삼천리 열처리(주)

삼천리열처리주 한국열처리공학회 1989 熱處理工學會誌 Vol.2 No.4

항암제 투여 환자의 우울 양상

주열,서완석,김진성,이종범,정성덕,송신호,배대석,이경희,현명수 한국정신신체의학회 2002 정신신체의학 Vol.10 No.2

아동기 외상에서 FK506 Binding Protein 5의 유전자 환경 상호작용과 후생유전적 조절

주열(Yeol Joo) 대한생물치료정신의학회 2014 생물치료정신의학 Vol.20 No.1

It is well known that trauma during childhood significantly increases risk for posttraumatic stress disorder(PTSD), other mood and anxiety disorder in adulthood. Childhood trauma is known as altered regulations of the HPA axis in adulthood. Considering the importance of the HPA system in the etiology of PTSD, the effect of childhhood trauma on adult with PTSD and other psychiatric disorders may be mediated by dysregulation of the HPA axis. Recently, it has been recognized that for the development of PTSD, complex interplay between genetic predisposition and environmental factors plays crucial roles. FKBP5, which is a HSP90-associated co-chaperone, regulates sensitivity of glucocorticoid receptor. Multiple studies replicated the findings that interaction of FKBP5 genetic variants and childhood trauma significantly increased the risk of adult PTSD, suicide attempt and aggressive behaviour. Recent studies suggest that in specific risk allele of FKBP5 single nucleotide polymorphism(SNP), 3D conformational change of intron increases the expression of FKBP5 in response to stress. In addition, the model which explains the difference of epigenetic modulation of FKBP5 between risk allele and protective allele has been proposed. The findings that in FKBP5 SNP risk allele, relative irreversibility of cytosine demethylation by environmental factor occurs only in developmentally vulnerable period, may shed light on molecular underpinnings of long lasting effect of childhood trauma.

Enhanced Magnetic Moments of Ultrathin Fe Film Epitaxially Grown on Ag(100) Surface

주열 이 한국물리학회 2005 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.46 No.1

The electronic structures of 3 monolayers of Fe ultrathin ¯lm epitaxially grown on Ag(100) surface were calculated by using a full-potential linearized-augmented-plane-wave method within the local-spin-density approximation to the density-functional theory. The magnetic moments of the Fe atoms are enhanced compared to that of bulk Fe. The lowest layer (closest to the bulk Ag) and the topmost layer have signi¯cantly enhanced magnetic moments of 2.94 and 2.99 ¹B/atom, respectively, compared to that of the bulk Fe metal (2.25 ¹B/atom). The middle layer Fe atom has the magnetic moment of 2.43 ¹B/atom, which is also slightly larger than that of the bulk Fe atom. The enhancement of the magnetic moments is mainly due to the change in the occupation numbers of the t2g components of the d-bands, and the eg components play an insigni¯cant role.

주의력결핍 과잉행동장애의 신경생물학적 병태생리

박형배,주열 영남대학교 의과대학 2000 Yeungnam University Journal of Medicine Vol.17 No.2

Background : Medels of attention deficit hyperactivity disorder(ADHD) that have proposed a hypodopaminergic state resulting in hypofunction of the prefrontal circuitry have assumed a unitary dopamine system, which largely ignores the distinct functional differences between mesocortical dopamine system and nigrostriatal dopamine system. Purpose : The author's goal was to develop a pathophysiological model for ADHD with greater explanotory power than dopaminergicc hypofunction hypothesis in prefronal circuitry. Material and Methods : Published clinical findings on ADHD were integrated with data from genetic, pharmacological, neuroimaging studies in human and animals. Results : Molecular genetic studies suggest that three genes may increase the susceptibility to ADHD. The three candidate genes associated with ADHD are each involved in dopaminergic function, and this consistent with the neurobiologic studies implicating catecholamines in the etiology of ADHD. Pharmacological data also provide compelling support for dopamine and noradrenergic hypothesis of ADHD. Neuroimaging studies lend substantial support for the hypothesis that right-sided abnormalities of prefrontal-basal ganglia circuit would be found in ADHD. Conclusions : The present hypothesis takes advantage of the major differences between the two pertinent dopamine systems. Mesocortical dopamine system, which largely lacks inhibitory autoreceptors, is ideally positioned to regulate cortical inputs, thus improving the signal-to-noise ration for biologically valued signals. In this circuit, therapeutic doses of stimulants are hypothesized to increase postsynaptic dopamine effects and enhance executive functions. By contrast, symptoms of hyperactivity/impulsivity in ADHD are hypothesized to be associated with relative overactivity of nigrostriatal circuit. This nigrostriatal circuit is tightly regulated by inhibitory autoreceptors as well as by long distance feedback from the cortex, and slow diffusion of therapeutic doses of stimulant via oral administration is hypothesized to produce a net inhibition of dopaminergic neurotransmission and improves hyperactivity.

