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( Jun Ki Hong ),( Hye Sung Han ),( Tae-rin Kwon ),( Jong Hwan Kim ),( Kwang Ho Yoo ),( Beom Joon Kim ),( Myeung Nam Kim ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: In recent decades, many attempts have been made to develop non-surgical and minimally invasive approaches to remove bulging lower eyelid fat, but there are no promising methods. Objectives: This study aimed to evaluate the efficacy and safety of treating lower eyelid fat bulging with ultrasound-assisted lipolysis (UAL) by performing a preclinical evaluation of the procedure on a Yorkshire pig. Methods: Two white Yorkshire pigs had lower eyelid fat bulging treated with UAL using a probe with a diameter of 1.0 mm or less. Fourteen days after treatment, we evaluated the changes in fat thickness from ultrasound, changes in skin contour from the Antera 3<sup>TM</sup>, and the disruption of fat cells and changes in collagen synthesis from histological evaluation. Results: Fourteen days after treatment, the fat layer was significantly reduced with no damage to the skin surface. The mean change in the subcutaneous fat layer thickness was decreased from 1.51 to 0.75 mm in ultrasound analysis. The skin contour of the treated area also decreased with time from 202.5 to 163.5 mm in mean volume and from 0.8111 to 0.646 mm in mean height. Masson's trichrome staining showed that the UAL treatment induced the regeneration and remodeling of collagen. Conclusion: UAL may be a beneficial and well-tolerated treatment option for lower eyelid fat bulging.
Effect of Korean Red Ginseng on metabolic syndrome
Sang Jun Yoon,Seul Ki Kim,Na Young Lee,Ye Rin Choi,Hyeong Seob Kim,Haripriya Gupta,Gi Soo Youn,Hotaik Sung,Min Jea Shin,Ki Tae Suk 고려인삼학회 2021 Journal of Ginseng Research Vol.45 No.3
Metabolic syndrome (MS) refers to a clustering of at least three of the following medical conditions: high blood pressure, abdominal obesity, hyperglycemia, low high-density lipoprotein level, and high serum triglycerides. MS is related to a wide range of diseases which includes obesity, diabetes, insulin resistance, cardiovascular disease, dyslipidemia, or non-alcoholic fatty liver disease. There remains an ongoing need for improved treatment strategies for MS. The most important risk factors are dietary pattern, genetics, old age, lack of exercise, disrupted biology, medication usage, and excessive alcohol consumption, but pathophysiology of MS has not been completely identified. Korean Red Ginseng (KRG) refers to steamed/dried ginseng, traditionally associated with beneficial effects such as anti-inflammation, anti-fatigue, anti-obesity, anti-oxidant, and anti-cancer effects. KRG has been often used in traditional medicine to treat multiple metabolic conditions. This paper summarizes the effects of KRG in MS and related diseases such as obesity, cardiovascular disease, insulin resistance, diabetes, dyslipidemia, or non-alcoholic fatty liver disease based on experimental research and clinical studies.
Pharma-Biotics, Strain X, Inhibits Inflammation of Non-Alcoholic Fatty Liver Disease
( Ye Rin Choi ),( Hyeong Seop Kim ),( Hee Jin Park ),( Ji Ye Hyun ),( Jung A Eom ),( Min Kyo Jeong ),( Byeong Hyun Min ),( Sang Jun Yoon ),( Satya Priya Sharma ),( Haripriya Gupta ),( Yoseph Asmelash 대한간학회 2021 춘·추계 학술대회 (KASL) Vol.2021 No.1
Tae-Rin Kwon,Dong Wook Moon,Jungwook Kim,Hyoung Jun Kim,Seong Jae Lee,Yunhee Han,Hee Won Dan,Sang Hoon Chi,Hwan Mo Seong,Hee Jung Kim,Guei-Sam Lim,Jungkwan Lee 대한의학레이저학회 2021 MEDICAL LASERS Vol.10 No.2
Background and Objectives: Skin aging is reportedly associated with regulation in collagen and elastin synthesis. This study investigated the potential of combining light-emitting diode (LED) treatments using a 630-nm and 850-nm LED with simultaneous microcurrent application. Materials and Methods: The dorsal skin of female pigs was treated with a home-use device. We examined the treatment effects using photography, thermocamera, microscopic pathology, and histological examination to determine the mechanism of action, efficacy, and safety of the procedure. A histological observation was performed using hematoxylin and eosin, Masson’s trichrome, Victoria blue, and immunohistochemical staining. We also used the Sircol soluble collagen and elastin assay kit to measure the amounts of collagen and elastin in the porcine back skin tissue after 2 and 6 weeks. Results: Evaluation by visual inspection and devices showed no skin damage or heat-induced injury at the treatment site. Histological staining revealed that accurate treatment of the targeted dermis layer effectively enhanced collagen and elastin deposition. Collagen type I, a protein defined by immunohistochemical staining, was overexpressed in the early stages of weeks 2 and 6. Combined therapy findings showed the superior capability of the 630-nm and 850-nm LED procedures to induce collagen; in contrast, elastin induction was more pronounced after microcurrent treatments. Conclusion: The home-use LED device, comprising a combination of 630-nm and 850-nm LEDs and microcurrent, is safe and can be used as an adjunctive treatment for self-administered facial rejuvenation.