백서의 복강내에 투여한 Mitomycin-C-Polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

송규상,강대영,최정목,노승무,정경수,오정연,김진향,양준목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

To evaluate the in-vivo effects of mitomycin-C-polyglycolic acid composite(MMC-PGA) the disk: shaped composite were implanted into the peritoneal cavity of the Sprague-Dawley rats. The pathologic changes were examined at various time points up to 12 weeks. Initially the soft tissue around the inserted disks showed capillary congestion at 3 days. Inflammatory infiltrates with foreign body giant cells appeared from the 2nd week and reached peak response at 6-8 weeks. These reaction diminished prominently at 12 weeks. No specific pathologic change was found in the liver, the kidneys, and the heart. The above results suggest that the MMC-PGA composite can serve as a new device for intraperitoneal chemotherapy of various types of cancers.

대형 충격해머를 이용한 구조물 동특성 실험

송민석,정현호,전종균 선문대학교 2001 공학계열 논총 Vol.4 No.-

본 논문에서는 대형 구조물 내의 진동원인 공조기, 펌프 등을 설치, 가동시 구조물의 동적 응답을 예측하고 건물 구조개선 방안을 제시하는데 목적을 두고 있다. 구조물에 대한 동특성 해석은 해석적인 방법과 실험적인 방법으로 이루어지고 있다. 두 가지 방법 중 본 논문에서는 실험적인 방법을 통해서 구조물 동특성 해석을 시도해 보았다. 자체 제작한 대형 충격 해머(Large Impact Hammer)를 이용해서 구조물 바닥부분에 충격을 가진하여 물체에 작용하는 힘과 이로 인하여 발생되는 진동을 각각의 센서에 의해 측정, 분석하여 구조물의 모드형상을 확인하고 고유주파수를 측정하였다. 해석결과에서는 대형 충격 해머를 이용하여 대형 구조물의 동특성 테스트가 가능할 것이라는 것도 예상할 수 있었고, 임의의 진동원 설비가 설치되어 있는 구역에서 구조물의 동특성을 알고 진동원 가동시 발생하는 진동레벨을 측정하여 실험적으로 구하면 임의의 진동원 설비에서 발생하는 동하중이 산출 가능함을 알 수 있었다. 역으로 구조물의 동특성과 진동원의 동하중을 알면 구조물에 발생하는 진동레벨을 예측할 수 있음을 확인하였다. This paper predicted dynamic responses of structures and presented the solution of structural improvements when vibration sources(pump, motor etc.) were activated in structures. The analyses for the dynamic characteristics are the experimental method and theoretical analysis. This study used the experimental method. The mode shapes and natural frequencies are obtained by large impact hammer. It is possible to test the dynamic characteristics of structures using impact hammer. If it is possible to measure the vibration level when vibration sources were operated, it would be possible to compute dynamic weight. On the other hand, the vibration level could be calculated if dynamic weight can be measured.

The Effects of Green Juice of Angelica Keiskei Koidz on the Toxicity of Several Selected Elements

Song,Sook Ja,Eom,Hyun Sook,Lee,Jin Hee,Choi,Soon Nam,Chung,Keun Hee 韓國營養學會 1997 Journal of Nutrition and Health Vol.30 No.9

손상정도계수와 외상치를 이용한 외상환자의 분석

송근정,장문준,김성중,조광현,김인병,최성욱,이한식 대한응급의학회 1993 대한응급의학회지 Vol.4 No.2

Trauma is one of the most common causes of death. Recently, injury severity score(ISS) is widely used to evaluate and classify the patients with multiple injury. Trauma score(TS) was developed as a means of providing rapid accurate assessment of the injured patient. Authors conducted a review of trauma patients who visited the emergency department of YongDong Severance Hospital from September 1992 to August 1993. ISS and TS were collected from comprehensive initial evaluation. The results were as follows : 1) The subjects were 10.2%(2,666 patients) of total 26,202 emergency patients. 2) Male to female ratio was 2.1 : 1. The age distribution was highest under 10 year(24.9%). The mean ISS was 3.5, and the mean ISS increased with ago. 3. Analysis of injury mechanism showed high incidence of traffic accident(35.3%), blunt trauma 25.7%, fall 24.2%, stabbing 10.7%, and others 4.3% in order. 4. The 8.0% of patients were admitted after initial management and their mean Iss was 12.6 mean TS was 15.5. 5. Among admitted traffic accident patients, the mean ISS of passenger T.A., pedestrian T.A. and driver T.A. were 19.0 ±9.9, 14.4 ±10.6, and 11.3 ±7.7 respectively. 6. Among 42 mortality cases, 25 patients were D.O.A. and 17 were expired. The mean ISS of D.O.A. Patients was 30.0; the mean Iss and mean Iss and mean TS of expired patients were 28.3 and 11.8 respectively. 7. The most common cause of death was head trauma(66.7%). 8. By comparing the ISS and TS of admitted and expired patients, mortality occurred above 16 point of ISS. The mortality increased with increasing ISS, but it was influenced by the trauma site and the severity of the particular injury site. Mortality also occurred below 15 point of TS, the mortality increased inversely with TS, and the mortality with TS, and the mortality was high below 13 point (above 40%).

