AOPWIN을 이용한 Acetanilide의 광분해 특성 평가

권민정,최윤호,송상환,박혜연,구현주,정성환,나진균,박광식 한국환경독성학회 2001 환경독성보건학회지 Vol.16 No.3

Acetanilide is a High Production Volume Chemical, which is produced about 2,300 tons/year in Korea as of 1998 survey. Most is used as an intermediate for synthesis of pharmaceuticals and dyes, and the chemical is one of seven chemicals of which human and environmental risk are being assessed by National Institute of Environmental Research under the frame of OECD SIDS program. The Atmospheric Oxidation Program for Microsoft Windows (AOPWIN) is used to estimates the rate constant for the atmospheric, gas-phase reaction between photochemically produced hydroxyl radicals and organic chemicals. It is also used to estimates the rate constant for the gas-phase reaction between ozone and olefinic/acetylenic compounds. The rate constants estimated by the program are then used to calculate atmospheric half-lives for organic compounds based upon average atmospheric concentrations of hydroxyl radicals and ozone. AOPWIN requires only a chemical structure to make these predictions. Structures are entered into AOPWIN by SMILES (Simplified Molecular Input Line Entry System) notations. In this study, one of environmental fate/distribution of the chemical elements, photodegradation of acetanilide was estimated using AOPWIN model based on SMILES notation and chemical name data.

임상검체에서 분리된 그람 음성 세균들에 대한 Isepamicin의 시험관내 항균력

권현희,박수진,소민욱,박현구,최성호,김미나,최상호,정진용,우준희,김양수 대한감염학회 2006 감염과 화학요법 Vol.38 No.6

Background : The increasing incidence of multidrug-resistant gram-negative bacteria causing nosocomial infections is an important clinical problem. Isepamicin is a recently developed aminoglycoside which has been known to have potent activity against gram-negative organisms. We evaluated the in vitro activities of isepamicin and other aminoglycosides against a large number of gram-negative organisms. Materials and Methods : We tested the in vitro antimicrobial activities of isepamicin, amikacin, gentamicin, and tobramycin against 566 gram-negative organisms collected between January 2006 and June 2006 in Asan Medical Center. Minimal inhibitory concentrations (MICs) were determined and interpreted according to the recommendations of Clinical and Laboratory Standard Institute (CLSI). The breakpoint MIC used for interpretation of isepamicin was MIC≤16 ㎍/mL as susceptible, 32 ㎍/mL as intermediate, and 64 ㎍/mL as resistant. Results : The MIC_(50)/MIC_(90) of isepamicln for Escherichia coli, Klebsiella pneumon/ae, Pseudomonas aeruginosa, Acinetobacter baumannii, and Enterobacter cloacae were 1/2, 0.5/>128, 4/16, 16/>128, and 1/2 ㎍/mL, respectively. The susceptibilities for E. coli, K. pneumoniae, P. aeruginosa, A. baumannii, and E. cloacae were 100%, 86.4%, 89.7%, 50.0%, and 96.6%, respectively. For E. coli, K. pneumoniae, P. aeruginosa, and E. cloacae, isepamicln had better in vitro activities than gentamicin and tobromycin, and had similar activities with amlkacin. For A. baumanii, all four tested aminoglycosides had similar in vitro activities. Conclusion : Isepamicin had excellent in vitro activities against gram-negative organisms, except A. baumanii. The overall in vitro activities were similar with amikacin. 목적 : 그람 음성 세균은 다양한 지역사회 및 병원 획득 감염의 원인균이다. 최근에는 병원 감염을 일으키는 그람 음성 세균에서 항균제 내성균의 출현과 확산이 큰 문제가 되고 있다. Isepamicin은 최근에 소개된 gentamicin B의 유도체로 외국에서의 연구에 의하면 그람 음성 세균들에 대한 항균력이 우수함이 보고 된 바 있다. 본 연구에서는 우리나라의 임상 균주들을 대상으로 그람 음성세균에서 isepamicin의 시험관내 항균력을 기존의 아미노배당체 제재들과 비교하여 평가하고자 하였다. 재료 및 방법 : 2006년 1월에서 6월 사이에 서울아산병원 환자에서 분리된 Escherichia coli 113 균주, Klebsiella pneumoniae 110 균주, Pseudomonas aeruginosa 117 균주, Acinetobacter baumannii 108 균주, 그리고 Enterobacter cloacae 118 균주를 대상으로 isepaimcin, amikacin, gentamicin, tobramycin에 대한 최소억제농도(minimal inhibitory concentration, MIC)를 한천 희석법(Mueller-Hinton Agar)을 이용하여 측정하였다. 감수성여부는 CLSI 기준에 따랐으며, isepamicin은 MIC≤16㎍/mL를 감수성, MIC=32 ㎍/mL를 중등도 내성, MIC≥64 ㎍/mL를 내성으로 판정하였다. 결과 : Isepamicm의 E. coli, K. pneumoniae, P. aeruginosa, A baumannii, E. cloacae에 대한 MIC_(50)/MIC_(90)은 각각 1/2, 0.5/>128, 4/16, 16/>128, 1/2 ㎍/mL였고, 항균제 감수성률은 차례대로 100%, 86.4%, 89.7%, 50.0%, 96.6%였다. 기존 아미노배당체 제재들과 비교하면 E. coli, K. pneumoniae, P. aeruginosa, E. cloacae에서는 amikacin과 비슷한 감수성률을 보였고, gentamicin과 tobramycin보다 높은 감수성률을 보였다. A baumannii의 경우 isepamicin의 감수성률이 50.0%로 비교적 낮았지만 amikacin, gentamicin, tobramycin도 각각 50.0%, 46.3%, 47.2%의 감수성률을 나타내어 4가지 항균제가 모두 비슷한 항균력을 보였다. 결론 : Isepamicin은 그람 음성 세균들에 있어 기존의 아미노배당체 제재들과 비교했을 때 amikacin과는 동등한 시험관내 항균력을 보이고 gentamicin, tobramycin보다 뛰어난 시험관내 항균력을 보여 사용이 유망한 아미노배당체 중 하나라 생각된다.

