한국인 본태성 고혈압환자에서 Angiotensinogen M235T 유전자 다양성

양동호(Dong Ho Yang),홍세용(Sea Yong Hong),김홍수(Hong Soo Kim),방차옥(Cha Ok Bang),김철현(Chul Hyun Kim),최종순(Jong Soon Choi),하권수(Kwun Soo Ha) 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.3

N/A Background: Potential involvement of the angio-tensinogen gene(M235T) in the pathogenesis of essen-tial hypertension has been suggested by some inves- tigators. However, an association between M235T gene polymorphism and essential hypertension has been reported by some, but not by others. Since genetic diversity exists among different ethnic population, we addressed the question of whether there is an association between M235T gene poly-morphism and essential hypertension in the Korean. Methods: 100 patients with essential hypertension and 100 control subjects were recruited from out- patients at the Department of Internal Medicine, Soon-chunhyang Hospital, Chunan City. The criteria for hypertension was defined as systolic blood pressure higher than 160mmHg and/or diastolic blood pressure higher than 95mmHg. For detection of the M235T polymorphism at the angiotensinogen locus, the primer sequences were: sense primer : 5'-TGAAGGAG- AAGGTGTCTGCGGGA-3' and antisense primer : 5'- AGGACGGTGCGGTGAGAGTG-3'. The PCR product mixture was exposed to restriction enzyme Tthlll I and then submitted to electrophoresis in polyacryl-amide gel. Differences between the molecular variants of the gene in hypertensives and normotensives were com- pared by using the X²test. p<0.05 was considered statistically significant. The odds ratio and 95% confidence interval were calculated using Woolf's method. Results: Compared with the control subjects, hypertensives had higher values of three established risk factors for hypertension : age, BMI cholesterol (total and LDL). X analysis showed no difference in the distribution of genotype or allele frequency between the hypertensives and normotensives(X²=1.14, p=0.29). The crude odds ratio was 0.73 for CC over CT(95% confidence interval 0.41-1.30). The adjusted odds ratio with age, sex, lipid profilcs and BMI was 0.68 for CC over CT(9596 confidence interval 037-1,23). Conclusion : The molecular varient M235T of the angiotensinogen gene is not associated with essential hypertension in Korean population.

Antioxidant and cytoprotective effects of morin against hydrogen peroxide-induced oxidative stress are associated with the induction of Nrf-2-mediated HO-1 expression in V79-4 Chinese hamster lung fibroblasts

Lee, Moon Hee,Cha, Hee-Jae,Choi, Eun Ok,Han, Min Ho,Kim, Sung Ok,Kim, Gi-Young,Hong, Su Hyun,Park, Cheol,Moon, Sung-Kwon,Jeong, Soon-Jeong,Jeong, Moon-Jin,Kim, Wun-Jae,Choi, Yung Hyun Spandidos Publications 2017 International journal of molecular medicine Vol.39 No.3

<P>Natural phytochemicals of plant origin, including flavonoids, have been found to be potent antioxidants providing beneficial effects against oxidative stress-related diseases. The present study was carried out to investigate the antioxidant properties of morin, a flavonoid originally isolated from the flowering plants of the Moraceae family. Superoxide dismutase (SOD)-like activity and 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS(center dot+)) radical scavenging activity were determined. We also investigated the cytoprotective effects of morin against hydrogen peroxide (H2O2)-induced DNA damage and apoptosis in V79-4 Chinese hamster lung fibroblasts. Our results demonstrated that morin had strong scavenging effects against ABTS' radicals with enhanced SOD activity, which varied in a dose-dependent manner. Morin was found to reduce H2O2-induced intracellular reactive oxygen species generation and nuclear DNA damage, and it recovered cell viability damaged by H2O2 via inhibition of mitochondrial dysfunction-mediated apoptosis. Notably, the treatment of V79-4 cells with morin markedly enhanced the expression of heme oxygenase-1 (HO-1) but not quinone oxidoreductase-1, which was associated with the increased expression and phosphorylation of nuclear factor-erythroid 2-related factor 2 (Nrf2) and the downregulation of Kelch-like ECH-associated protein 1 expression. Based on our findings, we conclude that morin effectively ameliorated oxidative stress-induced DNA damage through intrinsic free radical scavenging activity and activation of the Nrf2/HO-1 pathway.</P>

