Oxalate와 Enrofloxacin투여한 랫트신장에 대한 병리조직학적관찰

오원석,이차수,오규실,정원일,정재용,정다히,정규식 한국임상수의학회 2003 한국임상수의학회지 Vol.20 No.4

To investigate the renal effects of enrofloxacin administration on rats induced with dehydration or hyperoxaluria, male rats were treated with enrofloxacin of 50 mg to 500 mg/kg b.w.. The microscopical observations of kidney and urine sediment were carried out in the experimental groups. The result obtained were as follows; The male rats deprived of water for 72 hours and administered with enrofloxacin. As enrofloxacin administration dose was increased, clinical signs such as loss of appetite, depression, weakness, and loss of urine output became more severe. In the histopathological findings, there were hyperemia and hemorrhage in renal cortex, vacuolation and necrosis of renal tubular epithelia, proteinous casts within renal tubules. The male rats were orally administered with sodium oxalate and injected with enrofloxacin for 7days. As enrofloxacin administration dose was increased, clinical signs such as the loss of appetite and water consumption, and weakness became more severe. In the histopathological findings, there are hemorrhage of glomeruli and cortical hyperemia, vacuolation and necrosis of tubular epithelia, proteinous casts in renal tubules. In the microscopical findings of urine sediment, there are calcium oxalate crystal (diamond-like type) and magnesium ammonium phosphate crystals (rhomboid). The male rats were intraperitoneally injected with sodium oxalate and administered with enrofloxacin for 7days. As enrofloxacin administration dose was increased, clinical signs such as the loss of appetite and water consumption, weakness were more severe. In the histopathological findings, there were hyperemia and hemorrhage in both glomeruli and renal cortex. Severe necrosis of renal tubular epithelia, bluish materials within renal tubules were also found. In the microscopical findings of urine sediment, there were many calcium oxalate crystals. The present results suggest that enrofloxacin has some injurious effects in rats having dehydration or hyperoxaluria, and clinically, we should consider these renal injury effects when we use enrofloxacin in patients accompanied renal disease, dehydration and hyperoxaluria conditions.

Hepatic Cirrhosis Occurring in a Young Woodchuck(Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus(WHV)

Kyu-shik Jeong,정원일,Jae-yong Chung,Mi-young An,Chae-yong Jung,Gyoung-jae Lee,Jong-soo Kang,Byeong-cheol Kang,Young-heun Jee,Bruce H Williams,Young-oh Kwon,Da-hee Jeong 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2

Cirrhosis Occurring in a Young Woodchuck (Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus (WHV)Da-hee Jeong, Won-il Jeong, Jae-yong Chung, Mi-young An, Chae-yong Jung, Gyoung-jae Lee1, Jong-soo Kang1, Byeong-cheol Kang2, Young-heun Jee3, Bruce H Williams4, Young-oh Kwon5 and Kyu-shik Jeong*College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea1Shinwon Scientific Co., LTD, Research Institute, Suwon, Korea2Clinical Research Institute, Seoul National University, Seoul 110-744, Korea3College of Veterinary Medicine, Jeju National University, Jeju 690-756, Korea

