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- 저자 : Youquan Zhang (검색결과 5 건)
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PRR11 and SKA2 gene pair is overexpressed and regulated by p53 in breast cancer
Wang, Yitao,Zhang, Chunxue,Mai, Li,Niu, Yulong,Wang, Yingxiong,Bu, Youquan Korean Society for Biochemistry and Molecular Biol 2019 BMB Reports Vol.52 No.2
Our previous study found that two novel cancer-related genes, PRR11 and SKA2, constituted a classic gene pair that was regulated by p53 and NF-Y in lung cancer. However, their role and regulatory mechanism in breast cancer remain elusive. In this study, we found that the expression levels of PRR11 and SKA2 were upregulated and have a negative prognotic value in breast cancer. Loss-of-function experiments showed that RNAi-mediated knockdown of PRR11 and/or SKA2 inhibited proliferation, migration, and invasion of breast cancer cells. Mechanistic experiments revealed that knockdown of PRR11 and/or SKA2 caused dysregulation of several downstream genes, including CDK6, TPM3, and USP12, etc. Luciferase reporter assays demonstrated that wild type p53 significantly repressed the PRR11-SKA2 bidirectional promoter activity, but not NF-Y. Interestingly, NF-Y was only essential for and correlated with the expression of PRR11, but not SKA2. Consistently, adriamycin-induced (ADR) activation of endogenous p53 also caused significant repression of the PRR11 and SKA2 gene pair expression. Notably, breast cancer patients with lower expression levels of either PRR11 or SKA2, along with wild type p53, exhibited better disease-free survival compared to others with p53 mutations and/or higher expression levels of either PRR11 or SKA2. Collectively, our study indicates that the PRR11 and SKA2 transcription unit might be an oncogenic contributor and might serve as a novel diagnostic and therapeutic target in breast cancer.
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Liu, Bijin,Fu, Danjuan,Zhang, Youquan,Chen, Xiaoyun The Society of Naval Architects of Korea 2020 International Journal of Naval Architecture and Oc Vol.12 No.1
Taking the cylindrical float of the floating fence of a floating litter collection device as the research object, based on the shallow immersion characteristics of the cylindrical float, the Morison equation is modified, and the interaction between regular waves and the partially immersed horizontal cylindrical float is discussed in combination with scale model test. The results show that the modified Morison equation can accurately predict the wave force of the horizontal cylindrical float and reveal the influence of amplitude, immersion depth and period on the wave force of the cylindrical float. For partially immersed cylindrical floats, the wave force increases with the increase in wave height and decays with the increase in period. The positive value distribution of the wave force is larger than that of the negative direction, and the difference between the positive and negative directions is mainly affected by the immersion depth.
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Liu, Bijin,Fu, Danjuan,Zhang, Youquan,Chen, Xiaoyun The Society of Naval Architects of Korea 2020 International Journal of Naval Architecture and Oc Vol.12 No.-
Taking the cylindrical float of the floating fence of a floating litter collection device as the research object, based on the shallow immersion characteristics of the cylindrical float, the Morison equation is modified, and the interaction between regular waves and the partially immersed horizontal cylindrical float is discussed in combination with scale model test. The results show that the modified Morison equation can accurately predict the wave force of the horizontal cylindrical float and reveal the influence of amplitude, immersion depth and period on the wave force of the cylindrical float. For partially immersed cylindrical floats, the wave force increases with the increase in wave height and decays with the increase in period. The positive value distribution of the wave force is larger than that of the negative direction, and the difference between the positive and negative directions is mainly affected by the immersion depth.
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Aminated cassava residue-based magnetic microspheres for Pb(II) adsorption from wastewater
Xinling Xie,Jie Huang,Youquan Zhang,Zhangfa Tong,Anping Liao,Xingkui Guo,Zuzeng Qin,Zhanhu Guo 한국화학공학회 2019 Korean Journal of Chemical Engineering Vol.36 No.2
Aminated cassava residue magnetic microspheres (ACRPM) were synthesized via an inverse emulsion method by using chemically modified cassava residue as a crude material, and acrylic acid (AA), acrylamide (AM), and methyl methacrylate (MMA) as monomers and a polyethylene glycol/methanol system (PEG/MeOH) as the porogen. Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), N2 adsorption-desorption and vibrating sample magnetometry (VSM) were used to characterize the ACRPM. The results indicated that amino groups were grafted to the cassava residue magnetic microspheres, and the Fe3O4 nanoparticles were encapsulated in the microspheres. After porogen was added, the particle size of the ACRPM decreased from 16.5 μm to 150 nm with a pore volume of 0.05510m3/g, and the specific surface area of the ACRPM increased from 3.02 to 12.34m2/g. The ACRPM were superparamagnetic, and the saturation magnetization was 9.8 emu/g. The maximum adsorption capacity of Pb(II) on the ACRPM was 390mg/g. The ACRPM exhibited a large specific surface area and provided many adsorption sites for metal ion adsorption, which favored a high adsorption capacity. Additionally, the Pb(II) adsorption process was fitted to pseudo-second-order kinetic and Langmuir isothermal adsorption models. This suggests that the Pb(II) adsorption process was dominated by a chemical reaction process and that chemisorption was the rate-controlling step during the Pb(II) removal process. In addition, the adsorbent exhibited good stability after six consecutive reuses.
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Juan Feng,Xiang Li,Xiaolan Yang,Chun Zhang,Yonghua Yuan,Jun Pu,Yunsheng Zhao,Yanling Xie,Huidong Yuan,Youquan Bu,Fei Liao 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.11
The use of uricase-deficient mammals to screen formulations of engineered uricases as potential drugs for hyperuricemia involves heavy costs and presents a technical bottleneck. Herein, a new practical system was investigated to evaluate the pharmacological significance of a bacterial uricase based on its ability to eliminate uric acid in plasma in vitro, its pharmacokinetics in vivo in healthy rats, and the modeled pharmacodynamics in vivo. This uricase, before and after modification with the monomethyl ether of poly(ethylene glycol)-5000, effectively eliminated uric acid in vitro in rabbit plasma, but its action was susceptible to xanthine inhibition. After intravenous injection of the modified uricase without purification, a bi-exponential model fit well to uricase activities in vivo in the plasma of healthy rats; the half-life of the modified uricase was estimated without interference from the unmodified uricase leftover in the sample and was nearly 100-fold longer than that of the unmodified uricase. Using a model of the elimination of uric acid in vivo taking into account of uricase pharmacokinetics and xanthine inhibition, modeled pharmacodynamics supported that the half-life of uricase and its susceptibility to xanthine are crucial for the pharmacological significance of uricase. Hence,this practical system is desirable for doing preliminary screening of formulations of engineered uricases as potential drugs for hyperuricemia.
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