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Incidence of congenital hypothyroidism by gestational age: a retrospective observational study
Ha Young Jo,Eun Hye Yang,Young Mi Kim,Soo-Han Choi,Kyung Hee Park,Hye Won Yoo,Su Jeong Park,Min Jung Kwak 영남대학교 의과대학 2023 Yeungnam University Journal of Medicine Vol.40 No.1
Background: Congenital hypothyroidism (CH) is the leading cause of preventable physical and intellectual disabilities. This study aimed to assess the incidence and clinical characteristics of CH in newborns. Methods: We retrospectively reviewed the medical records of all newborns delivered at the Pusan National University Hospital between January 2011 and March 2021. The incidence of CH was compared according to gestational age, birth weight, and small for gestational age (SGA). The patients aged ≥3 years who could not maintain normal thyroid function and required levothyroxine treatment were diagnosed with permanent CH. Logistic regression analysis was performed to compare CH risks. Results: Of 3,722 newborns, 40 were diagnosed with CH (1.07%). Gestational age and birth weight were significantly associated with CH incidence. The odds ratios (ORs) of CH in infants delivered at 32–37, 28–31, and <28 weeks were 2.568 (95% confidence interval [CI], 1.141–5.778), 5.917 (95% CI, 2.264–15.464), and 7.441 (95% CI, 2.617–21.159) times higher, respectively, than those delivered at term. The ORs of CH in infants weighing 1,500–2,499 g, 1,000–1,499 g, and <1,000 g were 4.664 (95% CI, 1.928–11.279), 11.076 (95% CI, 4.089–29.999), and 12.544 (95% CI, 4.350–36.176) times greater, respectively, than those in infants weighing ≥2,500 g. The OR of CH was 6.795 (95% CI, 3.553–13.692) times greater in SGA than in non-SGA infants. Conclusion: The CH incidence in South Korea has increased significantly compared with that in the past. Gestational age, birth weight, and SGA were significantly associated with CH incidence.
Effect of Cadmium concentration on plant growth characteristics of Jatropha curcas L.
Yang-Gyu Ku,Won Park,Cho-Rong Kim,Ha-Young Jang,Ha-Na Park,Hyun-Sung Kim,Jeong-Min Oh,Jin-Ki Bang,Young-Seok Jang,Sung-Ju Ahn 한국작물학회 2008 한국작물학회 학술발표대회 논문집 Vol.2008 No.10
Cadmium (Cd) is one of heavy metals that can be easily absorbed by plant roots, and transported from soil to shoots. The effect of Cd concentration (0~200 μM) on the physiological responses, Cd content of shoot and root, and antioxidant enzymes by oil plants Jatropha curcas (cv. Biji Jarak) were investigated in hydroponics system for two weeks. Stomatal conductance was significantly depressed by Cd treated plants. However, the leaf chlorophyll content was unaffected by Cd treated plants. Cd contents in the roots of Jatropha were accumulated higher than those of shoots. Jatropha treated plants at 100 and 200 μM was found to accumulate more than 100 mg kg-1 of Cd in shoots. Jatropha plants had a high ablity to uptake Cd from soil and transport it from soil to shoot as a Cd hyperaccumulator plant because of plants accumulating more than 100 mg kg-1 of Cd in shoots are considered to define as Cd hyperaccumulator. These results confirm that Jatropha is a suitable candidate for the phytoremediation of high-level cadmium contaminated soils.
Study on Cd/Pb resistance and accumulation by AtHMA3 overexpressing plants
Won Park,Jung-A Sung,Ha-Young Jang,Ha-Na Park,Yang-Gyu Ku,Sung-Ju Ahn 한국작물학회 2008 한국작물학회 학술발표대회 논문집 Vol.2008 No.10
AtHMA3 is one of P1B-ATPase of Arabidopsis thaliana which transports and/or stores Cd and Pb in the plant cell. To test whether AtHMA3 can be used to develop enhanced resistance plant to Cd and Pb for phytoremediation, we overexpressed AtHMA3 in Columbia-0 using a pBI121vector containing the 35S promoter. To evaluate their Cd and Pb resistance, seeds of three different T3 homozygous(HMA3-1~3) and wild type plants(col-0) were germinated and grown on agar plates containing 50μM Cd, 500μM Pb and 50μM Cd+ 500μM Pb for 3 weeks. 35S::AtHMA3 grew better than wild type plants about 1.1-to 1.8-fold in Cd or Pb containg mediums. Fresh weights of all three lines of transgenic plants were 1.2-to 1.5-fold higher than those of wild type plants in Cd or Pb-containing medium. In addition to, we measured Cd and Pb content in both wild type and transgenic plants grown in solution with 50μM Cd, 500μM Pb and 50μM Cd+ 500μM Pb for 6 d. AtHMA3-overexpressing plants had consistently higher Cd and Pb contents than wild type plants. Chlorophyll contents were not significant difference between overlines and wild-types. These results show that HMA3 contributes to Cd and Pb resistance, and it might be useful for the phytoremediation.
