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녹농균의 quinolone제재에 대한 감수성 및 혈청형 분포
최승호,고한철,이현국,박정평,임용,양남웅,김학렬,박열 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.15 No.1
123 strains of Pseudomonas aeruginosa isolated from various clinical specimens were tested for the distrution of serotypes and the evaluation of the antimicrobial susceptibility to each generation quinolone impounds. The results were as follows : 1. 107 strains(87%) were typable out of clinical isolate 123 strains. Serotype G was prevalent with 33 strains (26.8%) and followed by serotype E, 31 strains (25.2%), serotype B, 15 strains (12.2%) and successively typed in the order of serotype A, C, D, F, H, I, L, M, but serotype J,K and N were not entirely typed. 2. MIC peak was 1024ug/ml in case of nalidixic acid, 32ug/ml in pipemidic acid, 0.25ug/ml in ciprofloxacin, 2ug / ml in ofloxacin. 2ug/ml in enoxacin. 0.5ug/ml in norfloxacin, finally 8ug/ml in rosoxacin. 3. The second generation quinolone compound, pipemidic acid exhibited 8 to 30 times higher activity to Pseudomonas aeruyrtcisa than the first generation quinlolne, nalidixic acid. And the third generation compounds showed 4 to 100 times higher activities than the second generation quinolone. Especially ciprofloxacin showed 2 to 30 times higher antimicrobial activity than other generation quinolone compounds. 4. There were no significant differences to susceptibility patterns among the serotypes.
다발성 글루카곤 생성 내분비세포종을 동반한 췌장 알파세포의 Nesidioblastosis 및 과다증식 1예
강화평 ( Hua Pyong Kang ),김세화 ( Se Wha Kim ),임태섭 ( Tae Seop Lim ),이혜원 ( Hye Won Lee ),최흔 ( Heun Choi ),강창무 ( Chang Moo Kang ),김호근 ( Ho Guen Kim ),방승민 ( Seung Min Bang ) 대한소화기학회 2014 대한소화기학회지 Vol.63 No.4
Nesidioblastosis is a term used to describe pathologic overgrowth of pancreatic islet cells. It also means maldistribution of islet cells within the ductules of exocrine pancreas. Generally, nesidioblastosis occurs in beta-cell and causes neonatal hyperinsulinemic hypoglycemia or adult noninsulinoma pancreatogenous hypoglycemia syndrome. Alpha-cell nesidioblastosis and hyperplasia is an extremely rare disorder. It often accompanies glucagon-producing marco- and mircoadenoma without typical glucagonoma syndrome. A 35-year-old female was referred to our hospital with recurrent acute pancreatitis. On radiologic studies, 1.5 cm sized mass was noted in pancreas tail. Cytological evaluation with EUS-fine-needle aspiration suggested serous cystadenoma. She received distal pancreatectomy. The histologic examination revealed a 1.7 cm sized neuroendocrine tumor positive for immunohistochemical staining with glucagon antibody. Multiple glucagon-producing micro endocrine cell tumors were scattered next to the main tumor. Additionally, diffuse hyperplasia of pancreatic islets and ectopic proliferation of islet cells in centroacinar area, findings compatible to nesidioblastosis, were seen. These hyperplasia and almost all nesidioblastic cells were positive for glucagon immunochemistry. Even though serum glucagon level still remained higher than the reference value, she has been followed-up without any evidence of recurrence or hormone related symptoms. Herein, we report a case of alpha-cell nesidioblastosis and hyperplasia combined with glucagon-producing neuroendocrine tumor with literature review.
임송택 ( Song Tak Lim ),양승룡 ( Seung Pyong Yang ) 한국축산경영학회,농업정책학회(구 한국축산경영학회) 2011 농업경영정책연구 Vol.38 No.4
Thsi study examined whether the plant factory is a sustainable alternative in Korea`s agriculture. We conducted the economic as well as environmental analysis. The results show that the production cost of plant factory lettuce is 14,432won per kg, which is about 14 times higher than the production cost of greenhouse lettuce (1,060won/kg). From the environmental perspective, energy inputs and CO2 emissions from a domestic plant factory were 63 and 58 times higher than those of greenhouse vegetable, respectively. In order to produce 1kg of plant factory lettuce, 309MJ energy that correspond to 8.7 liters of gasoline are needed, while emitting 14.6kg of CO2. According to the analysis on plant factories in Japan, although they are relatively small scale facilities, the economy of scale is not found. Moreover, the difference in yield per unit area between the old and latest facilities is not significant, and the yield per unit area seems to diminish as the cultivation area increases. It looks difficult to expect a significant increase in productivity from larger sizes or technical advances. The main reason behind the large consumption of energy and emission of CO2 is that the photosynthesis is performed with artificial light. The plant factories show a poor productivity increase compared to the input of artificial energy.
Ho Jin Heo,Hyun Jae Lee,Chi Soon Yoon,Seung Pyong Lim,Jeong Ho Seok,Un Kyo Seo,Choong Jae Lee 대한생리학회-대한약리학회 2005 The Korean Journal of Physiology & Pharmacology Vol.9 No.6
In the present study, we investigated whether ambroxol, S-carboxymethyl-L-cysteine, dextromethorphan and noscapine affect mucin release from airway goblet cells. Confluent primary hamster tracheal surface epithelial cells were metabolically radiolabeled and chased for 30 min in the presence of varying concentrations of the above agents to assess the effects on <SUP>3</SUP>H-mucin release. Noscapine stimulated mucin release during 30 min of treatment period in a dose-dependent manner. However, ambroxol, S-carboxymethyl-L-cysteine and dextromethorphan showed no significant effect on mucin release during 30 min of treatment period. We conclude that noscapine can affect mucin release by acting on airway mucin-secreting cells.
Heo, Ho-Jin,Lee, Hyun-Jae,Yoon, Chi-Soon,Lim, Seung-Pyong,Seok, Jeong-Ho,Seo, Un-Kyo,Lee, Choong-Jae The Korean Society of Pharmacology 2005 The Korean Journal of Physiology & Pharmacology Vol.9 No.6
In the present study, we investigated whether ambroxol, S-carboxymethyl-L-cysteine, dextromethorphan and noscapine affect mucin release from airway goblet cells. Confluent primary hamster tracheal surface epithelial cells were metabolically radiolabeled and chased for 30 min in the presence of varying concentrations of the above agents to assess the effects on $^3H$-mucin release. Noscapine stimulated mucin release during 30 min of treatment period in a dose-dependent manner. However, ambroxol, S-carboxymethyl-L-cysteine and dextromethorphan showed no significant effect on mucin release during 30 min of treatment period. We conclude that noscapine can affect mucin release by acting on airway mucin-secreting cells.