취학전 아동의 체력 실태와 평가

권영옥,김동권,민춘기,이용인,전종귀,진윤수,홍성표 忠南大學校體育科學硏究所 1995 體育科學硏究誌 Vol.13 No.1

The purpose of this study was analyze children's Physical Fitness and basic rate by observing the change in the heart rate of the 1230 children of five of six years of age. Following conclusions were obtained The muscular strength was relatively low according to places. And the muscular strength of boys was higher than that of girls. The flexibility of girls was higher than that of boys according to places and sexes. The muscular endurance, power, balance and agility of boys were higher than those of girls according to places and sexes. Thus the development of physical fitness was improved with their ages, the physical fitness for physique seemed rather low. So the programs of physical plays for children's physical fitness ought to be developed and physical play showed to be done at kindergarten school.

이륜차 무단변속기(CVT) 구동풀리의 시물레이션

권영웅,우영환,이종원,길성진 중앙대학교 생산공학연구소 1999 생산공학연구소 논문집 Vol.8 No.2

CVT 메카니즘은 공학적 분야에 많이 사용되고 있으며, 특히 CVT의 구동폴리느 중요한 역할을 한다. 본 연구에서는 이륜차의 CTV를 국산화 할 계획의 일환으로 구동폴리를 시뮬레이션하였다. 시뮬레이션한 결과느 구동폴리의 롤로 무게와 마찰 계수, 램프의 각변형을 통해 나온 수치르 장량화한 것이며, 이를 토대로 구동폴리의 각 요소들 즉, 롤러와 유동플랜지, 램프판 간의 상호관계를 규명하였다. CVT(Continuously Variable Transmission) mechanism has been used in many engineering applications. A driving pulley of CVT plays a vital role. In this study, computer simulation for a movable pulley was carried out for the purpose of producing a motorcycle CVT of Korean model. The effects of roller mass, friction coefficient, deformation of ramp plate on a given speed and torque during moving were quantified using the simulation results. Based on the simulation, relations between each component of driving pulley that consists of roller, movable flange and ramp plate etc. were investigated.

