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Park, J. M.,Choi, M.-G.,Kim, S. W.,Chung, I.-S.,Yang, C. W.,Kim, Y. S.,Jung, C. K.,Lee, K. Y.,Kang, J.-H. Wiley (Blackwell Publishing) 2010 American journal of transplantation Vol.10 No.9
<P>This study was to evaluate the frequency of colorectal neoplasia in renal transplant recipients and to investigate the association with Epstein-Barr virus (EBV) and cytomegalovirus (CMV) infection. We compared the frequency of colorectal neoplasia among renal transplant recipients with that of the healthy subjects. Specimens of colorectal neoplasia were examined for EBV and CMV using in situ hybridization and immunohistochemistry, respectively. Of 796 renal transplantation cohorts, 315 were enrolled. The frequency of colorectal neoplasia among the patients was 22.9%. Compared with the healthy subjects, the odds ratio (OR) for advanced adenoma was 3.32 (95% CI, 1.81-6.10). The frequency of cancer among the patients was 1.9% (OR, 12.0; 95% CI, 1.45-99.7). A long interval between transplantation and colonoscopy was a significant factor in the development of advanced colorectal neoplasia. EBV positivity was detected in 30.6% of colorectal neoplasia specimens from renal transplant recipients, which was higher than that for the controls (p = 0.002). CMV was not detected in any lesions of patients or controls. In conclusion, renal transplant recipients have a significantly increased risk of advanced colorectal neoplasia. EBV was more frequently found in specimens of advanced colorectal neoplasm obtained from the renal transplant recipients.</P>
A New Stent Design for the Treatment of True Bifurcation Lesions: H-Side Branch Stents
HONG, MYEONG-KI,SHIM, JAE-MIN,YOUN, YOUNG-JIN,LEE, KYUNG-HOON,KIM, JUNG-SUN,KO, YOUNG-GUK,LEE, SEUNG-HWAN,CHOI, DONGHOON,YOON, JUNGHAN,JANG, YANGSOO Wiley (Blackwell Publishing) 2010 Journal of interventional cardiology Vol.23 No.1
Pasaje, Charisse Flerida A.,Kim, Jeong-Hyun,Park, Byung-Lae,Cheong, Hyun Sub,Chun, Ji-Yong,Park, Tae-Joon,Lee, Jin-Sol,Kim, Yongha,Bae, Joon Seol,Park, Jong Sook,Yoon, Sang-Hyuk,Uh, Soo-Taek,Choi, Jae Wiley (Blackwell Publishing) 2010 Annals of human genetics Vol.74 No.4
<P>Aspirin-intolerant asthma (AIA) occurs from asthma exacerbation after exposure to aspirin. However, the underlying mechanisms of AIA occurrence are still unclear. The critical role of the solute carrier family 6 (neurotransmitter transporter, betaine/GABA) member 12 (SLC6A12) gene in GABAergic transmission, which is associated with mucus production in asthma, makes it a candidate gene for AIA association study. Eight single nucleotide polymorphisms (SNPs) in SLC6A12 were genotyped in 163 aspirin-intolerant asthma (AIA) and 429 aspirin-tolerant asthma (ATA) patients of Korean ethnicity. Associations between polymorphisms of SLC6A12 and AIA were analysed using multivariate logistic analysis. Results showed that two polymorphisms and a haplotype in SLC6A12, rs499368 (P= 0.005; P(corr)= 0.03), rs557881 (non-synonymous C10R, P= 0.007; P(corr)= 0.04), and SLC6A12_BL1_ht1 (P= 0.009; P(corr)= 0.05) respectively, were significantly associated with AIA after multiple testing corrections. In addition, SNPs of SLC6A12 were significantly associated with the fall rate of FEV(1) by aspirin provocation suggesting that SLC6A12 could affect reversibility of lung function abnormalities in AIA patients. Although these results are preliminary and future replications are needed to confirm these findings, this study showed evidence of association between variants in SLC6A12 and AIA occurrence among asthmatics in a Korean population.</P>
CHUNG, Jin Woong,JEON, Jun-Ho,YOON, Suk-Ran,CHOI, Inpyo Wiley (Blackwell Publishing) 2006 The Journal of Dermatology Vol.33 No.10
<P>Vitamin D(3) upregulated protein 1 (VDUP1) is a 46-kDa multifunctional protein, initially isolated in HL-60 cells as a protein of which expression is upregulated by vitamin D(3) administration. Subsequently, it was identified independently by investigators from diverse scientific backgrounds as a thioredoxin binding protein that negatively regulates the expression and the activity of thioredoxin, and is thus involved in redox regulation. Further studies have revealed that VDUP1 plays multiple roles in a wide range of cellular processes such as proliferation or apoptosis. Recently, it has been reported that VDUP1 is also involved in the immune system via positive regulation of natural killer development. In addition, VDUP1 has been revealed to be associated with the fatty acid utilization. In the present review, we discuss the novel aspects of VDUP1 function as well as the historical background of VDUP1. Future studies will explore the diagnostic and therapeutic potential of modulating the function of VDUP1 in vivo.</P>