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Kim, Bong-Seog,Jin, Jong-Youl,Kwon, Jung Hye,Woo, In Sook,Ko, Yoon Ho,Park, Suk-Young,Park, Hye-Jeong,Kang, Jin Hyung Wiley (Blackwell Publishing) 2018 Asia-Pacific journal of clinical oncology Vol.14 No.5
<P>ConclusionOxycodone/naloxone added to pregabalin or gabapentin provided additional pain relief and symptom control in Korean patients with CIPN, without clinically significant safety concerns.</P>
( Chi Hoon Maeng ),( Sung Woo Ahn ),( Seong Yoon Ryu ),( Sungjun Han ),( Young Hyeh Ko ),( Jun Ho Ji ),( Won Seog Kim ),( Seok Jin Kim ) 대한내과학회 2016 The Korean Journal of Internal Medicine Vol.31 No.3
Background/Aims: The Follicular Lymphoma International Prognostic Index (FLIPI) and FLIPI2 are well-known prognostic models for patients with follicular lymphoma (FL). However, their prognostic relevance has not been examined before in Korean patients with FL. Methods: We reviewed clinical and laboratory information from our database of patients between 1995 and 2012. In total, 125 patients were stratified in three categories according to FLIPI or FLIPI2 scores: low-, intermediate-, and high-risk groups. We compared FLIPI and FLIPI2 in terms of progression-free survival (PFS) and overall survival (OS). Results: Among the 125 patients, the prognostic value of FLIPI and FLIPI2 was evaluated in 73 patients who fulfilled the criteria of both prognostic models. Risk stratification by FLIPI and FLIPI2 showed significant differences in unfavorable parameters among each risk group, particularly between low- and intermediate- risk groups. The high-risk group b was significantly associated with poor PFS on both FLIPI and FLIPI2 (p < 0.05). However, the OS was significantly different only in the risk groups determined by FLIPI2 (p = 0.042). In a subgroup analysis of patients who received rituximab-containing chemotherapy, the risk stratification of both prognostic models showed a significant impact on PFS, especially in the low-risk group. Conclusions: FLIPI and FLIPI2 are appropriate prognostic models in Korean FL patients, especially for discriminating low-risk patients from intermediate- and high-risk groups.
홍택종,고우석,하재경,이한철,신영우 부산대학교 병원 암연구소 2006 부산대병원학술지 Vol.- No.20
Background The instent restenosis due to intimal hyperplasia after stent implantation occurs approximately 6~40%, so it is thought to be the significant problem. To overcome this problem, drug eluting stents are introduced, but only limited data are yet available on instent restenosis because of short term follow-up interval. I intended to assess the coronary angiographic finding, clinical features, incidence of instent restenosis by comparing with carbon stents or other bare metal stents. Method and Materials The study population comprised 193 patients undergoing follow-up coronary angiography between August 2003 and July 2004 not related to clinical symptoms, were implantated historically coronary stents because of significant ischemic heart disease. According to the chart records and quantative coronary angiographic analysis, I assort the instent restenosis(focal <10mm, diffuse ≥ 10mm), age, coronary artery lesion site, mimimal luminal diameter(MLD), stent diameter, stent length, follow up interval, ACC/AHA lesion classification, post MLD according to a kind of stents. Result Drug eluting stent implantation patients were 65 persons(male:52, female:13), mean age was 60.9±8.9 years. One patient of totally 55 Sirolimus eluting stent implantation patients(0.02%) occurred focal type instent restenosis(ISR), which was implantated 3.5mm x 18mm stent at proximal left circumflex, B2 lesion, and follow up interval was 170 days. Two patients of totally 10 Paclitaxel eluting stent implantation patients(20%) occured one focal type ISR, one diffuse type ISR. One focal type ISR patient was implantated 3.0mm x 28mm stent at left anterior descending artery, B1 lesion, follow up interval was 180 days. One diffuse type ISR patient was implantated 3.0mm x 24mm stent at left anterior descending artery, B2 lesion, follow up interval was 210 days. Carbon stent implantation patients were 55 persons(male:35, female:20), mean age was 62.9±11.5 years. 14 patients had ISR(25%), focal type was 9, diffuse type was 5 case. Other bare metal stent implantation patients were 73 persons(male:49, female:24), mean age was 58.9±9.1 years. 18 patients had ISR(22%), focal type was 14, diffuse type was 5 case. Conclusions Drug eluting stent implantation reduced incidence of angiographic instent restenosis compared with carbon or other bare metal stents.