한국에서 독일어 : 과거와 현재

홍명순,정시호,이광숙,이성만,하수권,Ammon, Ulrich 한국독일어교육학회 2002 외국어로서의 독일어 Vol.10 No.-

Es handelt sich bei dieser Arbeit um die Frage, welche Rolle die deutsche Sprache und Kultur in der koreanischen Gesellschaft bis heute gespielt haben und noch in Zukunft spielen werden, wobei die folgenden verschiedenen Bereiche in Betrachtung genommen wurden: Wissenschaft, Kunst, Wirtschaft und Werbesprache. Außerdem wurde einen U¨berblick u¨ber die Geschichte der Fremdsprachenausbildung in Korea gegeben. Bis in die 1950er war die deutsche Sprache in Korea in denmeisten wissenschaftlichen Bereichen von großer Bedeutung vor allem in der Philosophie, Sozialwissenschaft, Rechtswissenschaft, Medizin und Musik. Danach verlor die deutsche Sprache allma¨hlich ihre Bedeutung, wa¨hrend Englisch und Japanisch eine zunehmend dominierende Rolle spielten. Die deutsche Medizin und die deutsche Sprache haben zur entwicklung der westlichen Medizin in Korea einen großen Beitrag geleistet. Zum Beispiel hat Deutsch in den Curricula der Soul und der Kyungpook Medizinschule bis 1945 fast eine gleich starke Stellung wie Englisch oder zeitweise noch sta¨rkere Stellung gehabt. Aber das Jahr 1945, besonders der Korea Krieg(1950-1953) war ein entscheidender Wendepunkt. Seitdem sind die deutsche Medizin und Deutsch verdra¨ngt worden. Es hat heute vo¨llig an Boden verloren. Und um die Beeinflußung der deutschen Musik in Korea fest zustellen, wurden in Korea erschienene Musiklehrbu¨cher und wissenschaftliche Bescha¨ftgung in der Musikwissenschaft untersucht. Nach der Analyse der Musiklehrbu¨cher ist folgendes zubemerken: Im ersten Schuljahr werden u¨berwiegend Komponisten aus dem deutschsprachigen Raum behandelt. Auf dem Hochschulbereich u¨ben sie einen gro¨ßeren Einfluss aua. Bei der Untersuchung der Magisterarbeiten auf dem Gebiet Vokal-, Klavier-, Kammer- und Instrumentalmusik zwischen 1958 und 1987 fa¨llt auf, dass ca. 60-70% der arbeiten Komponisten des deutschsprachigen Raums behandeln. Anders als in den oben erwa¨hnten Bereichen ist die Einstellung koreanischer Firmen zur deutschen Sprache extrem negativ. Seitens der koreanischen Firmen wird der deutschen Sprache fu¨r ihre gescha¨ftlichen Aktivita¨ten keinerlei Bedeutung beigemessen, in vielen Fa¨llen wurde auch das negative Image der deutschen Sprache erwa¨hnt. So kommt es nicht von ungefa¨hr, wenn Absolventen eines Studienganges in Germanistik ihre deutsche Sprachkenntnis in Bewerbungsschreiben erst gar nicht erwa¨hnen, sondern stattdessen nur ihre in den Englischzertifikaten TOEIC und TOEFL erlangten Punktzahlen angeben. Neben solchen Bereichen wurde in dieser Arbeit auch die Frage untersucht, ob und welche Bezeichnungen von Gescha¨ften und Geba¨uden aus der deutschen Sprache und Kultur stammen. Auch in diesem Untersuchungsbereich dominiert Englisch und wird Deutsch selten verwendet. Allerdings sind bei Kaffee-, Bierha¨usern und Konditoreien deutsche Benennungen nicht selten zu beobachten. Viele Kaffeeha¨user tragen die Namen der in Korea beliebten Komponisten aus dem deutschsprachigen Raum : Mozart, Schubert, Brahms und Beethoven, oder auch ihrer Werke. Fu¨r