HPV에 감염된 자궁경부 상피세포의 Keratin 아형 변화에 관한 연구

기근홍,이영미,장원재,임용,임성철,김창원,전호종 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.2

The human papillomavirus (HPV) are wide spread in the world, causing proliferation of epidermal and mucosal surface. Certain papillomaviral types are oncogenic in vivo and in vitro. HPV DNA has been detected in most of cervical lesions such as condyloma acuminata, dysplasias, and invasive carcinomas. The materials for this study consisted of 5 dysplasias. 5 squamous cell carcinomas, and 5 exocervix for control, that resected for definite treatment of uterine disease at Chosen University Hospital from January, 1991 to December, 1993. All cases were performed of in situ hybridization for HPV DNA type 6/11, 16, and 18. And also immununohistochemical stain for panel of monoclonal cytokeratin (CK) antibodies were done. The result obtained is as fallows : 1. HPV DNA type 6/11 are detected in all dysplasias. HPV DNA type 16 and 18 are detected in squamous cell carcinomas. 2. Stratifed squamous epithelium of exocervix are positive staining for CK 1, CK 5/6, CK 8, CK 13, CK 14, and CK 19. HPV DNA type 6/11 infected cells are positive for CK 1, CK 13, CK 14, CK 17, CK 18, and CK 19. HPV DNA type 16/18 infected cells are positive for CK 1, CK 5/6, CK 10, CK 13, CK 14, CK 17, CK 18, and CK 19. In conclusion, HPV infection of uterine cervix is associated with change of normal cytokeratin expression pattern. Dysplastic cells are changed of CK 5/6, CK 8, CK 17 and CK18. Squamous cell carcinoma cells are changed of CK 8, CK 17, and CK 18.

韓國 노랑 초파리의 Heterochromatin 多型現象에 관한 硏究

성기창,박흥석 성균관대학교 기초과학연구소 1987 論文集 Vol.38 No.1

Heterochromatin polymorphism in the mitotic chromosomes from Taejeon and Kang-wha of Drosophila melanogaster has been examined by using Q-banding methods. The significant difference in fluorescence banding patterns was observed only in Y-chromosome, which was arbitrarily classified into Y-type S and Y-type P. The frequency of Y-type S and Y-type P for Taejeon population was found to be 80.26% and 19.74%, while it was 88.57% and 11.43% for Kangwha population, respectively. However, no difference was observed in the heterochromatin condensing patterens at interphase. The fluorecence banding patteren observed in the 2nd, 3d, 4th, and X-chromosome from flies of both population were similar to that reported previously. The genetic and evolutionary significance of the Y-type S, and Y-type P has been discussed.

쓰레기 소각재를 잔골재로 혼합한 콘크리트의 기초적 물성연구

홍기호,하상훈,김정규,어석홍 國立 昌原大學校 產業技術硏究院 2004 産技硏論文集 Vol.18 No.-

The purpose of this study is to investigate the material characteristics and strength properties of concrete mixed with waste incinerated bottom ash(BA), and to evaluate the leaching of environmentally harmful heavy metals from the bottom ash itself and from hardened concrete mixed with bottom ash. For this purpose, two reference mixed with W/C ratio of 0.45 and 0.55 were used, and the replacement proportion of BA was varied with ratios of 0, 30, 50, 70 and 100% by volume of fine aggregate in the reference mixes. The variation of compressive and splitting tensile strength, workability and unit weight of concrete were considered. Test results showed that the strengths, workability and unit weight decreased with increase in proportion of BA replaced. Leaching test results showed that there would be no environmentally harmful problem from using BA as substitutes of fine aggregates in concrete.

대학 전산 정책의 방향설정 및 추진계획에 관한 연구

홍상은,이병수,조충호,이상정,주경수,안종근,황순기 순천향대학교 1994 논문집 Vol.17 No.1

It has been rapidly given to the importance of the embodiment of the efficient computer systems in university education. Since the recent trend of the adoption of the openess policy in university education systems significantly affects on the realization of the embodiment of the efficient computer systems which is very essential to promote the international competition in many areas of university education. So it is greatly needed that our Soonchunhyang university must have the following principles for the embodiment of the efficient computer systems. (1) It is required that the appropriate computer education and the good quality of research environment must be given. (2) The establishment of the synthetic computer network system for efficient the university administrations is needed. (3) It is needed to establish the computer system for the consideration of the future performance. (4) It is also needed to improve the organization and the administration systems of the university computer center. (5) It is required on the establishment of the local area network(LAN) systems in the Soonchunhyang university, and the LAN must be connected to other outer national and international computer systems. And we propose the following requirement for the establishment of the convienent computer systems in our university and we have been greatly though about the significant change of the environment in university computer system. [1] The subject of the basic computer must become as the required subject for the all students in the curriulum. [2] The new computer systems both in hardware and software must be introduced. [3] It is needed to the change of the present name of the university computer center into the university information and computer center. And its organizations must be furthur developed [4] The training center for the university emploee is also needed. [5] The establishment of the database systems for the automtion of the university administation is needed. [6] It is strongly required on the establishment of the local area network system in the Soonchunhang university to connect the Bitnet and the Internet through the Hankook communication. [7] The computerization for the central library is needed. The indepent local area network system for the library is also needed to establish the own database system. Finally we hope that the LAN will be connected to the national wide library computer system.

