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- 저자 : Guei-Sam Lim (검색결과 4 건)
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Copper-Glucosamine Microcubes: Synthesis, Characterization, and C-Reactive Protein Detection
Veerapandian, Murugan,Subbiah, Ramesh,Lim, Guei-Sam,Park, Sung-Ha,Yun, KyuSik,Lee, Min-Ho American Chemical Society 2011 Langmuir Vol.27 No.14
<P>Cubelike microstructures of glucosamine-functionalized copper (GlcN-CuMC’s) have been fabricated by the integration of injection pump and ultrasonochemistry. Although bulk microstructures and the nanostructure of metallic copper exhibit distinct applications, the amino sugar surface-functionalized copper is almost biocompatible and exhibits advanced features such as more crystallinity, high thermal stability, and electrochemical feasibility toward biomolecule (C-reactive protein, CRP) detection. An electrochemical test of this GlcN-CuMC’s was demonstrated by immobilization on a conventional gold-PCB (Au-PCB) electrode. The combination of a biointerface membrane, from glucosamine functionalization, and electroactive sites of metallic copper provides a very efficient electrochemical response against various concentration of CRP. A perfect scaling of steady-state currents with <I>r</I><SUP>2</SUP> values of 0.9862 (<I>I</I><SUB>pa</SUB>) and 0.9972 (<I>I</I><SUB>pc</SUB>) indicate the promise of this kind of biofunctionalized microstructure electrode for many surface and interface applications.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/langd5/2011/langd5.2011.27.issue-14/la2009495/production/images/medium/la-2011-009495_0001.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/la2009495'>ACS Electronic Supporting Info</A></P>
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Kim, Seung-Wan,Cho, Il-Hoon,Lim, Guei-Sam,Park, Gi-Na,Paek, Se-Hwan Elsevier Applied Science 2017 Biosensors & Bioelectronics Vol. No.
<P><B>Abstract</B></P> <P>A hybrid-biosensor system that can simultaneously fulfill the immunoassay for protein markers (e.g., C-reactive protein (CRP) and procalcitonin (PCT)) and the enzyme assay for metabolic substances (e.g., lactate) in the same sepsis-based sample has been devised. Such a challenge was pursued through the installation of an enzyme-reaction zone on the signal pad of the typical immuno-strip for the rapid two-dimensional (2-D)-chromatography test. To minimize the mutual interference in the hybrid assays, a pre-determined membrane site was etched in a pattern and mounted with a biochemical-reaction pad, thereby allowing a loaded sample to enter and then stay in the pad for a colored-signal production over the course of an immunoassay. By employing such a constructed system, a serum sample was analyzed according to the vertical direction flowing along the strip, which supplied lactate to the biochemical-reaction zone and then protein markers to the immunological-binding area that was pre-coated with capture antibodies. Thereafter, the enzyme-signal tracers for the immunoassay and the substrate solution were sequentially furnished using a horizontal path for the tracing of the immune complexes that were formed with CRP or PCT. The color signal that was produced from each assay was detected at a pre-determined time and quantified on a smartphone-based detector. Under the optimal conditions, the dynamic ranges for the analytes covered the respective clinical ranges, and the total coefficient of variation was between 8.6% and 13.3%. The hybrid biosensor further showed a high correlation (R<SUP>2</SUP> > 0.95) with the reference systems for the target markers.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A biosensor that can simultaneously fulfill immunoassay and enzyme assay was devised. </LI> <LI> Triple markers (CRP, PCT, and lactate) in the same sepsis-based sample were targeted. </LI> <LI> The color signal produced from each assay was quantified on a smartphone detector. </LI> <LI> The dynamic ranges for the analytes covered the respective clinical ranges. </LI> </UL> </P>
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Tae-Rin Kwon,Dong Wook Moon,Jungwook Kim,Hyoung Jun Kim,Seong Jae Lee,Yunhee Han,Hee Won Dan,Sang Hoon Chi,Hwan Mo Seong,Hee Jung Kim,Guei-Sam Lim,Jungkwan Lee 대한의학레이저학회 2021 MEDICAL LASERS Vol.10 No.2
Background and Objectives: Skin aging is reportedly associated with regulation in collagen and elastin synthesis. This study investigated the potential of combining light-emitting diode (LED) treatments using a 630-nm and 850-nm LED with simultaneous microcurrent application. Materials and Methods: The dorsal skin of female pigs was treated with a home-use device. We examined the treatment effects using photography, thermocamera, microscopic pathology, and histological examination to determine the mechanism of action, efficacy, and safety of the procedure. A histological observation was performed using hematoxylin and eosin, Masson’s trichrome, Victoria blue, and immunohistochemical staining. We also used the Sircol soluble collagen and elastin assay kit to measure the amounts of collagen and elastin in the porcine back skin tissue after 2 and 6 weeks. Results: Evaluation by visual inspection and devices showed no skin damage or heat-induced injury at the treatment site. Histological staining revealed that accurate treatment of the targeted dermis layer effectively enhanced collagen and elastin deposition. Collagen type I, a protein defined by immunohistochemical staining, was overexpressed in the early stages of weeks 2 and 6. Combined therapy findings showed the superior capability of the 630-nm and 850-nm LED procedures to induce collagen; in contrast, elastin induction was more pronounced after microcurrent treatments. Conclusion: The home-use LED device, comprising a combination of 630-nm and 850-nm LEDs and microcurrent, is safe and can be used as an adjunctive treatment for self-administered facial rejuvenation.
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