LOW TEMPERATURE DEPOSITION OFSIO<SUB>x</SUB> FILMS BY PLASMA-ENHANCED CVD USING 100 ㎑ GENERATOR

Nobuyuki Kakinoki,Takenobu Suzuki,Osamu Takai 한국표면공학회 1996 한국표면공학회지 Vol.29 No.6

An approach for the task performance estimation using biological signals just before and after the onset of voluntary motion

Satoshi Suzuki,Takemi Matsui,Kentaro Mikajiri,Yusuke Sakaguchi,Kazuhiro Ando,Nobuyuki Nishiuchi 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8

In order to predict of accuracy of movement just before the onset of movement using biological signals, the relationships between MRCP measured as a physiological index and the accuracy of task performance were investigated. As experiments, subjects touched the target appearing 300 pixels away from a start point in a verticaldirection on a touch-sensitive screen with the forefinger. During experiments, EEG, EMG as trigger, high-speed camera images, and task efficiency were acquired. As a result, significant differences between the high- and low-performance groups were clearly confirmed on the slope of NS in MRCPs. Furthermore, a difference between these groups wasconfirmed in duration of ballistic movement.

Clinical outcomes of permanent stenting with endoscopic ultrasound gallbladder drainage

Eisuke Suzuki,Yuji Fujita,Kunihiro Hosono,Yuji Koyama,Seitaro Tsujino,Takuma Teratani,Atsushi Nakajima,Nobuyuki Matsuhashi 대한소화기내시경학회 2023 Clinical Endoscopy Vol.56 No.5

Background/Aims: Endoscopic ultrasound gallbladder drainage (EUS-GBD) is gaining attention as a treatment method for cholecystitis. However, only a few studies have assessed the outcomes of permanent stenting with EUS-GBD. Therefore, we evaluated the clinicaloutcomes of permanent stenting using EUS-GBD. Methods: This was a retrospective, single-center cohort study. The criteria for EUS-GBD at our institution are a high risk for surgery,inability to perform surgery owing to poor performance status, and inability to obtain consent for emergency surgery. EUS-GBD wasperformed using a 7-Fr double-pigtail plastic stent with a dilating device. The primary outcomes were the recurrence-free rate of cholecystitisand the late-stage complication-avoidance rate. Secondary outcomes were technical success, clinical success, and procedural adverseevents. Results: A total of 41 patients were included in the analysis. The median follow-up period was 168 (range, 10–1,238) days. The recurrence-free and late-stage complication-avoidance rates during the follow-up period were 95% (38 cases) and 90% (36 cases), respectively. There were only two cases of cholecystitis recurrence during the study period. Conclusions: EUS-GBD using double-pigtail plastic stent was safe and effective with few complications, even in the long term, in patientswith acute cholecystitis.

Study on the Frame Structure Modeling of the Beam Element Formulated by Absolute Nodal Coordinate Approach

Yoshitaka Takahashi,Nobuyuki Shimizu,Kohei Suzuki 대한기계학회 2005 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.19 No.1S

Accurate seismic analyses of large deformable moving structures are still unsolved problems In the field of earthquake engineering In order to analyze these problems, the nonlinear finite element method formulated by the absolute nodal coordinate approach is noticed Because, this formulation has several advantages over the standard procedures on mass matrix, elastic forces and damping forces In the case of large displacement problems But, It has not been fully studied to build frame structure models by using beam elements In the absolute nodal coordinate formulation In this paper, we propose the connecting method of the beam elements formulated by the absolute nodal coordinate The coordinate transformation matrix of this element is Introduced into the frame structure This beam element has the characteristic that the mass matrix and bending stiffiness matrix are constant even If m the case of large displacement problems, and this characteristic is being kept after the transformation In order to verify the proposed method, we show the numerical simulation results of frame structures for a vibration problem and a large displacement problem<br/>

Segmental Arteries and Veins at Higher Lumbar Levels Can Intersect the Adjacent Caudal Intervertebral Disc in the Anterior Part of the Spinal Column: A Cadaveric Analysis

Yagi Kiyoshi,Suzuki Nobuyuki,Mizutani Jun,Kato Kenji,Kondo Akira,Waseda Yuya,Goto Yuta,Murakami Hideki 대한척추외과학회 2022 Asian Spine Journal Vol.16 No.1

Study Design: A cadaveric study.Purpose: To investigate the anatomical features of segmental arteries and veins in the anterior part of the spinal column to prevent segmental vessel injury.Overview of Literature: The lateral transpsoas approach to the lumbar intervertebral discs (IVD) is associated with the risk of segmental vessel injury. Previous studies have described the vascular anatomy on the lateral part of the vertebral body. However, there are no studies that describe the segmental vessels on its anterior aspect. Here, we report the important anatomical features of the segmental arteries and veins that can intersect the anterior part of the IVD. These vessels are considered at risk of vascular injury when placing the anterior retractors during lateral lumbar interbody fusion or cutting the anterior longitudinal ligament during anterior column realignment.Methods: Five formalin-embalmed human cadavers were used. We assessed the proportion of segmental arteries and veins that intersected the IVD in the L2–L5 range and their course on the anterior part of the spinal column.Results: The segmental arteries and veins commonly intersect the anterior part of the IVD (artery, 28.1%; vein, 42.1%). Seven of 10 (70%) segmental arteries at L2 intersected the IVD, but only one artery intersected the IVD at L3 and L4. The proportions of segmental veins that intersected the IVD were 60%, 50%, and 16.7% at L2, L3, and L4, respectively.Conclusions: The segmental arteries and veins frequently intersect the IVD in the anterior part of the spinal column. Therefore, it is necessary to consider these individual anatomical features to prevent vascular damage during lateral lumbar interbody fusion surgery.

