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Xue Xu,Yue-sheng Huang,Qiong Zhang,Jiong-yu Hu,Dong-xia Zhang2,Xu-pin Jiang,jie-zhi Jia,Jing-ci Zhu 한국분자세포생물학회 2013 Molecules and cells Vol.36 No.4
Hypoxia-induced microtubule disruption and mitochondrial permeability transition (mPT) are crucial events leading to fatal cell damage and recent studies showed that microtubules (MTs) are involved in the modulation of mitochondrial function. Dynein light chain Tctex-type 1 (DYNLT1) is thought to be associated with MTs and mitochondria. Previously we demonstrated that DYNLT1 knockdown aggravates hypoxia-induced mitochondrial permeabilization, which indicates a role of DYNLT1 in hypoxic cytoprotection. But the underlying regulatory mechanism of DYNLT1 remains illusive. Here we aimed to investigate the phosphorylation alteration of DYNLT1 at serine 82 (S82) in hypoxia (1% O2). We therefore constructed recombinant adenoviruses to generate S82E and S82A mutants, used to transfect H9c2 and HeLa cell lines. Development of hypoxia-induced mPT (MMP examining, Cyt c release and mPT pore opening assay), hypoxic energy metabolism (cellular viability and ATP quantification), and stability of MTs were examined. Our results showed that phosph-S82 (S82-P) expression was increased in early hypoxia; S82E mutation (phosphomimic) aggravated mitochondrial damage, ele-vated the free tubulin in cytoplasm and decreased the cellular viability; S82A mutation (dephosphomimic) seemed to diminish the hypoxia-induced injury. These data suggest that DYNLT1 phosphorylation at S82 is involved in MTs and mitochondria regulation, and their interaction and cooperation contribute to the cellular hypoxic tolerance. Thus, we provide new insights into a DYNLT1 mechanism in stabilizing MTs and mitochondria, and propose a potential therapeutic target for hypoxia cytoprotective studies.
Sheng-hai Zhang,Ying-zi Wang,Fan-yun Meng,You-lin Li,Cai-xia Li,Fei-peng Duan,Qing Wang,Xiu-ting Zhang,Chun-ni Zhang 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.5
Flavonoid glycosides are metabolized byintestinal bacteria, giving rise to a wide range of phenolicacids that may exert systemic effects in the body. Themicrobial metabolism of flavonoids extracted from theleaves of Diospyros kaki (FLDK) by intestinal bacteria wasinvestigated in vitro. High-performance liquid chromatography/linear trap quadrupole orbitrap mass spectrometrywas performed to analyze the metabolites of flavonoidsin vivo using Xcalibur2.1 software. The results showed thatthe levels of flavonoid glycosides and flavonoid aglyconesdecreased rapidly in the process of microbial metabolismby intestinal bacteria in vitro, and the metabolic rate maybe related to the concentration of intestinal bacteria in theculture solution. In vivo metabolites of FLDK weredetected in rat plasma and urine after oral administration ofFLDK. Eight flavonoids were identified in the urine, andthree were identified in the plasma; however, flavonoidaglycones were not found in the plasma.
Revision of the spider genus Taira (Araneae, Amaurobiidae, Amaurobiinae)
Zhi-Sheng Zhang,Ming-Sheng Zhu,Da-Xiang Song 한국거미연구소 2008 한국거미 Vol.24 No.2
The cribellate amaurobiid genus Taira, which is suggested to be most similar to the genus Amaurobius and someother related genera, is revised based on genital characters. Eight species, one from Japan and seven from China, areincluded. Five new species from China are described: T. cangshan, T. concava, T. latilabiata, T. obtusa, and T. sulciformis.Titanoeca decorata Yin & Bao 2001 is newly transferred to this genus and its male is described for the first time. Tairalunaris Wang & Ran 2004 is newly synonymized with T. liboensis Zhu, Chen & Zhang 2004.
Two New Species of the Genus Allozelotes Yin & Peng, 1998 (Araneae, Gnaphosidae) from China
Yang Zi-Zhong, Zhang Zi-Sheng, Zhang Yao-Guang, Joo Pil Kim(김주필) 한국거미연구소 2009 한국거미 Vol.25 No.1-2
중국 Yunnan 지역에서 채집한 수리거미과의 Allozelotes 속의 2 신종을 기재하여 보고하는 바이다. 즉 Allozelotes songi sp. nov.와 A. microsaccatus sp. nov. 이다. 표본은 SWUC와 CDLC에 보관한다. 측정치는 millimeters이다. Two new species of the genus Allozelotes collected from Yunnan, China, are described and illustrated: Allozelotes songi sp. nov. and A. microsaccatus sp. nov. Type specimens are respectively deposited in School of Life Science, Southwest University(SWUC) and College of Life Science and Chemistry, Dali University(CDLC). All measurements given are in millimeters.
