부인두강에 발생한 혈관섬유종 1예

노영수,박일석,김정현,김성동 대한이비인후과학회 2002 대한이비인후과학회지 두경부외과학 Vol.45 No.11

Angiofibromas are rare histologicaly benign tumors that predominantly affect adolescent males and acount for approximately 0.5% of all neoplasms of the head and neck. Although angiofibromas are histologically benign, but locally invasive. These fosa, intracranium, and neck. The morbidity and mortality associated with these tumors are related to its prominent vascularity and its propensity for aggresive local growth. Pre-operative embolization is useful for reducing intraoperative blood loss and the risk of incomplete excision of the tumor. These tumors virtually arise from the nasopharynx in the region of the sphenopa-latine foramen and pterygopalatine fosa. We present a unique case of an angiofibroma limited to the left parapharyngeal space, after pre-operative embolization. (Korean J Otolaryngol 202 ;45 :1105-9)

인중백의 진통 · 진정 및 혈압강하작용에 관한 연구

노영수(Young Soo Rho),홍남두(Nam Doo Hong),조영환(Young Whan Cho) 한국생약학회 1985 생약학회지 Vol.16 No.2

These studies were conducted to investigate the effect of Inchungbaek water extract on analgesic and sedative actions, the relaxing action of isolated ileums, vasodilating action and blood pressure. The results of these studies were summarized as follows: Analgesic and sedative actions of Inchungbaek were recognized in mice and rats. The relaxing action of isolated ileums were seen in mice and rabbits, antagonist action was seen acetylcholine and BaCl₂-induced contraction of isolated ileums, and then recognized direct action in the ileum smooth muscle. Hypotensive and vasodilating actions due to vascular smooth muscle relaxation were noted in rabbits and cats.

Management of Cervical Metastasis and Locally Advanced Thyroid Cancer

노영수 대한두경부종양학회 2004 대한두경부종양학회 학술대회 논문집 Vol.2004 No.1

녹반의 항빈혈작유에 관한 연구

노영수(Young Soo Rho),홍남두(Nam Doo Hong),김신규(Shin Kyu Kim),조보선(Bo Sun Cho) 한국생약학회 1988 생약학회지 Vol.19 No.1

페놀수지 표면의 탄화도전로 생성과 분석

노영수(Young-Su Roh),박상택(Sang-Taek Park),김전원(Jun-Won Kim),송길목(Kil-Mok Shong) 대한전기학회 2007 대한전기학회 학술대회 논문집 Vol.2007 No.11

Recently, the dependence of the electric energy is increased in accordance with a growth of industry. Therefore, scientific investigation is needed for the security of electrical safety and the judgement of accident causes. Accordingly, this paper consist of the analysis for the carbonization patterns of phenolic resin and the mechanism. As the follows, spider-legs as a carbide are generated around the rods, when the electric current flows on the surface of phenolic resin. The IR absorption peak generated by the thermal effects is appeared at about 1720㎝?¹. As the case of Joule's heat, the crystal of a carbide is generated because of the rarefied oxygen. It's estimated that the formation of carbonization conductivity as the currents are easily flowed.

안면신경 침범시의 수술적 처치

노영수(Young Soo Rho) 대한두경부종양학회 2008 대한두경부 종양학회지 Vol.24 No.1

The most important concern to do parotidectomy is correct identification of the facial nerve and preservation of the nerve function. Many descriptions for the localization and branching types of the facial nerve trunk have existed. During the parotid surgery, it is necessary to have knowledges about the incidence and prognostic aspect of a invasion of the facial nerve by the parotid tumors. The method of the dissection and the surgical extent of the parotid gland would be decided not only by the anatomic variation of the facial nerve. but also the size and location of the tumor. Invasion of the facial nerve in parotid malignancies is the most significant factors affecting the prognosis, so radical parotidectomy which consists of the total extirpation of the parotid gland in conjunction with resection of the facial nerve is often required for proper management. Radical parotidectomy is advocated for the surgical treat-ment of high grade malignancies and in selective recurrent benign tumors intimately involving the facial nerve. Unfortunately, the morphologic and functional deficits created by sacrificing the facial nerve can be emotionally and physically traumatizing to the patient. Therefore, when the facial nerve is sacrificed, immediate reconstruction of the facial nerve should be necessary. Immediate nerve repair with direct anastomosis of the resected nerve ends or placement of a cable nerve graft provides the better cosmetic and functional results. Surgical resection remains the mainstay of treatment for cancer of the parotid gland, and there is general agree-ment that facial nerve should not be sacrificed unless the tumor is adherent to, or surrounds the nerve. The following statement is described general principles of troublesome management of the facial nerve during surgery for parotid tumor.

