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Eeda Venkateswara Rao,Vinay Kumar Sharma,Niti Sharma,Young-Soo Kim,Sang-Hun Jung 충남대학교 약학대학 의약품개발연구소 2014 藥學論文集 Vol.29 No.-
To define the role of substituents of chalcones as potent MD-2 inhibitors, we designed and synthesized analogs of 1-(2-hydroxy-6-(isopentyloxy)phenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one (1) for their in vitro activities against RAW 264.7 cell using the SEAP assay as well as for LPS displacement assay. Among all the derivatives, compound 5 (IC50=27.3 μM), showed good inhibition of NF-κB activation by blocking the TLR4-mediated NF-κB activation signalling in RAW 264.7 as well as the rhMD-2 binding to immobilized LPS with 53% inhibition at 30 μM. The SAR studies indicated that small alkyl group like 3-methylbutoxy at 6-position of ring A and substituent with hydrogen bonding capability at 4-position of ring B of chalcone should be very important for inhibition of LPS induced NF-κB activation and LPS displacement of MD-2.
Singh, Gajbir,Rao, G. Venkateswara,Iyengar, N.G.R. Techno-Press 1995 Structural Engineering and Mechanics, An Int'l Jou Vol.3 No.2
It is well known that two-dimensional simplified third-order theories satisfy the layer interface continuity of transverse shear strains, thus these theories violate the continuity of transverse shear stresses when two consecutive layers differ either in fibre orientation or material. The third-order theories considered herein involve four/or five dependent unknowns in the displacement field and satisfy the condition of vanishing of transverse shear stresses at the bounding planes of the plate. The objective of this investigation is to examine (i) the flexural response prediction accuracy of these third-order theories compared to exact elasticity solution (ii) the effect of layer interface continuity conditions on the flexural response. To investigate the effect of layer interface continuity conditions, three-dimensional elasticity solutions are developed by enforcing the continuity of different combinations of transverse stresses and/or strains at the layer interfaces. Three dimensional twenty node solid finite element (having three translational displacements as degrees of freedom) without the imposition of any of the conditions on the transverse stresses and strains is also employed for the flexural analysis of the laminated plates for the purposes of comparison with the above theories. These shear deformation theories and elasticity approaches in terms of accuracy, adequacy and applicability are examined through extensive numerical examples.
Dayakar, T.,Venkateswara Rao, K.,Park, Jinsub,Sadasivuni, Kishor Kumar,Ramachandra Rao, K.,Jaya rambabu, N. Elsevier 2018 Materials chemistry and physics Vol.216 No.-
<P><B>Abstract</B></P> <P>An enzyme-free glucose sensor developed based on silver nanoparticles (Ag NPs) via bio-mediated route using <I>Ocimum tenuiflorum</I> leaves extract. The Ag NPs were characterized by X-ray diffraction (XRD), ultraviolet-visible (UV-Vis) spectroscopy, Fourier transform infrared (FTIR) spectroscopy, Particle size analyzer (PSA), Scanning electron microscopy (SEM), Energy-dispersive X-ray (EDAX) spectroscopy, and Transmission electron microscopy (TEM), to study structural, optical and morphological properties. The electrocatalytic activity of Ag NPs towards the oxidation of glucose in the 0.1 M NaOH electrolyte solution was analyzed. The Ag NPs was coated on Glassy carbon electrode (GCE) and reports indicating the outstanding capability such as high sensitivity (895.8 μAmM<SUP>−1</SUP>cm<SUP>−2</SUP>), linear range (1–8.9 mM), response time (<4s), low detection limit (0.0048 μM, S/N = 3), long-term stability, reproducibility, repeatability, and selectivity of the sensor. Therefore, the bio-synthesized Ag NPs can markedly helpful to fabricate non-enzymatic, sustainable, simple, low cost, and eco-friendly glucose monitoring devices.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Ocimum tenuiflorum leaf extract and silver nitrate were used to prepare Ag NPs. </LI> <LI> Structural, optical and morphological properties of Ag NPs were studied. </LI> <LI> The GCE modified with Ag NPs showed a sensitivity of 895.8 μAmM<SUP>−1</SUP>cm<SUP>−2</SUP>. </LI> <LI> Bio-mediated synthesized NPs showed sustainable glucose sensing properties. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Ramamurti, V.,Rajarajan, S.,Rao, G. Venkateswara Techno-Press 2002 Structural Engineering and Mechanics, An Int'l Jou Vol.13 No.3
Three noded plate and shell finite element and 3D beam element in conjunction with Lanczos method are used for studying the effect of boat tail angle on the free vibration characteristics of a typical payload fairing for three different cylinder diameters with height to diameter ratio 1.5. Configurations without boat tail structural member are also studied. One half of the one side fairing structure is considered for the analysis and symmetric boundary conditions are used.
