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( Gang Xu ),( Yu-min Wang ),( Miao-miao Ying ),( Sui-dan Chen ),( Zong-rui Li ),( Hong-lei Ma ),( Ming-hua Zheng ),( Jian Wu ),( Chunming Ding ) 대한간학회 2021 Clinical and Molecular Hepatology(대한간학회지) Vol.27 No.2
Background/Aims: Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease (NAFLD) characterized by hepatic steatosis, inflammation, hepatocellular injury, and fibrosis. We aimed to investigate the usefulness of a key biomarker, lipocalin-2 (LCN2), for the detection of NASH progression. Methods: A mouse NASH model was established using a high-fat diet and a high-sugar drinking water. Gene expression profile of the NASH model was analyzed using RNA sequencing. Moreover, 360 NAFLD patients (steatosis, 83; NASH, 277), 40 healthy individuals, and 87 patients with alcoholic fatty liver disease were recruited. Results: Inflammatory infiltration, focal necrosis in the leaflets, steatosis, and fibrosis were documented in the mouse liver. In total, 504 genes were differentially expressed in the livers of NASH mice, and showed significant functional enrichment in the inflammation-related category. Upregulated liver LCN2 was found to be significantly interactive with various interleukins and toll-like receptors. Serum LCN2 levels were significantly increased in NAFLD patients. Serum LCN2 levels were correlated with steatosis, intralobular inflammation, semiquantitative fibrosis score, and nonalcoholic fatty liver disease activity score. The area under the curve of serum LCN2 was 0.987 with a specificity of 100% and a sensitivity of 93.5% for NASH diagnosis, and 0.977 with almost the same specificity and sensitivity for steatosis. Conclusions: LCN2 might be involved in the transition from NAFL to NASH by mediating inflammation. Serum LCN2 levels might be a novel biomarker for the diagnosis of NASH. (Clin Mol Hepatol 2021;27:329-345)
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Yi Xu,Kuanjun Fang,Weichao Chen,Xiangwu Zhang,Chunming Zhang 한국섬유공학회 2022 Fibers and polymers Vol.23 No.9
This paper develops a new clean production technology combining atmospheric pressure plasma jets and nanochitosanto prepare strong and durable bio-based coatings for improving the inkjet printing performance of antimicrobial silkfabrics. The key contribution of this study is to introduce green and environmental friendly production methods, avoiding theuse of chemicals and pollution caused by dye hydrolysis in traditional ways. By contradistinctive experiments, we presentdirect empirical evidence that the plasma-chitosan treatment can significantly improve the hydrophilicity of the silk surfaces. Wettability test indicates that the infiltration time of droplet on the surface of modified silk fabric was only 1/12 of the timespent on the untreated sample. The study of reactive dye inkjet printing illustrates that the antibleeding property on modifiedsamples was evidently enhanced. Meanwhile, in respect of color fixation of reactive dyes, there was also an increase in K/Svalue on modified samples, ranging from 76 % to 214 % in color depth of the four-color print blocks, even after gas steamingand washing. Scanning electron microscope (SEM) observation reveals that the surface of silk fibers modified with plasma iscovered with firmer and more uniform chitosan coatings in terms of morphology change. X-ray photoelectron spectroscopy(XPS) analysis verifies that the content of oxygenous groups on the silk fabric processed by plasma-chitosan increased bymore than 42 %. As to the antibacterial effect of nano-chitosan, the photographs of inhibition zone shows that the plasmaprocessing effectively enhanced the durability of chitosan against B. subtilis, and thus prepared long-lasting antibacterial silkfabric. Furthermore, measurements of washing and rubbing color fastness prove that the plasma-chitosan treated fabrics stillhad excellent inkjet printing effect even after 45 cycles of soaping. Taken together, it turns out that such nontoxic,nonpolluting, low energy-consumed chitosan coating combining with plasma can explicitly provide an innovative option forthe production of inkjet printing on natural fabrics.
