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Yong‑Ho Kim,Hyo‑Sang Yoo,Jeong‑Han Lee,Ik‑Hyun Oh,Hyun‑Kuk Park,Hyeon‑Taek Son 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.7
In order to investigate the microstructure and mechanical properties on Al–25Cr–5Si (at%) alloy, a mixed powder with pureelements and an alloy powder using a gas atomization process were used. Fine and high purity Al–25Cr–5Si (at%) alloypowder was successfully prepared by gas atomization and densified using a spark plasma sintering (SPS) process. The overallpowder size distribution of the mixed Al, Cr, and Si elemental powders was in the range of 10–15 μm. The atomized Al–Cr–Sialloy powder was fine and spherical in morphology and difficult to be formed by intermetallic formation. Densification wasclearly confirmed at 1000 °C, with almost isolated pores formed, by clear removal of pores between particles, deformationof particles, an increase in the number of contacts, and a change in size between particles. As a result of XRD analysis ofthe sintered compacts, single phase was observed using the mixed powder, but the compact using gas atomization remainedthe alloy phase even at the process temperature. The Vickers hardness of the compacts by mixed powder was observed at59.70 Hv and the compact using gas atomized powders on the temperature 1000 °C of the Vickers hardness increased to702.6 Hv. The compressive yield strength of the compact with mixed powder was 195.24 MPa and the compressive strengthof the compact with gas atomized powder increased to 802.07 MPa. It is considered not to be decomposed by the AlCrSi,Al13Cr4Si4and Al8Cr5phases sintering process, resulting from the improvement of mechanical properties.
One-step versus two-step sentinel lymph node mapping techniques in endometrial cancer
( Sang Wun Kim ),( Yoo-na Kim ),( Yong Jae Lee ),( Kyung Jin Eoh ),( Jung-yun Lee ),( Eun Ji Nam ),( Sunghoon Kim ),( Young Tae Kim ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-
Objective: Fluorescence image-guided sentinel lymph node (SLN) biopsy using two-step mapping technique incorporates sequential injection of indocyanine green into the bilateral uterine cornus, followed by cervical injection. Outcomes were compared between this and the conventional cervical method (one-step). Methods: Patients with FIGO stage I-III endometrial cancer who underwent laparoscopic or robotic staging operation, including SLN biopsy, from May 2014 to December 2018, were retrospectively reviewed. Patient characteristics, preoperative imaging, SLN detection pattern, pathological result, adjuvant treatment, and recurrence locations were analyzed. Results: A total of 199 patients received one-step (n=123) and two-step (n=76) SLN biopsy. Paraaortic SLNs were more frequently identified in the two-step group. Lower and upper paraaortic SLNs were identified in 67.1% and 38.2%, respectively, in the two-step group and in 18.7% and 5.7% in the one-step group (p < 0.001). The number of paraaortic SLNs harvested was superior in the two-step group (p < 0.001). Moreover, trend of a higher proportion of patients with metastatic paraaortic SLN was shown in the two-step group (7.9%) than in the one-step group (1.6%) (p = 0.056). The metastatic paraaortic SLNs were found in 7.9% of the two-step group and 2.4% of the one-step group. In detecting LN metastasis, sensitivities of the one- and two-step methods were 91.7% and 100.0%, negative predictive values were 99.0% and 100.0%, false negative rates were 8.3% and 0%, and accuracy were 99.1% and 100.0%, respectively. The one-step methods identified only 3 out of 8 paraaortic LN metastasis and missed 5 paraaortic LN metastasis. However, there was no missed paraaortic LN metastasis in two-step group. Recurrence was observed in two patients (2.6%; one vaginal vault and one adrenal gland) in the two-step and seven patients (5.7%) including three nodal recurrences in the one-step method. Conclusion: Two-step SLN mapping improved the paraaortic SLN detection rate, a known pitfall of conventional cervical injection. Proper evaluation of aortic nodal status will assist in the tailoring of adjuvant therapy and prevent under-treatment of patients with isolated paraaortic metastasis.