Analysis of a fast neutron-induced soybean mutant using next-generation sequencing
Won Joo Hwang,Moon Young Kim,Yang Jae Kang,Sang Rae Shim,Puji Lestari,Suk-Ha Lee 한국육종학회 2012 한국육종학회 심포지엄 Vol.2012 No.07
Mutagenesis approach in combination with whole genome sequencing has become an import role in genetic and molecular biological study and breeding of crop plants. In this study, we screened the fast neutron M4 10,000 soybean mutant plants based on morphological phenotypes of agronomically important traits and characterized the mutant of interest using resequencing. Fast neutron radiation has been known to be a very effective mutagen to cause large deletion in genome. The screened mutant showed abnormal phenotypes in plant heights, seed sizes, color of leaves, number of leaves, maturity and number of branches etc. Among them, the mutant displaying short plant height and bush type of growth habit was selected for identification of the altered genomic regions. Analysis of deletion sites of genome in interesting soybean mutant was performed using next generation sequencer Illumina Hi-seq. Mutant sequence reads generated by paired-end shotgun library were mapped on a draft soybean reference soybean (G. max cv. Williams 82). The paired-end DNA sequences of 21.6 Gb produced by Illumina Hi-seq produced 21 fold sequence depth. Among the predicted deletion sites, total 3 deletion regions confirmed by PCR. Glyma03g02390 gene and Glyma03g03560 gene were involved in the deletion regions. Glyma03g02390 gene was related to AMP binding, catalytic activity, cofactor binding and metabolic process of cell growth and Glyma03g03560 gene was concerned to oxygen binding, defense response to bacterium, and especially process of indole acetic acid (IAA) biosynthesis. These genes detected in this mutant will be studied about their molecular function in stunted phenotype.
Yang, Yoon-Mo,Won, Young-Bin,Ji, Chang-Jun,Kim, Jung-Hoon,Ryu, Su-Hyun,Ok, Youn-Ha,Lee, Jin-Won Elsevier 2018 Biochemical and biophysical research communication Vol.502 No.1
<P><B>Abstract</B></P> <P>Molybdenum cofactor (Moco), molybdopterin (MPT) complexed with molybdenum, is an essential cofactor required for the catalytic center of diverse enzymes in all domains of life. Since Moco cannot be taken up as a nutrient unlike many other cofactors, Moco requires <I>de novo</I> biosynthesis. During the synthesis of MPT, the sulfur atom on the C-terminus of MoaD is transferred to cyclic pyranopterin monophosphate (cPMP) which is bound in the substrate pocket of MoaE. MoaD is a ubiquitin-like (Ubl) protein and has a C-terminal di-Gly motif which is a common feature of Ubl proteins. Despite the importance of free C terminal di-Gly motif of MoaD as a sulfur carrier, some bacteria encode a fused MPT synthase in which MoaD- and MoaE-like domains are located on a single peptide. Although it has recently been reported that the fused MPT synthase MoaX from <I>Mycobacterium tuberculosis</I> is posttranslationally cleaved into functional MoaD and MoaE in <I>M. smegmatis</I>, the protease responsible for the cleavage of MoaD-MoaE fusion protein has remained unknown to date. Here we report that the JAMM/MPN<SUP>+</SUP> domain containing metalloprotease DR0402 (JAMM<SUB>DR</SUB>) from <I>Deinococcus radiodurans</I> can cleave the MoaD-MoaE fusion protein DR2607, the sole MPT synthase in <I>D. radiodurans</I>, generating the MoaD having a C-terminal di-Gly motif. Furthermore, JAMM<SUB>DR</SUB> can also cleave off the MoaD from MoaD-eGFP fusion protein suggesting that JAMM<SUB>DR</SUB> recognizes the MoaD region rather than MoaE region in the cleaving process of MoaD-MoaE fusion protein.</P> <P><B>Highlights</B></P> <P> <UL> <LI> <I>D. radiodurans</I> encodes a fused MPT synthase, MoaD-MoaE fusion protein DR2607. </LI> <LI> JAMM/MPN<SUP>+</SUP> metalloprotease DR0402 (JAMM<SUB>DR</SUB>) can cleave the MoaD-MoaE fusion. </LI> <LI> JAMM<SUB>DR</SUB> recognizes the MoaD region in the cleavage process of MoaD-MoaE fusion. </LI> </UL> </P>
( Ha Na Yang ),( Hye Won Kim ),( Myung Gyu Kim ),( Sang Kyung Jo ),( Won Yong Cho ),( Hyoung Kyu Kim ) 대한신장학회 2010 Kidney Research and Clinical Practice Vol.29 No.3
Purpose: The prevalence of Chronic Kidney Disease (CKD) is increasing worldwide and was recently reported to be up to 13.7% in general population in Korea. The purpose of this study was to investigate the prevalence of CKD in subjects undergoing coronary angiography (CAG). Methods: Six hundred six subjects who underwent CAG in Korea University Anam Hospital during the time frame of 4 months were included and prevalence of CKD was estimated by using K/DOQI guideline with MDRD equation. Coronary artery disease was defined as one or more significant stenosis (50% or more) at CAG. Results: The prevalence of CKD was 36.4%. The proportion of hypertension and diabetes, the well- known risk factors of CKD were not different with general population. The prevalence of coronary artery disease was not different between two groups with or without CKD. Conclusion: The prevalence of CKD in subjects who undergo CAG is higher than that in general population (36.4% vs. 13.7%). It seems to be related with or other factors than hypertension and diabetes. Subsequently, using contrast media to this population might carry a higher risk of developing contrast induced acute kidney injury. More attention to assessing kidney function before CAG in this population is needed.