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미술치료 석사과정생의 소아암 환아를 대상으로 한 병원학교 미술치료 실습 체험연구
김초롱 서울여자대학교 2010 심리치료: 다학제적 접근 Vol.10 No.2
본 연구의 목적은 미술치료전공 석사과정생들이 소아암 환아를 대상으로 진행하는 병원학교의 미술치료 실습을 통해 어떤 체험을 하며, 그 체험의 의미와 본질이 무엇인지를 이해하는데 두었다. 이를 위해 Max van Manen의 해석학적 현상학 연구방법을 적용하여, 체험을 더욱 생생하고 깊이 있게 이해하고자 하였다. 2010년 9월부터 2010년 11월까지 심층 면담에 자발적으로 참여 의사를 밝힌 9명의 연구 참여자를 통해 자료를 수집하였으며, 이를 토대로 9개의 본질적 주제와 25개의 하위주제들을 도출하였다. 현상학적 반성과 글쓰기 등의 과정을 통하여, 연구 참여자들의 소아암 환아를 대상으로 한 병원학교 미술치료 실습 체험은 다음과 같은 결론을 내리고 있다. 첫째, 면역력이 약한 소아암 환아를 대상으로 하는 병원학교의 미술치료 실습에서 실습 초기나 실습 종료기 이후에도 환아에게 지나치게 몰입되어 있는 자신을 발견한다. 둘째, 실습현장에서는 미술치료 적 접근이외에, 소아암 환아의 특성을 잘 알고 융통성 있게 대처할 수 있는 철저한 준비와 경험이 요구됨을 자각한다. 셋째, 집단 미술치료는 소아암 환아에게 내면 표출, 또래와의 소통, 공감의 기회 등을 통해 자기개방과 치유로 연결시킨다. 넷째, 소아암 환아를 위해서는 병원학교 의료진, 환아의 가족, 실습생 및 자원 봉사자, 이들 모두의 원활한 소통이 요망되며, 특히 소아암 환아의 심리적 돌봄을 위해 전문적이고 역량있는 미술치료사가 필요하다. Purpose of study will understand that meaning and substance that art therapy major students through practice for childhood cancer patient in hospital school. I applied a hermeneutic phenomenology study way of 'Max van Manen', and the nine people who showed spontaneously in a participation opinion to an interview were selected for this. I collected data through intense interviews until November 2010 from September 2010, and it was derived from 25 subordinate subjects of 9 main subjects. Based on the research result, this study about experience of group art therapy practice with pediatric cancer patients in the hospital school made the following conclusions. First, art therapy practice in hospital schools who it to the immune weak childhood cancer patients in hospital schools and I find oneself who is immersed in excessively to patients after the practice early days or practice end. Second, besides art therapy approaches in practice, I am conscious of required preparation and experience that know about childhood cancer patients characteristic and cope flexibility. Third, group art therapy lets childhood cancer patients connect by own open healing through inside expression, communication with an age, an opportunity of sympathy. Fourth, hospital medical staffs, patient's family, trainees, and volunteers are demanded communication without a hitch for pediatric cancer patients. Especially, need to professional and capable art therapist for pediatric cancer patient's psychological care.
Spatiotemporal Expression and Functional Implication of CXCL14 in the Developing Mice Cerebellum
Cho Rong Park,황종익,Dong-Kyu Kim,Eun Bee Cho,Dong-Joo You,Jean Luc do Rego,David Vaudry,선웅,김현,성재영 한국분자세포생물학회 2012 Molecules and cells Vol.34 No.3
Cerebellar granule neurons migrate from the external gra-nule cell layer (EGL) to the internal granule cell layer (IGL) during postnatal morphogenesis. This migration process through 4 different layers is a complex mecha-nism which is highly regulated by many secreted proteins. Although chemokines are well-known peptides that trigger cell migration, but with the exception of CXCL12, which is responsible for prenatal EGL formation, their functions have not been thoroughly studied in granule cell migration. In the present study, we examined cerebellar CXCL14 expression in neonatal and adult mice. CXCL14 mRNA was expressed at high levels in adult mouse cerebellum, but the protein was not detected. Nevertheless, Western blotting analysis revealed transient expression of CXCL14 in the cerebellum in early postnatal days (P1, P8), prior to the completion of granule cell migration. Looking at the distribution of CXCL14 by immunohistochemistry revealed a strong immune reactivity at the level of the Purkinje cell layer and molecular layer which was absent in the adult cerebellum. In functional assays, CXCL14 stimulated transwell migration of cultured granule cells and enhanced the spreading rate of neurons from EGL micro-explants. Taken together, these results revealed the transient expression of CXCL14 by Purkinje cells in the developing cerebellum and demonstrate the ability of the chemokine to stimulate granule cell migration, suggesting that it must be involved in the postnatal maturation of the cerebellum.