Bierha¨user beborzugt man Stadt- bzw. Ortsbezeichnungen wie Mu¨nchen, Bern, Berlin, Heidelberg, Schwabing und Mosel. Außer solchen Gesichtspunkten wurde hier auch die geschichtliche Entwicklung der Fremdsprachenausblidung in Korea untersucht. Diese Entwicklungsgeschichte hat eine enge Beziehung mit der politischen Geschichte. Chinesisch galt bis Ende des 19. Jahr hunderts als Bildungssprache, und zwar nur fu¨r ho¨here Schichten der Bevo¨lkerung. Der Fremdsprachenunterricht als allgemeine Bildung an Schulen hat seinen Ursprung in den spezifischen Fremdsprachenschulen, die Ende des 19. Jahrhundert gegru¨ndet wurden, in dem der Modernisierungsprozess Koreas begann: Englisch, Deutsch, Franzo¨sisch, Russisch, Chinesisch und Japanisch konnte man dort bei Muttersprachlern lernen. In der koreanischen Fremdsprachenausbildung haven aber heutzutage Englisch und Japanisch erste Priorita¨t vor allen anderen Sprachen. Deutsch wird zwar an den Schulen unterrichtet, findet aber daru¨ber hinaus, etwa im Berufsleben, so gut wie keine praktische Verwendung. Die Untersuchung zeigt auch in anderen Bereichen einen Wandel, na¨mlich bei der Benennung der Fremdsprachen, der Zahl der Fremdsprachen und den Unterrichtsinstitutionen. Es ist dabei festzustellen, dass die Unterrichtsmethoden und Lerngewohnheiten am wenigsten mobil sind. Wenn man solche Untersuchungsergebnisse zur Rechnung tra¨gt, scheint der Ru¨ckgang des Bedarfs der deutschen Sprache in Korea unvermeidbar sowohl in der Schule und als auch in der Universita¨t zu sein, obwohl auch in Zukunft Koreaner Interesse and de Kultur der deutschsprachigen La¨nder-im großen Abstand nach den USA, Japan und China-zeigen werden. Das ko¨nnte eine negative Kettenreaktion auslo¨sen : die Anzahl von Deutsch Experten geht zuru¨ck, ihre Berufschanchen verschlechtern sich weiter, viele Institutionen mu¨ssen zwangsweise geschlossen, Forschungaktivita¨ten beschra¨nkt werden usew. Wie vorher festgestellt, gru¨ndet sich das bestehende Lehrangebot an Deutsch in Korea weniger auf einem wirklich existierenden gesellschaftlichen Bedarf, sondem auf der Macht, u¨ber die Institutionen und Strukturen verfu¨gen. Eine am Anbieter orientierte Schulpolitik hat lange Zeit den Bedarf an Deutsch in Schulen und Universita¨ten garantiert. Mit dem nun stattfindenden Wandel hin zu einer nachfrageorientierten Schulpolitik verliert das Schulfach Deutsch sein bisheriges Fundament. Quantitativ gesehen hat der Markt fu¨r Deutsch als Fremdsprache in Korea eine Phase des Wachstums hinter sich und erlebt nun einen vielerorts deutlichen Abschwung. Die Krise, in der sich Deutsch als Frmdsprache in Korea zur Zeit befindet, wird sich vermutlich angesichts der gesellschaftlichen Bedingungen, des herrschenden Zeitgeists und der ungu¨nstigen Schulpolitik fu¨s Erste fortsetzen. Geht man von einem Ungleichgewicht zwischen Angebot und Nachfrage aus, wird dieser Abwa¨rtstrenderst zum Stillstand kommen, wenn ein Gleichgewicht hergestellt ist. Selbstversta¨ndlich sind solche Tendenzen im Zusammenhang mit der umfassenden Restrukturierung zu sehen, in der sich die koreanische Gesellschaft momentan befindet.

