 International Journal of Concrete Structures and M Vol.8 No.4

The volume fraction of the coarse aggregate in the conventional plastic concrete is controlled relatively low to ensure a required workability. In this paper, a new type of coarse aggregate interlocking concrete with strength ranging from C30 to C80 was prepared with scattering-filling aggregate process. The strength of concrete prepared with this method increases obviously whereas the shrinkage decreases significantly, the cement dosage in the concrete decreased 20 % at the same time. The microhardness of the ITZ between the cement paste and scattering-filling aggregate is higher than that of the original aggregate, the ITZ become narrower and tighter also. The interlocking and more even distribution of the coarse aggregate and the water absorption of the addition of extra amount of coarse aggregates contribute to the strength and performance improvement of the concrete prepared with scattering-filling aggregate process.