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사매가 Ovalbumin감작으로 유발된 천식 생쥐 모델에서 기관지염증 억제에 미치는 영향
임중근,노성수,길기정,이영철,서영배 대한본초학회 2005 大韓本草學會誌 Vol.20 No.1
Asthma is a chronic inflammatory disease of the airways, characterized by airway eosinophilia, goblet cell hyperplasia with mucus hypersecretion, and hyper-responsiveness to both inhaled allergens and nonspecific stimuli. Eosinophil are important in the pathogenesis of asthma, with release of inflammatory mediators such as histamine, leukotrienes, cytokines, and IgE after exposure to allergen. Objectives : This research investigates the effect of the extract of Duchesnea chrysanta (EDC) on OVA-indued asthma murine model. Methods : After i.p of C57BL/6 mice, OVA sensitization (day 0) were challenged intratracheally with OVA on days 8 and 21. EDC administered weeks 8, blocked the airway inflammatory response to OVA assessed 24 h after the last OVA challenge on day 22. Results : The CC chemokine receptor 3 (CCR3) is expressed by eosinophils, mast cells, and Th2 cells. The role of CCR3 in a murine model of allergic skin inflammation induced by repeated epicutaneous sensitization with ovalbumin (OVA), and characterized by eosinophil skin infiltration, local expression of Th2 cytokines, and airway hyperresponsiveness (AHR) to inhaled antigen. The administration of EDC during OVA inhalation significantly reduced CCR3 plays an essential role in eosinophil recruitment to the skin and the lung and in the development of AHR.. EDC extract reduced total lung cells and eosinophils in bronchoalveolar lavage fluid, airway tissue eosinophilia, goblet cell hyperplasia, mucus secretion, and peribronchial edema. The inhibitory effect on airway eosinophilia and AHR was associated with reduced levels of IL-4, IL-5, and IL-13 in the bronchoalveolar lavage fluid as well as reduced serum levels of OVA-IgE. We show that OVA inhalation following OVA immunization increased airway responsiveness to induced IL-113, IL-4 and IL-5 mRNA expression in the lung tissue. The administration of EDC during OVA inhalation significantly reduced this increased airway hyperresponsiveness and also inhibited airway inflammation. Conclusions : These results support EDC as a therapeutic target in asthma and indicate that selective EDC inhibitors can reduce allergic airway inflammation.
LC 공진형 PWM 인버터를 이용한 X선 발생장치의 특성에 관한 연구
이성길,박수강,임홍우,조금배,백형래,임양수 조선대학교 에너지.자원신기술연구소 2002 에너지·자원신기술연구소 논문지 Vol.24 No.1
The conventional types of X-ray generators were bulky in physical size and heavy in weight, and the control accuracies of the output voltages were not always satisfactory. The high frequency switching inverter and converter technology on power conversion and control systems have been greatly closed up introducing power semiconductor devices. In this paper, the newly developed converter to take the balance of the output voltage versus the ground are also presented in detail to decreasing the volume and the weight of high voltage transformer and to stabilize ripple. This converter consists of the two independent L-C series resonant circuits using the two capacitances and the two primary windings of high voltage transformer.
Analysis of the Stability of HLA-A2 Molecules Expressed on the Cell Surface
Lim, Jong-Seok,Lee, Ki-Young,Lee, Hee-Gu,Kim, Ik-Hwan,Lee, Chong-Kil,Han, Seong-Sun,Kim, Kil-Hyoun Korean Society for Biochemistry and Molecular Biol 1996 Journal of biochemistry and molecular biology Vol.29 No.4
Association of antigenic peptide with class I MHC is believed to be crucial for maintaining stable conformation of class I molecules. T2 cells that are defective in TAP gene function mainly express class I molecules with an unstable conformation due to little or no association with antigenic peptides, whereas T1 cells that are normal in TAP gene function mainly express the stable form of class I molecules. In this work, attempts were made to determine the molecular stability of stable and unstable class I molecules. Dissociation of HLA-A2 molecules on T1 and T2 cells was monitored by flow cytometry using anti-HLA-A2 antibody after the cells were treated with brefeldin A to shut down the transport of newly-assembled HLA-A2. Estimated dissociation rate constants for the stable and unstable forms of HLA-A2 were 0.076 $h^{-1}$ and 0.66 $h^{-1}$, respectively. It appeared that both T1 and T2 cells express stable and unstable class I complex, but with different ratios of the two forms. Furthermore, $interferon-{\gamma}$ treatment of T1 cells appeared to induce the expression of both the stable and unstable class I molecules. These results demonstrate that class I MHC molecules can be divided into two groups in terms of structural stability and that they exist on the cell surface in both forms in a certain ratio.
Analysis of the Stability of HLA-A2 Molecules Expressed on the Cell Surface
Lim, Jong-Seok,Lee, Ki-Young,Lee, Hee Gu,Kim, Ik-Hwan,Lee, Chong Kil,Hang, Seong Sun,Kim, Kilhyoun 이화여자대학교 생명과학연구소 1996 생명과학연구논문집 Vol.7 No.-
Association of antigenic peptide with class I MHC is believed to be crucial for maintaining stable conformation of class I molecules. T2 cells that are defective in TAP gene function mainly express class I molecules with an unstable conformation due to little or no association with antigenic peptides, whereas T1 cells that are normal in TAP gene function mainly express the stable form of class I molecules. In this work, attempts were made to detemine the molecular stability of stable and unstable class I molecules. Dissociation of HLA-A2 molecules on T1 and T2 cells wes monitored by flow cytometry using anti-HLA-A2 antibody after the cells were treated with brefeldin A to shut down the transport of newly-assembled HLA-A2. Estimated dissociation rate constants for the stable and instable forms of HLA-A2 were 0.076 h^1 and 0.66 h^-1, respectively. It appeared that both T1 and T2 cells express stable and unstable class I complex, but with different ratios of the two forms. Furthermore, interferon-γ treatment of T1 cells appeared to induce the expression of both the stable and unstable class I molecules. These results demonstrate that class I MHC molecules can be divided into two groups in terms of structural stability and that they exist on the cell surface in both forms in a certain ratio.