Surgical Role of Nasopharyngeal Cancer

노영수 대한두경부종양학회 2006 대한두경부종양학회 학술대회 논문집 Vol.2006 No.2

Surgical Dilemma of Facial Nerve Invasion

노영수 대한두경부종양학회 2007 대한두경부종양학회 학술대회 논문집 Vol.2007 No.2

1,3-비스페닐치오 프로판을 배위자로 한 백금 (II)착체의 선택적 세포독성

노영수,윤기주,이경태,장성구,정지창 대한약학회 1999 약학회지 Vol.43 No.3

A new series of highly water soluble platinum(II) complexes {Pt(II)[1,3-bis(phenylthio) propane](trans- -1,2-diaminocyclohexane) (PC-1) and Pt(II)[1,3-bis-(phenythio)propane] cis-1,2-diaminocyclohexane(PC-2)} were synthesized, and characterized by their elemental analysis and by various spectroscopic techniques[infrared(IR), 13C-nuclear magnetic resonance (NMR)]. In vitro antitumor activity of new Pt(II) complexes was tested against P-388 and L-1210 mouse lymphocytic leukemia cell lines, PC-14 / P, PC-14/ADM and PC-14 / CDDP human pulmonary adenocarcinima, DU-145 human prostate carcinoma, HT-1376 human bladder carcinoma, ZR-75-1 human breast carcinoma, MKN-45/P and MKN-45/CDDP human gastric adenocarcinoma cell lines using colorimetric MTT[3-(4,5-dimethyl thiazol-2-yl)-2.5-diphenyltetrazoliumbromide] assay for cell survival and proliferation. PC-1 showed active against L-1210, P-388 leukemia, human lung, stomach, prostate, bladder and breast cancer cell lines, and the antitumor activity of these compounds were comparable or superior to those of PC-2 and displatin. The nephrotoxicities of PC-1 and PC-2 were found quite less than that of cisplatin using MTT and [3H] thymidine uptake in rabbit proximal tubule cells and human kidney cortical cells. Based on these results, this novel platinum (II) complex compound (PC-1) represents a valuable lead in the development of a new anticancer chemotherapeutic agent capable of improving antitumor activity and low nephrotoxicity.

경부식도암

노영수,김진환 대한기관식도과학회 2003 大韓氣管食道科學會誌 Vol.9 No.1

Cancers of the cervical esophagus occur uncommonly, but treatment is remaining a challenging problem and surgery demands special knowledge of abdominal, thoracic, and neck surgery. The primary risk factor is chronic heartburn, leading to a sequence of esophagitis, Barrett's esophagus, reflux esophagitis and etc. Among the various treatment modalities, Surgery is still a mainstay of treatment. The main aim of surgery is not only oncologically adequate resection but also preservation or restoration of physiologic functions, such as deglutition and phonation. Surgical treatment of cervical esophageal cancer is influenced by special problems arising from tumor factors, patient factors and surgeon factors. Complete clearance of loco-regional disease and prevention of postoperative complications are of particular importance for the improvement of long-term survival in patients with these cancers. So the cervical and thoracic extension of these tumors usually required an extensive lymphadenectomy with primary resection. Radical resection of the primary site almostly include sacrifice of the larynx, but the voice could be rehabilitated with various methods, such as tracheoesophageal prosthesis or tracheoesophageal shunts, etc. Restoration of the esophageal conduit can be performed using gastric or colon interposition, radial forearm free flap or jejunum free flap, etc. Recently, the advances of radiation therapy and chemotherapy will enable less extended resections with greater rates of laryngeal preservation. At initial presentation, up to 50% to 70% of patients will have advanced locoregional or distant disease with virtually no chance for cure. Patients with advanced but potentially resectable esophageal cancer are generally treated by surgery with some form of neoadjuvant chemotherapy, radiotherapy, or both, with 5-year survivals in the 20% to 30% range. So the significant adverse factors affecting survival should be taken into account to select the candidates for surgery.