외배엽 이형성증 환자의 임상적 치험례

오소희,권순원,김종수,김용기,임헌송 대한소아치과학회 2000 大韓小兒齒科學會誌 Vol.27 No.2

Ectodermal dysplasia(외배엽 이형성증)은 외배엽성 기관에 한가지 이상의 선천적 이상소견을 특징으로 하는 질환이다. Ectodermal dysplasia는 약 120종류 이상이 보고되고 있고, 이 중 Hypohidrotic ectodermal dysplasia가 가장 잘 알려져 있으며 이는 성염색체 열성인자에 의해 유전되며 남성에서 호발한다고 한다. 임상증상으로는 무한증, 감모증, 무치증 혹은 핍지증이 가장 특징적이다. 이외에도 무피지증, 손톱이형성증, 가늘고 성긴 머리카락, 두드러진 이마, 안장코, 돌출된 안와상부, 입술의 돌출과 함께 피부가 건조하고 땀샘이 결핍되어 있어서 더위를 참지 못하고 발열이 일어나기 쉽다. 본 증례의 환자는 단국대학교 치과병원 소아치과에 내원한 6세 6개월된 남아로써 무치증을 보이는 Hypohidrotic ectodermal dysplasia로 진단되었고 환자의 심미적, 기능적 결함을 해소하기 위해 총의치로 치료를 시행하는 동안 다소의 지견을 얻어 이를 보고하는 바이다. 주요어 : 외배엽 이형성증, 무치증, 총의치

A Study on DNA Sequences and Mutation of Integrase Region of Korean-type Bovine Leukemia Virus (BLV) pol Gene

권오식,--,--,-- THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 2004 Journal of biomedical laboratory sciences Vol.10 No.1

Bovine leukemia virus (BLV) is a causative agent for lymphoma disease in cattle including cows worldwide. BLV shares similar virion structure and characteristics with other retroviruses. The pol gene of the BLV genome produced reverse transcriptase (RT) and integrase (IN) for important roles for BLV genome integration into host cell chromosomes that is known to be coded in the 3' side of the BLV pol gene (one third portion). In this study, we have sequenced 978 bp in the 3'side of the BLV pol gene from BLV 10C3 in order to determine the BLV IN region of it. And we compared it to the nucleotide sequences of an Australian BLV isolate. As a result, nucleotide sequences of the IN region of the Korean-type BLV pol gene were mutated at a rate of 3.7%. We can confirm that the typical mutations are such as Arg (AGG) → Lys(AAG), Thr (ACG) → Met (ATG), Ile (ATT) → Val (GTT), Asn (ACC) → His (CAC), Phe (TTT) → Leu (TTG) and Asn (ACC) → Asp (GAC). From the analysis of the sequencing data, we were able to determine the zinc-finger-like "HHCC" motif in the amino terminus of BLV IN, that was H-X_(3)-H-X_(25)-C-X_(2)-C. It was also found the DD35E motif in the IN catalytic domain as D-X_(56)-D-X_(35)-E. It fits very well to the consensus sequences of retroviral IN as well as HHCC motif.

노인요양시설의 적정 침실 면적에 관한 연구

권순정,한정한,오은진,김석준,김노석,이특구 한국의료복지시설학회 2008 의료·복지 건축 Vol.14 No.3

The purpose of this study is to suggest optimum size of residents' bedrooms in nursing homes. Bedroom is an essential part of nursing homes because nursing home residents spend most of their times in bedrooms and occupy the largest part of facility area. Therefore it is necessary to set an adequate standard related to resident room area in nursing facilities, which have a great effect on planning longterm care facilities for the elderly. The body dimensions of elderly people and care givers have been collected from the previous study. Based on the body dimensions data, the behaviors of elderly as well as care givers have been analysed. The minimum areas-exclusive of toilets, closets, vestibules and so on - have been proposed from the results of the behavior analysis.