Effectiveness of Duloxetine for Postsurgical Chronic Neuropathic Disorders after Spine and Spinal Cord Surgery

Tsuji Osahiio,Kosugi Shizuko,Suzuki Satoshi,Nori Satoshi,Nagoshi Narihito,Okada Eijiro,Fujita Nobuyuki,Yagi Mitsuru,Nakamura Masaya,Matsumoto Morio,Watanabe Kota 대한척추외과학회 2021 Asian Spine Journal Vol.15 No.5

Study Design: This is a retrospective observational study with an outpatient setting. Purpose: This study aimed to describe the effects of duloxetine (DLX) administration for postsurgical chronic neuropathic disorders (both pain and numbness) following spinal surgery in patients without depression. Overview of Literature: Although several reports indicated the potential of DLX to effectively treat postoperative symptoms as a perioperative intervention, there have been no reports of its positive effect on postsurgical chronic neuropathic disorders. Methods: A total of 24 patients with postsurgical chronic pain and/or numbness Numeric Rating Scale (NRS) scores of ≥4 were enrolled. All patients underwent spine or spinal cord surgery at Keio University Hospital and received daily administration of DLX for more than 3 months. The mean postoperative period before the first administration of DLX was 35.5±57.0 months. DLX was administered for more than 3 months at a dose of 20, 40, or 60 mg/day, and the degree of pain and numbness was evaluated using the NRS before administration and 3 months after administration. Effectiveness was defined as more than a 2-point decrease in the NRS score following administration. Results: In terms of the type of symptoms, 15 patients experienced only numbness, eight experienced both pain and numbness, and one experienced only pain. Of the 24 patients, 19 achieved effective relief with DLX. DLX was effective for all patients with postsurgical chronic pain (n=9), and it reduced postsurgical chronic numbness in 18 of 23 patients. No significant difference was observed in background spinal disorders. DLX was not effective for five patients who complained only of postsurgical chronic numbness. Conclusions: This study reports the effectiveness of DLX for postsurgical chronic neuropathic disorders. Although DLX reduced postsurgical chronic pain (efficacy rate=100%) and numbness (78.3%) in certain patients, further investigation is needed to determine its optimal use.

Flux Coating Innovation of Inorganic Crystal Layers for Next-Generation Energy and Environmental Applications

Katsuya Teshima,Fumitaka Hayashi,Tetsuya Yamada,Sayaka Suzuki,Tomohito Sudare,Nobuyuki Zettsu 한국표면공학회 2017 한국표면공학회 학술발표회 초록집 Vol.2017 No.11

Coronal Plane Gap Increases Postoperative Pseudoarthrosis after Lateral Interbody Fusion for Adult Spinal Deformity

Okada Eijiro,Yagi Mitsuru,Yamamoto Yusuke,Suzuki Satoshi,Nori Satoshi,Tsuji Osahiko,Nagoshi Narihito,Fujita Nobuyuki,Nakamura Masaya,Matsumoto Morio,Watanabe Kota 대한척추외과학회 2022 Asian Spine Journal Vol.16 No.3

Study Design: This is a retrospective study.Purpose: This study aims to evaluate the risk factor associated with pseudoarthrosis after placement of lateral interbody fusion (LIF) cages for adult spinal deformity (ASD) treatment. Overview of Literature: LIF technique is widely used for ASD correction. Furthermore, pseudoarthrosis is a major complication of fusion surgery required for revision surgery.Methods: This study included 42 patients with ASD (two men and 40 women; 112 segments; mean, 68.5±8.4 years; and mean follow-up, 31.6±17.0 months) who underwent LIF and posterior correction surgery. The concave slot of the LIF cage was filled with an autologous iliac crest bone graft (IBG), and the convex slot with a porous hydroxyapatite/collagen (HAp/Col) composite was soaked with bone marrow aspirate. Endplate injury, the gap between vertebral endplate and cage in the coronal or sagittal plane, and fusion status were evaluated using computed tomography multiplanar reconstruction at 12 months after surgery. Moreover, the associated risk factors for pseudoarthrosis were analyzed.Results: Fusion at LIF segments were observed in 71.4% segments at 12 months after surgery. Fusion on the concave slot (autologous IBG side), convex slot (porous HAp/Col composite side), and both concave and convex slots were observed in 66.1%, 37.5%, and 36.6% of patients, respectively. Moreover, pseudoarthrosis was observed in 28.6% at 12 months after surgery. Consequently, logistic regression analysis of the fusion at the LIF segment revealed that the gap between the LIF cage and endplate in the coronal plane (p=0.030; odds ratio, 0.183; 95% confidence interval, 0.030–0.183) was significantly associated with pseudoarthrosis at the LIF segments.Conclusions: ASD surgery fusion rate using LIF cages was 71.4% at 12 months after surgery. The fusion rate was higher on the concave slot filled with autologous IBG than on the convex slot filled with a porous HAp/Col composite. The gap in the coronal plane was a risk factor for pseudoarthrosis at the LIF segment.