고명연,장용석,허준영,안용우,Ko, Myung-Yun,Jang, Yong-Seog,Heo, Jun-Young,Ahn, Yong-Woo 대한안면통증구강내과학회 2006 Journal of Oral Medicine and Pain Vol.31 No.4
The purpose of this study was to investigate whether there were any changes in taste function with buring mouth syndrome(BMS). 133 subjects (31 males and 99 females) were included for the study and they were categorized into 2 groups BMS 33 persons, control 100 persons) and investigated in the Dept. of Oral Medicine, Pusan National University Hospital from April,2005 to February,2006. The electrical taste thresholds were measured using an electrogustometer of 4 different sites in oral cavity (tongue tip, tongue lateral, circumvallate papillar and soft palate). The results were as follows : 1. The electrical taste threshold in BMS group was very significantly low. 2. The electrical taste thresholds in male and female of BMS group were significantly lower each other than those of control group 3. The electrical taste threshold of BMS group according to single/multiple lesions and chronicity were not different. 4. After treatment, electrical taste threshold and NAS decreased more significantly.
추궁절제수술후에 발생한 의인성 가성수막척수류 : 증례보고 Report of Cases
백광흠,김용석,김재민,고용,오성훈,오석전,김남규,김광명,박동우 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.10
Two unique cases of delayed nerve root herniation and entrapment into the pseudomeningocele through an unrepaired dural laceration at lumbar laminectomy were reported. Both patients presented with recurred radiculopathy. 3 and 6 years after first operation respectively. Lumbar myelography showed an extradural pseudomeningocele pouch in case 1 while showing no abnormality in case 2. Lumbar MRI in case 1 showed tangled herniated nerve root in the pouch of pseudomeningocele. Lumbar myelographic CT of case 2 showed delayed partial filling of the pseudomeningocele pouch only.
NF-κB 활성 저해를 통한 협죽도 에탄올 추출물의 항염증 효능
김태환(Tae-Hwan Kim),고석순(Seog Soon Ko),박철(Cheol Park),박상은(Sang-Eun Park),홍상훈(Sang-Hoon Hong),김병우(Byung Woo Kim),최영현(Yung Hyun Choi) 한국생명과학회 2010 생명과학회지 Vol.20 No.8
정상세포뿐 만 아니라 형질 전환된 세포의 증식조절에 중요한 역할을 하는 것으로 알려진 COX-2는 전사조절 인자인 NF-κB에 의해서 조절되며, 염증반응에 있어서 중요한 역할을 하는 PGE2의 생성에 관여하는 것으로 알려져 있다. 본 연구에서는 U937 인체혈구세포에서 염증유발인자인 PMA에 의해서 유발되는 염증반응에 있어서 중요한 역할을 하는 COX-2 및 COX-2의 산물인 PGE2와 COX-2의 발현에 영향을 미치는 전사조절인자인 NF-κB의 발현에 협죽도 잎 및 줄기의 에탄올 추출물인 ENIL 및 ENIS가 어떠한 영향을 미치는 지를 조사하였다. PMA가 처리된 U937 세포에서 COX-1의 발현에는 아무런 영향을 미치지 못하였지만 COX-2의 발현 증가가 유도되었고 이에 따른 PGE2의 생성이 증가되었다. PMA에 의해서 증가된 COX-2의 발현이 ENIS 선처리에 의하여 거의 완벽하게 억제되었고 그에 따른 PGE2의 생성도 현저하게 감소되었다. ENIS에 의한 COX-2의 발현 및 PGE2의 생성억제가 전사조절인자인 NF-κB와 상관성이 있는지를 조사한 결과, 핵 내로의 NF-κB 이동이 ENIS 선처리에 의하여 억제되는 것으로 나타났다. 이는 ENIS가 NF-κB의 활성 억제를 통하여 COX-2의 발현 및 PGE2의 생성을 효과적으로 억제함으로서 항염증 효능을 가진다는 것을 의미하는 결과이다. 하지만 ENIL의 경우에는 이상에서와 같은 이러한 변화들이 매우 약하게 나타나는 것으로 조사되어 ENIS와 비교해서 항염증 효능이 낮은 것으로 나타났다. 본 연구 결과는 협죽도의 항염증기전에 대한 생화학적 해석 및 이를 활용한 향후 지속적인 연구를 위한 귀중한 자료가 될 것으로 생각된다. Nerium indicum, an India-Pakistan-originated shrub belonging to the oleander family, is reported to possess many pharmacological activities including cardiac muscle stimulation, and anti-diabetes, anti-angiogenesis, anti-cancer and neuro-protective activities. However, the anti-inflammatory properties of N. indicum were unclear. In this study, we investigated the effects of ethanol extract of the N. indicum leaf and stem (ENIL and ENIS) on the expression of anti-inflammatory mediators in U937 human pre-monocytic cell models. In U937 cells stimulated with phorbol 12-myristate-13-acetate (PMA), pre-treatment with ENIS significantly inhibited the expression of both cyclooxygenase-2 (COX-2) mRNA and protein, which are associated with inhibition of the release of prostaglandin E₂ (PGE₂), whereas the inhibitory effects appeared weakly in ENIL. Moreover, ENIS significantly attenuated PMA-induced IkappaB (IκB) degradation and suppressed elevated nuclear factor kappa B (NF-κB) nuclear translocation. Taken together, these findings provide important new insights that N. indicum exhibits anti-inflammatory properties by suppressing the transcription of pro-inflammatory cytokine genes through the NF-kB signaling pathway.