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High-resolution crystal structure of the catalytic domain of human dual-specificity phosphatase 26.
Won, Eun Young,Xie, Yong,Takemoto, Chie,Chen, Lirong,Liu, Zhi Jie,Wang, Bi Cheng,Lee, Daeyoup,Woo, Eui Jeon,Park, Sung Goo,Shirouzu, Mikako,Yokoyama, Shigeyuki,Kim, Seung Jun,Chi, Seung Wook Wiley-Blackwell 2013 Acta crystallographica. Section D, Biological crys Vol.69 No.6
<P>Dual-specificity phosphatases (DUSPs) play an important role in regulating cellular signalling pathways governing cell growth, differentiation and apoptosis. Human DUSP26 inhibits the apoptosis of cancer cells by dephosphorylating substrates such as p38 and p53. High-resolution crystal structures of the DUSP26 catalytic domain (DUSP26-C) and its C152S mutant [DUSP26-C (C152S)] have been determined at 1.67 and 2.20 ? resolution, respectively. The structure of DUSP26-C showed a novel type of domain-swapped dimer formed by extensive crossover of the C-terminal α7 helix. Taken together with the results of a phosphatase-activity assay, structural comparison with other DUSPs revealed that DUSP26-C adopts a catalytically inactive conformation of the protein tyrosine phosphate-binding loop which significantly deviates from that of canonical DUSP structures. In particular, a noticeable difference exists between DUSP26-C and the active forms of other DUSPs at the hinge region of a swapped C-terminal domain. Additionally, two significant gaps were identified between the catalytic core and its surrounding loops in DUSP26-C, which can be exploited as additional binding sites for allosteric enzyme regulation. The high-resolution structure of DUSP26-C may thus provide structural insights into the rational design of DUSP26-targeted anticancer drugs.</P>
Case Report : Crohn`s Disease in a Patient Undergoing Hemodialysis Caused by IgA Nephropathy
Bi Ro Kim,Jae Won Yang,Joung Wook Choi,Young Sub Kim,Jong Myeong Yu,Seung Ok Choi,Byoung Geun Han 대한신장학회 2009 Kidney Research and Clinical Practice Vol.28 No.5
IgA nephropathy is usually localized to the kidney, however, it can accompany systemic disease, including gastrointestinal disease, skin disease, connective tissue disease, and malignant tumor. In some patients with IgA nephropathy which manifested as an extraintestinal symptom of Crohn`s disease, recovery of renal function was achieved following treatment of Crohn`s disease. The pathophysiology of each disease remains unclear. According to some studies, however, immunological, genetic, and environmental factors may be involved in a complex manner. In patients receiving renal replacement therapy for treatment of renal dysfunction due to IgA nephropathy, occurrence of Crohn`s disease as an extrarenal symptom has not been reported. We experienced a case of Crohn`s disease which developed in a patient receiving hemodialysis for treatment of end-stage renal disease due to IgA nephropathy.
Eun-Bi Yoon(윤은비),Sun-Woo Kim(김선우),Yong-Min Shin(신용민),Won-Yong Shin(신원용) 한국통신학회 2021 한국통신학회 학술대회논문집 Vol.2021 No.6
그래프 신경망(GNN: graph neural network)은 그래프 마이닝 분야에서 큰 주목을 받고 있지만 내부 결정 과정을 알 수 없는 블랙박스로 간주되었다. 최근 들어 모델의 결정을 설명하는 eXplainable AI(XAI)를 그래프 신경망에 적용하려는 연구가 시도되었다. 본 논문에서는 프로토타입 노드를 도입하여 모델의 결정에 대한 설명을 프로토타입과의 유사도를 기반으로 설명하는 방법론을 제안한다. Infection dataset을 사용하여 제안된 방법론이 모델 결정에 직관적인 설명을 제공함을 실험적으로 보인다.
( Jae Won Yang ),( Min Soo Kim ),( Jae Seok Kim ),( Jong Myoung Yoo ),( Seung Tae Han ),( Bi Ro Kim ),( Yun Deok Kim ),( Jeong Wook Choi ),( Seung Ok Choi ),( Byoung Geun Han ) 대한내과학회 2008 The Korean Journal of Internal Medicine Vol.23 No.4
Background/Aims: Brain natriuretic peptide (BNP) levels are known to be elevated in patients with chronic kidney disease (CKD) and normal heart function. Therefore, the present study was performed to examine the effectiveness of BNP level in diagnosing heart failure in patients with CKD and to determine its effects on survival rate and prognosis. Method: A total of 182 patients with CKD who visited the hospital due to dyspnea of NYHA class II were included in the study. BNP levels were measured and echocardiography was performed to divide the subjects into groups with and without heart failure. Their BNP levels, clinical courses, and survival rates were analyzed retrospectively. Results: When BNP level was ≥858.5 pg/mL in CKD patients, heart failure could be diagnosed with sensitivity and specificity of 77% and 72%, respectively. Survival rate of the group with BNP levels of ≥858.8 pg/mL was significantly lower than that of the group with BNP level below this threshold (p=0.012) and multivariate analysis showed that BNP level, age, and sex affected survival rate in the group with BNP level ≥858.8 pg/mL. Conclusions: BNP levels of patients with CKD showed a positive correlation with creatinine levels, and the critical point of BNP level for diagnosis of heart failure was 858.5 pg/mL. As the survival rate in patients with BNP level above the critical point was significantly low, this level was a useful indicator for predicting their prognosis. Care should be taken in interpreting BNP level because patients with stage 5 CKD may show a high concentration of BNP without heart failure.