유방암에서 종양의 크기와 액와림프절 전이의 상관성을 근거로 한 액와림프절 절제술의 생략

송근영,조현진,김권천 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

Purpose: The aim of this study is evaluation of the relations between axillary lymph node status and tumor size, and then applied the omission criteria of axillary lymph node dissection in early breast cancer. Materials and Methods: We reviewed 110 patients underwent radical mastectomy and axillary lymph node dissection in breast cancer at Chosun university Hospital between Feb. 1996 and Mar. 2003. We evaluated the correlations between clinicopathologic factors, axillary lymph node status, and presence of metastasis. Results: Correlations between clinicopathologic factors and axillary lymph node status were statistically significant (p=0.01). Correlation between locoregional metastasis and distant metastasis and axillary lymph node status was significant (p=0.03). Results from the number of histologically-positive lymph nodes were significant (p=0.02) as that of lymph node status. Conclusions: The rate of axillary lymph node metastasis in Tla breast cancer is minute. And, preoperative evaluations and postoperative routine radiation therapy can control the axillary lymph node metastasis in Tla breast cancer. So, omission of the axillary lymph node dissection in Tla breast cancer may be considerable.

AGT 시스템의 동적 증가계수 시뮬레이션

송재필,김기봉,정인근,김현호 中央大學校 建設環境硏究所 2002 環境科學硏究 Vol.13 No.2

무인궤도운전열차(Automated Guide-way Transit, AGT) 시스템의 접지력 및 교량-차량의 동적 응답을 구하기 위해 노면조도가 있는 주행로를 운행하는 AGT 시스템에 대한 동적 운동방정식을 유도하였다. AGT 시스템의 차량은 3차원 11 자유도 모델로 이상화하였고, 교량은 3차원 프레임 모델로 단순화하였다. 동적 운동방정식의 해를 구하기 위하여 컴퓨터 프로그램을 개발하였고, 해석된 결과는 실험자료의 결과치와 비교 분석하였다. 본 연구에서 개발된 프로그램의 해석결과 AGT 교량, 차량 그리고 노면요철의 상호 작용에 의한 교량과 차량의 동적 응답을 구하여 정밀한 교량의 동적증가계수를 산정할 수 있었다. The equations of motion for an automated guide-way transit(AGT) system running on a path with roughness have been derived to investigate dynamic responses and wheel loads of moving vehicles of the AGT system. A vehicle of the AGT system is idealized as three-dimensional model with 11 degree-of-freedom, and a bridge is modelized with three F.E. method. The computer program is developed to solve the dynamic equations, and analytical results are verified by comparing the results with experimental ones. As a result, the computer program which developed in this study can be used for estimate the dynamic responses of bridge and vehicle due to dynamic interaction of bridge, vehicle and surface roughness, and with these results the dynamic increment factor of bridge can be obtained.

응급실의 약물중독 환자

송근정,조광현,이한식 大韓應急醫學會 1992 대한응급의학회지 Vol.3 No.1

Any short of medical drug, insecticide or foods sometimes makes harmful situation whether it is beneficial or not. Nowadays, the treatment for drug intoxication started mostly in emergency department. The initial treatment must start as soon as possible. The prognosis is depend upon a kind of drug, exposure time and time of initial treatment. Authors conducted a review of acute poisoned patients seen from April 1983 to July 1992, who visited emergency department of Yong Dong Severance Hospital. The results were as follows, 1. The patients of Drug intoxication account for 0.68% of total emergency department patients. 2. Male to female ratio was 1:1.9 and the age distribution revealed a high incidence in second decade(35.7%) 3. From all the cases of drug intoxication and 67.2% was done on purpose. 4. The drug used were sedatives, CO intoxication, pharmaceuticals, pesticide, in order. 5. Admission rate was 23.8% and mean hospital day 6.0 days. 6. ICU admission rate was 30.0% and mean staying time was 4.7 days.

