A RSVP Integration Method with Hierarchical Mobile IPv6 Networks

Fang Nie,Woo-suk Cha,Gi-hwan Cho 한국정보과학회 2004 한국정보과학회 학술발표논문집 Vol.31 No.2Ⅲ

Because the Resource reSerVation Protocol (RSVP) was originally designed for stationary networks, it is insufficient to accommodate Mobile Nodes (MNs) which frequently change their points of attachment. This paper deals with how to integrate the RSVP and Hierarchical MIPv6 (HMIPv6), in order to quickly establish the QoS guaranteed path and minimize the service disruption when the MN moves around. That can be achieved with the utilization of the common path between the new and old path. Therefore a new method is proposed in detail to find out an anchor node and re-establish a new reservation path.

A new green alternative solvent for extracting echinacoside and acteoside from Cistanche deserticola based on ternary natural deep eutectic solvent

Fang Nie,Changyin Feng,Naveed Ahmad,Mengfei Tian,Qinglong Liu,Weihao Wang,Ziqi Lin,Chunying Li,Chunjian Zhao 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.118 No.-

Echinacoside and acteoside, the representative constituents of Cistanche deserticola Y. C. Ma (C. deserticola),are known for its many important biological activities. In this study, a novel ternary natural deepeutectic solvent (NADES) (citric acid, fructose and glucose in a 1:2:1 molar ratio, 30 % water content)was obtained through the adjustment and optimization of single-factor experiments. And through theBox-Behnken design optimization, the optimal extraction conditions were obtained, at the moment,the yields of echinacoside and acteoside were 6.16 and 2.13 mg/g, respectively. In addition, through computermolecular simulation, it was found that there are strong hydrogen bonds and interactions betweenthe molecules of NADES, and the hydrogen bonds, van der Waals forces and p-p interactions played animportant role in the extraction of echinacoside and acteoside from C. deserticola by NADES. Finally, comparedwith the traditional method, NADES ultrasound-assisted extraction of echinacoside and acteosidehas a shorter time (15 min), the maximum extraction yield is 1.54–2.86 times and 1.26–2.52 times thanthat of traditional extraction methods for echinacoside and acteoside, respectively. This study demonstratesthat NADES can provides a new direction for developing new sustainable alternatives, improvinggreen extraction process and efficiency for extracting natural active substances.

Research about the Degree of Relation between Chaotic Characteristics of Physiological Signals and Emotions

Nie Chun yan,He Fang,Xia Ying,Wang Ju 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.12

Physiological information can objectively reflect the emotional state. Emotion recognition based on physiological signals has the important practical application value. In this paper, six kinds of chaotic characteristics were extracted from physiological data about Electromyogram, Skin conductivity, Respiration, which come from Augsburg university in Germany. Six kinds of chaotic characteristics contain the largest Lyapunov exponent, correlation dimension, box dimensions, information entropy, approximate entropy and complexity. On the basis of this, the degree of relation between chaotic characteristics of physiological signals and emotions was researched. The results showed that different chaotic characteristic values of different physiological signals sensitive to the emotion is different. Therefore, in order to improve the recognition rate, the chaotic characteristics of the multiple physiological information need to be merged to establish chaos matrix, which provide a new method for emotion recognition.

Automatic brain labeling via multi-atlas guided fully convolutional networks

Fang, Longwei,Zhang, Lichi,Nie, Dong,Cao, Xiaohuan,Rekik, Islem,Lee, Seong-Whan,He, Huiguang,Shen, Dinggang Elsevier 2019 Medical image analysis Vol.51 No.-

<P><B>Abstract</B></P> <P>Multi-atlas-based methods are commonly used for MR brain image labeling, which alleviates the burdening and time-consuming task of manual labeling in neuroimaging analysis studies. Traditionally, multi-atlas-based methods first register multiple atlases to the target image, and then propagate the labels from the labeled atlases to the unlabeled target image. However, the registration step involves non-rigid alignment, which is often time-consuming and might lack high accuracy. Alternatively, patch-based methods have shown promise in relaxing the demand for accurate registration, but they often require the use of hand-crafted features. Recently, deep learning techniques have demonstrated their effectiveness in image labeling, by automatically learning comprehensive appearance features from training images. In this paper, we propose a <I>multi-atlas guided fully convolutional network (MA-FCN)</I> for automatic image labeling, which aims at further improving the labeling performance with the aid of prior knowledge from the training atlases. Specifically, we train our MA-FCN model in a patch-based manner, where the input data consists of <I>not only</I> a training image patch <I>but also</I> a set of its neighboring (i.e., most similar) affine-aligned atlas patches. The guidance information from neighboring atlas patches can help boost the discriminative ability of the learned FCN. Experimental results on different datasets demonstrate the effectiveness of our proposed method, by significantly outperforming the conventional FCN and several state-of-the-art MR brain labeling methods.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Additional atlas intensity and corresponding label information are used to help the MA-FCN model to better label the target ROIs. </LI> <LI> The additional anatomical structural information is revised in the unique pathway in the MA-FCN model. </LI> <LI> The fusion of atlas information is in a hierarchical way. </LI> <LI> The proposed method does not need a non-rigid registration step for aligning atlases to the target image, which is efficient for brain labeling. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Three-Dimensional Seismic Isolation Study of Single-Layer Reticulated Domes by Parameter Analysis

Gui-Bo Nie,Dong-fang Li,Xudong Zhi,Qiang Chen,Fuyang Wang 한국강구조학회 2021 International Journal of Steel Structures Vol.21 No.6