p38 Mitogen-Activated Protein Kinase Is Involved in Interleukin-6 Secretion from Human Ligamentum Flavum–Derived Cells Stimulated by Tumor Necrosis Factor-α

Yagi Kiyoshi,Goto Yuta,Kato Kenji,Suzuki Nobuyuki,Kondo Akira,Waseda Yuya,Mizutani Jun,Kawaguchi Yohei,Joyo Yuji,Waguri-Nagaya Yuko,Murakami Hideki 대한척추외과학회 2021 Asian Spine Journal Vol.15 No.6

Study Design Human ligamentum flavum–derived cells (HFCs) were obtained from surgical samples for a basic experimental study. Purpose We sought to evaluate the inflammatory response of human ligamentum flavum cells to investigate hypertrophic changes occurring in the ligamentum flavum. Overview of Literature Lumbar spinal stenosis (LSS) is a disease commonly observed in the elderly. The number of patients with LSS has increased over time, yet the pathomechanisms of LSS still have not been fully elucidated. One of the clinical features of LSS is hypertrophy of the ligamentum flavum, which results in narrowing of the lumbar spinal canal. Some reports have suggested that ligamentum flavum hypertrophy is associated with inflammation and fibrosis; meanwhile, the p38 mitogen-activated protein (MAP) kinase is involved in the hypertrophy of human ligamentum flavum cells. Methods HFCs were obtained from patients with LSS who underwent surgery. HFCs were stimulated by tumor necrosis factor-α (TNF-α) and a p38 MAP kinase inhibitor, SB203580. Phosphorylation of the p38 MAP kinase was analyzed by western blotting. The concentration of interleukin-6 (IL-6) in the conditioned medium was measured by enzyme-linked immunoassay and IL-6 messenger RNA expression levels were determined by real-time polymerase chain reaction. Results TNF-α induced the phosphorylation of p38 MAP kinase in a time-dependent manner, which was suppressed by the p38 MAP kinase inhibitor, SB203580. TNF-α also stimulated IL-6 release in both a time- and dose-dependent manner. On its own, SB203580 did not stimulate IL-6 secretion from HFCs; however, it dramatically suppressed the degree of IL-6 release stimulated by TNF-α from HFCs. Conclusions This is the first report suggesting that TNF-α stimulates the gene expression and protein secretion of IL-6 via p38 MAP kinase in HFCs. A noted association between tissue hypertrophy and inflammation suggests that the p38 MAP kinase inflammatory pathway may be a therapeutic molecular target for LSS.

Chin on Chest Deformity Caused by Upper Cervical Kyphosis Associated With Ankylosing Spondylitis: A Case Report

Ryosuke Maruiwa,Kota Watanabe,Satoshi Suzuki,Satoshi Nori,Osahiko Tsuji,Narihito Nagoshi,Eijiro Okada,Mitsuru Yagi,Nobuyuki Fujita,Masaya Nakamura,Morio Matumoto 대한척추신경외과학회 2020 Neurospine Vol.17 No.3

Chin on chest deformity caused by upper cervical kyphosis associated with ankylosing spondylitis is rare. A 66-year-old woman presented at our institute with chief complaints of difficulty in horizontal gaze and opening her mouth. Cervical radiographs showed a C0–2 angle of 1° on flexion and 7° on extension, and her chin-brow vertical angle was 49°. We planned fixation surgery at C0–5 posteriorly to prevent the progression of kyphosis, with slight correction of the kyphosis at C0–2. The correction was performed by pushing down the over lordotically contoured titanium rods connected to an occipital plate onto the C3–5 lateral mass screws, just like cantilever technique. No palpable cracking or loss of resistance was noticed during the correction. However, intraoperative radiographs revealed apparent anterior separation of the vertebral bodies between C3 and C4. Postoperative computed tomography images at the C3/4 level suggested hemorrhage from the fracture site. Tracheostomy was performed because of massive edema around the pharynx. To secure solid bone fusion, staged surgery to extend the fusion to T3 and to graft an additional iliac bone was performed. Fortunately, the C2–7 angle was corrected to 40°, and her chin-brow vertical angle was restored to 17° without any catastrophic complications. Although the patient finally obtained an ideal sagittal alignment, the surgeon should be aware that the technique had a higher perioperative risk for iatrogenic fracture, resulting in neurological and vascular injuries.