Korean Dictionaries and Some Model Dictionaries of the World : Critical Essays toward the Plan for a New Korean Dictionary

Lee, Sang Sup,Nam, Ki Shim,Ahn, Sam Huan,Choi, Young Ai,Hong, Chai Song 연세대학교 언어정보개발원 1988 사전편찬학 연구 Vol.1 No.1

After briefly reviewing the history of lexcoigraphy in modem Korea, Nam Kishim tackles many problems created by the general deficiency of current Korean monolingual dictionaries in phonological morphological and semantic points. For example, most Korean dictionaries do not treat such phonological changes as the shortening of the stem vowel ㅓ in 더운, the prenominal form of the adjective 덥다, whose stem vowel ㅓ is pronounced long. He also takes issue with the practice of Korean dictionaries of including all kinds of proper names on little reliable principles : a typical dictionary enters a 600m-high hill while excluding better-known mountains higher than that. Hong Chai-song concentrates on the often misguiding information on transitive / intransitive verbs in current dictionaries. For example, a representative dictionary designates the verb 뛰다 simply as intransitive. But it is quite often used as an transitive also. In the sentence, 철수는 운동장을 뛰었다, 운동장 is the object of the transitive verb 뛰다. How could the compilers miss such an obvious fact? Hong suggests that they may have not been interested in being grammatically informative. A historical survey of the Oxford English Dictionary(OED) is given by Lee Sang-sup, with special emphasis on the vast amount of quotations from real sources contributed by thousands of volunteer readers through several decades and on its unwavering historical principle. A comparison between the OED's definition of Kimchi and a Korean dictionary's 김치 is given, showing the difference of principle in treating the same lexical item. Ahn Sam-huan presents a detailed account of Grimm's Deutsches Wo¨rterbuch which took generations of German lexicographers 133 years from its inception to its completion in 1971. On the basis of his study, Ahn suggests that future dictionary makers should cooperate as a group on a long-range comprehensive project. A moltivolume dictionary is an all-important cultural event for the whole nation, not to be influenced by private commercial interests. Choi Young-ai's survey of Chinese lexicography highlights the now on-going publication of 漢語字典 and 漢語詞典, admirable results of the cooperative effort of hundreds of Chinese scholars, a modus operandi for the Yonsei University graze to adopt in planning a new dictionary of the Korean language.

상 분리 모선 시스템에서의 자계 및 와전류 특성 해석

심재학,정운관,윤인식,김성영 조선대학교 에너지.자원신기술연구소 2003 에너지·자원신기술연구소 논문지 Vol.25 No.2

In the analysis of isolated phase bus bar(IPB), the magnetic field distribution generated by large current must be understood accurately. Especially, while the current of bus conductor is flowing, almost the same amount of current as the current of bus conductor is induced in the enclosures under the influence of time varying magnetic field, and the large electric loss and the deterioration of insulating capability might occur due to Joule heating effect. Therefore the optimal design of IPB satisfying the condition of minimizing the electric loss, the magnetic field distribution and eddy current characteristics around the enclosures must be analysed accurately. In this paper, the magnetic field distribution and the eddy current characteristics of three phase isolated phase bus have been studied along the phase angle by comparing the effect of eddy current on the magnetic field distribution with the case that eddy current is not considered, and also the effect of material thickness and radius of enclosure on the eddy current distribution is discussed. In the analysis of time varying magnetic field, instead of finite difference method(FDM) which is generally used, finite element method(FEM) with phasor concept is investigated under the assumption that the bus current is purely sinusoidal. The characteristics

