한국형 우울장애 약물치료 알고리듬 2006 (Ⅰ)

서정석,민경준,김원,석정호,박원명,송해철,이상열,전덕인,전현태,홍진표,한국형 우울장애 약물치료 알고리듬 2006 연구그룹 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.5

Objectives : Since the publication of Korean Medication Algorithm Project for Major depressive Disorder (KMAP-MD) in 2002, there has been a substantial need for a revision due to rapid progress in the pharmacological management for depressive disorder. We revised KMAP-MD to Korean Medication Algorithm Project for Depressive Disorder (KMAP-DD) in 2006. This paper is one of the following 4 papers consisting of Korean pharmacological algorithm for depressive disorder. Methods : The questionnaire consisted of 4 parts ; initial treatment of 1) non-psychotic depressive disorder, 2) psychotic depressive disorder, 3) treatment strategy for clinical subtypes and drug choice considering adverse effects, and 4) treatment for depressive disorder in women. It was composed of 22 questions, and each question had 54 sub-items. The questionnaire was completed by the review committee consisting of 101 experienced Korean psychiatrists. We classified the expert opinion to 3 categories (the first-line, the second-line, or the third-line). Results : For non-psychotic major depression, regardless ofthe severity of an episode, the antidepressant (AD) monotherapy was the optimal first-line treatment. SSRI, venlafaxine, and mirtazapine were the 1st-line AD. In case of a partial or no response to initial strategy, adding another AD was recommended. For psychotic major depression, combination of an AD and an atypical antipsychotic (AAP) was the treatment of choice. Among AAPs, quetiapine, rispendone, olanzapine were preferred. For non-responder to initial strategy, the next step was adding or changing AD before changing AAP. For women with premenstrual dysphoric syndrome or postpartum depression without psychotic features, AD monotherapty was a preferred strategy while for psychotic postpartum depression, combination of AD and AAP was recommended. Experts recommended various ADs according to adverse effect. Conclusion : These results suggest that the medication strategies for depressive disorder are rapidly changing and reflect the recent studies and clinical experiences.

기능성 소화불량증 환자의 질병특이적 삶의 질과 질병 의거

이상열,박민철,최석채,설지환,서현우,류미경,최명규 圓光大學校 醫科學硏究所 2004 圓光醫科學 Vol.19 No.1

多收性도토리의 遺傳資源과 優良種의 選拔에 관한 硏究

趙顯瑞,李喆浩,安相烈 진주산업대학교 1998 論文集 Vol.37 No.-

상수리나무, 굴참나무, 졸참나무, 갈참나무, 신갈나무 및 떡갈나무를 중심으로 우수한 형질을 나타내는 48개체 중 선발된 수종의 형질 특성을 농촌진흥청 원예시험장 과수조사 기준에 따라 果樹化를 위한 주요 형질인 葉長, 葉幅, 新梢長, 節間數, 新梢莖, 果重, 과종경, 과횡경 및 熱期를 각 지역별로 조사한 결과를 요약한다. 가. 선발 1년차 1. 굴참나무의 개체선발 결과 평균 흉고직경이 21㎝, 수고10m, 수관폭 4m 정도이고 수령은 20-25년생으로 그 중 우량종으로 개체선발된 굴참나무는 흉고직경 23㎝, 수고 12m, 수령 25년생이었으며, 떡갈나무는 평균 흉고직경 20㎝, 수고 8-9m, 수관폭 4m, 수령 20년생으로 그 중 우량종으로 개체선발된 떡갈나무는 흉고직경 20㎝, 수고 8m, 수령 20년생으로 수간이 곧고 수관폭이 4m 정도였다. 2. 졸참나무는 평균 흉고직경 25㎝, 수고 13m, 수관폭 4m, 수령 25년생 정도로 그 중 우량종은 흉고직경 25㎝, 수고 10m, 수령 20년생으로 수간이 곧고 수관의 폭은 5m였다. 3. 농가 탐문조사에 의한 개체선발 결과 우수종의 신초장 생육은 함양선발종Ha-6, 7, 14호가 가장 크게 신장했고, 잎의 형태는 수종별로 다양한 것으로 나타났으며, 종실의 무게는 산청선발종S-2, 9호가 7.2g과 5.7g으로 가장 무거운 것으로 나타났고, 종실의 형태는 난형, 장타원형 등 수종에 따라 다양하였다. 나. 선발 2년차 1. 상수리나무의 과중이 무겁고, 졸참나무류의 과종경이 횡경에 비해 길었으며 다수종의 평균 과중은 3.1g이고 과종경은 평균 20.4㎜인 것으로 나타났다. 2. 평균 과중이 무거운 종은 산청선발종S-2, 9호등이고, 가벼운 종은 함양선발종H-7, 19호등이며, 숙기 조사 결과 함양선발종H-4, 진주금곡면수집종JS-1, 구례종G-1 등이 조생종이고 함양종H-10, 산청종S-7, 합천종Ha-1 등은 중생종, 함양종H-7, 산청종S-3, 산청생비락면종SS-0 등은 만생종이었다. To improve the genetic resources of acorn, we selected some genetically desirable ones among a population of acorn trees. The survey sites for this study were natural forests where mother trees were growing, and where their genetic characteristics were developed through natural selection. According to the standard list of elite tree collection, 6 species(48 individual Fagaceae trees) were selected, among which 21 were in their 1st year and 27 in their 2nd year. The extension of shoot length was longest in Hamyang line(H-6, H-7 and H-14). The weight of acorn was heavier than others in Sancbung line(Sa-2 and Sa-9), and the acorn type was ovate and oblong. The average weight of individual acorn was 3.1g and its average diameter was 20.4㎜. With respect to fruit maturing period, H-4 of Hamyang variety, CK-1 of Kumgok line and G-1 of Gurye line were precocious species; H-10 of Hamyang line, Sa-7 of Sancbung line and WH-1 of Hapcbun line were intermediate ripening species; H-7 of Hamyang line, Sa-3 of Sancbung line and Ss-0 of Sangbirak line were late ripening species.