현존재의 존재세계 : 공간성을 중심으로

성홍기 새한철학회 1999 哲學論叢 Vol.17 No.-

치료저항 만성 정신분열증 환자에서 Clozapine과 Haloperidol의 치료효과에 대한 비교

이홍식,김찬형,이희상,남궁기,송동호,이영문,한은선 大韓臨床藥理學會 1993 臨床藥理學會誌 Vol.1 No.2

고환에 발생한 표피양낭

정기욱,정웅교,김재웅,이홍우,강성학 大韓泌尿器科學會 2001 Korean Journal of Urology Vol.42 No.9

QS 9000 인증이 기업에 미치는 효과 분석

홍성일,이동기,최희영 한국의사결정학회 2000 경영과학연구 Vol.9 No.-

These days most companies are required to acquire quality assurance systems, such as ISO 9000, ISO 14000, ISO 18000, and QS 9000 etc. To analyze the effects of QS 9000 Quality System on company quality improvement, empirical data is collected from quality assurance engineers who has on certification activities. QS 9000 is an international standard which defines the basic features of an effective ISO 9000 Quality Management System. It is essential to acquire certification of Quality Assurance System to improve competitive power of the firm. But, most of the domestic firms struggling to acquire those certifications face on the many problems. Results of the study showed that : ⅰ)Most machine manufacturing companies in korea employ some sorts of Quality Management System. Some beneficial effects were produced when the QS 9000 Quality Management System was used. ⅱ) The Big 3 automakers use quality manuals and procedures of QS 9000, but although used, there was still unsolved problems.

범주에 관한 존재론적 고찰 : 「비판적 존재론」을 중심으로

성홍기 영남철학회 1996 哲學論叢 Vol.12 No.-

Enamel Microabrasion을 시행한 법랑질과 복합레진의 전단결합강도

홍기상,이상훈,이상대 大韓小兒齒科學會 2000 大韓小兒齒科學會誌 Vol.27 No.1

Enamel microabrasion은 염산과 연마제를 사용하여 치아의 착색을 제거하는 술식으로서, 그 효과는 법랑질 표층에 국한된다. Enamel microabrasion으로 모든 착색이 치료 가능한 것은 아니므로, 착색이 깊을 경우에는 microabrasion후에도 제거되지 않고 남은 착색부위를 광중합 복합레진을 사용해 수복할 것이 권장된다. 본 연구의 목적은 enamel microabrasion의 방법과 시간이 법랑질에 대한 복합레진의 전단결합걍도에 미치는 영향을 조사하는 것이었다. 아무런 처치도 하지 않은 대조군을 1군으로 하였고, 18% 염산과 fine pumice의 혼합물을 hand applicator로 치면에 5초씩 5,10회 적용시킨 것을 각각 2,3군으로 하였다. 10% 염산과 연마제의 혼합물인 기성품 PREMA를 10:1 gear reduction handpiece로 20초씩 5, 10회 적용시킨 것을 각각 4,5군으로 하였다. 여기에 37% 인산으로 부식 후 복합레진을 결합시켜 thermocycling 후 전단결합강도를 측정하여 다음과 같은 결론을 얻었다. 1. 2군이 가장 높은 결합강도(24.36±3.34MPa)를 나타내었고, 3군이 가장 낮은 결합강도 (19.35±3.43MPa)를 보였다. 전단결합강도는 2>4>5>1>3군의 순서로 감소하였다. 2. 2군은 1군과 3군보다 통계학적으로 유의성있게 높은 결합강도를 나타내었다(p<0.05). 3. 염산과 pumice로 enamel microabrasion을 시행한 2,3군과 PREMA를 사용한 4,5군 사이에는 유의한 결합강도의 차이가 없었다 (p<0.05) 4. 파절면 검사에서, adhesive failure는 3,4군에서 나타났고, cohesive failure는 1,2,3,4군에서 관찰되었다. 5군에서는 mixed failure만이 관찰되었다. 5. SEM관찰에서, 염산과 pumice로 enamel microabrasion을 시행한 2,3군에서는 인산으로 부식한 것과 비슷한 표면양상이 관찰되었고, PREMA로 처리한 4,5군에서는 1군과 흡사한 매끈한 표면양상이 관찰되었다. 각 군의 시편을 인산으로 부식시킨 다음에는 전형적인 산부식 후의 표면양상이 관찰되었고, 군간 별다른 차이가 없었다. Enamel microabrasion is a means by which superficial enamel discoloration is removed using hydrochloric acid and fine pumice. As enamel microabrasion alone may not by sufficient in cases of deeper discoloration, composite resin restoration is recommended in areas where there is remaining discoloration. The purpose of this study was to investigate the effects of different methods and number of applications of enamel microabrasion on the shear bond strength of composite resin to enamel. Untreated control was designated as groups1,5-second applications of a mixture of 18% HCI and fine pumice were performed 5 and 10 times on groups 2 and 3, respectively. A commercially available mixture of 10% HCI and abrasives (PREMA) was appliedusing a 10:1 gear reduction handpiece 5 and 10 times on groups 4 and 5, respectively, with each application lasting 20 seconds. After etching with 37% phosphoric acid, composite resin was bonded. Thermocycling was performed and shear bond strength was measured. The following results were obtained: 1. Group 2 showed the highest bond strength(24.36±3.34), while group 3 showed the lowest (19.35±3.43). Shear bond strength decreased in the following order: 2>4>5>1>3. 2. Group 2 showed bond strength significantly higher compared to groups 1 and 3(p<0.05). 3. There were no significant differences between groups 2 and 3, which had been microabraded using HCI and pumice, and groups 4 and 5, to which PREMA had been applied, when bond strengths were compared(p>0.05) 4. When modes of fracture were examined, adhesive failure was observed in groups 3 and 4, while cohesive failure was observed in groups 1,2,3 and 4. Only mixed failures were found in group 5. 5. When viewed using a SEM, groups 2 and 3, which had been microabraded using HCI and pumice, showed surface appearances similar to that of enamel etched with phosphoric acid. Groups 4 and 5, treated with PREMA, exhibited a smooth surface similar to that of group 1. All groups showed similar, typical surface characteristics following phosphoric acid etching.