뇌 손상 정도 및 전두엽 손상 유무에 따른 외상성 뇌 손상 환자의 주관적 정신병리

김경근(Kyoung-Keun Kim),주열(Yeol Joo),김진성(Jin-Sung Kim),이종범(Jong-Bum Lee),김오룡(Oh-Lyong Kim),서완석(Wan-Seok Seo),배대석(Dai-Seg Bai),구본훈(Bon-Hoon Koo) 대한생물치료정신의학회 2010 생물치료정신의학 Vol.16 No.1

외상성 뇌손상(traumatic brain injury;이하 TBI)환자에서 외상의 심각도와 전두엽 손상 여부에 따른 정신과적 증상에 대해 알아보기 위해 1998년 7월부터 2008년 10월까지 TBI 환자 110명을 대상으로 연구를 시행하였다. 이들을 손상의 심각도에 따라 경도 뇌손상군(mild TBI, 이하 MTBI)과 중등도 뇌손상군(moderate TBI, 이하 MOTBI)으로 나누고, 이를 전두엽 손상 유무에 따라 각각 전두엽 손상군(frontal lobe injury, 이하 FLI)과 비전두엽 손상군(non-frontal lobe injury, 이하 NFLI)으로 구분하였다. 각 군에 대해 병록지 자료 수집 및 SCL-90-R과 MMPI를 시행하였다. SCL-90-R에서 뇌 손상이 심한 경우 정신증 척도가 높고 증상을 더 많이 호소하는 경향을 보였으나 전두엽 손상 유무에 따라서는 차이가 없었다. MMPI의 경우에는 경조증 척도가 뇌손상의 심각도와 전두엽 손상 여부 간의 상호작용이 나타났다. 따라서 뇌손상의 정도가 증가하는 경우 인지기능의 저하에 따른 경조증 증상에 대한 주의가 필요하다. Objectives:The objective of this study was to investigate the subjective psychopathology in patients with traumatic brain injury according to their severity and existent of frontal lobe injury. Methods:S110 patients with traumatic brain injury were selected for study. After classifying patients into mild traumatic brain injury(MTBI) group and moderate traumatic brain injury(MOTBI) group with Glasgow Coma Scale score, each group was subdivided into frontal lobe injury(FLI) group and non frontal lobe injury(NFLI) group. Psychological tests were administered using Korean Wechsler adult intelligence scale(K-WAIS), Symptom checklist 90 revised (SCL-90-R) and Minnesota multiphasic personality inventory(MMPI). Results:Psychoticism score and positive symptom distress level in SCL-90-R was higher in MOTBI group than MTBI group. There was significant interaction between injury severity and existent of frontal lobe injury in hypomanic scale score of MMPI. Conclusion:Careful evaluation of psychotic and affective symptoms are warranted for TBI patients with increasing severity and existent of frontal lobe injury.

중국거주 조선족 여성의 영적 안녕정도가 정신건강에 미치는 영향

정성덕,이종범,김진성,서완석,배대석,박순재,주열,염형욱,김승원,김구묘,안영록,황대홍,표미자,조창열,정태길 영남대학교 의과대학 2004 Yeungnam University Journal of Medicine Vol.21 No.2