대장암에서 개복 대장절제술, 복강경 대장절제술 및 수부 보조 복강경 대장절제술의 단기 추적 관찰 결과의 비교

홍경숙,노경태,오보영,이령아,정순섭,김광호 이화여자대학교 의과학연구소 2011 EMJ (Ewha medical journal) Vol.34 No.2

Objectives: Hand-assisted laparoscopic surgery had both technical advantages of open surgery and better postoperative short-term follow-up results of laparoscopic surgery. We compared open colectomy, laparoscopic colectomy and hand-assisted laparoscopic colectomy, and tried to find the most effective operative modality. Methods: 90 patients, who were diagnosed with colorectal cancer and underwent colectomy in our institution, were categorized as 3 groups of open colectomy (OC) group, laparoscopic colectomy (LC) group and hand-assisted laparoscopic colectomy (HALC) group by the surgical modality. Results: In this study, ratio of male and female was 57:37, and mean age was 64.1 years old. LC group and HALC group showed longer operation time, shorter hospital stay after operation, lesser pain and earlier removal of closed drainage catheter than OC group. Amount of bleeding during operation, frequency of transfusion and incidence of complication showed no significant difference. In permanent pathologic results, the number of harvested lymph nodes had significant difference between OC group and other groups (P=0.030), but it was probably caused by the bias of the different distribution of the stages in each group. Overall 14 of the cases resulted in complications while there was no mortality. Conclusion: Laparoscopic colectomy and hand-assisted laparoscopic colectomy showed better short-term follow-up results rather than open colectomy. And hand-assisted laparoscopic surgery could provide tactile sensation to operator, which lacked in laparoscopic surgery. Hand-assisted laparoscopic colectomy could be an alternative surgical option for colorectal cancer with these advantages.

교합기의 전방 기준점에 관한 연구

홍순호 慶北大學校 齒科大學 1989 慶北齒大論文集 Vol.6 No.3

To evaluate the validity of the use of infraorbitale as anterior reference point of articulator system, the vertical distances form FH plane to Nasion, and that from FH plane to incisal edge of maxillary central incisor were measured on lateral cephalograms taken from 76 normal subjects. Results of this study were obtained as follows : 1. The average distance from FH plane to nasion was 22.57±2.67㎜. 2. The average distance from FH plane to the incisal edge of maxillary central incisor was 60.61±4.07㎜.

침전법에 의한 알루미나 분말제조 IV.ZrO₂의 분산에 의한 Al₂O₃/ZrO₂ 복합체의 제조 및 기계적 특성

홍기곤,이홍림,이형직,이호순 연세대학교 산업기술연구소 1992 논문집 Vol.24 No.2

In this study, a precipitation method, one of the most effective liquid phase reaction, was adopted in order to prepare high-tech Al₂O₃/ZrO₂ composite ceramics. Al₂(SO₄)₃·18H₂O, ZrOCl₂·8H₂O and YCl₃·6H₂O were used as starting materials and NH₄OH as a precipitation agent. Fine powders were prepared at optimum calcination condition. Sinterability of each fine powder and the effects of ZrO₂ on the grain size and mechanical properties of Al₂O₃ were investigated. The composition of Al₂O₃/ZrO₂ composites was fixed as Al₂O₃-15v/o ZrO₂(+3m/o Y₂O₃). The effect of MgO on the grain size of Al₂O₃ZrO₂ ceramics was also investigated.

탄소성 변형을 받는 냉간 압연강의 X선 잔류응력 특성에 관한 연구

홍순혁,이동우,양광호,조석수,주원식 동아대학교 생산기술연구소 2000 生産技術硏究所硏究論文集 Vol.5 No.1

In textured material, diffraction angle 2θ usually shows a nonlinear relation against sin^2Ψ due to elastic anisotropy of crystals. SPHD and SPCD steel is cold-rolled carbon steel for automobile. The characteristics X-ray for stress measurement is Cr K_α and Mo K_α1characteristic X-ray. The sin^2Ψ-2θ diagram under elastic strain seems to have a linear behavior using regression line of data but has a nonlinear behavior in distribution of data by Cr K_αcharacteristic X-ray. As the plastic strain of specimen increases, the nonlinearity of 2θ with respect to sin^2Ψ increases remarkably. On the other hand, the diffraction angle 2 θ by Mo K_α1 characteristic X-ray shows a good linearity on sin^2Ψ-2θ diagram under plastic strain as well as elastic strain. Therefore, This paper presents the measurement of residual stress in cold-rolled carbon steel for automobile using penetration depth of Mo K_α1 charateristic X-ray and multiplicity factor of crystal diffraction plane.