한국형 우울장애 약물치료 알고리듬 2006 (Ⅲ) : 정신병적 양상을 동반한 주요우울삽화

김원,박원명,서정석,민경준,석정호,전덕인,전현태,이상열,송해철,홍진표,한국형 우울장애 약물치료 알고리듬 2006 연구그룹 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.6

Objectives : Since the publication of Korean Medication Algorithm Project for Major DepressiveDisorder (KMAP-MD) in 2002, there has been a substantial need for a revision due to rapid progress in the pharmacological management of depressive disorder. We revised KMAP-MD 2002 and developed the Korean Medication Algorithm Project for Depressive Disorder (KMAP-DD) 2006. Methods : We developed a questionniare for surveying the opinion of experts on pharmacotherapy of depressive disorder. The questionnaire consisted of 4 parts ; 1) treatment of non-psychotic depressive disorder, 2) treatment of psychotic de-pressive disorder, 3) treatment according to clinical subtypes and drugs choice considering adverse effects, and 4) treatment of depressive disorder in women. The questionnaire was completed by the review committee consisting of 101 experienced Korean psychiatrists. It is composed of 22 questions, and each question includes 54 sub-items. We classified the expert opinionto 3 categories (the first-line, the second-line, or the third-line) by χ²-test. Results : For depressive disorder with psychotic features, most reviewers prefer the combination of antidepressant and atypical antipsychotics. Electroconvulsive therapy and the combination of antidepressant and typical antipsychotics were the second-line treatment. Among antidepressants, venlafaxine was the most preferred, and SSRI and mirtazapine followed. Among atypical antipsychotics, quetiapine, risperidone and olanzapine were the most preferred, in this order. In patients who have no response to the first-line treatment, many reviewers recommended switching to another antidepressant or adding another atypical antipsychotics Conclusion : For severe depressive disorder with psychotic features, the combination of antidepressant and atypical antipsy-chotics was preferred for the first-line treatment. These results suggest that the medication strategies of depressive disorder are rapidly changing and reflects the recent studies and clinical experiences.

한국형 우울장애 약물치료 알고리듬 (Ⅳ) : 우울장애의 아형 및 부작용에 따른 항우울제의 선택과 여성우울장애에서의 치료전략

전현태,이상열,김원,민경준,박원명,서정석,석정호,송해철,전덕인,홍진표,한국형 우울장애 약물치료 알고리듬 2006 연구그룹 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.6