Nickel and nickel oxide nanocrystals selectively grafting on multiwalled carbon nanotubes
Prabhu Yendrapati Taraka,Rao Kalagadda Venkateswara,Kumari Bandla Siva,Sai Vemula Sesha,Pavani Tambur 나노기술연구협의회 2015 Nano Convergence Vol.2 No.2
Nickel and nickel oxide nanocrystals in their pure phase are carefully embellished by a facial method on oxygen-functionalized multi-walled carbon nanotubes (O-MWCNTs) using nickel nitrate (NN) was effectively accomplished for the first time by calcining them in hydrogen, nitrogen and air, respectively, at suitable temperatures. Nickel and nickel oxide nanocrystals impregnated O-MWCNTs were examined for its structure and morphology by various techniques, such as powder X-ray diffraction, Fourier transform infrared spectroscopy, transmission electron microscopy and field emission scanning electron microscopy. The nanocrystals on the O-MWCNTs were determined of 15–20 nm size. Decorated nanocrystals on CNT’s have potential applications in semiconductor industries.
V.Sucharita,P.Venkateswara Rao,Debnath Bhattacharyya,Tai-hoon Kim 보안공학연구지원센터 2016 International Journal of Bio-Science and Bio-Techn Vol.8 No.1
This research is to present a new approach for the classification of the Penaeid Prawn Species. The extraction of Texture features based on the Gabor filter is proposed in this method. These extracted features are used for the classification of Penaeid Prawn Species based on Radial Basis Probabilistic Neural Networks and Support Vector Machines. The texture of the prawn image are extracted based on different scales and orientations by which mean and standard deviation are calculated. The resultant Gabor feature values are fed as input to Radial basis Probabilistic Neural Network Classifier for the classification of the species. The experimental results show the performance of the extracted feature vectors for Penaeid Prawn species recognition. The RBPNN gives better recognition when compared with Support vector machines.
Mamatha Tirunagari,Mukkanti Khagga,Ramesh Gannu,Venkateswara Rao Jangala 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.7
Isradipine (ISDP) is an effective calcium channel blocker used in the treatment of hypertension. It undergoes extensive first pass metabolism and bioavailability through the oral route is only about 15 to 24%. Hence we attempted to develop a matrix type controlled transdermal drug delivery system for ISDP. Formulations A1, A2, A3 were composed of Eudragit RL100 and hydroxypropyl methyl cellulose (HPMC) in 1:3, 1:1, 3:1 ratios; A4, A5, A6 were composed of Eudragit RS100 and HPMC in 1:3, 1:1, 3:1 ratios. All six formulations carried 5 mg of ISDP/patch area, 5% v/w of D-limonene, 15 % v/w of propylene glycol in methanol:dichloromethane (1:1). The physicochemical compatibility of the drug and the polymers was studied by infrared spectroscopy and differential scanning calorimetry. The results suggested no physicochemical incompatibility between the drug and the polymers. The prepared transdermal drug delivery system were evaluated for physicochemical characteristics, mainly in vitro release and ex vivo permeation. The ex vivo permeation studies were carried out across excised rat skin using Franz diffusion cell. All the formulations exhibited satisfactory physicochemical characteristics. Cumulative amount of the drug released in 36 h from the six formulations were 1695.32, 1527.89, 1455.54, 1485.65, 1282.81 and 916.88 μg/cm2 respectively. Corresponding values for the cumulative amounts of drug permeated across the rat skin for the above matrix films were 1456.29, 1284.70, 1182.99, 1212.72, 1046.05, and 782.60 μg/cm2 respectively. By fitting the data into zero order, first order and Higuchi models, it was concluded that drug release from matrix films followed Higuchi model and the mechanism of drug release was diffusion mediated. Based on the physical evaluation, in vitro drug release and ex vivo permeation characteristics, it was concluded that for potential therapeutic use, monolithic drug matrix films A1, may be suitable for the development of a transdermal drug delivery system of ISDP.