보행시 발생되는 하지 운동근의 장력과 관절 토오크의 수리적 해석

홍성표,이순호 忠南大學校體育科學硏究所 1994 體育科學硏究誌 Vol.12 No.1

The purpose of this study is to present the mathematical interpretation on joint torque while being normal gait which include the muscle tension and use equation of motion with a double rigid-pendulum model. then, the estimates of the stance and swing phase were obtained from photoghaphs. When the angel of thigh(θ₁) and calf (θ₂) of lower leg measured from vertical direction to counterclockwise are compared, the results as follow; 1. It is possible to interpret the mathematical model on the joint torque of lower extremity with double rigid pendulum model. 2. With the conition of double rigid pendulum model, the length of center of mass does not effect at the change of angle.

상체의 중량 변화에 따른 보행의 운동현상학적 특성

홍성표,이순호 忠南大學校體育科學硏究所 1991 體育科學硏究誌 Vol.9 No.1

The purpose of this study was to find out the effect for carrying load of 20% & 40% of body weight by means of two different carrying systems on selected kinematic characteristic describe the walking gait patterns. 1. The gait cycle-time for loading of upperpart of body during walking gait was the longest at back pack system Ⅱ. The period of double support of back pack system condition tended to increase with loading of body and swing period tended to decrease. 2. Angle displacement of knee and ankle of joint was the most large at toe off phase and the most short at heel for gait cycle period. The angle displacement of ankle and knee in the condition of exteral load of body was slight increase at double pack system condition and decrease at back pack system condition. 3. The body posture and gait pattern for double pack condition were more similar to those for normal walking than for the back pack system condition, suggest that the double pack system was Kinematically more effective than the conventional back pack system for carrying the loads investigated.

소아청소년기에 치수치료를 받은 제1대구치의 술전 상태 조사

이순영,이경호,노홍석,정태성,김신 大韓小兒齒科學會 2011 大韓小兒齒科學會誌 Vol.38 No.4

제1대구치는 막중한 역할을 함에도 불구하고, 청소년 이전에 건강을 상실하는 경우가 드물지 않다. 본 연구는 청소년기 이 전에 치수치료를 받게 된 제1대구치의 우식 및 수복 상태와 분포를 파악할 목적으로 시도되었다. 최근 5년간 부산대학교 치 과병원에서 치수치료를 받은 18세 이하 106명 환자의 135개 제1대구치를 대상으로 의무기록에 대한 조사를 시행하여 다음 과 같은 결과를 얻었다. 1. 평균 연령은 11.9세(남 11.5세, 여 12.5세)였고 유의한 성차를 보였으며(p<0.05), 악별로는 상악 47개, 하악 88개로 하악 치아가 더 많았다. 2. 치수 치료 전 치료 기왕력이 없는 치아는 74개, 치수 또는 수복 치료를 받은 치아는 61개였다. 그 중 재치수치료를 받게 된 경우는 22개로 치수절제술-치수절단술의 순이었으며, 단순 수복치료를 받았던 치아는 39개로 복합레진-아말감-GI- 인레이-수복물 탈락 후 미치료-열구전색 및 주조 전장관의 순이었다. 3. 병소 위치가 분류 가능한 73개의 병소 중에서는 근심면 병소가 22개, 교합면 혹은 협설면 병소 39개, 원심면 병소가 12 개를 차지하였다. In clinical dentistry, it is not difficult to meet the permanent first molars with severe coronal caries lesions in children or adolescents. The circumstances surrounding the first molars of children and adolescents are so immature and imperfect compared with those of adults. So we thought it significant to understand the status of these teeth at the moment of endodontic treatment and immediate cause of it. 106 patients with 135 permanent molars necessitating endodontic treatment in childhood and adolescence were included in this study, and the dental records and radiographs were examined. 1. The mean age was 11.9 year (male 11.5, female 12.5) and the result shows significant difference between gender(p<0.05). The mandibular teeth took more than half percentage than maxillary teeth. 2. Of 135 teeth, 45.2 percent of teeth had history of dental treatment previously and 16.3 percent of teeth showed necessity of re-endodontic treatment. 3. Of 73 teeth, 22 teeth had mesial-wall cavity causing endodontic treatment, 39 had occlusal cavity, and 12 had distal cavity.