한국 초파리 집단의 선택불리에 관한 지구 자기장이 소거된 자기장 영향

정승문,최오옥,박은규 圓光大學校 1996 論文集 Vol.32 No.2

본 연구에서는 한국 남해안 거제도의 자연집단의 야생형 초파리와 성연관 돌연변이형 황색체-백색안 초파리를 Helmholtz coils 장치를 사용해서 유도한 지구 자기장이 소거된 초파리집단과 비교집단인 지구 자기장내의 초파리 집단으로 사육해서 발생된 성적 선택빈도를 조사하여, 선택불리에 관한 다음과 같은 결과를 얻었다. 야생형 유전자를 운반한 염색체의 선택빈도는 20세대까지 전체 평균 빈도가 위의 2집단에서 각각 0.7212, 0.7180으로 관찰되었다. 이 결과는 지구 자기장이 소거된 집단에서 더 약한 선택분리 행동을 보여주었다. 성연관 돌연변이형 yw 유전자를 운반한 염색체의 선택빈도는 위의 각각의 조절된 자기장내의 초파리 집단에서 각각 0.0306, 0.0372로 관찰되었다. 이 결과는 자기장이 소거된 초파리 집단 보다 지구 자기장 내의 초파리 집단에서 더 약한 선택불리 행동을 보여 주었다. 초파리 집단의 전체 평균 발생율은 위의 초파리 집단에서 각각 53.40%, 40.60%로 관찰되었다. 이 결과는 지구 자기장내의 초파리 집단의 발생율이 상대적으로 낮은 수치로 조사되었다. Duncan's multiple range test와 LSD값으로 유의 차이를 검정하였던 바 야생형 그룹과 다른 3개의 돌연변이형 그룹 사이에서 고도의 유의차이가 있음이 밝혀졌다. To elucidate the genetic behavior of selective disadvantage among sex-linked mutants of Drosophila melanogaster bred and kept by the genetic study laboratory room, Wonkwang University and the wild type collected at Keojaedo island, and reared under the influence of two different strength of magnetic fields, i.e. the without magnetic field generated by Helmholtz coils and the ambient magnetic field, this study was carried out at the above indicated laboratory room. The mean selective frequencies of wild type gene-carrying chromosomes up to twentieth generation, affected by two different mafnetic fields, showed 0.7212 and 0.7180 with the magnetic field strength as mentioned other before. The data explains that Drosophila melanogaster population reared in the without magnetic field showed lower selective disadvantage. The selective frequencies of the individual of yw gene-bearing chromosomes showed 0.0306 and 0.0372 by the same order of magnetic field strength indicated above. It was shown that the fly population reared at the ambient magnetic field cleared the relatively lawer selective disadvantage. The over-all mean emergence rates of Drosophila melanogaster populations reared in controlled magnetic fields indicated above showed 53.40% and 46.60% respectively. Referring to these data, the fly population raised in the ambient magnetic field showed a relatively lower emergence rate than the without magnetic field population. Through Duncan's multiple range test and LSD value, the highly significant differences between the wild type and anyone of the other three mutants were calculated.

실험적 녹농균성 각막염에 대한 Cefotetan의 치료 효과

오명주,박정규,백태현,최대경 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.2

This study was carried out for the purpose of evaluation of effect of cefotetan against the pseudomonas induced keratitis. The corneal infection caused by pseudomonas organisms have a poor prognosis and their increased prevalence and general resistance to therapy make them a serious problem for to ophthalmologists. So, the author introduced experimental keratitis in the rabbit cornea by Ps. aeruginosa and Compared effects of the cefotetan and tobramycin. The cefotetan is a new antibiotic of cephalosporin system which is effective in vivo and vitro against not only gram positive but also gram negative organism and is stable against the β-lactamase. The results obtained were as follows: 1. Clinically, cefotetan and gentamicin were both effective against experimentally induced .pseudomonas keratitis and there was no significant difference between the efficacy of cefotetan and that of tobramycin. 2. In culture study, the test after treatment showed significantly fewer colonies on the platesfrom the cefotetan, tobramycin treated groups than those from the saline treated group, and there was no significant difference between cefotetan treated, and tobramycin treated group.

메타놀 混合燃料를 使用한 디젤機關의 燃燒變動에 關한 硏究

鄭奎祚,吳永澤 全北大學校 1993 論文集 Vol.36 No.-

Many of the promising alternative fuels have relatively low cetane numbers, and may result in combustion variation problems. The combustion variations are non-periodic phenomena and affected by methanol mixing rate, engine speed and other various operating conditions. The purpose of this study is that describe the cycle-to-cycle combustion variation on the characteristics of combustion peak pressure and period of ignition delay in the diesel engine. The obtained results are as follows: 1. As methanol mixing ratio and engine speed are increasing, fuel injection timing is delayed, engine load is decreasing, cycle-to-cycle combustion variations are increasing. 2. Cycle-to-cycle combustion variations result from the increment of the ignition delay period and misfire. 3. The variations of the brake mean effective pressure doesn't affect the misfire, but in case of the methanol mixing ratio is increasing and fuel injection timing is delayed, a remarkable combustion variations by misfire occurs. 4. The engine is better operated above 0.2 MPa, BMEP and front BTBC 4℃A, injection timing in the fuel of methanol mixing.

