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- 저자 : Wen Jun Gong (검색결과 12 건)
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Wen Jun Gong,Zhigang Tao,Man Chao He,Hui Jun Hou 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.9
As a typical and complex failure type of rock slopes, flexural toppling failure has increasingly received attention, mainly focused on its failure mechanism and introducing a proper numerical method to reproduce the failure phenomena. However, there are few studies related to the supporting mechanism against flexural toppling failure. This study attempted to make a preliminary analysis on the research gap. For this purpose, an anti-dip layered rock slope supported with anchor cables that failed owning to flexural toppling was taken as an example, and the numerical method discontinuous deformation analysis (DDA) was taken as the major analytical tool. Firstly, the rationality of DDA was verified by correctly simulating the failure state of the anti-layered rock slope and the underlying failure mechanism was studied. The results indicated that the lack of the support from slope toe is the crucial factor inducing the flexural toppling failure, which posed a great obstacle to the further excavation of the open-pit mine. Secondly, by introducing the anchor cable support to the slope toe in the DDA model, the interaction mechanism between the anchor cables and the rock slope was investigated. the results indicated that the supporting system of the ordinary anchor cables is very sensitive to the inhomogeneous flexural toppling deformation. The tension values of the anchor cables are very inhomogeneous, and once some of anchor cables beyond their tension limit, the anchor cables failed, which will greatly threaten the safety of the adjacent anchor cables and even the stability of the whole slope. Meanwhile, a novel anchor cable called constant-resistance-large-deformation (CRLD) anchor cable was introduced for a comparative study using DDA. just replacing the anchor cables of the original slope with the CRLD anchor cables, the slope can reach stable state eventually even without the slope toe being enhanced. In addition, the CRLD anchor cables were able to support the slope well against the inhomogeneous deformation, because they can provide high constant resistances and withstand large deformations. This study can provide a deeper insight into the support mechanism for the snit-layered rock slope against flexural toppling failure and introduce a novel supporting method for such slopes.
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Zhang, Wen-Ying,Zhang, Wen-Jun,Bai, Yu,Yuan, Hai-Hua,Liu, Feng,Gao, Jun,Gong, Yan-Fang,Jiang, Bin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1
Aims: The aim of this study was to investigate the effects of adjuvant chemotherapy cycles on the prognosis of patients with post-operative stomach cancer through retrospective analysis. Methods: A total of 128 patients with gastric cancer who underwent gastrectomy, followed by adjuvant chemotherapy consisting of epirubicin, cisplatin or oxaliplatin, leucovorin, and 5-fluorouracil, according to a defined schedule, were divided into three groups according to the number of chemotherapy cycles: Group I (<6 cycles); Group II (6 cycles); and Group III (>6 cycles). Results: The 5-year overall survival (OS) was 20.8% in Group I, 45.0% in Group II, and 42.9% in Group III, with a median follow-up of 43 months. The 5-year relapse-free survival (RFS) was 15.1% in Group I, 40% in Group II, and 40% in Group III. The OS and RFS in Groups II and III were significantly better than in Group I (OS, p = 0.002 and p=0.003; RFS, P<0.001 and P=0.002). There was no difference in OS (p = 0.970) or in RFS (p = 0.722) between Groups II and III. Multivariate Cox hazard analysis determined that the number of adjuvant chemotherapy cycles was an independent factor that influenced OS and RFS. Conclusion: Six cycles of adjuvant chemotherapy gave encouraging outcomes in patients with resectable gastric cancer. Further prospective randomized controlled investigations are warranted in a multi-center setting.
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Gong, Shu-Wen,Liu, Li-Jun,Zhang, Qian,Wang, Liang-Yin Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.4
Silica supported $Cs_{2.5}H_{0.5}PMo_{12}O_{40}$ catalyst was prepared through sol-gel method with ethyl silicate-40 as silicon resource and characterized by X-ray diffraction, infrared spectroscopy, scanning electron microscopy, nitrogen adsorption-desorption and potentiometric titration methods. The $Cs_{2.5}H_{0.5}PMo_{12}O_{40}$ particles with Keggin-type structure well dispersed on the surface of silica, and the catalyst exhibited high surface area and acidity. The catalytic performance of the catalysts for benzene liquid-phase nitration was examined with 65% nitric acid as nitrating agent, and the effects of various parameters were tested, which including temperature, time and amount of catalyst, reactants ratio, especially the recycle of catalyst was emphasized. Benzene was effectively nitrated to mononitro-benzene with high conversion (95%) in optimized conditions. Most importantly, the supported catalyst was proved has excellent stability in the nitration progress, and there were no any other organic solvent and sulfuric acid were used in the reaction system, so the liquid-phase nitration of benzene that we developed was an eco-friendly and attractive alternative for the commercial technology.