Objectives : In 2002, the Korean Medication Algorithm Project for Major depressive Disorder (KMAP-MD) was published, but there has been a need for a guideline about detailed issues of depressive disorder. We revised KMAP-MDD andreestablished Korean Medication Algorithm Project for Depressive Disorder (KMAP-DD) in 2006. Methods : A questionnaire had been developed by the executive committee for KMAP-DD. The review committee consisted of 101 experienced psychiatrists. From the total of 22 questions in the questionnaire, 7 questions were evaluated for these subjects . We classified the expert opinions to 3 categories according to its confidence interval; first, second and third line. Results : SSRI and venlafaxine were the first line antidepressants (AD) for atypical and melancholic depression. For dysthymic disorder and minor depressive disorder, SSRI was recommended as the first line medications. Only AD medications was a preferred initial strategy for treating premenstrual dysphoric disorder, mild to moderate and severe non-psychotic postpartum depression. In severe psychotic postpartum depression, combination therapy of AD and atypical antipsychotics was the treatment of choice. SSRI was preferred when considering sedation, anticholinergic and cardiovascular adverse effects. Also, experts recommended mirtazapine against gastrointestinal adverse effects and bupropion in avoiding sexual dysfunction. Conclusion : These results suggest that clinicians have to consider both clinical situations and drug adverse effects in the choice of antidepressant medications.

간척지에서 옥수수 나방류 해충 3종의 발생소장

이휘종,최원영,김상열,서종호,황정동,오성환,정진교,김주일,구현나,김길하 忠北大學校 農業科學硏究所 2015 農業科學硏究 Vol.31 No.2

Occurrence of three troublesome lepidopterous pests, Ostrinia furnacalis, Helicoverpa armigera and Pseudaletia separata in corn cultivation of the reclaimed land were recorded using sex pheromone traps from 2012 to 2014. In case of O. furnacalis adult, two generations were observed in a year and its occurrence pattern was very regular. The 1st generation showed the highest occurrence in late May-early June and the 2nd generation was in late July-early August. On the other hand, H. armigera occurred at least three times a year but its occurrence was somewhat irregular. H. armigera adult showed the highest occurrence in mid May, late June, early August, respectively in 2012 but their occurrence patterns of the 2nd and 3rd generations were varied in 2013 and 2014. In case of P. separata, a few number of adult were captured during the survey period, indicating few number of P. separata migrated from China. Based on the control effect of O. furnacalis by Etofenprox and Carbofuranin 2012, June 26 treatment showed the highest control rate with 96.8% for Etofenprox, 85.8% for Carbofuran, respectively. Late treatment at June 19 and June 26 significantly decreased the control rate of O. furnacalis and June 26 treatment showed the lowest control rate of 1.9% for Etofenprox. 18.1% for Carbofuran, respectively.

Swanson의 주의력결핍 장애척도의 한국판 표준화

이종범,박성찬,정성덕,김진성,서완석,배대석,주열 대한생물치료정신의학회 2002 생물치료정신의학 Vol.8 No.2

연구목적 : 한국판 Swanson의 주의력 결핍 장애 척도(이하 SNAP)의 신뢰도와 타당도를 검증하고, 이를 국내 실정에서 주의력결핍 과잉행동장애 환자를 선별할 수 있는 평가용 도구로서 적합한지 여부와 연구에 사용할 수 있는지를 알아보고자 하였다. 방 법 : 1998년 7월 1일부터 2001년 9월 30일까지 영남대학교 의료원 신경정신과 외래를 방문한 주의력결핍 과잉행동장애 환자 392명과 정상대조군 432명을 대상으로 SNAP을 시행하였다. 결 과 : 남녀 간의 SNAP 척도 점수비교에서, 환자군에서는 유의한 차이가 없었으나 정상 대조군에서는 남자가 유의하게 높게 나타났다(p<.01 ∼ .001). 검사-재검사 신뢰도 검증에서 신뢰도 계수는 각 하위 척도에서 .85에서 .92로 모두 만족할 만큼 높았다(p<.05). 내적일관성에 의한 신뢰도 검증에서 정상 및 환자군에서 각 하위척도별로 Cronbach α값이 .80(p.05)이상으로 나타났고, 반분신뢰도는 정상 및 환자군에서 각 하위척도별로 0.731에서 .866사이였다(p<.05). 주의결핍장애 평가 척도-가정관(Attention Deficit Disorder Evaluation Scale-Home Version) 및 소아기 집중력 문제 척도(Childhood Attentin Problem Scale)와의 준거 타당도는 ADHD 환자군에서 .342에서 .713사이였고(p<.05), 정상 대조군에서 .551에서 .789였다(p<.05). 요인분석을 해 본 결과 본 척도는 3개의 요인으로 분류되었는데, 부주의(inattention) 요인, 충동성/과잉행동(impulsivity/hyperactivity)요인, 또래 관계(peer interaction)요인으로 구분되었다. 본 척도가 정상인과 환자를 감별할 수 있는 척도인가를 알아보기 위한 감별 타당도 검사를 해본 결과 87.5%를 분류하여 높게 나타났다. 환자와 정상인을 구분하는 점수인 절단점은 표준편차 1.5를 절단점으로 잡을 때 이는 백분율로 93percentile에 해당하는 점수로서 각 소척도 점수에서 남자(0.98∼1.65)와 여자(0.64∼1.38)의 절단점이 다르게 나타났으며 남자가 높게 나타났다. 결 론 : 이상의 결과에서 볼 때 한국판 SNAP 평가 척도의 신뢰도와 타당도가 입증되었고 환자를 판별하는 능력이 우수하여 향후 ADHD 연구에 유용한 도구로 사료된다. Objectives : The purpose of this study was to examine reliability and validity of Swanson's attention deficit disorder sacale(SNAP). Method : SNAP was administered to 432 elementary school students and 392 patients who were diagnosed as attention deficit hyperactivity disorder in Yeungnam university hospital from 1998 July to 2001 September. Results : In the reliability test, the test-retest reliability coefficient was significantly high and that of inattention was 0.85, that of impulsivity was 0.90, that of hyperactivity was 0.90 and that of peer interaction was 0.92(p<.05). In the reliability test by internal consistency, the Cronbach α coefficient was above 0.80 at each subscale in both patients and normal control group(p<.05). The split-half reliability coefficient by first-second half method showed high correlation and those of each scales were from 0.731 to 0.866 in both patients and normal control group(p<.05). The criterion validity of SNAP with Attention Deficit Disorder Evaluation Scale-Home Version(ADDES-HA) and Childhood Attention Problem Scale(CAP) scale was from 0.342 to 0.713 in patients group, from 0.551 to 0.789 in normal control group(p<0.05). The discriminant ability between ADHD and normal subjects by SNAP was 87.5%. Conclusion : In this point of view, SNAP scale showed high reliability and validity in applying to Korean subjects and was proved to be useful screening tool for attention deficit hyperactivity disorder reserch.