폐부종과 심정지가 발생한 페노바비탈 중독환자

오동렬,이운정,박규남,김세경,김영민,이환,유은영,최경호,정시경 大韓應急醫學會 1999 대한응급의학회지 Vol.10 No.2

Phenobarbital is a long-acting barbiturate causing generalized depression of neuronal activity in the brain. Its effect is primarily achieved through enhanced GABA-mediated synaptic inhibition. Its use as an antiepileptic agent was first described in 1912. Before the introduction of phenytoin, phenobarbital is used as sedative-hypnotics. It is used for the treatment of epilepsy and status epilepticus. All barbiturates, including phenobarbital, have a high potential for abuse. They were frequently used for suicide attempts in the past, but they have in large part been replaced by benzodiazepines. The onset of symptoms depends on the drug and the route of administration. Mild to moderate barbiturate intoxication resembles ethanol inebriation with slurred speech, ataxia, and lethargy. Severe acute barbiturate intoxication is life threatening. Early deaths are generally cardiovascular-related. Hypotension, shock, pulmonary edema, and cardiac arrest that occurs with large doses are caused by depression of central sympathetic tone and as well as by direct depression of cardiac contractility. The potentially fatal oral dose of phenobarbital is 6-10g. We describe an 23-year-old woman with pulmonary edema, and cardiac arrest ingestion of 18grams of phenobarbital. She was completely recovered by successful cardiopulmonary resuscitation and homoperfusion. We report a case with literature review.

슬개골 골절과 동반된 후방 십자인대 손상

오정환,신규철 건국대학교 의과학연구소 1994 건국의과학학술지 Vol.4 No.-

Patellar fractures result from direct and/or indirect forces. The majority of the patellar fractures result from direct injuries and a fall on the knee or a direct blow sustained in the vehicular trauma is one of the common causes. Patellar fractures from indirect forces occur when the intrinsic strength of the patella is exceeded by the pull of the musculotendinous and ligamentous units attaching to it and typically occurs in the act of stumbling or partially falling. Posterior cruciate ligament disruption is generally caused by a posteriorly directed force on the proximal tibia, and hyperextension with abduction or external rotation movements have been also described in the production of posterior cruciate ligament injuries. Posterior cruciate ligament injuries are apt to be negelected frequently, and ipsilateral femoral shaft fracture or posterior dislocation of the hip also may be seen with direct injuries to the patella, but patellar fractures are rarely associated with posterior cruciate ligament injuries. So we are reporting four cases of the posterior cruciate ligament injuries as one of the combined entity, which had been neglected and associated with the patellar fracture after a review of the literatures.

디젤機關의 燃料噴射特性에 關한 實驗的 硏究

鄭奎祚,吳永澤 全北大學校 1993 論文集 Vol.36 No.-

This paper deals with the spray characteristics, combustion characteristics and engine performance by changing the kind of fuel and temperature in IDI diesel engine. It is known that the spray characteristics have very complicated flow process in the cylinder after injecting, and the prediction and measurement of the spray characteristics are very difficult at the actual operating condition of engine. Therefore, the experiments are tried to spray which is injected into quiescent air at room temperature and atmosphere. The results obtained with this experiments are as follows; 1. The spray penetration and spray angle for diesel fuel are increased when the fuel is heated as compared with the normal temperature. And for methanol, the spray penetration is reduced slightly while the spray angle increased. 2. With increasing fuel temperature, the spray penetration decreases considerably and the spray angle increases rapidly above the boiling temperature of various kinds of fuel. And the spray droplets are considerably atomized. 3. The significant improvement in BSFC, smoke emission and CO concentration can be obtained by heating fuel to an optimum temperature and engine noise and NO_x are increased. 4. There is an optimum fuel temperature for BSFC and smoke emission, and this temperature for diesel fuel is about 120℃.

