老齡者의 建康을 위한 生活習慣 實態調査

申東敏,長鳳愚,李揆文,金賢俊,金昌範,崔宗洙,崔鍾晥,李鍾珏,金圭碩,趙庚旭,金鍾聲,朴鍾振 平生體育硏究所 論文集 1987 平生體育硏究所 論文集 Vol.2 No.-

With a view to examining the habit and method in which old people maintain and improve their health, we consulted 551 men and 444 women who were over 65 years old, and concluded as follows: 1. Habit of eating It's been revealed that most of the old people keep a regular eating hour, control the quantity of meal or eat a little food, and prefer vegetables to meat. 2. Mental health Old people feel the necessity for mental health and most of them (about 80%) keep good mental health without becoming pessimistic. Their chief concenrs have turned out to be about their sons and daughters and their own health and finance. 3. Managing Good Health It has been revelaed that old people do not possess any special kind of secret to keep good health but taking plenty of rest, regular meal, and proper exercise, and many of them (about 60%) have been shown to eat invigorant food that they can easily get around their living area. 4. Physical Functions It has been revealed that many old people are conscious of some symptoms about their parts of body and about to percent of them suffers from neuralgia. Some measures like medical aid especially for old people need to be taken as soon as possible. As we have found that the health-keeping method of old people consists plenty of rest, proper exercise, and appropriate nutrition, we can conclude that the recreatonal and culture facilities and programs for keeping old people in good health should be developed. It is also necessary to study food that contribute to their health and develop ways to get rid of the stresses to which they are exposed in their daily life. Presides, it is natural that government found an administrative department to deal with these matters effectively.

노인의 영적 간호요구

최미혜,김경희,김귀옥,김기숙,김수강,김정신,김춘숙,노흥진,박지연,성혜연,오명선,이선희,이원옥,이윤영,이현수,장명재,차혜경,채정선,홍상희 중앙대학교 의과대학 간호학과 간호과학연구소 2001 중앙간호논문집 Vol.5 No.1

This study was designed to exam the aged's needs for spiritual nursing care. The purpose was to serve as a basis for the development of spiritual nursing practice. The major findings are as follows : 1. The degree of needs for spiritual nursing care as area was that needs of love and relationship mean 22.0, needs of meaning and object mean 28.2, needs of forgiving mean 13.5. Total needs for spiritual nursing care mean 63.7, which was on the upper middle level. The needs of meaning and object was rated highest. 2. Among the general characteristics of the subjects, needs of love and relatiohship wasn't significanlty different. 3. Among the general characteristics of the subjects, needs of meaning and object was significantly different according to two factors : age(F=7.260, p=0.001), religion(F=5.275, p=0.001). Higher needs of meaning and object was possessed by the older than the younger, by the one who have religion than the other. 4. Among the general characteristics of the subjects, four factors made a significantly difference to needs of forgiving : sex(t=-2.851, p=0.006), age(F=8.201, p=0.001), religion(F=6.928, p=0.000), disease(t=2.327, p=0.024). Higher needs of forgiving was possessed by man than woman, by the older than the younger, by the one who have religion than the other, by the one who have disease than the other.