지역 사회 감염성 폐렴에서 Cefodizime의 효능 및 안전성을 Ceftriaxone과 비교한 연구

심영수,오명돈,한성구,최강원,정희순,김영환,유철규,최형석 대한감염학회 1994 감염 Vol.26 No.3

목적: Cefodizime은 새로운 주사용 제 3세대 항생제이다. 저자들은 감염성 폐렴 환자들에서 이 약물을 하루 1번 정맥주사하였을 때 관찰되는 임상적및 세균학적 효과와 안전성을 ceftriazone과 비교하기 위하여 본 연구를 시행하였다. 방법: 1992년 6월부터 1993년 11월까지 서울대학교 병원에 지역사회 감염성 폐렴으로 입원하였던 환자 32명을 무작위로 3군으로 나누고 제 1군 : Cefodizime 1g(n=11), 제2군 : Cefodizime 2g(n=10), 제3군 : Ceftrizxone 1g(n=11)을 각각 하루 1회 정맥주사로 투여하여 그 치료율및 안전성을 비교하였다. 결과: 1)Cefodizime은 제1군 100%, 제2군 80.0%의 임상적 반응율을 보였다. Ceftriaxone을 투여하였던 제 3군에서는 81.8%의 임상적 반응율을 보였다. 이러한 임상적 반응율의 결과는 세 군간에 통계적으로 유의한 차이를 보이지 않았다(p>0.05). 2)세균학적 반응율도 세 군간에 유의한 차이를 보이지 않았다. 3)Cefodizime의 안전성의 평가에서 제1군 및 제2군에서 구토 및 오심이 2예(9.5%)에서 관찰되었고 일시적인 간효소치의 상승이 1예(4.8%)에서 관찰되었다. 경미한 공복시 위통이 1예(4.8%)에서 관찰되었다. Ceftriaxone으로 치료한 군에서는 특별한 부작용은 관찰되지 않았다. 결론: 이상의 결과로 지역사회 감염성 폐렴의 치료에 있어서 cefodizime 1내지 2g을 정맥 주사로 하루 1회 치료할 경우 적어도 ceftriaxone과 유사하게 효과적이며 안전한 것으로 사료된다. Background:Cefodizime(Modivid) is a new parenteral form of cephalosporin showing the antibacterial specturm of the third generation. The clinical efficacy and safety of cefodizime have been well proven by some previous clinical studies performed in European countries and Japan. The objective of this study was to evaluate the clinical, radiological and antimicrobial efficacy of this drug in patients with community-acquired pneumonia compared to that of ceftriaxone. Methods: We performed an open, controlled, randomized study in 32 patients with community-acquired pneumonia at Seoul national University hospital from June 1992 to November 1993. In the first group(n=11) 1g of cefodizime, and in the second group(n=10) 2g of cefodizime were respectively administered intravenously once a day. and in the third group(n=11), 1g of ceftriaxone was administered intravenously. Results: The results were as follows. 1) Cefodizime showed the clinical response rate of 100% in group I, and 80.0% in group Ⅱ. The clinical response rate of ceftriaxone in group Ⅲ was 81.8%. There was no significant statistical difference(p>0.05). 2) The rates of bacteriological efficacy wee not statistically different among three groups. 3) In the cefodizime treatment group(group Ⅰ, group Ⅱ) nausea and vomiting were observed in 2 cases(9.5%) and transient elevations of hepatic transaminases in 1 case(4.8%). Mild abdominal pain occurred in 1 case(4.8%). No significant adverse reactions were observed in the ceftriaxone treatment group. Conclusion: We could conclude that once a day intravenous cefodizime therapy was as effective and well tolerated as ceftriaxone in the treatment of community-acquired pneumonia.

Agar-Gel Immunodiffusion Test를 이용한 돼지흉막폐염(Swine Pleuropneumoniae)의 진단에 관한 연구

심항섭,장경수,조용성,전무형 충남대학교 수의과대학 동물의과학연구소 1994 動物醫科學硏究誌 Vol.2 No.-

To establish an effective diagnostic measure for detection of the antibodies against Actinobacillus pleuropneumoniae, that is the primary agent of swine pleuropneumoniae, the methods for micro-agglutination test(MAT) and agar-gel immunodiffusion test(AGID) were improved and standarized and the comparative studies were carried out. The results obtained through the experiments were summarized as follows. 1. The rabbit hyperimmune sera to reference serotypes 1 to 6 were cross-tested with MAT and AGID. The range of antibody titers on MAT was 80 to 1280, showing the cross-reaction in serotypes 3, 4, 5 and 6. In AGID, the range of antigen titers was 8 to 32, and cross-reaction was observed in serotype 5. The optimal concentration of antigen MAT were 1.25㎎/㎖ 2. In AGID, the most promising antigen and the buffer for agar-gel were EDTA-treated antigen and 0.05M tris buffer(pH 7.2), respectively. 3. By the tests for 200 swine sera, it was found that the accumulative frequency of positive reaction for the 6 serotypes were 240 in MAT and 163 in AGID. 4. when compared the results of AGID with those of MAT for 200 swine sera, all sera with MAT titier under 20 were negative in AGID. Of the sera with MAT titer 40 and 80, 24.7% and 93.9% were positive in AGID, respectively. All sera with MAT titer over 160 showed positive in AGID. 5. In conclusion, the established MAT showed high sensitivity but low specificity, whereas AGID revealed low sensitivity but high specificity. The established AGID test was considered very efficient for detection of antibodies and serotyping of swine sera.

