Reliability Based Structural Topology Optimization Considering Non-stationary Stochastic Excitations

Zhiqiang Hu,Ziqi Wang,Cheng Su,Haitao Ma 대한토목학회 2018 KSCE Journal of Civil Engineering Vol.22 No.3

This paper studies the optimum structural design considering non-stationary stochastic excitations. The topology optimization of the lateral bracing system of frame structures is conducted and the first-passage probability of a displacement response is minimized under the material volume constraint. The concept of Solid Isotropic Material with Penalization (SIMP) model is employed for describing the material distribution. An efficient optimization algorithm based on explicit time-domain method is developed. Numerical examples of frame structures subjected to non-stationary seismic excitations are investigated to demonstrate the effectiveness of the proposed approach.

Stem cells from human exfoliated deciduous teeth attenuate trigeminal neuralgia in rats by inhibiting endoplasmic reticulum stress

Yang, Zhijie,Wang, Chun,Zhang, Xia,Li, Jing,Zhang, Ziqi,Tan, Zhao,Wang, Junyi,Zhang, Junyang,Bai, Xiaofeng The Korean Pain Society 2022 The Korean Journal of Pain Vol.35 No.4

Background: The treatment of trigeminal neuralgia remains a challenging issue. Stem cells from human exfoliated deciduous teeth (SHED) provide optimized therapy for chronic pain. This study aimed to investigate the mechanisms underlying the attenuation of trigeminal neuralgia by SHED. Methods: Trigeminal neuralgia was induced by chronic constriction injury of the infraorbital nerve. The mechanical threshold was assessed after model establishment and local SHED transplantation. Endoplasmic reticulum (ER) morphology and Caspase12 expression in trigeminal ganglion (TG) was evaluated as well. BiP expression was observed in PC12 cells induced by tunicamycin. Results: The local transplantation of SHED could relieve trigeminal neuralgia in rats. Further, transmission electron microscopy revealed swelling of the ER in rats with trigeminal neuralgia. Moreover, SHED inhibited the tunicamycin-induced up-regulated expression of BiP mRNA and protein in vitro. Additionally, SHED decreased the up-regulated expression of Caspase12 mRNA and protein in the TG of rats caused by trigeminal neuralgia after chronic constriction injury of the infraorbital nerve mode. Conclusions: This findings demonstrated that SHED could alleviate pain by relieving ER stress which provide potential basic evidence for clinical pain treatment.

Genome-wide locus-specific DNA methylation repatterning may facilitate rapid evolution of mercury resistance in rice

Cong Weixuan,Li Ning,Wang Jinbin,Kang Ying,Miao Yiling,Xu Chunming,Wang Ziqi,Liu Tongtong,Gong Lei,Liu Bao,Ou Xiufang 한국유전학회 2022 Genes & Genomics Vol.44 No.3

Background: Albeit a relatively stable epigenetic modification, DNA methylation in plants can be repatterned and play important roles in response to biotic and abiotic stresses. However, whether DNA methylation dynamics may contribute to cope with mercury (Hg) stress in plants remains to be fully investigated. Objective: To probe the potential roles of DNA methylation dynamics in coping with Hg stress in rice. Methods: Whole-genome bisulfite sequencing was used to profile the DNA methylation patterns of a rice Hg-resistant line (RHg) selected from a heterozygous mutant of the DNA methyltransferase 1 gene (OsMET1+/-), together with its Hg-sensitive wild-type plants of cv. Nipponbare (Nip) under both normal and Hg stress conditions. Results: Genome-wide locus-specific differential methylation regions (DMRs) were detected between RHg and Nip under normal condition, the predominant DMR patterns were CG hypo-DMRs, CHG hypo-DMRs and CHH hyper-DMRs. In both lines, more hyper- than hypo-DMRs were detected at all three sequence contexts (CG, CHG and CHH) under Hg stress relative to normal condition. Comparison of DNA methylation changes in the two lines under Hg stress indicates that RHg had a more dynamic methylome than the control (Nip). Original DMRs in RHg trended to transform to opposite status (from hyper- to hypo- or vice versa) under Hg stress condition. Gene ontology analysis revealed that Hg-resistance-related DMGs were enriched in diverse biological processes. Conclusions: Our results suggest genome-wide locus-specific DNA methylation repatterning can facilitate rapid acquisition of Hg resistance in rice.

