Embedded TCP/IP Achievements on the basis of S3C44B0X Microprocessor

Dongjie Wang,Shusen Tang,Qing Jiang 한국멀티미디어학회 2006 한국멀티미디어학회 국제학술대회 Vol.2006 No.-

TCP/IP is an essential communication protocol existing in the present Internet communication. More and more embedded products are required to hold capability accessing to the Internet. This paper mainly introduces how it achieves the interconnection between embedded system and Internet through predigesting the communication protocol, and finally puts forward that it realizes an entire embedded TCP/IP stack on the basis of S3C44BOX & uC/OS operating system.

Dexamethasone enhances glucose uptake by SGLT1 and GLUT1 and boosts ATP generation through the PPP-TCA cycle in bovine neutrophils

Xinbo Wang,Mingyu Tang,Yuming Zhang,Yansong Li,Jingdong Mao,Qinghua Deng,Shusen Li,Zhenwei Jia,Liyin Du 대한수의학회 2022 Journal of Veterinary Science Vol.23 No.5

Background: Clinical dexamethasone (DEX) treatment or stress in bovines results in extensive physiological changes with prominent hyperglycemia and neutrophils dysfunction. Objectives: To elucidate the effects of DEX treatment in vivo on cellular energy status and the underlying mechanism in circulating neutrophils. Methods: We selected eight-month-old male bovines and injected DEX for 3 consecutive days (1 time/d). The levels of glucose, total protein (TP), total cholesterol (TC), and the proinflammatory cytokines interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α in blood were examined, and we then detected glycogen and adenosine triphosphate (ATP) content, phosphofructosekinase-1 (PFK1) and glucose-6-phosphate dehydrogenase (G6PDH) activity, glucose transporter (GLUT)1, GLUT4, sodium/glucose cotransporter (SGLT)1 and citrate synthase (CS) protein expression and autophagy levels in circulating neutrophils. Results: DEX injection markedly increased blood glucose, TP and TC levels, the Ca2+/P5+ ratio and the neutrophil/lymphocyte ratio and significantly decreased blood IL-1β, IL-6 and TNF-α levels. Particularly in neutrophils, DEX injection inhibited p65-NFκB activation and elevated glycogen and ATP contents and SGLT1, GLUT1 and GR expression while inhibiting PFK1 activity, enhancing G6PDH activity and CS expression and lowering cell autophagy levels. Conclusions: DEX induced neutrophils glucose uptake by enhancing SGLT1 and GLUT1 expression and the transformation of energy metabolism from glycolysis to pentose phosphate pathway (PPP)-tricarboxylic acid (TCA) cycle. This finding gives us a new perspective on deeper understanding of clinical anti-inflammatory effects of DEX on bovine.

Adaptive robust control for fully electric pitch system of tank with dynamic friction compensation

Darui Lin,Xiuye Wang,Guolai Yang,Shusen Yuan,Qinqin Sun 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.10

This article addresses a problem of dynamic friction compensation for fully electric pitch system of tank based on modified LuGre model. Aiming to design a controller to realize friction modeling and compensating of fully electric pitch system of tank in large range of motion speeds. First, a nonlinear mathematical model including modified friction model and time-varying disturbance is established for fully electric pitch system of tank. Second, a disturbance compensation robust feedback term is designed to compensate the time-varying disturbance to reduce the impact of the disturbance on the control performance by adaptive estimation of the upper bound of the unmodeled disturbance. Third, the uncertainty parameters and friction state of the system are estimated and the adaptive control law combined with friction compensation is designed to reduce the sensitivity of the system to parameter uncertainty and nonlinear friction. Fourth, the global stability of the system is proved by Lyapunov stability theory. Finally, a virtual prototype model of tank moving based on friction disturbance and road excitation is established. The co-simulation results show that the proposed method can accurately estimate and compensate model parameters, nonlinear friction states and disturbances, and has the advantages of high control precision, good stability and strong robustness.

Efficacy and Safety of a Steroid-Free Immunosuppressive Regimen after Liver Transplantation for Hepatocellular Carcinoma

Qiang Wei,Xiao Xu,Chao Wang,Runzhou Zhuang,Li Zhuang,Lin Zhou,Haiyang Xie,Jian Wu,Min Zhang,Yan Shen,Weilin Wang,Shusen Zheng 거트앤리버 소화기연관학회협의회 2016 Gut and Liver Vol.10 No.4