稻熱病 抵抗性에 關한 硏究

金明運,盧愼圭,白壽鳳,李成泰,任文淳,朴澤奎,李麗夏 건국대학교 1974 學術誌 Vol.17 No.1

This study was made to investigate the degree of rice blast disease developing in various plants and also the relationship between the disease developing and the amount of content of nutrients in rice plants which were differently dressed. Possibility for culture of rice-blast race was studied and the structure of infected leaves were observed by electron microscope. 1) The varieties sampled, Pung-kwang, Jin-heung, Pal-tal, Pung-ok and Tong-il, were seeded and cultivated in pots. When fifth or sixth leaf emerged, the races of blast T,C,N were innoculated in all varieties. In dressing test Pung-ok, which leas susceptible to blast, was dressed with nitrogen fertilizer in ordinary and twofold and in none-dressing or dressing of silicon fertilizer. When the fifth or sixth leaf was appeared, races T, C, N was innoculated in each varieties of pot. In all experiment the degree of infection was checked out according to the order of leaf, and at the same time, the relationship between the degree of disease developing and the contents of nutrients by determining the total nitrogen, total sugar, phosphoric acid, kalium, silicon dioxide soluble nitrogen and soluble sugar was studied. The occurance of symptom was relatively frequent in upper primary or secondary leaf in all varieties regardless of the kind of fertilizers or their dressing amount. Comparing the occurrencies of disease development in examined varieties, Jin heung was lowest and Pung-ok was highest, while Tong-il was completely free from the infection of the disease. The race T-type attacked most seriously the varieties of Jin-heung, Pal-Tal and Pung-kwang except Pung-ok, C-type was moderate and N-type was very weak in Pung-ok. In the amount of dressing, the occurance of disease was very rare in the rice plant of N-ordinary-silicon fertilizer dressed and frequent in that of nitrogen fertilizer-twofold-and-silicon fertilizer none dressed. The disease developing differed with the races, indicating T-type was most poweful, C-type moderate while N-type was weak. In the interaction between the contents of nutrients in riceplant and the degree of disease developing, Pung-ok, which was very abundant in nitrogen, phosporic acid, glutamic acid, asp artic acid glutamine, asparagine, cystine, serine and sucrose but little in sugar, kalium and silicondioxide, was most susceptible to the disease. Jin-heung, resistant one, was opposite to Pung-ok in all aspects. As a result there was a correlation between the kind or amount of nutrients in rice plant and the disease attack. According to the amount of dressed fertilizer, the rice plant dressed in N-twofold and silicon dioxide none dressed had the larger amounts of total nitrogen, phosphoric acid, aspartic acid, glutamic acid and gldtamine but little in sugar and silicon dioxide contents. While in the rice plant dressed with N-ordinary and silicon fertilizer. the tendancy of disease occuring was low respectively. 2) The study on the cultivation of race T,C,N in the media added such organic acid as succinic acid, valeric acid, malic acid, ketoglutaric acid and such phenolic chlorogenic acid and salicylic acid was made. The result of which was as follow: ① There were no differences in growth of T,C,N type races. ② In the media added organic acid the growth was favorable. ③ In the media added chlorogenic acid the growth was promoted but in the one added salicylic acid the growth was inhibited. 3) The morphological changes of the infected waves alls the structure of hypha of blast which had penetrated into the leaf cell of Pung-ok, which was susceptible one to the disease, was observed by electric microscope. The following facts were found. ① In healthy leaves normal nucleus, mitohcondria, chloroplast, entoplasmic reticulum, vacuole and cytoplasm, especially round substances, were chearly observed by electron microspcope. ② In the infected leaves, the space of the nucleus double memberance was enlarged, and some of the nucleu walls were destroyed. The thinlayer structure of glanalamelae in lamela system was enlarged, somewhere spates were appeared while stromas were disappeared. In mitochondria the spaces of the double membrance were enlarged. ③ Cytoplasm of cell which were attacked by hypha was completely destroyed and the hypha lost their normal structure. ④ In the structure of hypha which penetrated into the cell wall of epidermis, nucleus, mitochondria, round ectoplasmic reticulum, vacuole and substances were clearly observed.

Berberine 骨格變換에 關한 合成硏究

金申圭,盧榮洙 慶熙大學校 1983 論文集 Vol.12 No.-

Reaction of Berberine hydrochloride with CH_3MgBr afforded the 5,6-dihydro-8-methyk-9, 10-diet-hyxybenzo[g]-1,3-benzodioxalo[5, 6-a]-quinolizium [Ⅰ]good yield. Oxidation of the [Ⅰ]with m-chloroperbenzoic acid in CH_2 Cl_2 in a stream of N_2 at -20°∼-30° gave the 8-methyl phenol betaine [ⅱ]. And treatment of[Ⅱ]with dimethyl acetylent-dicarbamate in terahydrofurance[THF] under reflux for 6 hr. afforded the cycloadduct[Ⅲ]. Heating of[Ⅲ]in ethanol effected smooth isomerization leaching to the azocine [Ⅳ].