無等山 標高에 따른 季節別 昆蟲相에 關한 硏究(Ⅰ) : -春季分布相-

丁聖淑,金美蓮,金奎眞,吳貞子 全南大學校 農漁村開發硏究所 1992 農業科學技術硏究 Vol.27 No.-

無等山 標高에 따른 季節別 昆蟲相을 調査하기 위해 1991-1992年 2個年에 걸쳐 調査한 結果를 要約하면 다음과 같다. 1. 無等山의 봄에 分布하는 昆蟲種類는 總 10目 39科 120種이 調査되었다. 2. 標高別 調査에서는 100-500M에서 10目 37科 110種이, 500-900m에서는 9目 35科 101種이, 900-1200m에서는 5目 12科 18種이 調査되었다. 3. 표고에 따른 출현빈도가 높고 발생량이 많은 種은 100-500m 에서는 흰나비科의 줄흰나비(Artogeia napi), 배추흰나비 (Artogeia rapae), 배추흰나비 (Artogeia rapae), 네발나비科의 청띠신선나비 (kanisha canace), 애기세줄나비 (Neptis dsppho), 풍뎅이科의 검정풍뎅이 (Holotrichia kiotensis), 꿀벌科의 꿀벌(Apis melica), 뒤영벌科의 어리호박벌(Xylocopa appendiculata)로 밝혀졌고, 500-900m 사이에서는 네발나비科의 애기세줄나비(Neptis dssppho), 허리노린재科의 큰허리노린재(Molipteryz fulignosa), 집게벌레科의 노란다리민집게벌리(Euborellia pallopes), 꿀벌科의 꿀벌(Apis melifica)이었고 900-1200m에서는 부전나비科의 부전나비(Pelbejus angus), 꿀벌科의 꿀벌 Apis melifica), 길앞잡이科의 아이누길앞잡이(Cicindela gemmata)等이었다. 4. 무등산 정상인 1,000-1,200m 지대에서 봄에만 볼수있는 종으로서 호랑나비科의 이른봄애호랑나비(Luehdorfia puzilor), 흰나비과의 갈고리나비(Anthocharis scolymus) 2種이 관찰되었다. This study was carried out to investigate the insects fauna of Mt. Mudeung in spring season from 1991 to 1992. The results obtain summaries as follows. 1. The total of 120 species belongs to 39 families of 10 orders were investigated. 2. In different sea levels,10 orders 37 families 110 species at 100-500m. 9 orders 35 families 101 species at 500-900m and 5 orders 12 families 18 species at 900-1200m in sea level investigated respectively. 3. High grequency and population density of Insects by sea level were investigated : Artogeia rapae, Kanisha canace, Neotis dspho, Holotrichia kiotensis, Apis melifica and Xylocopa appendiculata in 100-500m. Plebejus angus, Apis melifica and Cicinedela gemmata in 900-1200m above sea level. 4. Both species of Luehdorfia puzilor and Anthocharis solymus were observed at 1000-1200m of Mt.Mudeung as species appeared only spring season.

심한 낙타혹(Hump)의 형성을 동반한 제 2 형 막증식성 사구체신염(Dense Deposit Disease) 1예

오희정,유민아,이영숙,김미연,김승정,강덕희,윤견일,최규복,성순희 이화여자대학교 의과대학 2004 EMJ (Ewha medical journal) Vol.27 No.1

Dense deposit disease (DDD), known as type Ⅱ MPGN, is an uncommon form of glomerulonephritis. It is an acquired primary glomerular disease, characterised by electron microscopic evidence of a continous, dense membrane deposition replacing the lamina densa. There is associated alternative pathway complement activation and a C3 nephritic factor maybe present. Patients with dense deposit disease tend to be young at clincal onset and more commonly have persistent nephrotic syndrome, gross hematuria, and acute nephritis episode and persistent depression of the serum complement level. The prognosis of dense deposit disease is worse than that of typeⅠMPGN. We experienced a patient with dense deposit disease that presenting persistent nephrotic syndrome, gross hematuria and having subepithelial hump. It is a first report of dense deposit disease having subepithelial hump in Korea, therefore we report this case with the review of relevant literatures.