Sadra Souzanchi,Laleh Nazari,Kasanneni Tirumala Venkateswara Rao,Zhongshun Yuan,Zhongchao Tan,Chunbao Charles Xu 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.101 No.-
This work aimed to produce 5-hydroxymethylfurfural (5-HMF) from glucose in a biphasic continuousflowtubular reactor with various heterogeneous solid acid catalysts or combined solid acid-base catalysts. Among the catalysts tested, niobium phosphate (NbP) was found to be the most active catalystfor glucose dehydration with a maximum 5-HMF yield of 45% at 150 C. The higher activity of NbPwas attributed to its higher total number of acid sites and BET surface area, as well as the presence of bothLewis acid and Brønsted acid sites. The effects of different operating conditions such as aqueous toorganic (A/O) phase ratio, reaction temperature and feeding flow rate on the activity of some selected catalystswere studied. Reducing A/O ratio by increasing the extracting organic phase flow rate and increasingthe reaction temperature (up to 150 C) were found to positively affect 5-HMF production fromglucose in the presence of NbP. Kinetics study demonstrated that the overall reaction of glucose dehydrationto 5-HMF over the NbP catalyst is a first-order reaction with the reaction rate constants (k) determinedas 0.06, 0.21 and 0.6 min 1 at 110, 130 and 150 C, respectively, and the apparent activationenergy (Ea) calculated to be 77 kJ/mol.
Paswan, Shravan Kumar,Gautam, Arti,Verma, Pritt,Rao, Chandana Venkateswara,Sidhu, Om Prakash,Singh, Ajeet Pratap,Srivastava, Sajal KOREAN PHARMACOPUNCTURE INSTITUTE 2017 Journal of pharmacopuncture Vol.20 No.2
Objectives: Selaginella bryopteris L. (family: Selaginaceae), is often used in traditional Indian systems of medicine for the prevention and cure of several disorders and for the treatment of patient with spermatorrhoea, venereal disease, constipation, colitis, urinary tract infections, fever, epilepsy, leucorrhoea, beri-beri and cancer. It is also used as a strength tonic. This study aimed to evaluate the mechanisms underlying the anti-inflammatory effects of topically administered aqueous, polar and non-polar methanolic fractions ($10mg/20{\mu}L$) of Selaginella bryopteris. Methods: An acute oral toxicity study of Selaginella bryopteris at doses from 250 to 2,000 mg/kg body weight (bw) was performed. Aqueous, polar and non-polar methanolic extracts ($10mg/20{\mu}L$) applied topically for 5 days were evaluated for their anti-inflammatory effects against 12-tetra-O-decanoyl phorbol acetate (TPA)- induced inflammation by using the redness in the ear, the ear's weight (edema), oxidative stress parameters, such as lipid-peroxide (LPO) and nitric oxide (NO), and the pro-inflammatory cytokines involved in inflammation, such as tumour necrosis factor $(TNF)-{\alpha}$, interleukin $(IL)-1{\beta}$ and IL-6. Indomethacine ($0.5mg/20{\mu}L$) was used for the positive control. Results: Selaginella bryopteris produced no mortalities when administered orally at doses from 250 to 2,000 mg/kg bw. Topical treatment with the non-polar methanolic fraction ($10mg/20{\mu}L$) significantly suppressed redness ($2.4{\pm}0.5$) and edema ($30.4{\pm}1$) and effectively reduced the LPO level ($32.3{\pm}3.3$). The NO level was ($8.07{\pm}0.55$), and the $TNF-{\alpha}$, $IL-1{\beta}$, and IL-6 levels were decreased to $69.6{\pm}15.5$, $7.7{\pm}4.8$ and $82.6{\pm}5.9$, respectively. Conclusion: This study demonstrated for the first time the mechanisms underlying the anti-inflammatory effect of medicinal plants like Selaginella bryopteris and quantified the pharmacological interactions between them. The present study showed this herbal product to be a promising anti-inflammatory phytomedicine for the treatment of patients with inflammatory skin diseases.