노인전문요양시설 건축모델연구 : 디자인 가이드라인

권순정,오은진,안희창 한국의료복지시설학회 2006 의료·복지 건축 Vol.12 No.1

노인전문요양시설의 거주단위 모형개발에 관한 연구

권순정,오종희 한국의료복지시설학회 2004 의료·복지 건축 Vol.10 No.2

With its rapid modernization and unparalleled speed of aging, South Korea faces the need for dramatic increase in its supply of nursing homes. Among the spacial components of nursing homes, residential units are considered as an essential part because the older person in nursing homes usually spend most of their time in residential units and the nursing homes are mainly composed of various residential units. It is necessary, therefore, to prepare a guideline for the plan of residential units in order to design the healthy and efficient nursing homes. This paper has first identified the concept of residential unit and analyzed 66 cases in the 62 nursing homes from 4 countries. And 4 nursing homes in Korea have been surveyed for the in-depth study. On the basis of this analysis, architectural prototypes of residential units have been proposed and the architectural characteristics of them have been compared analytically.

해마 theta리듬과 pyramidal neuron의 세포내 특성과의 상관관계

권오흥,조진화,남순현,김현정,최병주,김영진,이만기 大韓小兒齒科學會 1998 大韓小兒齒科學會誌 Vol.25 No.4

Eledctrophysiological phenomena of pyramidal cells in the CAI area of the dorsal hippocampus were recorded from and filled with neurobiotin in anesthetized rats. The electropharmacological properties of membrane as well as the cellular-synaptic generation of rhythmic slow activity (theta)were examined. The intracellular response characteristics of these pyramidal cells were distinctly different from responses of inteneurons. Pyramidal cells had a high resting membrane potential, a low input resistance, and a large amplitude action potential. A afterhyperpolarization was followed a single action potential. Most of pyramidal cells did not display a spontaneous firing. Pyramidal cells displayed weak inward rectification and anodal break excitation. The slope of the frequency-current relation was 53.4 Hz/nA for the first interspike interval and 15.9 Hz/nA for the last intervals, suggesting the presence of spike frequency adaptation. Neurobiotin-filled neurons showed pyramidal morphology. Cells were generally bipolar dendritc processes ramifying in stratum lacunosum-moleculare, radiatum, and oriens. Commissural stimulation discharged pyramidal cells, followed by excitatory and inhibitory postsynaptic potentials (EPSPs and IPSPs). The frequency of theat-related membrane potential oscillation was voltage-independent in pyramidal neurons. At strong depolarization levels (less than 30 mV) pyramidal cells emitted sodium spike oscillation, phase-locked to theta. The observations provide direct evidence that theta-related rhythmic hyperpolarization of principal cells is brought by the rhythmically discharging interneurons. Furthermore, the findings in which interneurons were also paced by rhythmic inhibitory postsynaptic potentials during theta suggest that they were periodically hyperpolarized by their GABAergic septal afferents.

식품위생관련 세균에 대한 가열처리 조건의 최적화

권오진,이보순 한국식품영양학회 1999 韓國食品營養學會誌 Vol.12 No.6

반응표면분석법으로 식품위생관련 세균의 불활성화를 위한 가열처리 조건(온도. 시간)을 최적화하다. 균주의 생육에 대한 반응표면 회귀식의 R^2은 P.aeruginosa가 0.9155(P<0.05). E. coli는 0.8997(P<0.05).S. typhinurium은 0.9690(P<0.01), E. aerogenes는 0.9393(P<0.05) 및 V. parahaemolyticus는 0.7905로 나타났다 가열처리 온도 및 시간에 따라 주의 생육에 유의적인 영향을 미치는 것으로 나타났으며. 생육억제에는 반응온도가 가장 큰 상관관계가 있음을 보여주었다. 각각의 가열처리 조건에 따른 균주의 불활성화를 종합하여 superimposed contour map을 작성한 결과. 55.62∼60℃에서 19.25∼30분간의 처리가 균주으 불활성화 최적조건이었다. Response surface methodology(RSM) was applied to determine the optimum heating conditions(temperature and time) for the inactivation of bacteria associated with food hygiene, Coefficients of determinations(R^2) for the cell growth were 0,9155 (P<0.05) in Pseudomonas aeruginosa, 0.8997(P<0.05) in Escherichia coli, 0.9690 (P<0.01) in Salmonella typhimurium, 0.9393(P<0.05) in Enterobacter aerogenes and 0.7905 in Vibrio parahaemolyticus. The growth of strains was significantly affected by the temperature and time, and reaction to temperature was most closely correlated to the inhibition of growth. On the basis of superimposed contour maps of cell growth, the optimum range of heating conditions were 55.62∼60℃ and 19,25∼30 min.