Conceptual design for a multi-rotor UAV based on variable paddle pitch

Zhen Qin,Xiaoran Tang,Ziqi Meng,Yu-Ting Wu,류성기,Yue Wang 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.10

The field of unmanned aerial vehicles has experienced a "golden era" of progress in recent years (UAV). UAVs come in a vast variety, from the commercial to the military sectors. The UAVs available today are tiny, mini multirotor devices. The advantages of the small multi-rotor structure are its small size, straightforward design, high hovering effectiveness, adaptability in changing directions, and quick flight speed. For activities like tracking and aerial photography, it is especially useful. However, the majority of multi-rotor UAVs, according to current UAV offers, are built around cameras and sensors. As a result, they can't complete other kinds of missions due to their large overall size, light weight, and small cargoes. The outbreak has sparked interest in and study into whether contactless distribution and logistics are practical. Unmanned mechanical devices for various rescue and specialized duties are also being researched by organizations. Therefore, a medium to big multi-rotor UAV needs to be researched and developed. The assembly of paddle holders and auto-tilters for medium- to large-sized multi-rotor UAVs is examined in this work. The multi-rotor UAV is intended to mount an auto-tilter. Its component strength checks are analyzed. Additionally, the blade requirements are chosen, along with strength tests of the individual components, and the structural design of the UAV rotor system is provided. The mechanical viability of the UAV is then confirmed using a motion simulation of its mechanical design.

부분집합 시뮬레이션 기반 사회기반시설 네트워크의 지진취약도 분석

이동규(Lee, Dongkyu),Wang, Ziqi,송준호(Song, Junho) 대한토목학회 2023 대한토목학회 학술대회 Vol.2023 No.10

Antioxidant capacity, flavor and physicochemical properties of FH06 functional beverage fermented by lactic acid bacteria: a promising method to improve antioxidant activity and flavor of plant functional beverage

Yan Xian-Tao,Zhang Ziqi,Wang Yubao,Zhang Wenmiao,Zhang Longfei,Liu Yang,Chen Dawei,Wang Wenqiong,Ma Wenlong,Qian Jian-Ya,Gu Ruixia 한국응용생명화학회 2023 Applied Biological Chemistry (Appl Biol Chem) Vol.66 No.-

The ability of natural plants to treat chronic diseases is closely related to their antioxidant function. Lactic acid bacteria (LAB) fermentation is an effective way to improve the nutritional value, biological activity and flavor of food. This study investigated the pH, titratable acidity, total polysaccharide, total flavone, total saponin, total polyphenol, and antioxidant activity of the FH06 beverage before and after probiotic fermentation. Results: After fermentation, FH06 had lower contents of total polysaccharides, total flavonoids, total saponins and total polyphenols but higher titratable acidity. The antioxidant activity was tested by total antioxidant capacity (FRAP method) and DPPH· scavenging ability. The FRAP value significantly increased after fermentation (P < 0.05), and the maximum increase was observed for Lactobacillus fermentum grx08 at 25.87%. For DPPH· scavenging ability, the value of all fermentations decreased, and L. fermentum grx08 had the smallest reduction at 2.21% (P < 0.05). The results of GC–MS and sensory analysis showed that fermentation eliminated bad flavors, such as grass, cassia and bitterness, and highlighted the fruit aroma and soft sour taste. Conclusion: The FRAP value and sensory flavor of FH06 fermentation by L. fermentum grx08 were significantly improved, indicating its great potential as a functional food with both strong antioxidant activity and good flavor.