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Association between STAT4 polymorphisms and risk of primary biliary cholangitis: a meta-analysis
Li Zhang,Chunming Gao,Chuanmiao Liu,Jiasheng Chen,Kuihua Xu 한국유전학회 2018 Genes & Genomics Vol.40 No.10
Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease. Several studies reported that SATA4 (signal transducer and activator of transcription 4) polymorphisms were significantly associated with PBC susceptibility. In order to derive a more comprehensive estimation of the association between STAT4 and PBC risk, this meta-analysis was conducted. Thirteen eligible studies from 8 articles with a total number of 11,310 cases and 27,844 controls were included in this meta-analysis. Pooled odds ratios (OR) and 95% confidence intervals (CI) were estimated with fixed effects model or random effects model. The results showed statistically significant association between polymorphisms of rs7574865, rs3024921, rs6752770, rs7601754 and rs10168266 in STAT4 and PBC risk under the allelic effect model (rs7574865, T vs. G, OR = 1.24, 95% CI 1.14–1.35; rs3024921, T vs. A, OR = 1.65, 95% CI 1.44–1.91; rs6752770, G vs. A, OR = 1.24, 95% CI 1.11–1.39; rs7601754, A vs. G, OR = 1.35, 95% CI 1.17–1.55; and rs10168266, T vs. C, OR = 1.31, 95% CI 1.22–1.41). Furthermore, the rs7574865 polymorphism was significantly associated with PBC risk under all genotype genetic models (dominant effect model: TT + TG vs. GG, OR = 1.43, 95% CI 1.19–1.71; recessive effect: TT vs. TG + GG, OR = 1.40, 95% CI 1.24–1.58; and co-dominant effect: TT vs. GG, OR = 1.67, 95% CI 1.37–2.02). The sensitivity analysis by omitting one study at a time showed that the results were stable. No publication bias was indicated from both Begg’s test and Egger’s weighted regression. This meta-analysis suggested that polymorphisms of rs7574865, rs3024921, rs6752770, rs7601754 and rs10168266 in STAT4 were significantly associated with the risk of PBC.
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Data density-based RGB color component feature extraction and area measurement method for silkworm
Luo Yunyun,Wen Chunming,Wen Jie,Xu Qing,Liang Xiang,Yang Jie,Lan Zimian 한국응용곤충학회 2023 Journal of Asia-Pacific Entomology Vol.26 No.4
Accurate measurement of silkworm area is an essential part of efficient automated farming. The manual mea surement of silkworm area in large silkworm mounts has problems such as low accuracy and low efficiency. To address the problem that it is difficult to measure the area of silkworms in the silkworm holders accurately, this paper proposed a method to remove the background of color images based on RGB color components. In this method, the color component features of the silkworm rearing bed image were extracted. The K-means method was improved by the offset of component data peak density and the recalculation of the clustering center. Then, using the new clustering center to calculate the segmentation threshold point. After removing the background area, estimated the proportion of silkworm area in the silkworm rearing bed. In this paper, the area measurement experiments were carried out in different luminance environments for sparse and dense silkworm rearing bed images. After processing, the results of the proposed method were compared and analyzed with those of other segmentation methods. The results showed that the proposed intelligent segmentation threshold judgment method based on the RGB components difference feature has the lowest error rate, and the average accuracy of measurement is 87.29%. The method in this paper could effectively reduce the interference of ambient light on silkworm and mulberry leaves segmentation recognition, which might help improve the accuracy of measuring silkworm area.
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Fei Yan,Daorong Xu,S.C. Wu,Qinde Sun,Chunming Wang,Yajun Wang 대한기계학회 2012 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.26 No.12
It has been mainly studied in this paper on brazing of Cu to Al using Al–Si filler metal. The optimized scanning rate of 2.5 mm/s is first obtained through simulating the temperature field of Cu-Al brazing process based on ANSYS software. Then the brazing of Cu-C11000 to Al-3003 using Al–Si–La–Sr filler is carried out by torch brazing technology. It is found that the brazing seam region is mainly consisted of α-Al solid solution and CuAl2 IMC. Further experimental results also show that the rare earth element La in filler metal can not only refine the grain, but also promote the dispersion of intermetallic compounds into the brazing seam, which significantly improves the brazing seam microstructure and mechanical properties of the joints.
