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Ho Jin Heo,Hyun Jae Lee,Chi Soon Yoon,Seung Pyong Lim,Jeong Ho Seok,Un Kyo Seo,Choong Jae Lee 대한생리학회-대한약리학회 2005 The Korean Journal of Physiology & Pharmacology Vol.9 No.6
In the present study, we investigated whether ambroxol, S-carboxymethyl-L-cysteine, dextromethorphan and noscapine affect mucin release from airway goblet cells. Confluent primary hamster tracheal surface epithelial cells were metabolically radiolabeled and chased for 30 min in the presence of varying concentrations of the above agents to assess the effects on <SUP>3</SUP>H-mucin release. Noscapine stimulated mucin release during 30 min of treatment period in a dose-dependent manner. However, ambroxol, S-carboxymethyl-L-cysteine and dextromethorphan showed no significant effect on mucin release during 30 min of treatment period. We conclude that noscapine can affect mucin release by acting on airway mucin-secreting cells.
Jin, Un-Ho,Suh, Seok-Jong,Chang, Hyen Wook,Son, Jong-Keun,Lee, Seung Ho,Son, Kun-Ho,Chang, Young-Chae,Kim, Cheorl-Ho Wiley Subscription Services, Inc., A Wiley Company 2008 Journal of cellular biochemistry Vol.104 No.1
<P>Smooth muscle cell (SMC) migration plays an important role in normal angiogenesis and is relevant to disease-related vascular remodeling in conditions such as brain arteriovenous malformations, pulmonary hypertension, arteriosclerosis, and restenosis after angioplasty. In this present study, we showed that tanshinone IIA, the major lipid-soluble pharmacological constituent of Salvia miltiorrhiza BUNGE, inhibits human aortic smooth muscle cell (HASMC) migration and MMP-9 activity. Tanshinone IIA significantly inhibited IκBα phosphorylation and p65 nuclear translocation through inhibition of AKT phosphorylation. Tanshinone IIA inhibited TNF-α-induced ERK and c-jun phosphorylation, but not other MAPKs such as JNK and p38. Tanshinone IIA also inhibited NF-κB and AP-1 DNA-binding. Moreover, tanshinone IIA inhibited the migration of TNF-α-induced HASMCs. Our results provide evidence that tanshinone IIA has multiple effects in the inhibition of HASMC migration and may offer a therapeutic approach to block HASMC migration. J. Cell. Biochem. 104: 15–26, 2008. © 2007 Wiley-Liss, Inc.</P>
( Ho Jin Heo ),( Cheol Su KIM ),( Hyun Jae Lee ),( Seung Won Shin ),( Young Sik Kim ),( Sam Sik Kang ),( Yang Chun Park ),( Yun Hee Kim ),( Un Kyo Seo ),( Jeong Ho Seok ),( Choong Jae Lee ) 한국응용약물학회 2006 Biomolecules & Therapeutics(구 응용약물학회지) Vol.14 No.4
Angelicae Koreanae Radix has been used for controlling inflammatory respiratory diseases in folk medicine and their components, imperatorin, marmesinin and oxypeucedanin were reported to have diverse biological effects. In this study, we investigated whether imperatorin, marmesinin and oxypeucedanin affect adenosine triphosphate (ATP)-induced mucin secretion from cultured airway epithelial cells. Confluent primary hamster tracheal surface epithelial (HTSE) cells were metabolically radiolabeled using 3H-glucosamine for 24 h and chased for 30 min in the presence of varying concentrations of each agent to assess the effects on 3H-mucin secretion. The results were as follows: 1) imperatorin significantly inhibited ATP-induced mucin secretion; 2) However, marmesinin and oxypeucedanin did not affect ATP-induced mucin secretion, significantly. We conclude that imperatorin might inhibit ATP-induced mucin secretion by directly acting on airway mucin-secreting cells. Therefore, imperatorin should further be investigated for the possible use as mucoregulators in the treatment of inflammatory airway diseases.
Jin, Jeong-Un,Lee, Dong-Hoon,Nam, Ki-Ho,Yu, Jaesang,Kim, Young-Kwan,Goh, Munju,Kim, Seo Gyun,Lee, Heon Sang,Ku, Bon-Cheol,You, Nam-Ho Elsevier 2019 APPLIED SURFACE SCIENCE - Vol.464 No.-
<P><B>Abstract</B></P> <P>We synthesized methylpiperidine-functionalized graphene oxide (MP-GO) by introducing 4-amino-1-methylpiperidine into reactive epoxy and/or carboxylic acid groups on pristine GO. Then, we applied the MP-GO as a curing catalyst for polyimide (PI) nanocomposites. The MP-GO was found to be an effective base-catalysts for the thermal conversion of polyamic acid (PAA) precursor to PI. Interestingly, when 3 wt% of MP-GO was added to the PI matrix, the complete imidization of nanocomposites was achieved at a temperature lower than 200 °C. In addition, the PI/MP-GO nanocomposite films exhibited reinforcement of the oxygen barrier properties which were even better than those of pristine PI, due to the excellent dispersion state of MP-GO and the favorable non-covalent interaction between MP-GO and the PI matrix. Comparison to pristine PI, the oxygen permeability of nanocomposite films that contained only 1 wt% of MP-GO loading was significantly decreased, by about 80%. Furthermore, all the PI/MP-GO nanocomposites exhibited high thermal stability.</P> <P><B>Highlights</B></P> <P> <UL> <LI> MP-GO was prepared by introducing 4-amino-1-methypiperidine. </LI> <LI> The MP-GO can act as a curing catalyst for polyimide nanocomposites. </LI> <LI> The oxygen barrier property of PI/MP-GO 1 wt% was 80% better than pristine PI. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Large‐Deformation Behavior of Honeycomb‐Structured Polymer Sheets as a Function of Polar Angle
Jin, Kwang‐,Yong,Kim, Dae‐,Yoon,Kim, So‐,Eun,Kuo, Shiao‐,Wei,Lee, Joong Hee,Lyu, Min‐,Young,Hwang, Seok‐,Ho,Gent, Alan N.,Nah, Changwoon,Jeong, Kwang‐,Un WILEY‐VCH Verlag 2011 Macromolecular chemistry and physics Vol.212 No.9
<P><B>Abstract</B></P><P>To construct the structure/property relationships of patterned polymer architectures depending on symmetry, the large‐deformation behavior of 2D HSPS with respect to the polar angle was studied. Holes aligned along the HSPS apex were more effective in decreasing tensile force and reducing stress concentration than those located along the plane. On varying the polar angle from 0 to 30°, the tensile force fluctuated up and down like an undamped negative sinusoidal wave with a wavelength of 15°. Additionally, molecular orientations of HSPS were monitored in situ. By comparing experimental measurements with computer simulations, it was concluded that the tensile force depends on the number of holes as well as the orientation of the axes of the honeycomb structure. </P>