흰쥐 선조체에서 6-OHDA-유도 도파민 고갈 및 SH-SY5Y 세포주에서 6-OHDA-유도 산화적 스트레스에 대한 I-Deprenyl의 신경 보호효과

김은미,최신규,이경림,김화정 이화여자대학교 약학연구소 2005 藥學硏究論文集 Vol.- No.15

A neurotoxin, 6-hydroxydopamine (6-OHDA) has long been used to form a Parkinson's disease (PD) model by inducing the lesion in catecholaminergic pathways, particularly the nigrostriatal dopamine (DA) pathway. Whereas I-deprenyl, a selective inhibitor of monoamine exidase (MAO) type B, is now widely used in the treatment of PD, the precise action mechanism of the drug remains elusive. In this studym, we investigated whether I-deprenyl shows protective effect against the DA depletion induced by 6-OHDA in rat brain, and against 6-OHDA-induced neurotoxicity and oxidative stress in catecholaminergic neuroblastoma SH-SY5Y cells that are known to lack MAO-B activity. Pretreatment fo I-deprenyl significantly enhanced the striatal DA, 3,4-dihydroxyphenylacetic acid, homovanilic acid, and 3-methoxytyramine levels compared to the untreated 6-OHDA-lesioned rat, indicating that I-deprenyl pretreatment prevents 6-OHDA-induced depletion of not only striatal dopamine but also its metabolites. Treatment of 6-OHDA for 24 hrs decreased the cell viability and increase the generation of ROS in dose-dependent manners.We further investigated whether caspase activity is involved in the action of I-deprenyl. Treatment of I-deprenyl (0.1~100μM) did not produce any changes in 6-OHDA-induced cleavage of poly (ACP-ridose) polymerase in SH-SY5Y cells. Our result suggest that the neuroprotective effect of I-deprenyl against 6-OHDA is due to its incresed scavenger activity, but independent of inhibition of MAO-B or caspase-3activation.

Benzo[a]-quinolizine 합성

김신규,김남재,황순호,이마세 한국분자생물학회 1994 분자생물학뉴스 Vol.22 No.-

Berberine 骨格變換에 關한 硏究 [第Ⅱ報]

金申圭 慶熙大學校 1984 論文集 Vol.13 No.-

Irradiation (100W high pressure Hg Lamp, with Pyrex filter) of 8-methyl berberinephenol betaine in MeOH in a stream of N_2 for 30 mi, at room temperature effected valence tautomeriza-tion leading to the 8-methyl spirobenzyl isoquinoline (Ⅰ). Acidic treatment of (Ⅰ) with aniline in absoluted tetrahydrofuran under reflux for 8 hr. afforeded the 8-methyl-8-phenylamino-9, 10-dimethoxy-2-methylene-1, 3-dioxy berbine-13-one(Ⅱ). Reduction of (Ⅱ) with Sodium boro hydride in CH_2Cl_2 to gave the 8-methyl-8-phenyl amino-13-hydroxy-9, 10-dimethoxy-2-methylene-1, 3-dioxy berbine(Ⅲ), and treatmet of (Ⅰ) win Boron trifluoride ethyl ether in acetone under reflnx for 3 hr. afforeded the 8-methyl-8-hydroxy-9, 10-dimethoxy-2-methylene-1, 3-dioxy berbine-13-one(Ⅳ).

違法性의 槪念에 관한 一考察

김신규 대구대학교 법정연구소 1986 法政論叢 Vol.1 No.-

Rechtswidrigkeit bedeuted "Widerspruch gegen das Recht." Das Wesen der Rechtswidrigkeit ist demgemäβ darin zu erblicken, daβ ein Verhalten gegen eine in einer Rechtsnorm aufgestellte Handlungs oder Unterlassungspflicht verstöβt. Mann nennt diese Seite die formelle Rechtswidrigkeit, weil dabei allein der Widerspruch der Handlung zum Normbefehl im Betracht gezogen wird. Die Rechtswidrigkeit erschöpft sich aber nicht in dem Verhältnis von Handlungs und Norm, sondern Sie hat auch inhaltliche Bedeutung materielle Rechtswidrigkeit. Die Auffassung vom Wesen der Rechtswidrigkeit wird enscheidend von der Stellungnahme zu der Frage bestimmt, ob die Rechtssätze Bewertungs oder Bestimmungsnormen der beides sind. Die klassische Dogmatik legte ihren Verbrechensbegriff die Unterscheidung zwischen rein objektiv verstandenem Unrecht und rein subjektiv verstandener Schuld zugrunde. Daraus ergibe sich für die heutige Dogmatik die sinnreiche Unterscheidung von Erfolgs und Handlungsunwert im Unrecht. Die Reihenfolge dieser Abhandlung ist: (1) Einleitung (2) Die Unterscheidung zwischen dem Unrecht und der Rechtswidrigkeit (3) Formelle und materielle Rechtswidrigkeit (4) Subjektive und objektive Rechtswidrigkeit (5) Erfolgsunwert und Handlungsunwert (6) Die Aufgabe und die Perspektive der modernen Rechtswidrigkeitstheorie.