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Cong Weixuan,Li Ning,Wang Jinbin,Kang Ying,Miao Yiling,Xu Chunming,Wang Ziqi,Liu Tongtong,Gong Lei,Liu Bao,Ou Xiufang 한국유전학회 2022 Genes & Genomics Vol.44 No.3
Background: Albeit a relatively stable epigenetic modification, DNA methylation in plants can be repatterned and play important roles in response to biotic and abiotic stresses. However, whether DNA methylation dynamics may contribute to cope with mercury (Hg) stress in plants remains to be fully investigated. Objective: To probe the potential roles of DNA methylation dynamics in coping with Hg stress in rice. Methods: Whole-genome bisulfite sequencing was used to profile the DNA methylation patterns of a rice Hg-resistant line (RHg) selected from a heterozygous mutant of the DNA methyltransferase 1 gene (OsMET1+/-), together with its Hg-sensitive wild-type plants of cv. Nipponbare (Nip) under both normal and Hg stress conditions. Results: Genome-wide locus-specific differential methylation regions (DMRs) were detected between RHg and Nip under normal condition, the predominant DMR patterns were CG hypo-DMRs, CHG hypo-DMRs and CHH hyper-DMRs. In both lines, more hyper- than hypo-DMRs were detected at all three sequence contexts (CG, CHG and CHH) under Hg stress relative to normal condition. Comparison of DNA methylation changes in the two lines under Hg stress indicates that RHg had a more dynamic methylome than the control (Nip). Original DMRs in RHg trended to transform to opposite status (from hyper- to hypo- or vice versa) under Hg stress condition. Gene ontology analysis revealed that Hg-resistance-related DMGs were enriched in diverse biological processes. Conclusions: Our results suggest genome-wide locus-specific DNA methylation repatterning can facilitate rapid acquisition of Hg resistance in rice.
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Witnessing a Large-scale Slipping Magnetic Reconnection along a Dimming Channel during a Solar Flare
Jing, Ju,Liu, Rui,Cheung, Mark C. M.,Lee, Jeongwoo,Xu, Yan,Liu, Chang,Zhu, Chunming,Wang, Haimin American Astronomical Society 2017 ASTROPHYSICAL JOURNAL LETTERS - Vol.842 No.2
<P>We report the intriguing large-scale dynamic phenomena associated with the M6.5 flare (SOL2015-06-22T18:23) in NOAA active region 12371, observed by RHESSI, Fermi, and the Atmospheric Image Assembly (AIA) and Magnetic Imager (HMI) on the Solar Dynamics Observatory (SDO). The most interesting feature of this event is a third ribbon (R3) arising in the decay phase, propagating along a dimming channel (seen in EUV passbands) toward a neighboring sunspot. The propagation of R3 occurs in the presence of hard X-ray footpoint emission and is broadly visible at temperatures from 0.6 MK to over 10 MK through the differential emission measure analysis. The coronal loops then undergo an apparent slipping motion following the same path of R3, after a similar to 80 minute delay. To understand the underlying physics, we investigate the magnetic configuration and the thermal structure of the flaring region. Our results are in favor of a slipping-type reconnection followed by the thermodynamic evolution of coronal loops. In comparison with those previously reported slipping reconnection events, this one proceeds across a particularly long distance (similar to 60 Mm) over a long period of time (similar to 50 minutes) and shows two clearly distinguished phases: the propagation of the footpoint brightening driven by nonthermal particle injection and the apparent slippage of loops governed by plasma heating and subsequent cooling.</P>
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