Background/Aims: We aimed to evaluate the efficacy and safety of an immunosuppressive regimen without steroids after liver transplantation (LT) for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Methods: Sixty-six HCC patients who underwent an immunosuppressive regimen without steroids after LT were enrolled in the steroid-free group. The preoperative characteristics and postoperative outcomes of these patients were compared with those of 132 HCC recipients who were placed on an immunosuppressive regimen using steroids (steroid group). The incidence of acute rejection, HBV recurrence, infection, and new-onset diabetes mellitus and the overall and tumor-free survival rates were compared between the two groups. Results: Differences were not observed in the 1-year (83.3% vs 97.0%, p=0.067), 3-year (65.4% vs 75.8%, p=0.067) or 5-year (56.3% vs 70.7%, p=0.067) patient survival rates or in the 1-year (62.1% vs 72.7%, p=0.067), 3-year (49.8% vs 63.6%, p=0.067) or 5-year (48.6% vs 63.6%, p=0.067) tumor-free survival rates between the two groups, respectively. In the steroid-free group, the patients who fulfilled the Milan criteria had higher overall and tumor-free survival rates than those in the steroid group (p<0.001). The prevalence of HBV recurrence (3.0% vs 13.6%, p=0.02) was significantly lower in the steroid-free group compared with the steroid group. Conclusions: After LT, an immunosuppressive regimen without steroids could be a safe and feasible treatment for HBVrelated HCC patients, thus resulting in the reduction of HBV recurrence. Based on the observed survival rates, patients who fulfill the Milan criteria may derive benefits from steroidfree immunosuppression.

Ultrasonic Vibration and Rheocasting for Refinement of Mg–Zn–Y Alloy Reinforced with LPSO Structure

Shulin Lü,Xiong Yang,Liangyan Hao,Shusen Wu,Xiaogang Fang,Jing Wang 대한금속·재료학회 2018 METALS AND MATERIALS International Vol.24 No.6

In this work, ultrasonic vibration (UV) and rheo-squeeze casting was first applied on the Mg alloy reinforced with long periodstacking ordered (LPSO) structure. The semisolid slurry of Mg–Zn–Y alloy was prepared by UV and processed by rheosqueezecasting in succession. The effects of UV, Zr addition and squeeze pressure on microstructure of semisolid Mg–Zn–Yalloy were studied. The results revealed that the synergic effect of UV and Zr addition generated a finer microstructure thaneither one alone when preparing the slurries. Rheo-squeeze casting could significantly refine the LPSO structure and α-Mgmatrix in Mg96.9Zn1Y2Zr0.1alloy without changing the phase compositions or the type of LPSO structure. When the squeezepressure increased from 0 to 400 MPa, the block LPSO structure was completely eliminated and the average thickness ofLPSO structure decreased from 9.8 to 4.3 μm. Under 400 MPa squeeze pressure, the tensile strength and elongation of therheocast Mg96.9Zn1Y2Zr0.1alloy reached the maximum values, which were 234 MPa and 17.6%, respectively, due to its fineα-Mg matrix (α1-Mg and α2-Mg grains) and LPSO structure.

Ultrasensitive SERS-Based Immunoassay of Tumor Marker in Serum Using Au-Ag Alloy Nanoparticals and Ag/AgBr Hybrid Nanostructure

Yongfeng Gao,Yuanhui Feng,Lu Zhou,Lucia Petti,Zhe Wang,Jun Zhou,Shusen Xie,Jian Chen,Yanping Qing 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.1

Ultrasensitive detection of alpha-fetoprotein (AFP) is critical for the early diagnosis of liver cancer. In this work, a novel surface-enhanced Raman scattering (SERS)-based immunoassay complex has been successfully developed for the detection of AFP by using the Au-Ag alloy nanoparticals and the Ag/AgBr hybrid nanostructure. As the typical bimetal or metal/semiconductor plasmonic materials, besides the strong SERS enhancement characteristics, the Au-Ag alloy nanoparticals exhibit excellent monodispersity and the Ag/AgBr hybrid nanostructure demonstrates good stability. The experimental results show that the SERS-based immunoassay of AFP presents a low limit of detection of 1.86 fg/mL and a broad dynamic range from 2 fg/mL to 0.8 g/mL. Furthermore, the clinical applicability of the proposed SERS-based immunoassay has been assessed by the detection of AFP in the human serum samples of cancer patient and healthy person. The test data are consistent well with that of chemiluminescence immunoassay (CLIA) in the relative errors of –8.82–8.06% and show better detection sensitivity. It reveals that the proposed immunoassay protocol is significant for giving insight into the design of ultrasensitive biosensor and the point-of-care testing of cancers.

Overexpression of CXCL2 inhibits cell proliferation and promotes apoptosis in hepatocellular carcinoma

( Jun Ding ),( Kangdi Xu ),( Jie Zhang ),( Bingyi Lin ),( Yubo Wang ),( Shengyong Yin ),( Haiyang Xie ),( Lin Zhou ),( Shusen Zheng ) 생화학분자생물학회(구 한국생화학분자생물학회) 2018 BMB Reports Vol.51 No.12