시민․전문가 경관 인식에 근거한 통합경관마스터플랜 수립 방안 연구

김용진, 권일, 김성희 한국교통대학교 2016 한국교통대학교 논문집 Vol.51 No.-

The need for a unified landscape starts from cities that are thus spatially and functionally linked together. It is necessary to plan and manage the city landscape more integrally because the administrative regions are different but functional and spatial closely in addition to the case of restructuring the cities into a unified form by being bound by a single living zone. This study is a basic research for establishing a comprehensive and systematic landscape plan of urban landscape over the whole city integrated in 2010, centered on integrated municipalities. For this purpose, this study conducted a survey of residents' awareness of the landscape, and based on the results, we propose implications for the establishment of a master plan integrated landscape. As a result of the analysis, the shipping factors such as roads, pedestrian roads, rivers and green spaces were found to be important factors for landscape formation for both residents and professionals. In the direction of establishing the integrated landscape master plan, it is necessary to establish the unity of the whole city and strengthen the inherent characteristics of each of the existing cities.

Yield of Rice Affected by Meteorological Elements in Yeosu Area of Korea

Kwon,Byung-Sun,Choi,Seong-Kyu,Shin,Jeong-Sik,Shin,Jong-Sup,Shin,Dong-Young,Hyun,Kyu-Hwan,Kuk,Yong-In,Park,Hee-Jin 한국자원식물학회 2003 Plant Resources Vol.6 No.2

This study was conducted to investigate the relationships between yearly variations of meteorological elements and yearly variations of productivity in rice. In addition, correlation coefficients among yield and yield components were used to find out the relationships between meteorological elements and productivity. Yearly variation of the mean air temperature in May was large with coefficients of variation(C.V.) of 25.0%, but the variation of the duration of sunshine in May were relative small. No. of panicles per hill and 1,000 grains wt. of brown rice were great with C.V. of 21.1, 19.7%, respectively, brown rice yield show more or less C.V. of 5.5% and milled rice show still less variation. Correlation coefficients between temperatures in period of cultivation from May and yield were positive correlations. Correlation Coefficients between precipitation in period of cultivation from Sep. to Oct. and yield are positive correlations. Correlation coefficients amount the panicle length, no. of panicles, no. of spikelets, ratio of ripened grains, 1,000 grains wt. of brown rice, milled rice yield, brown rice yield and milled rice yield were positively significant at the level of 1 %, respectively.

Effect of Fertilizer Levels on Growth Characters, Dry Matter Yield and Nutrient Quality of Forage Rape in Spring Sowing

Kwon,Byung-Sun,Shin,Jeong-Sik,Shin,Dong-Young,Hyun,Kyu-Hwan,Park,Hee-Jin,Sin,Jong-Sup,Seong-Kyu 한국자원식물학회 2003 Plant Resources Vol.6 No.2

To find out the optimum fertilizer level for high yielding variety, Velox, experiment was conducted with 15 compositions of fertilizer levels at the experiment field of forage crop in Sunchon National University from Mar. 2000 to Aug. 2000. The effects of nitrogen fertilizer on plant growth were significant but increasing rate of application in potassium and phosphate fertilizers above 6 kg/a had negligible effects on plant growth. The optimum nitrogen application level of fertilizers turned out to be 16-6-6 kg/l0a of N-P2O5-K5O. Content of crude protein was highest and that of crude fiber such as NDF, ADF, cellulose and lignin were lowest at this rate of fertilizer application. Furthermore, IVDMD was high and dry matter yield were highest at the optimum raterate

Relationship between Meteorological Elements and Yield of Hot Pepper in Yeosu Area of Korea

Kwon,Byung-Sun,Choi,Seong-Kyu,Shin,Jeong-Sik,Shin,Jong-Sup,Shin,Dong-Young,Hwan,Kyu-Hyun,Kim,Hak-Jin,Kuk,Yong-In,Choi,Kyong-Ju 한국자원식물학회 2003 Plant Resources Vol.6 No.1

This study was conducted to investigate the relationships between yearly variations of meteorological elements and yearly variations of productivity in hot pepper. In addition, correlation coefficients among the yields and yield components were used to find out the relationships between meteorological elements and productivity. Yearly variation of the mean air temperature in May and July showed large with coefficients of variation(C.V.) of 25.0,8.9%, respectively, but the variation of the duration of sunshine in May were relative small. Yield and plant height was greatly with C.V. of 7.14,11.6%, respectively, diameter of fruit showed more or less C.V. of 2.28% and length of fruit showed less variation. Correlation coefficients between maximum temperature in period of cultivation from May and yield are positively significant at the level of 1 %. Correlation Coefficients between precipitation in period of cultivation from May to August and yield are negative significant at the level of 5 and 1 %, respectively. Correlation coefficients amount the plant height, length of fruit, diameter of fruit per plant, and seed yield were positively significant at the level of 1 %, respectively.

