http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Shin Dong Guk (검색결과 154 건)
- 무료
- 기관 내 무료
- 유료
-
김국희,김봉석,신동범,정덕상,이선주 제주대학교 방사능이용연구소 2002 연구보고 Vol.16 No.-
Methanol extracts of 30 different plants collected in Jeju Island were tested for α-glucosidase inhibition. When the final concentration of extracts was 0.2㎎/㎖ for each sample, Ardisia japornica Blume. showed 91%, 92% and 87% of inhibition for maltase, sucrase, and nonspecific α-glucosidase activity, respectively. Potentilla chinensis inhibited maltase and sucrase activities for 90% and 82%, respectively. Euphorbia helioscopia exerted 90% and 88% inhibition for maltase and nonspecific α-glucosidase activity, respectively.
-
ECAP 강가공에 의한 5083 Al 합금의 초소성 변형
이정국,서창우,김병철,신동혁 漢陽大學校 工學技術硏究所 2000 工學技術論文集 Vol.9 No.1
초기 결정립 크기가 200 μm인 상업용 5083 Al 합금에서 equal channel anglar pressing(ECAP) 강가공에 의하여 결정립을 초미세화 시킬 수 있었다. ECAP는 200℃에서 수행되었고, 반복 passes시 180˚ 회전을 주면서 같은 시편에 8 passes까지 강가공을 가하였다. 미세조직 특징은 1 pass후 평균 0.2 μm의 폭과 0.8 μm의 길이를 갖는 연신된 평행한 bands가 균일하게 형성 되었고, 4 passes후 결정립 크기가 약 0.3 μm인 등축의 초미세 결정립이 얻어졌다. 이러한 초미세 결정립을 갖는 5083 Al 합금에서 저온 초소성 성질이 얻어졌는데, 약 0.5 μm의 결정립 크기를 갖을 때 250℃이하의 온도에서 연신율이 200 %이상인 초소성 거동을 나타내었다. An ultrafine grained structure was introduced into a commercial 5083 Al alloy with the initial grain size of ∼200 μm using the equal channel angular pressing technique. Equal channel angular pressing was successfully conducted at 200℃ and the results showed that the microstructure was reasonably homogeneous after single passage and consisted of parallel bands of elongated substructure having the average width of 0.2 μm and the average length of 0.8 μm. Repetitive passes were conducted on the same sample up to total 8 passes through the die so that the sample was rotated 180˚ around its longitudanal axis between passes. An equiaxed ultrafine grained structure of ∼0.3 μm was obtained in the present alloy after 8 passes. It was found that a 5083 Al alloy with the grain size of ∼ 0.3 μm exhibited a superplastic-like behavior with elongation to failure in excess of 200% below.
-
시상하부-뇌하수체 질환에서 종합적 뇌하수체전엽 기능검사의 진단적 의의
김수동,김신우,김정국,하승우,김보완 慶北大學校 醫科大學 1993 慶北醫大誌 Vol.34 No.4
시상하부-뇌하수체질환의 기저질환에 따른 종합적 뇌하수체전엽 자극검사의 진단적 가치를 알아보고자 81례의 뇌하수체 기능부전증환자를 대상으로 시상하부질환군과 Sheehan증후군, 말단비대증과 프로랙틴종, 그리고 뇌하수체선종에서 시야장애가 동반된 군과 장애가 없는 군으로 나누고 기능검사의 결과를 비교하였다. 1. Sheehan증후군 15례 가운데 GH 및 cortisol결핍이 전례(각각 100%)에서 FSH, LH 및 TSH결핍이 11∼12례(73∼80%)에서 관찰되었고 13례(86%)에서는 TRH에 대한 PRL분비증가가 저하 또는 소실되었다. 두개인두종 10례를 포함한 시상하부질환 14례 가운데 12례(86%)는 PRL의 기저지가 비정상직으로 증가되어 있었으며 TRH자극에 대해 PRL분비 증가가 11례(79%)에서 둔화되어 있었다. GH분비능도 11례(79%)에서 저하되었으며 그 밖의 cortisol, LH, TSH, FSH의 순으로 분비능이 저하되어 있었으나 그 빈도는 Sheehan증후군에 비해 전반적으로 낮았다. 2. 