Spatial structures, represented by reticulated domes, have developed rapidly in the last several decades due to their reasonable mechanical properties and beautiful structural shape. However, several spatial structure collapses have occurred during the recent frequent earthquakes in China, especially the 2013 Lushan earthquake. These collapses have altered the traditional understanding that the spatial structure has good seismic performance. Real seismic damage cases reveal that a spatial structure in a severe earthquake zone with unreasonable seismic design cannot maintain its functional characteristics; therefore, there is an urgent need for improvements to enhance the seismic performance of spatial structures. This paper proposes a new three-dimensional isolation spring support (TISS). To study the mechanical properties of this support, corresponding experiments were performed, and the constitutive relation of this support was investigated. A simplifi ed fi nite element model of the new TISS was defi ned in ABAQUS to conduct a seismic isolation study of single-layer reticulated domes. And then the infl uence of diff erent parameters on the seismic isolation performance of the TISS was analysed. The parameter analysis results indicated that friction plays an important role in the mechanical properties of the support and thus causes diff erent seismic isolation eff ects under small earthquakes and severe earthquakes. At the same time, because of the design concept of the support, a non-linear relation exists between the seismic isolation eff ect and stiff ness such that under severe earthquakes. On the other hand, the TISS also has preferable isolation performance on the defective reticulated domes. Therefore, the three-dimensional isolation support presented in this paper has preferable application prospects and potential economic benefi ts that could be applied extensively in the three-dimensional isolation area of spatial structures. In addition, the numerical analysis procedure based on ABAQUS can be used to accurately analyse the isolation property and to lay the foundation for the practical function of isolation supports and the seismic design of structures.

Effects of fission product doping on the structure, electronic structure, mechanical and thermodynamic properties of uranium monocarbide: A first-principles study

Ru-Ting Liang,Tao Bo,Wan-Qiu Yin,Chang-Ming Nie,Lei Zhang,Zhi-Fang Chai,Wei-Qun Shi Korean Nuclear Society 2023 Nuclear Engineering and Technology Vol.55 No.7

A first-principle approach within the framework of density functional theory was employed to study the effect of vacancy defects and fission products (FPs) doping on the mechanical, electronic, and thermodynamic properties of uranium monocarbide (UC). Firstly, the calculated vacancy formation energies confirm that the C vacancy is more stable than the U vacancy. The solution energies indicate that FPs prefer to occupying in U site rather than in C site. Zr, Mo, Th, and Pu atoms tend to directly replace U atom and dissolve into the UC lattice. Besides, the results of the mechanical properties show that U vacancy reduces the compressive and deformation resistance of UC while C vacancy has little effect. The doping of all FPs except He has a repairing effect on the mechanical properties of U_1-xC. In addition, significant modifications are observed in the phonon dispersion curves and partial phonon density of states (PhDOS) of UC_1-x, Zr_xU_1-xC, Mo_xU_1-xC, and Rh_xU_1-xC, including narrow frequency gaps and overlapping phonon modes, which increase the phonon scattering and lead to deterioration of thermal expansion coefficient (α_V) and heat capacity (C_p) of UC predicted by the quasi harmonic approximation (QHA) method.

SPON2 Promotes M1-like Macrophage Recruitment and Inhibits Hepatocellular Carcinoma Metastasis by Distinct Integrin–Rho GTPase–Hippo Pathways

Zhang, Yan-Li,Li, Qing,Yang, Xiao-Mei,Fang, Fang,Li, Jun,Wang, Ya-Hui,Yang, Qin,Zhu, Lei,Nie, Hui-Zhen,Zhang, Xue-Li,Feng, Ming-Xuan,Jiang, Shu-Heng,Tian, Guang-Ang,Hu, Li-Peng,Lee, Ho-Young,Lee, Su-J American Association for Cancer Research 2018 Cancer research Vol.78 No.9

<P>Matricellular protein SPON2 acts as an HCC suppressor and utilizes distinct signaling events to perform dual functions in HCC microenvironment.</P><P>Tumor-associated macrophages (TAM) represent key regulators of the complex interplay between cancer and the immune microenvironment. Matricellular protein SPON2 is essential for recruiting lymphocytes and initiating immune responses. Recent studies have shown that SPON2 has complicated roles in cell migration and tumor progression. Here we report that, in the tumor microenvironment of hepatocellular carcinoma (HCC), SPON2 not only promotes infiltration of M1-like macrophages but also inhibits tumor metastasis. SPON2-α4β1 integrin signaling activated RhoA and Rac1, increased F-actin reorganization, and promoted M1-like macrophage recruitment. F-Actin accumulation also activated the Hippo pathway by suppressing LATS1 phosphorylation, promoting YAP nuclear translocation, and initiating downstream gene expression. However, SPON2-α5β1 integrin signaling inactivated RhoA and prevented F-actin assembly, thereby inhibiting HCC cell migration; the Hippo pathway was not noticeably involved in SPON2-mediated HCC cell migration. In HCC patients, SPON2 levels correlated positively with prognosis. Overall, our findings provide evidence that SPON2 is a critical factor in mediating the immune response against tumor cell growth and migration in HCC.</P><P><B>Significance:</B> Matricellular protein SPON2 acts as an HCC suppressor and utilizes distinct signaling events to perform dual functions in HCC microenvironment.</P><P><B>Graphical Abstract:</B> http://cancerres.aacrjournals.org/content/canres/78/9/2305/F1.large.jpg. <I>Cancer Res; 78(9); 2305–17. ©2018 AACR</I>.</P><P><B>Graphical Abstract</B></P><P> [Figure]</P>