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Epigenetics: general characteristics and implications for oral health
Seo, Ji-Yun,Park, Yoon-Jung,Yi, Young-Ah,Hwang, Ji-Yun,Lee, In-Bog,Cho, Byeong-Hoon,Son, Ho-Hyun,Seo, Deog-Gyu The Korean Academy of Conservative Dentistry 2015 Restorative Dentistry & Endodontics Vol.40 No.1
Genetic information such as DNA sequences has been limited to fully explain mechanisms of gene regulation and disease process. Epigenetic mechanisms, which include DNA methylation, histone modification and non-coding RNAs, can regulate gene expression and affect progression of disease. Although studies focused on epigenetics are being actively investigated in the field of medicine and biology, epigenetics in dental research is at the early stages. However, studies on epigenetics in dentistry deserve attention because epigenetic mechanisms play important roles in gene expression during tooth development and may affect oral diseases. In addition, understanding of epigenetic alteration is important for developing new therapeutic methods. This review article aims to outline the general features of epigenetic mechanisms and describe its future implications in the field of dentistry.
자궁경부 편평상피암에서 DDRT-PCR 기법을 이용한 유전자 발현 및 Gene Ontology 분석
서민제 ( Seo Min Je ),배수미 ( Bae Su Mi ),박경미 ( Park Gyeong Mi ),김병훈 ( Kim Byeong Hun ),김용완 ( Kim Yong Wan ),서경윤 ( Seo Gyeong Yun ),서경아 ( Seo Gyeong A ),김용욱 ( Kim Yong Ug ),허수영 ( Heo Su Yeong ),노덕영 ( No De 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.4
목적: 인유두종 바이러스 감염에 의한 자궁경부암 발생에 대한 자연사 (natural history)는 비교적 잘 알려져 있으나 분자생물학적인 면에서의 병태생리는 아직 명확하게 규명되어 있지 않다. 자궁경부 편평상피암 조직에서 유전자 발현 양상을 조사하여 암화과정에 관여하는 유전자들의 다양한 기능과 상호작용에 대해서 알아보고자 하였다. 연구 방법: 양성질환으로 자궁 적출술을 시행한 17명의 자궁경부에서 추출한 RNA를 동일한 농도로 섞어 대조군으로 이용하 Objective: The molecular pathology of cervical cancer associated with human papillomavirus infection is presently unclear. In an effort to clarify the multiple interactions of a number of genes involved in cervical carcinogenesis, the gene expression prof
A 0.9 – 1.5 GHz CMOS UWB Radar IC for Through the Wall Human Detection
Byeong Jae Seo,Gu Jung,Sunghun Jung,Dong-Min Seol,Sungmoon Chung,Yun Seong Eo 대한전자공학회 2023 Journal of semiconductor technology and science Vol.23 No.1
In this paper, a UWB radar IC for the through wall radar is presented to achieve the smaller form factor of the module and low power operation. For the penetration performance enhancement, the radar IC s designed for the lower 0.9 – 1.5 GHz band. The radar IC employs the 4-channel time-interleaved equivalent time sampling receiver for 200 ps fine resolution, and the digitally synthesized impulse generator for the transmitter. The human target behind the concrete brick wall can be detected in the distance over 9.4 m with the help of signal processing part and additional amplifiers. The radar transceiver IC is fabricated in a 0.13 μm CMOS technology and the current consumption is 116.3 mA at the 1.2 V supply.
Byeong-Eon Park,Jeong-Seop Lee,Hee-Yun Kim,Jae-Nam Bae,Won-Hyoung Kim,Hye-Young Kim,Mi-Roo Rim,Sang-Gu Kang,Seo-Hyun Choi 대한소아청소년정신의학회 2019 소아청소년정신의학 Vol.30 No.1
Objectives: This study aimed to compare the quality of life reported by patients with attention-deficit/hyperactivity disorder (ADHD) to the patients’ quality of life as reported by their caregivers. In addition, it aimed to examine how emotional problems, including depression and anxiety, and the severity of the symptoms affect the quality of life reported by the patients and their caregivers. Methods: The patients’ quality of life and their degree of depression and anxiety were measured using the Pediatric Quality of Life Inventory (PedsQL) 4.0 Child Self-Report, the Children’s Depression Inventory (CDI), and the Revised Children’s Manifest Anxiety Scale, respectively. The caregivers’ perception of the patients’ quality of life and severity of the ADHD symptoms were measured using the PedsQL 4.0 Parent Proxy Report and the Conners’ Parent Rating Scale (CPRS), respectively. A total of 66 participants completed the survey. The independent-samples t-test, Pearson’s correlation analysis, and multiple regression analysis were conducted. Results: The mean score of the PedsQL 4.0 Child Self-Report was significantly higher than the mean score of the PedsQL 4.0 Parent Proxy Report. However, for school function, the PedsQL 4.0 Child Self-Report score was significantly lower than that of Parent Proxy Report. The correlation between the PedsQL 4.0 Child Self-Report and PedsQL 4.0 Parent Proxy Report scores was significant only for emotional function and social function. The multiple regression analysis showed that the PedsQL 4.0 Child Self-Report and PedsQL 4.0 Parent Proxy Report scores were significantly predicted by the CDI and CPRS scores, respectively. Conclusion: Our results demonstrate that there are clear differences between the quality of life reported by the patient themselves and that reported by their caregivers. In addition, the findings suggest that it is critical to treat the patients’ accompanying depressive symptoms.