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Gong-Chen Zhang,Wen-Li Zhu,Jun-Yi Gai,Yue-Lin Zhu,Li-Fei Yang 한국원예학회 2015 Horticulture, Environment, and Biotechnology Vol.56 No.1
Vegetable soybeans [Glycine max (L.) Merrill] are susceptible to salt stress and, thus, soil salinity can severely affect their growth and productivity. To enhance the salt tolerance of vegetable soybeans, a novel Solanum torvum Swartz Δ1-pyrroline-5-carboxylate synthetase gene (StP5CS, GenBank accession number: JN606861) that encodes a critical regulatory enzyme in proline biosynthesis was transformed into the cultivar NY-1001 using an Agrobacteriummediated transformation method. PCR and Southern blot analyses indicated that two independent T0 fertile transgenic plants were generated. The transgenic plants transmitted the transgenes into their T1 progeny in a 3:1 ratio. The T2 and T3 homozygous transgenic lines (HTLs) were examined for salt tolerance in pot and hydroponic cultures, respectively. The StP5CS overexpression conferred salt tolerance in T2 and T3 HTLs. Under NaCl stress conditions, the leaf scorch scores of T2 and T3 HTLs were significantly lower than those of wild-type (WT) plants. The plant height, leaf area, relative chlorophyll content, and number of fresh pods of T2 and T3 HTLs were significantly higher than those of WT plants. Compared with WT plants, T2 and T3 HTLs had significantly higher levels of proline and significantly lower levels of membrane lipid peroxidation. These results indicate that StP5CS overexpression in HTLs results in enhanced salt tolerance associated with higher levels of proline accumulation under salinity stress and that StP5CS can be utilized to improve salinity tolerance in vegetable crop genetic engineering.
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Yadong Gong,Yunguang Zhou,Xuelong Wen,Jun Cheng,Yao Sun,Lianjie Ma 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.7
Nickel-based single crystal superalloy has no grain boundary, which leads to the removal mechanism difference between single crystal material and polycrystalline material. Firstly, the removal mechanism of grinding nickel-based single crystal superalloy is analysed. Then, the developed prediction model of the tangential force F t and the normal force F n are established. Forthermore, the impacts of grinding parameters on grinding force and microstructure of grinding surface and sub-surface are analysed. Finally, some measurements to reduce or prevent recrystallization are proposed. As a result, the most shear slipping planes of nickel-based single crystal superalloy are {111} planes; with the increasing of the feeding rate and grinding depth, the micro-grinding force and the thickness of subsurface plastic deformation increase; the micro-grinding force and the thickness of subsurface plastic deformation decrease with the increasing of spindle speed. These results have some theoretical and engineering significance to the production of single crystal material parts.
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Ling Chen,Wen-jun Xiao,Qiong-xian Yan,Zhi-hua Gong,Sheng Zhang,Li Zeng,Ming Yang,Yan-he Zhou 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.8
The aim of this study is to evaluate the antiinflammatory and protective eff ects of L -theanine in infl ammatorybowel disease (IBD) and to identify the underlyingmolecular mechanisms. Rats were pre-treated with L -theanineat 0, 50, 200, or 800 mg/kg/day. IBD was induced inrats using dextran sulfate sodium (DSS). Histopathologicalanalysis suggests that L -theanine can suppress DSS-inducedIBD with signifi cant inhibition of infl ammation in large andsmall intestinal tissues. Moreover, the 200 mg/kg/day L -theanine-treated DSS group had higher body and small intestineweights, a lower disease activity index and expression ofinfl ammatory factors than the DSS group without pre-treatment. In RNA sequencing and tandem mass tag labelinganalyses, large number of mRNAs and proteins expressionlevel diff ered when compared with the DSS-induced ratswith and without 200 mg/kg/day L -theanine pre-treatment. Moreover, Kyoto Encyclopedia of Genes and Genomes pathwayanalysis indicates the anti-infl ammatory activities ofL -theanine in DSS-induced IBD, with a high representationof genes in “Cholesterol metabolism” and “Retinol metabolism”pathways. Analysis of protein–protein interaction networksfurther indicates the involvement of these two pathways. These studies suggest that medium-dose L -theaninepre-treatment could ameliorate DSS-induced IBD throughmolecular mechanisms involving cholesterol and retinolmetabolism.