자아초월 정신의학이 체계화되면서 영성(spirituality)은 인성의 한 부분이라는 이론이 대두되었는데 이 영성은 정신건강에 큰 영향을 미친다고 했다. 인간의 성향 중 영적 안녕 정도를 파악하여 그 정도가 정신건강 중 허위성 경향, 정신병적 경향 및 불안과 우울 경향 등에 어떠한 영향을 미치는지를 조사하고저 본 연구를 실시하였다. 대상은 중국의 연변 조선족 자치구에 거주하는 여성 400명을 대상으로 하여 한국판 영적 안녕척도를 사용하여 영적 안녕정도를 파악하였다. 영적 안녕척도의 총점과 이 척도의 2개 하위 척도인 종교적 안녕과 실존적 안녕 척도 양자로 평가한 성적이 불안-우울통합척도와 정신분열증 척도 및 허위성 척도로 평가한 성적에 미치는 영향을 검증하기 위하여 상관관계분석 및 회기분석을 실시하였다. 그 결과는 다음과 같다. 1) 영적 안녕척도로 평가한 조선족 여성의 총점은 68.29로 한국의 기독교 여성이 평가한 100.65보다 훨씬 낮은 점수였다. 2) 불안·우울통합척도로 평가한 총점은 44.88로 연변노인이 평가한 점수와 일개지역의 한국농촌주민이 평가한 점수와 비슷한 결과였다. 3) 허위성 척도로 평가한 성적은 평균 74.57로 70점 이상이 86%(344명)이었으나 영적 안녕 성적과 허위성 성적 간에는 유의한 상관이 없었다. 4) 영적 안녕총점은 정신분열증 척도로 평가한 정신병적 경향에 유의한 영향을 미치지 않았으나 종교적 안녕하위척도의 성적은 정신병적 경향을 높여준데 비하여 실존적 안녕하위척도의 성적은 정신병적 경향을 낮게 해주었다. 5) 영적 안녕척도의 총점 및 두 하위척도인종교적 안녕과 실존적 안녕은 불안과 우울에유의한 상관을 보였는데 영적 안녕총점이 높을수록 불안·우울 총점이 다소 낮아지는 경향을 보였다. 6) 종교적 안녕 하위척도와 불안과 우울과의 관계는 종교적 안녕점수가 높을수록 불안과 우울을 각각 다소 유의하게 높여주었으며 이에 비하여 실존적 안녕하위척도와 불안과 우울과의 관계는 실존적 안녕정도가 높을수록 불안 및 우울점수는 유의하게 낮아졌다. 이와 같은 성적을 미루어볼 때 연변에 거주하는 조선족 여성이 평가한 영적 안녕정도는 정신병적 경향과 불안 및 우울에 유의한 상관을 보였으면 이 척도의 하위 척도인 종교적 안녕정도는 정신건강에 부정적인 영향을 미치는 반면 실존적 안녕정도는 정신건강에 긍정적 영향을 미친 결과로 평가되었다. 이러한 결과는 공산주의 사회에서 실존적 안녕은 긍정적인 가치관으로 평가되는 반면 종교적 안녕은 정신건강에 부정적으로 작용한 것을 입증해 주었다고 하겠다. Background: Spirituality has been an important part of Transpersonal Psychology and is believed to have a large effect on the mental health because it has been systematized. The aim of this study was to determine the level of spiritual disposition on human beings along with its effects on one's mental health. Materials and Methods: The study targeted 400 women residing in Youn-Gil city of JiLin Prov., which is a district of the Cho-Sun tribe in China. Their spiritual well-being was studied using the Spiritual Well-being Scale-Korean Version. The spiritual well-being scale consists of 2 sub-scales of religious well-being and existential well-being. The study was evaluated using a lie scale, psychotic trend, and a combined anxiety-depression scale. The results were considered to be factors of one's mental health. The correlation between the spiritual well-being and each tendency was analyzed by regression analysis. Results: The total score of the Cho-Sun tribal women according to the spiritual well-being scale was 68.29 which was much less than the 100.65 of Korean Christian women. There was no significant correlation between the spiritual well-being and the Lie trend. However, it was found that 86%(344) of Cho-Sun tribal women scored above 70 in the Lie trend with a mean score of 74.57 which is higher than normal populations. Regarding the correlation between the spiritual well-being and psychotic trend, the psychotic trend became significantly higher when the religious well-being was at a high level. On the other hand, the psychotic trend became significantly lower when the existential well-being was at a high level. Regarding the correlation between the spiritual well-being and anxiety, the anxiety was significantly higher when the religious well-being was at a high level. However, the anxiety level was significantly low when the existential well-being was at a high level. Regarding the correlation between the spiritual well-being and depression, the depression level was somewhat significantly high when the religious well-being was at a high level. However, the depression level was significantly low when the existential well-being was at a high level. Conclusion: This study evaluated the effects of spiritual well-being on a person's mental health among Cho-Sun tribal women in Youn-Gil city of JiLIn Prov., P.R. of China. The results found that the religious well-being, which is a sub-scale of spiritual well-being, had negative effects while the existential well-being had positive effects on the mental health. These results proved that a person's religious disposition had negative effects on their mental health in a communitarian society.