Nanogenerators: Fully Rollable Transparent Nanogenerators Based on Graphene Electrodes (Adv. Mater. 19/2010)

Choi, Dukhyun,Choi, Min-Yeol,Choi, Won Mook,Shin, Hyeon-Jin,Park, Hyun-Kyu,Seo, Ju-Seok,Park, Jongbong,Yoon, Seon-Mi,Chae, Seung Jin,Lee, Young Hee,Kim, Sang-Woo,Choi, Jae-Young,Lee, Sang Yoon,Kim, Jo WILEY-VCH Verlag 2010 ADVANCED MATERIALS Vol.22 No.19

<B>Graphic Abstract</B> <P>The cover shows an image of fully rollable transparent nanogenerators synthesized using chemical vapor deposition grown large-scale graphene sheets as transparent electrodes and piezoelectric ZnO nanorod arrays. Sang-Woo Kim, Jae-Young Choi, and co-workers report on p. 2187 the electrical and structural stability of the nanogenerators, with excellent charge scavenging performance under external mechanical loads such as bending and rolling. This study shows that graphene-based nanogenerators are very promising for self-powered rollable transparent device applications. <img src='wiley_img_2010/09359648-2010-22-19-ADMA201090066-content.gif' alt='wiley_img_2010/09359648-2010-22-19-ADMA201090066-content'> </P>

The Impact of Unrecognized Anxiety on Health-related Quality of Life in Patients with Functional Dyspepsia

( Sang Yeol Lee ),( Suck Chei Choi ),( Yong Sung Kim ),( Young Woo Sohn ),( Yong Yeol Oh ),( Geom Seog Seo ),( Tae Hyeon Kim ),( Myung Gyu Choi ),( Yong Ho Nah ) 대한소화관운동학회 2005 대한소화관운동학회 춘계학술대회 Vol.16 No.-

<Objective> Gastroenterologists have been criticized for underrecognizing and undertreating mental health disorders. This criticism assumes patients with recognized disorders and those with unrecognized disorders suffer the same burden of illness. The cur

Differential Sensitivity of Rice Cultivars to HPPD - Inhibiting Herbicides

Sang-Yeol Kim,Sang-Ik Han,Jong-Hee Lee,Seong-Hwan Oh,Woo-Duck Seo,Ki-Chang Jang,Ji-Eun Na,Jun-Hyeon Cho,Ji-Yoon Lee,Kyung-Jin Choi,You-Chun Song,Un-Sang Yeo,Hang-Won Kang 한국잡초학회 2011 한국잡초학회 별책(학술대회 초록집) Vol.31 No.2