Influence of Sowing Time on Growth, Yield and Nutritional Quality of Forage Rape in Spring

Kwon,Byung-Sun,Shin,Jeong-Sik,Park,Hee-Jin,Shin,Jong-Sup,Choi,Seong-Yu 한국자원식물학회 2003 Plant Resources Vol.6 No.1

To determine as optimal sowing time of forage rape in spring time in southern areas of Korea, forage rape cv. Velox, the highest yielding variety among introduced varieties of forage rape, was grown under five different sowing times. Yield components such as plant length, number of branches and number of leaves etc. were higher at the sowing time of Mar. 15 and Mar. 25. The plants sown at Mar. 15 and Mar. 25 also showed highest fresh and dry matter yield. When plants were grown under later sowing time, they showed higher values in content of crude protein and lower values in contents of crude fiber such as Neutral Detergent Fiber (NDF), Acid Detergent Fiber (ADF), cellulose and lignin. There was no relationship between variation of In Vitro Dry matter Digestibility (IVDMD) and sowing time. The plants sown at Mar. 15 and Mar. 25 showed highest digestible dry matter yields.

정신과 환자들의 의료서비스 이용에 관한 연구 : 경기도 연천 지역에서 In Yonchon Area of Kyunggi Province

황성혜,홍진표,권준수,우종인,김중술,조두영,이부영,조맹제,양병국,배재남 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.4

본 연구는 농촌지역 정신과 환자들의 의료서비스 이용 형태를 알아보고자 하여 행하여졌다. 경기도 연천군 주민중 1993년 1년간 지역 의료보험과 의료보호자료에서 정신과적 진단을 받은 사람들 1295명 중 209명을 대상으로 하였다. 연구자들이 제작한 반구조화된 면담도구를 사용하여 13명의 훈련된 면담자에 의해 증상을 처음 느낀 후 이용한 의료서비스를 차례대로 조사하였다. 결과는 다음과 같다. 정신증적 장애 환자들은 정신과 치료만을 받은 경우가 28.8%이며 처음 방문한 의료서비스는 정신과 45%, 일반의 28%, 약국 6%, 한방치료 5%, 요양원 6%, 기타 10%였다. 비정신증적 장애 환자들은 정신과를 한번이라도 이용한 경우는 32.1%였고 처음 방문한 의료서비스는 정신과 15%, 일반의59%,약국 17%, 한방치료8%, 기타1%였다. 진단에 따라서는, 정신분열병의 경우 64.5%가 처음에 정신과를 방문하였고 정동형 정신병의 경우는 20.8%에 불과했고 64.1%가 일반이나 약국을 처음에 방문하였다. 신경증적 장애(ICD-9 300)는 40.0%가 일반의만을 방문했다. 이상의 결과로 정신분열병 환자들은 대다수가 정신과 치료를 받는 것으로 나타났으나 정동형 정신병과 신경증적 장애는 다수가 일반의를 이용하는 것으로 나타났다. 지역사회 정신보건에서 일반의의 역할이 매우 중요하며 일반의에 대한 정신과 교육이 절실하고, 보다 전문적인 치료환경과 기술을 요하는 경우에는 정신과와의 연계 체계의 필요성도 요구된다. The purpose of this study was to investigate the pathways of health care seeking by the psychiatric patients at a well - defined rural area in Korea. Among 1,295 patients diagnosed to have mental disorders by ICD-9 in a year, all the psychotic patients(184 in number) and randomly selected 15% of nonpsychotic patients(162 in number) were selected as subjects of this study. Thirteen well - trained interviewers collected the data using semi-structurd inter-view instrument developed by the authors. Two hundred nine patients(60.4%) fully responded to the interviews. As for psychotic patients, 28.8% used only psychiatric services, and the first visits for help were psychiatrists, general practitioners, pharmacists, asylums and oriental herb medicine in the order of decreasing frequency. Only 32.1% of nonpsychotic patients used mental health specialties during the course of their illness, and their most common first visits for care were general practitioners(59%) followed by pharmacists(17%) and psychiatrists(15%). Majority(64%) of schizophrenic patient visited psychiatrist first, while 64.1% of affective psychosis patients visited general practitioners and pharmacists first. The forty percent of neurotic patients(ICD-9 300) visited general practitioners only for their health care.