화학기상응축법으로 제조한 Fe-Co 나노입자의 구조 및 자기적 상태에 관한 뫼스바우어 분석

오세진,최철진,권순주,진상호,김병기 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.7

Nine nano-sized Fe-Co particle samples synthesized by Chemical Vapor Condensation(CVC) were analyzed using Mo¨ssbauer spectroscopy, XRD, BET and HRTEM. The synthesized nanoparticles consisted of metallic core and oxide shell structures, and their surfaces were covered with a-FeOOH, γ-FeOOH and Fe_(3)O_(4). The increase of cobalt content enhanced magnetic field. However, when the decomposition temperature and the oxygen content in the carrier gas (Ar) increased, the magnetic field of nanoparticles reduced with decreasing the average particle size. with increasing the vacuum pressure, the average particle size and the magnetic field increased.

야생더덕과 재배더덕의 함유성분 비교

오세명,정형진,권순태 安東大學校 農業科學技術硏究所 1997 農業科學技術 硏究論文集 Vol.4 No.-

야생더덕은 재배더덕에 비해 조섬유와 석유에텔추출물 함량 비율이 높았고 수분, 환원당 및 조단백질 함량은 낮았다. 더덕의 뿌리가 오래된 것일수록 조섬유, 환원당, 조회분 및 석유에텔성분의 함량이 높았고 수분과 조단백질은 낮았다. 항산화효소인 superoxide dismutase와 peroxidase의 활성은 더덕뿌리의 년수가 오래된 것일수록 높았고 야생더덕이 재배더덕에 비해 높았으나 catalase의 활성은 년근수가 적을수록 높았고 야생 및 재배더덕간에는 차이가 없었다. 야생더덕이 재배더덕에 비해 malic산의 함량이 현저히 낮았으나 타 성분은 큰 차이를 보이지 않았고, 년근이 오래된 것일수록 유기산의 함량이 증가하는 경향이었다. 지방산인 oleic, linoleic 및 palmitic 산은 년근이 오래된 것일수록 함량이 높았고 야생더덕이 더욱 높았다. Content of crude lipid, petroleum ether extracts and crude fiber were higher in wild grown species than in cultivated species, and that of water, reducing sugar and crude protein were vice versa. The older roots showed the higher contents of crude fiber, reducing sugar, crude ash and petroleum ether extracts. However, content of water and crude protein were higher in younger roots than in older roots. Wild grown species and/or older roots showed higher enzyme activity of superoxide dismutase and peroxidase than those of cultivated species and/or younger roots. Younger roots showed higher catalase activity than older roots. Wild species contained lower malic acid and citric acid contents than those of cultivated species tested. Content of fatty acids such as oleic, plamitic and linolenic acid were higher in wild species and/or older roots than cultivated species and/or ypunger roots. However, content of linoleic acid was lower in wild species.

Salmonella 균 증식에 있어서 Ox-bile 의영향

권오필,고광균,이강순 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.1

This study was performed to investigate the effect of bile on the growth of Salmonella spp., and to find out the reason for the seasonal changes of epidemics and the carrier of gallbladder in the infection of Salmonella typhi and the results were follows. 1. Salmonella typhi and Salmonella choleraesuis can remain alive in distilled water for more than 90 days, the other hand Salmonella enteritidis can survive for about 70days. 2. Salmonella spp. can persist for long periods in the stock media contained with 5% ox-bile. 3. This results suggest that the growth of Salmonella was not inhibited with ox-bile in broth and agar plate media. 4. We could not find out any relation between becoming a gallbladder carrier in Salmonella typhi infection and ox-bile. But Salmonella typhi survive longer than Salmonella choleraesuits and Salmonella enteritidis in the distilled water containing 20% oxbile.