말단비대증 18례 가운데 14례(78%)에서 GH기저치가 비정상적으로 증가되어 있었고 13례(72%)는 저혈당자극에 대해 정상적인 GH의 증가를 보였으며 8례(44%)에서 고프로랙틴 혈증이 동반되었다. 프로랙틴종 18례 가운데 전례(100%)에서 PRL기저치가 증가되었고 13례(72%)에서 TRH에 대한 PRL의 증가반응이 둔화되었다. LH, FSH, cortisol 및 TSH분비능의 장애는 말단비대증군에서 프로랙틴종에 비해 다소 높은 빈도를 보이는 경향이었다. 3. 뇌하수체선종 가운데 시야장애가 동반된 21례에서 시야장애가 없는 23례에 비해 GH, cortisol및 LH의 분비반응이 저하된 빈도가 다소 높은 경향이었다. 이상의 결과로 보아 종합적 뇌하수체전엽 기능검사는 시상하부-뇌하수체질환의 기저질환을 진단하는데 중요한 정보를 제공할 수 있다고 생각한다. The combined stimulation test using TRH, LHRH and insulin has allowed investigation of the reserve of all pituitary tropic hormones under physiological and pathological conditions. To evaluate the diagnostic efficacy of this test for differentiating the underlying causes of hypopituitarism, we analyzed retrospectively the results of these tests done in 81 patients with proven hypothalamo-pituitary disorders. 1. In 15 patients with Sheehan's syndrome as a typical type of primary hypopituitarism, responses of both GH and cortisol to insulin-induced hypoglycemia were decreased in 15 cases all (100% in both) and of FSH, LH and TSH in 11 to 12 cases(73-80%). Incremental response of prolactin(PRL) to TRH was diminished or absent in 13 cases(86%). In 14 patients with hypothalamic diseases, including 10 cases of craniopharyn-gioma, as a representative secondary hypopituitarism, the basal PRL levels were abnormally elevated in 12 cases (86%) and both responses of PRL to TRH and of GH to hypoglycemia were blunted in 11 cases (79% in both). The frequency of impaired cortisol secretion was 50%, followed by LH, TSH and FSH secretion : overall frequency much lower than in Sheehan's syndrome. 2. In 18 acromegalics with pituitary adenoma, basal GH levels were abnormally elevated in 14 cases(78%) and incremental responses of GH to hypoglycemia were found in 13(72%). Hyperprolactinemia was accompanied in 8 (44%). In 18 patients with prolactinoma, basal PRL levels were moderately to markedly elevated in all of them(100%) and responses of PRL to TRH were blunted in 13(72%). The frequency of impaired secretion of LH, FSH, cortisol and TSH was slightly higher in acromegalics than in patients with prolactinoma. 3. The frequency of impaired secretion of GH, cortisol and LH tended to be slightly higher in patients with pituitary adenoma associated with visual field defect than those without visual field defect. These results suggest that the combined pituitary stimulation test will give us some of reliable information for evaluating the underlying causes of hypopituitarism.