Sang O Park,Young Bum Yoo,Yong Hun Kim,Kwang Je Baek,Jung-Hyun Yang,Pil Cho Choi,Jeong Hun Lee,Kyeong Ryong Lee,Kyoung Sik Park 대한외과학회 2015 Annals of Surgical Treatment and Research(ASRT) Vol.88 No.2
Purpose: The anticancer property and cytoprotective role of selenium in chemotherapy have been reported. However, the combination effects of selenium on chemotherapy for advanced breast cancer have not yet been clearly defined. The purpose of this study was to investigate the combined effects of selenium on chemotherapy using docetaxel on breast cancer cell lines. Methods: Under adherent culture conditions, two breast cancer cell lines, MDA-MB-231 and MCF-7, were treated with docetaxel at 500pM and selenium at 100nM, 1μM, or 10μM. Changes in cell growth, cell cycle duration, and degree of apoptosis after 72 hours in each treated group were evaluated. Results: In the MDA-MB-231 cells, the combination therapy group (docetaxel at 500pM plus selenium at 10mM) showed a significantly decreased percentage of cell growth (15% vs. 28%; P = 0.004), a significantly increased percentage of late apoptosis (63% vs. 26%; P = 0.001), and an increased cell cycle arrest in the G2/M phase (P = 0.001) compared with the solitary docetaxel therapy group. Isobologram analysis demonstrated the synergistic effect of the combination therapy in the MDA-MB-231 cells. However, in the MCF-7 cells, no significant differences in the percentage of cell growth apoptosis, the percentage of apoptosis, and the pattern of cell cycle arrest were noted between the combination therapy groups and the solitary docetaxel therapy group. Conclusion: Our in vitro study indicated that the combination of selenium with docetaxel inhibits cell proliferation through apoptosis and cell arrest in the G2/M phase in MDA-MB-231 breast cancer cells.
Shear Effects on Production of Lignin Peroxidase by Phanerochaete chrysosporium
Sang, Byeong-In,Kim, Yong-Hwan,Yoo, Young-Je The Korean Society for Biotechnology and Bioengine 1996 Biotechnology and Bioprocess Engineering Vol.1 No.1
Since biosynthesis of lignin peroxidase from Phanerochaete chrysosporium was known to be sensitive to shear, it is interesting to understand the effects of the shear sensitivity for the overproduction of lignin peroxidase. In stirred-tank fermentor, the shear-sensitivity in lignin peroxidase biosynthesis was quantified by using Kolmogorov length scale. It was found that agitation at 80$\mu$m Kolmogorov length scale is advantageous for the production of lignin peroxidase from P. chrysosporium. To overcome the shear sensitivity in lignin peroxidase biosynthesis caused by the agitation,P. chrysosporium was immobilized on various solid carriers. The nylon-immobilized P. chrysosporium was chosen in the present study as a way to overcome the shear sensitivity at the ranges of above 50$\mu$m Kolmogorov length scale. The adhesion force between immobilized cell and carrier can be predicted by thermodynamic approach and used as a criteria to select an adequate carrier materials for immobilization.