안면부, 유방 및 상완부에 발생한 홍반성 루푸스 지방층염 1예

송유근,손두식,명형준,이현정,임중규,김순호,김윤아 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.2

Lupus erythematous panniculitis is a chronic inflammatory disease of subcutaneous fat that occurs in 2-3% of patients with systemic lupus erythematosus. Lupus erythematous panniculitis typically presents with firm, indurated subcutaneous nodules or plaques commonly developed in proximal extremities, trunks, head and neck. Face, breast and upper extremities involvement with lupus erythematous panniculitis has been infrequently reported. We report a case of lupus erythematous panniculitis developed in a 27-year-old female confirmed by histologic features and laboratory findings.

PSC 교량의 보강공법에 대한 실험적 연구

김현호,김기봉,정인근,송재필 中央大學校 建設環境硏究所 2002 環境科學硏究 Vol.13 No.2

많은 수의 국도상의 교량이 교통량 증가 및 차량의 대형화에 따라 내하력 증가의 필요성이 시급히 제기되고 있다. 본 연구에서는 국도상 교량 중 대다수를 차지하고 있는 프리스트레스트 콘크리트(Prestressed Concrete, PSC) 교량에 대해 유리섬유 부착 공법과 외부 후긴장 보강 공법을 적용하여 내구성 및 내하력의 증가방안을 확인하고자 한다. 실험체는 표준도면의 1/5 축소모델로서 지간길이 6m이며 총 15개의 실험체를 제작하여 정적 및 피로실험을 수행하였다. 실험 결과, 유리섬유 및 외부 후긴장 보강 방법을 적용하였을 때 균열하중 및 파괴하중의 크기가 증가되었고, 처짐의 감소효과와 균열에 대한 억제 능력이 증가하였다. 그리고 보강 실험체가 피로파괴 반복회수도 증가하며 유리섬유 보강 실험체의 경우 외부 후긴장 실험체보다 피로성능이 더 우수한 것으로 나타났다. 본 연구 결과를 통해 적용된 보강 기법이 노후된 PCS 교량의 성능증가와 수명 연장의 효과가 큰 것을 확인하였다. Most of the bridges on national road are needed capacity-enhancement, because of the increase of heavy traffic loads and aging of bridges. Among those bridges, prestressed concrete(PSC) bridges take a large portion. But there are not many related researches about strengthening PSC bridges. In this study, the practicability of strengthening methods for PSC beam were studied by the static and fatigue experimental method. For the experiment, 1/5 scale and six meters long PSC beams were made with concrete slabs. Glass fiber sheeting and external post-tensioning methods were used for strengthening PSC beams. Total 15 beams were made for static test and fatigue test. As a result, the strengthening methods, which used in this study, are efficient at increasing cracking load and failure load, to decrease deflection and prevent cracks. The experimental results show that the failure cycle of strengthened members are increased compare to non-strengthened members. The members strengthened with glass fiber show better enhancement in fatigue problem than the members strengthened with external post-tensioning method. With these experimental results, it can be said that the strengthening methods used in this study are efficient at extending the life time of aged PSC bridges.

중독한 추체로 증상을 보인 cyclosporine에 의한 뇌증 1예

강정현,곽승근,신현영,김성은,이정호,이정찬,곽상혁,윤환중,조덕연,김삼용,김제,송창준 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.1

The use of cyclosporine(CsA), a potent immunosuppressive agent, is associated with numerous side effects. Neurotoxicity was earlier less well known, but with growing experience central nervous system side effects are now reported up to 40% of patients. Among various CsA-induced neurotoxicities, tremor is most common and posterior leukoencephalopathy is well characterized. An encephalopathy presenting with pyramidal weakness, however, seems to be rare and poorly documented. We report here a case of encephalopathy presenting with multiple generalized seizures followed by fluctuating quadriparesis developed a few days after starting CsA and resolved spontaneously after withdrawal of the drug . A 48-year-old woman with aplastic anemia was placed upon immmunosuppressive treatment consisting of antithymocyte globulin(ATG), CsA, and methylprednisolone. Two days after starting the therapy, she developed a generalized seizure. The next day she developed 2 more episodes of seizure and the therapy was stopped. Computed tomogram of the brain was normal. Six days after starting therapy, she developed mild motor weakness and paresthesia of both lower extremities, which progressed to a definite quariparesis confining her to a bed in 3 days. Magnetic resonance imaging(MRI) of the brain revealed asymmetric, bilateral high-signal abnormalites in the subcortical white matter of fronto-temporal areas. After reaching to a maximum with some fluactuation(14 days after starting the therapy) the motor weakness started to be resolved. She was discharged with a almost complete resolution of the weakness 45 days after starting the therapy. Five months later she did well and brain MRI was negative.