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Min Ji Kim,Jong Min Kim,Jong Hyun Moon,Hyo Lim Lee,Hye Rin Jeong,Min Ji Go,Tae Yoon Kim,Seung Gyum Joo,Ho Jin Heo 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
In this study, anti-inflammatory effect of the ethyl acetate fraction of Eucommia ulmoides leaves (EFEL) on particulate matter (PM)2.5-induced intestinal damage mice model was evaluated. The EFEL showed a cytoprotective effect against PM2.5-induced cell death in HT29 cells. The EFEL ameliorated reduced glutathione (GSH) and superoxide dismutase (SOD) level in intestinal tissue. In addition, EFEL inhibited the intestinal malondialdehyde (MDA) levels. Furthermore, myelin peroxidase (MPO) level using the marker of intestinal inflammation was decreased in the EFEL group. Furthermore, the inflammatory cytokines such as (IL-1β, TNF-α and p-IκB-α) levels were decreased in the EFEL group. Also, intake of EFEL protected the tight junction proteins such as occluding and claudin-1 on PM2.5-induced intestine damage mice.
Hye Rin Jeong,Jong Min Kim,Jong Hyun Moon,Min Ji Kim,Hyo Lim Lee,Min Ji Go,Tae Yoon Kim,Seung Gyum Joo,Ho Jin Heo 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
This study was investigated to evaluate a protective effect of ethyl acetate fraction from Cedrela sinensis (EFCS) on H₂O₂ and corticosterone-induced oxidative stress in hippocampal HT22 and human neuroblastoma MC-IXC cells. 40% ethanolic extracts of Cedrela sinensis showed higher total phenolic and total flavonoid contents than other ethanolic extracts. The EFCS showed the significant, 2,2"-azino-bis (3-ethyl benzothiazoline-6-sulfonic acid) (ABTS) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities. The EFCS presented significant antioxidant capacity by evaluating the ferric reducing/antioxidant power (FRAP). The EFCS showed considerable inhibitory effect of malondialdehyde (MDA) levels and acetylcholinesterase (AChE) activity. In addition, the EFCS inhibited ROS production and increased cell viability in H₂O₂ and corticosterone-induced cytotoxicity in HT22 and MC-IXC cells. Main physiologically compounds of EFCS were identified as rutin, isoquercetin, ethyl gallate, quercetin, kampferol-3-O-rhamnose and ethyl digallate using ultrahigh performance liquid chromatography-quadrupole time of flight/mass spectrometer (UPLC-QTOF/MS).
Min Ji Go,Jong Min Kim,Jong Hyun Moon,Min Ji Kim,Hyo Lim Lee,Hye Rin Jeong,Tae Yoon Kim,Seung Gyum Joo,Ho Jin Heo 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
In this study, the improvement effect of Korean red pine (Pinus densiflora) bark extract (PineXol<SUP>®</SUP>) against the behavioral dysfunction and neurotoxicity in amyloid beta (Aβ)1-42-induced ICR mice was confirmed. Consumption of PineXol<SUP>®</SUP> improved learning and memory dysfunctions compared to the Aβ group by evaluating the Y-maze, passive avoidance and Morris water maze tests. The PineXol<SUP>®</SUP> regulated acetylcholinesterase (AChE) activity, acetylcholine (ACh) content and expression of choline acetyltransferase (ChAT) and AChE related to a cholinergic system. In addition, the PineXol<SUP>®</SUP> restored antioxidant defisit by regulating the malondialdehyde (MDA) and reduced glutathione (GSH) levels in mouse brain tissue. Furthermore, PineXo<SUP>l®</SUP> significantly improved mitochondrial activity by ameliorating the mitochondrial membrane potential (MMP) and mitochondrial reactive oxygen species (ROS) level.