Sodium nitrite와 L-histidine과의 反應 및 反應生成物의 突然變異原性에 關한 硏究

鄭圭燦,金榮信 嶺南大學校 環境問題硏究所 1983 環境硏究 Vol.3 No.1

The reactivity between sodium nitrite and L-histidine in acidic conditions and the mutagenicity of the reaction product were experimented. 1) N-nitroso compound was easily formed by reaction of L-histidine with sodium nitrite in acidc conditions at 36.5℃. 2) L-histidine was changed to N-nitroso compound in a short time (10 min.). The formation of N-nitroso compound increased with increasing the acidity of reaction soln. from pH 10 to pH 1, was proportional to the concentration of sodium nitrite and L-histidine. 3) Sodim citrate, sodium tartrate accelerated the formation of N-nitroso compound, while sodium thiocyanate, sodium chloride and ascorbic acid inhibited the formation of N-nitroso compound, respectively. 4) "Rec-assay" showed that reaction product had DNA damaging effect on Bacillus subtilis. 5) Ames' test using Salmonella typhimurium TA series showed that reaction product was a frame-shift type mutagen.

구강 편평상피세포암 환자에서 치료전 혈청 CEA와 SCCA의 측정

장신남,김상규,김진수,변기정 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.3

본 연구에서는 구강 편평상피세포암에서의 종양표지자의유용성을 평가하기위해 21명의 구강 편평상퍼세포암 환자들과 대조군인 22명의 양성질환자들에서 방사면역검사를 통해 치료전 혈청 CEA와 SCCA를 측정한 결과 다음과 같은 결론을 얻었다. 1. 양성질환자들의 혈청 CEA 평균치는 2.25±1.39ng/ml (최소 0.4 ng/ml), 최대 5.6 ng/ml)인 반면, 구강 편평상피세포암 환자들에서는 2.77±2.03 ng/ml (최소 0.3 ng/ml, 최대 6.7 ng/ml)로 두 군 사이에 통계적으로 유의한 차이를 나타내지 않았다(P= 0.3380) 2. 구강 편평상피세포암 환자들의 혈청 CEA의 양성률은 19.05%로 대조군인 양성질환자들의 양성률 4.55%와 통계적으로 유의한 차이를 보이지 않았다(P= 0.1853). 3. 양성질환자들의 혈청 SCCA 평균치는 1.21±1.74 ng/ml (최소 0.1 ng/ml, 최대 6.9 ng/ml)인 반면, 구강 편평상피세포암 환자들에서는 2.11±1.78 ng/ml (최소 0.1 ng/ml, 최대 6.1 ng/ml)로 두 군 사이에 통계적으로 유의한 차이를 나타내지 않았다(P= 0.1011) 4. 구강 편평상피세포암 환자들의 혈청 SCCA의 양성률은 47.62%로 대조군인 양성질환자들의 양성률 13.64%와 통계적으로 유의 한 차이를 나타내었다(P= 0.0153). 5. CEA와 SCCA 둘 중 하나라도 양성인 경우를 포함하는 조합 검사에서 민감도는 52.38%로 CEA의 민감도19.05% 보다는 크게 증가하였으나 SCCA의 민감도47.62%와 비교해서는 약간의 증가를 나타내었고, 특이도는 감소하였다 The study evaluated the usefulness of tumor markers in the diagnosis of oral sequamous cell carcinoma. Serum levels of two tumor markers(carcinoembryonic antigen〔CEA〕and squamous cell carcinoma antigen〔SCCA〕)were simultaneously measured by radiommunoassay in 21 patients with oral sequamous cell carcinoma and in 22 patients with oral benign diseases. The positive rates were 19.05% for CEA and 47.62% for SCCA in patients with oral sequamous cell carcinoma. The sensitivity of the combination assay(52.38%) was higher than that obstained with individual markers, but specificity was low in combination assay. Serum CEA seema to be inadequate for diagnostic purpose, but serum SCCA may be useful for diagnostic purpose in patients with oral sequamous cell carcinoma. A combination assay may be useful in the diagnosis of oral sequamous cell carcinoma.