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Ying-Long Chen,Wen-Shuo Li,Qiang Guo,Yong-Jun Gong 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.1
In this paper, a novel kinematics model based on segmented variable curvature (SVC) method is proposed to describe the deformation of soft manipulator under the condition of environmental contact. Firstly, the variable curvature (VC) framework is used to the spatial backbone curve, which is to discrete the soft manipulator into tangent arcs with different curvatures. When the contacts with surroundings occur, the contacted arcs are further divided into several separate sub-segments at the contact points. Then, combining kinematics and statics of all the segments, the model of soft manipulator is established under environmental constraints. The proposed model inherits the generality of the continuous VC method, and resolves the complex contact problem with environmental constraints. Finally, simulations and experiments are conducted to verify the effectiveness of the proposed SVC method under contact conditions. The results show that compared with the traditional VC method the proposed model can obtain higher accuracy in describing contact segment deformation under contact constraints without knowing the contact force in advance.
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Fan, Li-Qun,Zhang, Yu-Ping,Gong, Wen-Jun,Qu, Ling-Bo,Lee, Kwang-Pill Preston Publications 2010 Journal of Chromatographic Science Vol.48 No.5
<P>Butyl-methacrylate-based porous monoliths were rapidly prepared in the fused-silica capillary with a 10-cm stripe of polyimide removed from its exterior. The photopolymerization could be carried out in 150 s using ethylene glycol dimethacrylate as a cross-linking agent; 1-propanol, 1,4-butanediol, and water as tri-porogenic solvents; and Irgacure 1800 as a photo-initiator. The effect of different morphologies on the efficiency and retention properties was investigated using pressure-assisted CEC (p-CEC), CEC, and low pressure-assisted liquid chromatography modes (LPLC). Baseline separation of the model analytes was respectively achieved including thiourea, toluene, naphthalene, and biphenyl with the lowest theoretical height up to 8.0 microm for thiourea in the mode of p-CEC. Furthermore, the influence of the tri-porogenic solvents on the morphology of methacrylate-based monoliths was systematically studied with mercury intrusion porosimetry and scanning electron microscopy.</P>
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Bai, Lian-Song,Chen, Chuang,Gong, Yi-Ping,Wei, Wen,Tu, Yi,Yao, Feng,Li, Juan-Juan,Wang, Li-Jun,Sun, Sheng-Rong Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2
Objective: To evaluate the relationships between lymph node ratio (LNR, the ratio of positive lymph nodes in excised axillary lymph nodes) and disease-free survival (DFS) by comparing with traditional absolute positive lymph node number (pN classification) for prediction of breast cancer (BC) progrnosis. Methods and Patients: We retrospectively reviewed patients who received comprehensive therapy in Department of Breast Surgery, Hubei Cancer Hospital, China from Jan 2002 to Dec 2006 (Group A), and Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, China from Jun 2008 to May 2012 (Group B). Patients were allocated to low-risk (${\leq}0.20$), intermediate-risk (> 0.20 but ${\leq}0.65$), high-risk (>0.65) groups by LNR. The primary endpoint was 5-DFS. Results: A total of 294 patients were included in our study. LNR was verified as a negative prognostic factor for DFS (P=0.002 in Group A, P<0.0001 in Group B). Then we found the effects of pN and LNR delamination on disease-free survival (DFS) had statistical significance (P=0.012 for pN and P=0.031 for LNR stratification in Group A, both of them P<0.001 in Group B). Compared to pN staging, LNR staging displayed superior performance in prognosis, the adjusted hazard ratio of recurrence being 2.07 (95%CI, 1.07 to 4.0) for intermediate risk group (P=0.030) and 2.44 (95%CI, 1.21 to 4.92) for high risk group (P=0.013) in Group A. Conclusions: LNR stratification proved an adverse prognostic factor of DFS in lymph nodes positive invasive BC using cut-off values 0.20 and 0.65, and was more predictive than traditional pN classification for 5-DFS.
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