Swanson의 주의력결핍 장애척도의 한국판 표준화

이종범,박성찬,정성덕,김진성,서완석,배대석,주열 대한생물치료정신의학회 2002 생물치료정신의학 Vol.8 No.2

연구목적 : 한국판 Swanson의 주의력 결핍 장애 척도(이하 SNAP)의 신뢰도와 타당도를 검증하고, 이를 국내 실정에서 주의력결핍 과잉행동장애 환자를 선별할 수 있는 평가용 도구로서 적합한지 여부와 연구에 사용할 수 있는지를 알아보고자 하였다. 방 법 : 1998년 7월 1일부터 2001년 9월 30일까지 영남대학교 의료원 신경정신과 외래를 방문한 주의력결핍 과잉행동장애 환자 392명과 정상대조군 432명을 대상으로 SNAP을 시행하였다. 결 과 : 남녀 간의 SNAP 척도 점수비교에서, 환자군에서는 유의한 차이가 없었으나 정상 대조군에서는 남자가 유의하게 높게 나타났다(p<.01 ∼ .001). 검사-재검사 신뢰도 검증에서 신뢰도 계수는 각 하위 척도에서 .85에서 .92로 모두 만족할 만큼 높았다(p<.05). 내적일관성에 의한 신뢰도 검증에서 정상 및 환자군에서 각 하위척도별로 Cronbach α값이 .80(p.05)이상으로 나타났고, 반분신뢰도는 정상 및 환자군에서 각 하위척도별로 0.731에서 .866사이였다(p<.05). 주의결핍장애 평가 척도-가정관(Attention Deficit Disorder Evaluation Scale-Home Version) 및 소아기 집중력 문제 척도(Childhood Attentin Problem Scale)와의 준거 타당도는 ADHD 환자군에서 .342에서 .713사이였고(p<.05), 정상 대조군에서 .551에서 .789였다(p<.05). 요인분석을 해 본 결과 본 척도는 3개의 요인으로 분류되었는데, 부주의(inattention) 요인, 충동성/과잉행동(impulsivity/hyperactivity)요인, 또래 관계(peer interaction)요인으로 구분되었다. 본 척도가 정상인과 환자를 감별할 수 있는 척도인가를 알아보기 위한 감별 타당도 검사를 해본 결과 87.5%를 분류하여 높게 나타났다. 환자와 정상인을 구분하는 점수인 절단점은 표준편차 1.5를 절단점으로 잡을 때 이는 백분율로 93percentile에 해당하는 점수로서 각 소척도 점수에서 남자(0.98∼1.65)와 여자(0.64∼1.38)의 절단점이 다르게 나타났으며 남자가 높게 나타났다. 결 론 : 이상의 결과에서 볼 때 한국판 SNAP 평가 척도의 신뢰도와 타당도가 입증되었고 환자를 판별하는 능력이 우수하여 향후 ADHD 연구에 유용한 도구로 사료된다. Objectives : The purpose of this study was to examine reliability and validity of Swanson's attention deficit disorder sacale(SNAP). Method : SNAP was administered to 432 elementary school students and 392 patients who were diagnosed as attention deficit hyperactivity disorder in Yeungnam university hospital from 1998 July to 2001 September. Results : In the reliability test, the test-retest reliability coefficient was significantly high and that of inattention was 0.85, that of impulsivity was 0.90, that of hyperactivity was 0.90 and that of peer interaction was 0.92(p<.05). In the reliability test by internal consistency, the Cronbach α coefficient was above 0.80 at each subscale in both patients and normal control group(p<.05). The split-half reliability coefficient by first-second half method showed high correlation and those of each scales were from 0.731 to 0.866 in both patients and normal control group(p<.05). The criterion validity of SNAP with Attention Deficit Disorder Evaluation Scale-Home Version(ADDES-HA) and Childhood Attention Problem Scale(CAP) scale was from 0.342 to 0.713 in patients group, from 0.551 to 0.789 in normal control group(p<0.05). The discriminant ability between ADHD and normal subjects by SNAP was 87.5%. Conclusion : In this point of view, SNAP scale showed high reliability and validity in applying to Korean subjects and was proved to be useful screening tool for attention deficit hyperactivity disorder reserch.

멀티 에이전트를 이용한 도로정체에 따른 교통흐름 예측 및 통합제어

조기용(Kiyong Cho),배철호(Chulho Bae),이정환(Junghwan Lee),주열(Yul Chu),서명원(Myungwon Suh) 한국자동차공학회 2006 한국 자동차공학회논문집 Vol.14 No.5

멀티 에이전트를 이용한 도로정체에 따른 교통흐름 예측 및 통합제어Ⅰ

조기용(Kiyong Cho),배철호(Chulho Bae),김현준(Hyunjun Kim),주열(Yul Chu),서명원(Myungwon Suh) 한국자동차공학회 2007 한국 자동차공학회논문집 Vol.15 No.1