A Small Bipedal Trans-Scale Precision Positioning Stage Based on Inertial Stick-Slip Driving

Xi Zhang,Bowen Zhong,Bin Liu,Ziqi Jin,Zhenhua Wang,Lining Sun 한국정밀공학회 2021 International Journal of Precision Engineering and Vol.22 No.3

The small size and high flexibility of the mobile platform is widely used in many fields such as electron scanning microscope (SEM), but the mobile platform still adopts the structure of guide rail at present and has the problem of large volume and poor flexibility, which cannot meet the requirements of SEM for small cavity. Therefore, this paper proposes a small bipedal trans-scale precision positioning stage based on the inertial stick-slip driving to achieve small size and high flexibility. The mobile platform consists of two piezoelectric actuators, a frame structure, two bottom plates, two pre-tightening screws, and magnets, and the volume is 15 mm × 10 mm × 9.5 mm. To investigate the locomotion characteristics of the mobile platform, a prototype is manufactured, and a series of experiments are carried out. The experimental results show that its linear motion velocity can reach 3.553 mm/s and its angular velocity can reach 462.72mrad/s, which means that the mobile platform has good motion performance.

Pectin oligosaccharides improved lipid metabolism in white adipose tissue of high-fat diet fed mice

Zixin Fan,Xuejiao Chen,Tianzhi Liu,Qianhui Yu,Ziqi Song,Fei Wang,Tuoping Li 한국식품과학회 2022 Food Science and Biotechnology Vol.31 No.9

Impacts of pectin oligosaccharide (POS) got from hawthorn fruitage on adiponectin signaling pathway and white adipose metabolism in mice fed with high-fat control. The results showed that POS significantly inhibited the levels of inflammatory cytokines TNF-α and IL-6, and down-regulated expression of CD68. POS dramatically reduced gene expression contents of fatty acid composite concerning enzymes ACC and FAS, as well as TG synthesis-related enzymes SCD-1 and DGAT1 as compared to a high-fat group (HFC). POS dramatically increased expression levels of oxidation-related enzymes of fatty acid ACO, CPT-1, and TG deposition-related enzymes ATGL and HSL as contrast to the high-fat control group. In addition, POS activated adiponectin-mediated AdipoR1/AMPK/PPARα signaling path by upregulating expression levels of AdipoR1, AMPK and PPARα. The results demonstrated that POS can improve lipid metabolism of adipose tissue, and contribute to the creation of functional foods to prevent and treat lipid metabolism disorders.

A new green alternative solvent for extracting echinacoside and acteoside from Cistanche deserticola based on ternary natural deep eutectic solvent

Fang Nie,Changyin Feng,Naveed Ahmad,Mengfei Tian,Qinglong Liu,Weihao Wang,Ziqi Lin,Chunying Li,Chunjian Zhao 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.118 No.-

Echinacoside and acteoside, the representative constituents of Cistanche deserticola Y. C. Ma (C. deserticola),are known for its many important biological activities. In this study, a novel ternary natural deepeutectic solvent (NADES) (citric acid, fructose and glucose in a 1:2:1 molar ratio, 30 % water content)was obtained through the adjustment and optimization of single-factor experiments. And through theBox-Behnken design optimization, the optimal extraction conditions were obtained, at the moment,the yields of echinacoside and acteoside were 6.16 and 2.13 mg/g, respectively. In addition, through computermolecular simulation, it was found that there are strong hydrogen bonds and interactions betweenthe molecules of NADES, and the hydrogen bonds, van der Waals forces and p-p interactions played animportant role in the extraction of echinacoside and acteoside from C. deserticola by NADES. Finally, comparedwith the traditional method, NADES ultrasound-assisted extraction of echinacoside and acteosidehas a shorter time (15 min), the maximum extraction yield is 1.54–2.86 times and 1.26–2.52 times thanthat of traditional extraction methods for echinacoside and acteoside, respectively. This study demonstratesthat NADES can provides a new direction for developing new sustainable alternatives, improvinggreen extraction process and efficiency for extracting natural active substances.