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Wen Jun Gong,Zhigang Tao,Man Chao He,Hui Jun Hou 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.9
As a typical and complex failure type of rock slopes, flexural toppling failure has increasingly received attention, mainly focused on its failure mechanism and introducing a proper numerical method to reproduce the failure phenomena. However, there are few studies related to the supporting mechanism against flexural toppling failure. This study attempted to make a preliminary analysis on the research gap. For this purpose, an anti-dip layered rock slope supported with anchor cables that failed owning to flexural toppling was taken as an example, and the numerical method discontinuous deformation analysis (DDA) was taken as the major analytical tool. Firstly, the rationality of DDA was verified by correctly simulating the failure state of the anti-layered rock slope and the underlying failure mechanism was studied. The results indicated that the lack of the support from slope toe is the crucial factor inducing the flexural toppling failure, which posed a great obstacle to the further excavation of the open-pit mine. Secondly, by introducing the anchor cable support to the slope toe in the DDA model, the interaction mechanism between the anchor cables and the rock slope was investigated. the results indicated that the supporting system of the ordinary anchor cables is very sensitive to the inhomogeneous flexural toppling deformation. The tension values of the anchor cables are very inhomogeneous, and once some of anchor cables beyond their tension limit, the anchor cables failed, which will greatly threaten the safety of the adjacent anchor cables and even the stability of the whole slope. Meanwhile, a novel anchor cable called constant-resistance-large-deformation (CRLD) anchor cable was introduced for a comparative study using DDA. just replacing the anchor cables of the original slope with the CRLD anchor cables, the slope can reach stable state eventually even without the slope toe being enhanced. In addition, the CRLD anchor cables were able to support the slope well against the inhomogeneous deformation, because they can provide high constant resistances and withstand large deformations. This study can provide a deeper insight into the support mechanism for the snit-layered rock slope against flexural toppling failure and introduce a novel supporting method for such slopes.
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Crosstalk between gut microbiota and Sirtuin-3 in colonic inflammation and tumorigenesis
Yong Zhang,Xiao-lan Wang,Min Zhou,Chao Kang,He-dong Lang,Meng-ting Chen,Suo-cheng Hui,Bin Wang,Man-tian Mi 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Colorectal cancer (CRC) is a disease involving a variety of genetic and environmental factors. Sirtuin-3 (Sirt3) is expressed at a low level in cancer tissues of CRC, but it is unclear how Sirt3 modulates colonic tumorigenesis. In this study, we found that gut microbiota play a central role in the resistance to CRC tumor formation in wild-type (WT) mice through APC (Adenomatous Polyposis Coli)-mutant mouse microbiota transfer via Wnt signaling. We also found that Sirt3-deficient mice were hypersusceptible to colonic inflammation and tumor development through altered intestinal integrity and p38 signaling, respectively. Furthermore, susceptibility to colorectal tumorigenesis was aggravated by initial commensal microbiota deletion via Wnt signaling. Mice with Sirt3-deficient microbiota transfer followed by chemically induced colon tumorigenesis had low Sirt3 expression compared to WT control microbiome transfer, mainly due to a decrease in Escherichia/Shigella, as well as an increase in Lactobacillus reuteri and Lactobacillus taiwanensis. Collectively, our data revealed that Sirt3 is an anti-inflammatory and tumor-suppressing gene that interacts with the gut microbiota during colon tumorigenesis.
ScienceON
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