Conceptual Graph Matching Method for Reading Comprehension Tests
Zhang, Zhi-Chang,Zhang, Yu,Liu, Ting,Li, Sheng The Korea Institute of Information and Commucation 2009 Journal of information and communication convergen Vol.7 No.4
Reading comprehension (RC) systems are to understand a given text and return answers in response to questions about the text. Many previous studies extract sentences that are the most similar to questions as answers. However, texts for RC tests are generally short and facts about an event or entity are often expressed in multiple sentences. The answers for some questions might be indirectly presented in the sentences having few overlapping words with the questions. This paper proposes a conceptual graph matching method towards RC tests to extract answer strings. The method first represents the text and questions as conceptual graphs, and then extracts subgraphs for every candidate answer concept from the text graph. All candidate answer concepts will be scored and ranked according to the matching similarity between their sub-graphs and question graph. The top one will be returned as answer seed to form a concise answer string. Since the sub-graphs for candidate answer concepts are not restricted to only covering a single sentence, our approach improved the performance of answer extraction on the Remedia test data.
Physical properties and chemical composition of the cores in the California molecular cloud
Zhang, Guo-Yin,Xu, Jin-Long,Vasyunin, A. I.,Semenov, D. A.,Wang, Jun-Jie,Dib, Sami,Liu, Tie,Liu, Sheng-Yuan,Zhang, Chuan-Peng,Liu, Xiao-Lan,Wang, Ke,Li, Di,Wu, Zhong-Zu,Yuan, Jing-Hua,Li, Da-Lei,Gao, Springer-Verlag 2018 Astronomy and astrophysics Vol.620 No.-
<P><I>Aims.</I> We aim to reveal the physical properties and chemical composition of the cores in the California molecular cloud (CMC), so as to better understand the initial conditions of star formation.</P><P><I>Methods.</I> We made a high-resolution column density map (18.2′′) with <I>Herschel</I> data, and extracted a complete sample of the cores in the CMC with the fellwalker algorithm. We performed new single-pointing observations of molecular lines near 90 GHz with the IRAM 30m telescope along the main filament of the CMC. In addition, we also performed a numerical modeling of chemical evolution for the cores under the physical conditions.</P><P><I>Results.</I> We extracted 300 cores, of which 33 are protostellar and 267 are starless cores. About 51% (137 of 267) of the starless cores are prestellar cores. Three cores have the potential to evolve into high-mass stars. The prestellar core mass function (CMF) can be well fit by a log-normal form. The high-mass end of the prestellar CMF shows a power-law form with an index <I>α</I> = −0.9 ± 0.1 that is shallower than that of the Galactic field stellar mass function. Combining the mass transformation efficiency (<I>ε</I>) from the prestellar core to the star of 15 ± 1% and the core formation efficiency (CFE) of 5.5%, we suggest an overall star formation efficiency of about 1% in the CMC. In the single-pointing observations with the IRAM 30m telescope, we find that 6 cores show blue-skewed profile, while 4 cores show red-skewed profile. [HCO<SUP>+</SUP>]/[HNC] and [HCO<SUP>+</SUP>]/[N2H<SUP>+</SUP>] in protostellar cores are higher than those in prestellar cores; this can be used as chemical clocks. The best-fit chemical age of the cores with line observations is ~5 × 10<SUP>4</SUP> yr.</P>
Zhang, Cong-Hai,Yan, Sheng-Jiao,Pan, Sheng-Qiang,Huang, Rong,Lin, Jun Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.4
A series of novel chiral tert-amino alcohols 4a-h derived from enantiomerically pure phenylalanine were synthesized efficiently and used as chiral ligands in the catalytic enantioselective ethylation of aldehydes with diethylzinc (diethylzinc-to-aldehyde addition). The use of 10 mol % of the amino alcohols led to the corresponding sec-alcohols with excellent enantioselectivities (up to 100% ee) and high yields.
The Research and Application of Modular Mobile Phone Web Front-end Based on MVCS Mode
Zhang Wen-sheng,Chen Hong 보안공학연구지원센터 2015 International Journal of Future Generation Communi Vol.8 No.5
With the popularity of mobile devices in recent years, the application of mobile phone Web front-end has become a research hotspot. This paper has constructed the MVCS (Model-View-Controller-Store) model by taking the MVC model as the framework, the ExtJS modular as the basis, and data storage (Store) as the data container, explained by taking the book information system the methods and steps of adopting such model to complete the design of modular mobile phone Wed front-end, and displayed the real-time data chart of mobile phone web front-end. Finally, it also has discussed the research trend.
RANKS OF SUBMATRICES IN A GENERAL SOLUTION TO A QUATERNION SYSTEM WITH APPLICATIONS
Zhang, Hua-Sheng,Wang, Qing-Wen Korean Mathematical Society 2011 대한수학회보 Vol.48 No.5
Assume that X, partitioned into $2{\times}2$ block form, is a solution of the system of quaternion matrix equations $A_1XB_1$ = $C_1,A_2XB_2=C_2$. We in this paper give the maximal and minimal ranks of the submatrices in X, and establish necessary and sufficient conditions for the submatrices to be zero, unique as well as independent. As applications, we consider the common inner inverse G, partitioned into $2{\times}2$ block form, of two quaternion matrices M and N. We present the formulas of the maximal and minimal ranks of the submatrices of G, and describe the properties of the submatrices of G as well. The findings of this paper generalize some known results in the literature.