Cho, Ah-Rong,Kim, Sung-Min,Kim, Seong-Cheol,Kim, Jung-Wan,Lee, Sang-Yul American Scientific Publishers 2016 Journal of nanoscience and nanotechnology Vol.16 No.11
<P>In this work, Pt-Pd nanoalloys with various compositions were synthesized using a solution plasma process with pure Pt, pure Pd and Pt80Pd20 (wt.%) alloy electrodes. The elemental compositions, structures and morphologies of the Pt-Pd nanoalloys were characterized using an inductively coupled plasma-optical emission spectrometer, energy dispersive X-ray spectroscopy, X-ray diffraction and high resolution transmission electron microscopy. In order to examine the electrochemical activities for formic acid oxidation, cyclic voltammetry was conducted using a potentiostat in a nitrogen-purged 0.5 M H2SO4 and 0.5 M HCOOH electrolyte solution. The compositions of as-synthesized Pt-Pd nanoalloys were measured by following: Pt82Pd18, Pt69Pd31, Pt41Pd59 and Pt29Pd71. From the results of the electrochemical characterization, the Pt69Pd31 nanoalloys showed much higher catalytic activity than the other Pt-Pd nanoalloys. Furthermore, and the CO poisoning was strongly affected by the Pd amounts in the synthesized Pt-Pd nanoalloys.</P>
Kim, Jae Kyeom,Lim, Ho-Jeong,Kim, Mi-So,Choi, Soo Jung,Kim, Mi-Jeong,Kim, Cho Rong,Shin, Dong-Hoon,Shin, Eui-Cheol Medknow PublicationsMedia Pvt Ltd 2016 Pharmacognosy magazine Vol.12 No.47
<P><B>Background:</B></P><P>The central nervous system is easily damaged by oxidative stress due to high oxygen consumption and poor defensive capacity. Hence, multiple studies have demonstrated that inhibiting oxidative stress-induced damage, through an antioxidant-rich diet, might be a reasonable approach to prevent neurodegenerative disease.</P><P><B>Objective:</B></P><P>In the present study, response surface methodology was utilized to optimize the extraction for neuro-protective constituents of <I>Camellia japonica</I> byproducts.</P><P><B>Materials and Methods:</B></P><P>Rat pheochromocytoma cells were used to evaluate protective potential of <I>Camellia japonica</I> byproducts.</P><P><B>Results:</B></P><P>Optimum conditions were 33.84 min, 75.24%, and 75.82°C for time, ethanol concentration and temperature. Further, we demonstrated that major organic acid contents were significantly impacted by the extraction conditions, which may explain varying magnitude of protective potential between fractions.</P><P><B>Conclusions:</B></P><P>Given the paucity of information in regards to defatted <I>C. japonica</I> seed cake and their health promoting potential, our results herein provide interesting preliminary data for utilization of this byproduct from oil processing in both academic and industrial applications.</P><P><B>SUMMARY</B></P><P><P>Neuro-protective potential of <I>C. japonica</I> seed cake on cell viability was affected by extraction conditions</P><P>Extraction conditions effectively influenced on active constituents of <I>C. japonica</I> seed cake</P><P>Biological activity of <I>C. japonica</I> seed cake was optimized by the responsive surface methodology.</P></P> >[FIG OMISSION]</BR><P><B>Abbreviations used:</B> GC-MS: Gas chromatography-mass spectrometer, MTT: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, PC12 cells: Pheochromocytoma, RSM: Response surface methodology.</P>
Ischemia Reperfusion Injury Triggers TNFα Induced-Necroptosis in Rat Retina
Kim, Cho Rong,Kim, Jie Hyun,Park, Hae-Young Lopilly,Park, Chan Kee IRL Press 2017 Current eye research Vol.42 No.5
<P>Conclusions: We showed that IR injury triggered increases in both activation of astrocytes and the expression of TNF. In addition, TNF, which was activated by IR, triggered the release of necroptosis factors, particularly, in GCL. Inhibition of necroptosis using Nec-1 decreased the level of RIP1 and retinal cell loss in IR-injured retinas.</P>
Kim, Cho-Rong,Kim, Young-Min,Lee, Min-Kyeong,Kim, In-Hye,Choi, Youn-Hee,Nam, Taek-Jeong UNKNOWN 2017 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.39 No.1
<P><I>Pyropia yezoensis</I> (<I>P. yezoensis</I>) is a marine algae that exhibits antioxidant, anti-inflammatory, antitumor and anti-aging activities. In this study, we investigated the effects of the <I>P. yezoensis</I> peptide, PYP1-5, on collagen synthesis in the human dermal fibroblast cell line Hs27. Skin aging is related to reduced collagen production and the activities of multiple enzymes, including matrix metalloproteinases (MMPs), which degrade collagen structure in the dermis, and tissue inhibitor of tissue inhibitor of metalloproteinases (TIMPs), which inhibit the action of MMPs. While collagen synthesis is associated with a number of signaling pathways, we examined the increased collagen synthesis via the upregulation of the transforming growth factor-β (TGF-β)/Smad signaling pathway. Using MTS assay, we found that PYP1-5 did not affect cell viability. Moreover, we confirmed that PYP1-5 increased type 1 collagen expression using enzyme-linked immunosorbent assay (ELISA), western blot analysis and quantitative PCR. In addition, we identified changes in various enzymes, as well as the mechanisms behind the PYP1-5-induced collagen synthesis. PYP1-5 decreased the MMP-1 protein and mRNA levels, and increased the TIMP-1 and TIMP-2 protein and mRNA levels. In addition, PYP1-5 activated the TGF-β/Smad signaling pathway, which increased TGF-β1, p-Smad2 and p-Smad3 expression, while inhibiting Smad7, an inhibitor of the TGF-β/Smad pathway. Furthermore, PYP1-5 upregulated transcription factor specificity protein 1 (Sp1) expression, which is reportedly involved in type 1 collagen expression. These findings indicate that PYP1-5 activates the TGF-β/Smad signaling pathway, which subsequently induces collagen synthesis in Hs27 cells.</P>
Kim, Myung-Chul,Kim, Da-Hye,Yun, Cho-Rong,Chung, Ju-Hee,Kim, Hyun-Soo,Choi, Hyo-Eun,Kong, Kwang-Hoon Food & Nutrition Press 2017 Journal of sensory studies Vol.32 No.2
<P>Practical applicationsThe refined SIAM yes-no task suggested in this study would enable researchers to accurately obtain thresholds of various sweet-tasting molecules, in order to develop potential sugar substitutes and elucidate interactions with their corresponding sweet-taste receptors T1R2-T1R3 for sweet-taste mechanism studies.</P>