-
Streptozotocin-당뇨병 백서에서 당뇨병 이환기간에 따른 대동맥의 이완능 저하 및 Oxygen-Free Radical에 의한 이완능의 손상정도
김정국,김신우,김수동,서예경,하승우,김보완,백운이,권삼,강승완 경북대학교 병원 1997 경북대학교병원의학연구소논문집 Vol.1 No.1
목적: 당뇨병의 이환기간이 혈관의 내피세포 의존성 및 비의존성 이완능의 저하에 미치는 영향과 이환기간에 따라 oxygen-free radical(OFR)에 의한 동맥이완능의 손상정도에 차이가 있는지를 알아보고자 하였다. 방법: Streptozotocin(STZ)으로 당뇨병이 유도된 3 주 및 10주째의 백서군과 연령이 비슷한 정상 대조백서군의 적출 대동맥환을 norepinephrine으로 수축시킨 상태에서 내피세포 의존성 이완제인 acetylcholine(ACh) 및 비의존성 이완제인 nitroglycerine(NTG)에 대한 이완능을 즉정하여 비교 관찬하였다. 또한 xanthine과 xanthine oxidase의 혼합으로 생성된 H₂O₂에 대동맥환을 노출시킨뒤 역시 ACh과 NTG에 대한 이완능의 손상정도를 비교하였다. 결과: 3주및 10주째 당뇨병 백서의 대동맥환은 모두 대조군 백서의 대동맥환에 비해 ACh에 대한 이완능이 유의하게 감소하였으며 10주째 당뇨병 백서군에서의 ACh에대한 이완능의 저하는 3 주째 당뇨병 백서군에 비해 유의하게 심하였다.H₂O₂에 노출시킨 뒤 ACh에대한 이완능은 3주 및 10주 째 당뇨병 백서군에서 모두 대조군에 비해 유의하게 심한 손상을 보였으나 3주와 10주째 당뇨병 백서군 사이의 손상정도의 차이가 통계학적으로 유의하지는 않았다. 한편 3주 및 10주째 당뇨병 백서군 모두 NTH에 대한 대동맥환의 이완능은 대조 백서군과 별다른 차이가 없었으며 또 H₂O₂에 노출시킨 뒤에도 NTG에 대한 이완능의 손상은 관찰되지 않았다. 결론: STZ-당뇨병백서에서 대동맥의 이완능은 당뇨병에 이환된지 3 주째에 이미 ACh에 대한 내피세포 의존성 이완능이 선택적으로 저하되며 당뇨병의 이환기간이 길수록 이완능의 저하가 심하였고, OFR에 의한 동맥 이완능의 손상도 내피세포 의존성 이완능에만 선택적으로 나타나나 이환기간에 따라 OFR에 의한 이완능 손상정도에는 뚜렷한 차이가 없음을 시사하고 있다. Objectives: Diabetes mellitus produces histological evidence of endothelial as well as changes in vascular function in experimental animal. Oxygen free radicals interfere with of destroy endothelium-dependent relaxation in normal and diabetic blood vessels. The present study was investigated whether the duration of diabetic state can affect the severity of impairment in endothelium-dependent and/or independent relaxation and the sensitivity to oxygen free fadical (OFR)-induced damage in diabetic rat vasculature. Methods: The relaxative responses of aortic ring precontracted with norepinephrine in vitro to cumulative concentrations of acetylcholine (ACh) and nitroglycerine (NTG) were conducted in 3- and 10- week streptozotocin (STZ)-diabetic rats and agematched controls. After exposure to H₂O₂generated by mixing xanthine and xanthine oxidase, the degree of impairment in relaxative responses to ACh and NTG were also compared between 3- and 10-week diabetic rats. Results: The relaxative responses of aortic rings produced by cumulative concentrations of ACh were significantly lower in both 3- and 10-week diabetic rats than in the age-matched controls. The impairments of relaxative responses to ACh in 10-week diabetic rats were significantly greater than those in 3-week ones. After H₂O₂ exposure, the impairments of relaxative responses to ACh in 3- and 10-week diabetic aortas was also significantly greater than those in the control in the control ones. However, the severity of H₂O₂-induced damage in 10-week diabetic aortas was not significantly different than that in 3-week ones. In contrast, aortic rings of 3- and 10-week diabetic rats could still be fully relaxed by NTG, even after exposure to H₂O₂. Conclusion: These findings suggest that in SRZ-diabetic rat aortas selective impairment of endothelium-dependent relaxation to Ach can be found early even over a 3-week period after the induction of diabetes and the impairment may be greater in those with the longer duration of the diabetic state and that the impairment of the vascular relaxation by OFR is also selective to endothelium-dependent response but the sensitivity of OFR-induced damage may not be related to the duration of the diabetic state.