Yong-Joon Lee,Yongsung Suh,Jung-Sun Kim,Yun-Hyeong Cho,Kyeong Ho Yun,Yong Hoon Kim,Jae Young Cho,Ae-Young Her,Sungsoo Cho,Dong Woon Jeon,Sang-Yong Yoo,Deok-Kyu Cho,Bum-Kee Hong,Hyuckmoon Kwon,Sung-Jin 대한심장학회 2022 Korean Circulation Journal Vol.52 No.4
Background and Objectives: Identifying patients with high bleeding risk (HBR) is important when making decisions for antiplatelet therapy strategy. This study evaluated the impact of ticagrelor monotherapy after 3-month dual antiplatelet therapy (DAPT) according to HBR in acute coronary syndrome (ACS) patients treated with drug eluting stents (DESs). Methods: In this post-hoc analysis of the TICO trial, HBR was defined by 2 approaches: meeting Academic Research Consortium for HBR (ARC-HBR) criteria or Predicting Bleeding Complications in Patients Undergoing Stent Implantation and Subsequent DAPT (PRECISE-DAPT) score ≥25. The primary outcome was a 3–12 months net adverse clinical event (composite of major bleeding and adverse cardiac and cerebrovascular events). Results: Of the 2,980 patients without adverse events during the first 3 months after DES implantation, 453 (15.2%) were HBR by ARC-HBR criteria and 504 (16.9%) were HBR by PRECISE-DAPT score. The primary outcome rate was higher in HBR versus non-HBR patients (by ARC-HBR criteria: hazard ratio [HR], 2.87; 95% confidence interval [CI], 1.76–4.69; p<0.001; by PRECISE-DAPT score: HR, 3.09; 95% CI, 1.92–4.98; p<0.001). Ticagrelor monotherapy after 3-month DAPT was associated with lower primary outcome rate than ticagrelor-based 12-month DAPT regardless of HBR by ARC-HBR criteria, with similar magnitudes of therapy effect for HBR and non-HBR patients (p-interaction=0.400). Results were consistent by PRECISE-DAPT score (p-interaction=0.178). Conclusions: In ACS patients treated with DESs, ticagrelor monotherapy after 3-month DAPT was associated with lower rate of adverse clinical outcomes regardless of HBR, with similar magnitudes of therapy effect between HBR and non-HBR.
Yoo, Seung Ho,Kim, Tae Hong,Shin, Jun Jae,Shin, Hyung Shik,Hwang, Yong Soon,Park, Sang Keun The Korean Neurosurgical Society 2012 Journal of Korean neurosurgical society Vol.52 No.4
Objective : To evaluate the surgical efficacy of and factors associated with decompressive craniectomy in patients with an internal carotid artery (ICA) territory infarction. Methods : Seventeen patients (8 men and 9 women, average age 61.53 years, range 53-77 years) were treated by decompressive craniectomy for an ICA territory infarction at our institute. We retrospectively reviewed medical records, radiological findings, and National Institutes of Health Stroke Scale (NIHSS) at presentation and before surgery. Clinical outcomes were assessed using the Glasgow Outcome Scale (GOS). Results : Of the 17 patients, 15 (88.24%) achieved a poor outcome (Group A, GOS 1-3) and 2 (11.76%) a good outcome (Group B, GOS 4-5). The mortality rate at one month after surgery was 52.9%. Average preoperative NIHSS was $27.6{\pm}10.88%$ in group A and $10{\pm}4.24%$ in group B. Mean cerebral infarction fraction at the septum pellucidum level before surgery in group A and B were 33.67% and 23.72%, respectively. Mean preoperative NIHSS (p=0.019) and cerebral infarction fraction at the septum pellucidum level (p=0.017) were found to be significantly associated with a better outcome. However, no preexisting prognostic factor was found to be of statistical significance. Conclusion : The rate of mortality after ICA territory infarction treatment is relatively high, despite positive evidence for surgical decompression, and most survivors experience severe disabilities. Our findings caution that careful consideration of prognostic factors is required when considering surgical treatment.
A Triangulation-Invariant Method for Anisotropic Geodesic Map Computation on Surface Meshes
Yoo, Sang Wook,Seong, Joon-Kyung,Sung, Min-Hyuk,Shin, Sung Yong,Cohen, Elaine IEEE 2012 IEEE transactions on visualization and computer gr Vol.18 No.10
<P>This paper addresses the problem of computing the geodesic distance map from a given set of source vertices to all other vertices on a surface mesh using an anisotropic distance metric. Formulating this problem as an equivalent control theoretic problem with Hamilton-Jacobi-Bellman partial differential equations, we present a framework for computing an anisotropic geodesic map using a curvature-based speed function. An ordered upwind method (OUM)-based solver for these equations is available for unstructured planar meshes. We adopt this OUM-based solver for surface meshes and present a triangulation-invariant method for the solver. Our basic idea is to explore proximity among the vertices on a surface while locally following the characteristic direction at each vertex. We also propose two speed functions based on classical curvature tensors and show that the resulting anisotropic geodesic maps reflect surface geometry well through several experiments, including isocontour generation, offset curve computation, medial axis extraction, and ridge/valley curve extraction. Our approach facilitates surface analysis and processing by defining speed functions in an application-dependent manner.</P>