C-X-C motif chemokine ligand 2 (CXCL2) is a small secreted protein that exhibits a structure similar to the proangiogenic subgroup of the CXC chemokine family. Recently, accumulating evidence suggests that chemokines play a pivotal role in cancer progression and carcinogenesis. We examined the expression levels of 7 types of ELR+ CXCLs messenger RNA (mRNA) in 264 clinical samples. We found that CXCL2 expression was stably down-regulated in 94% of hepatocellular carcinoma (HCC) specimens compared with paired adjacent normal liver tissues and some HCC cell lines. Moreover, CXCL2 overexpression profoundly attenuated HCC cell proliferation and growth and induced apoptosis in vitro. In animal studies, we found that overexpressing CXCL2 by lentivirus also apparently inhibited the size and weight of subcutaneous tumours in nude mice. Furthermore, we demonstrated that CXCL2 induced HCC cell apoptosis via both nuclear and mitochondrial apoptosis pathways. Our results indicate that CXCL2 negatively regulates the cell cycle in HCC cells via the ERK1/2 signalling pathway. These results provide new insights into HCC and may ultimately lead to the discovery of innovative therapeutic approaches of HCC. [BMB Reports 2018; 51(12): 630-635]

Use of Ecosystem Flux Data and a Simulation Model to Examine Seasonal Drought Effects on a Subtropical Coniferous Forest

Na Mi,Guirui Yu,Wuefa Wen,Xiaomin Sun,Shusen Wang,Leiming Zhang,Xia Song 한국기상학회 2009 Asia-Pacific Journal of Atmospheric Sciences Vol.45 No.2

The Qianyanzhou (QYZ) forest site is located in the mid-subtropical region under typical subtropical continentalmonsoon climate. Despite its plentiful water and heat resources, changes in their seasonal distributions result in frequent occurrences of seasonal drought, influencing both the structure and function of forest ecosystems. In order to examine the effects of drought stress on energy and water fluxes and the related physiological processes, we used tower flux measurements from 2003 and 2004 from the QYZ site and the ecosystemmodel EALCO (Ecological Assimilation of Land and Climate Observations). The model explained almost 90%of the variance in the daily LE for both years; whereas 71%and 55% of the variance in H for 2003 and 2004, respectively. Simulations suggested that, during the 2003 summer drought, about 80% of water extraction by roots occurred below 0.45 m, and canopy stomatal conductance decreased in response to soil dryness at a threshold r (relative water content) of 0.5 m. The response of canopy stomatal conductance appeared to be linked to the soil water exposed to themajority of the roots, even if substantialwater was being extracted fromgreater depth. The decrease of canopy stomatal conductance made the ratio of transpiration to ET relatively constant along the years with only a small difference. The different extent of the seasonal drought resulted in different water fluxes for the two years with more distinct influence on evaporation than on transpiration.

Pyrotinib Combined with Vinorelbine in Patients with Previously Treated HER2-Positive Metastatic Breast Cancer: A Multicenter, Single-arm, Prospective Study

Kuikui Jiang,Ruoxi Hong,Wen Xia,Qianyi Lu,Liang Li,Jianhao Huang,Yanxia Shi,Zhongyu Yuan,Qiufan Zheng,Xin An,Cong Xue,Jiajia Huang,Xiwen Bi,Meiting Chen,Jingmin Zhang,Fei Xu,Shusen Wang 대한암학회 2024 Cancer Research and Treatment Vol.56 No.2

Purpose This study aims to evaluate the efficacy and safety of a new combination treatment of vinorelbine and pyrotinib in human epidermal growth factor receptor 2 (HER2)–positive metastatic breast cancer (MBC) and provide higher level evidence for clinical practice. Materials and Methods This was a prospective, single-arm, phase 2 trial conducted at three institutions in China. Patients with HER2-positive MBC, who had previously been treated with trastuzumab plus a taxane or trastuzumab plus pertuzumab combined with a chemotherapeutic agent, were enrolled between March 2020 and December 2021. All patients received pyrotinib 400 mg orally once daily plus vinorelbine 25 mg/m2 intravenously or 60-80 mg/m2 orally on day 1 and day 8 of 21-day cycle. The primary endpoint was progression-free survival (PFS), and the secondary endpoints included the objective response rate (ORR), disease control rate (DCR), overall survival, and safety. Results A total of 39 patients were enrolled. All patients had been pretreated with trastuzumab and 23.1% (n=9) of them had accepted trastuzumab plus pertuzumab. The median follow-up time was 16.3 months (95% confidence interval [CI], 5.3 to 27.2), and the median PFS was 6.4 months (95% CI, 4.0 to 8.8). The ORR was 43.6% (95% CI, 27.8% to 60.4%) and the DCR was 84.6% (95% CI, 69.5% to 94.1%). The median PFS of patients with versus without prior pertuzumab treatment was 4.6 and 8.3 months (p=0.017). The most common grade 3/4 adverse events were diarrhea (28.2%), neutrophil count decreased (15.4%), white blood cell count decreased (7.7%), vomiting (5.1%), and anemia (2.6%). Conclusion Pyrotinib plus vinorelbine showed promising efficacy and tolerable toxicity as second-line treatment in patients with HER2-positive MBC.