-
고영옥,이종옥,신동국 진주산업대학교 농업기술연구소 2002 農業技術硏究所報 Vol.15 No.-
현대인의 기호에 맞는 지리산 반발효차(구황차)를 개발하기 위하여 옛날 제차법이 보존되어 있는 절간의 기술에 새로운 과학기법을 접목하여 개발한 차의 결과는 다음과 같다. 1. 총질소함량은 고온황토방의 녹차에 비하여 황토방의 녹차의 함량이 다소 높았다. 2. 총아미노산, 카페인 및 비타민-C함량은 황토방과 고온황토방의 제차방법에 따른 차이는 그다지 높지 않았다. 3. Geraniol함량은 황토방의 녹차(2회차)가 2.4%이며, 고온황토방의 녹차에 비하여 높은 경향이었다. 4. Pyrrole류의 pyrrole성분은 고온황토방이 다소 높았으나, ethyl pyrrole는 황토방에서 조성비가 현저히 높았다. 5. 꽃향기에 기여하는 Jasmone함량은 고온황토방의 녹차에서 조성비가 다소 높았다. In the order to taste go well with half-ferment green tea(kuhwang green tea) in the products of Mt. jiri garden were made try to development for modern people, according to once upon time there buddhist temple preserve course of green tea processing was approachable to new science of skill . The results were summarized as follows: 1. The amount of total nitrogen in green tea was high for yellow soil room than high temperature of yellow soil room 2. The amounts of total amino acid, caffeine and Vit. C in green tea were not difference according to yellow soil according to making method 3. The amount of geraniol in green tea was high tendency of yellow soil room(2.4%) than high temperature of yellow soil room 4. The component of pyrrole, in green tea was a few high such as high temperature yellow soil room, but the ethyl pyrrole was high ratio with yellow soil room. 5. The aroma component of amount of jasmone in green tea was a few high with high temperature of yellow soil room
-
-
-
-
Genetic Association of the ACE Gene Polymorphisms with Essential Hypertension in Korean Females
( Dong Jik Shin ),( Yoon Sun Bae ),( Ji Hye Han ),( Chan Mi Park ),( Sung Ha Park ),( Hyun Joon Shin ),( Young Guk Ko ),( Dong Hoon Choi ),( Ki Chul Hwang ),( Ji Hyung Chung ),( Sung Joo Kim ),( Yang 한국조직공학과 재생의학회 2006 조직공학과 재생의학 Vol.3 No.3
The renin-angiotensin system(RAS) genes have been extensively studied as etiologic essential hypertension( EH) candidate genes in human populations worldwide. The angiotensin I-converting enzyme(ACE) plays a key role in the RAS for the regulation of blood pressure. Recent studies on the association of ACE gene polymorphisms with EH and the related cardiovascular diseases presented conflicting results. Therefore, we investigated the association of three polymorphisms(I/D, G14480C and A22982G) in the ACE gene with EH in Koreans. We studied a sample population of 699 Koreans, comprising of 471 controls and 228 cases with EH, which were recruited from Cardiovascular Genome Center in Korea. The ACE gene polymorphisms were determined by polymerase chain reaction and SNP-IT assay. The allele frequency of G14480C polymorphism showed significant difference between normotensives and hypertensives in female group(P=0.0353). After adjustment for age and BMI, logistic regression analysis indicated that the odds ratio(OR) of the ACE I carriers(II+ID) for a risk of EH over the DD genotype was 1.698(95% CI, 1.006-2.864, P=0.0458), and OR for the comparison of 14480 GG subjects versus GC and CC subjects combined was for EH 1.787(95% CI, 1.076-2.967, P=0.0236) in females. In haplotype analysis, major three haplotypes(ICA, IGG, and DGG) were significantly associated with EH in study populations. We conclude that ACE polymorphisms appeared to have apparent association with EH in Koreans, who have a more homogeneous genetic structure than any other ethnic groups.
-
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