紅景天(Rhodiola sachlinensis)에서 항균성 물질의 분리 및 동정

심창주,이규희,정재홍,이상덕,김영호,오만진 한국식품저장유통학회 ( 구 한국농산물저장유통학회 ) 2004 한국식품저장유통학회지 Vol.11 No.1

홍경천의 천연 보존료로서의이용성을 검토하기 위하여 각종 용매로 홍경천 추출물을 제조하고 극성에 따라 순차분획, silica-gel chromatography, thin-layer chromatography, high perfomance liquid chromatography의 분리과정을 거쳐 순수 분리된 각 물질을 GC/MS(EI) spectrum, ¹H-NMR spectrum, ¹³C-NMR spectrum을 이용하여 항균물질을 동정하여 다음과 같은 결과를 얻었다. 홍경천에 대해 acetone, ethyl acetate, ethanol, methanol, chloroform, water의 각 용매로 추출한 결과 항균성분의 추출 용매로는 methanol이 가장 우수하였다. 홍경천 methanol 추출물을 n-hexane, chloroform, ethyl ether, ethyl acetate, n-butyl alcohol로 분획한 결과 ethyl acetate와 n-butyl alcohol 분획에서 우수한 항균력을 나타내었다. 홍경천 methanol 추출물은 그람양성 4균주와 그람음성 4균주에 대해 고체 배지의 경우 대체로 500 μg/mL에서 최소저해를 나타냈으며, 액체배지의 경우 100 μg/mL 내외에서 최소저해를 나타내었다.] Silica gel column chromatography에서 용매의 배율을 높여가며 용출한 결과 chloroform : methanol(8:2, v/v)의 비율에서 항균력이 가장 높게 나타났다. 분리된 항균성분을 silica-gel TLC plate에 용매의 비율을 높여가며 전개시켜 chloroform : methanol(9:1, v/v)에서 9개의 물질군을 얻을 수 있었으며, 그 중 항균력이 확인된 3개의 물질군을 HPLC와 NMR spectrum을 분석한 결과 gallic acid, (-)-epicatechin 및 kaempferol로 동정되었다. gallic acid, (-)-epicatechin 및 kaempferol의 항균물질 각각의 최소저해농도는 Staphylococcus aureus와 Listeria monocytogenes에 대해 gallic acid와 kaempferol 이 500 μg/mL, (-)-epicatechin이 100 μg/mL에서 저해를 나타내었다. The antimicrobial substances from Rhodiola sachalinensis were extracted, isolated and identified. The highest level of antimicrobial activity and its yield were obtained in methanol extract. The minimum inhibition concentrations of the methanol extract were 500 μg/mL on agar plate and 100 μg/mL in broth media for four gram positive and four gram negative microbials. The methanol extract was fractionated by n-hexane, chloroform, ethyl ether, ethyl acetate, and butanol, orderly. The separate was developed on the TLC plate with different solvent system ratio of chloroform and methanol. Nine substances were isolated from chloroform and methanol mixture(9:1, v/v). Among them, three isolates showed antimicrobial activity. Three substances separated by HPLC were identified by GC/MS(EI) spectrum and ^(1)H, ^(13)C-NMR spcetrum. They were gallic acid, (-)-epicatechin and kaempferol. The antimicrobial activites of each substances were shown gallic acid, (-)-epicatechin, kaempferol, orderly.

정신분열병 환자의 우울증에서 Paroxetine과 삼환계 항우울제 병용치료

심주철,공보금,박정환,윤영란,신재국,김정익,안동성,김용관,차인준,김영훈 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.4

저자들은 마산동서병원에 입원중인 우울증이 동반된 정신분열증 환자 10명을 대상으로 사용중인 항정신병약물에 paroxetine과 저용량의 삼환계 항우울제를 6주간 병용투여한 후 우울증상에 대한 효과와 치료의 안전성 및 약물상호작용을 알아보았다. Paroxetine은 고정량의 항정신병약물과 삼환계 항우울제에 부가하여 일일 20㎎을 6주간 병용하게 하였으며, 임상상태는 HDRS, HARS, UKU Side Effect Rating Scale등의 평가척도를 사용하여 평가하였다. 또한 약동학적 약물상호작용은 삼환계 항우울제들의 혈장농도를 HPLC로 측정하여 분석하였다. 결과는 다음과 같다. 1) 10명의 전체 대상환자에서의 HDRS 평균점수는 TCA와 paroxetine 병용투여 6주후에 통계적으로 유의하게 감소되었다. 이중 40%의 환자에서는 병용투여 6주후에 HDRS 점수상 50% 이상의 감소를 보여, 일부의 환자들에서는 정신분열병에 동반된 우울증상의 치료에 소량의 삼환계 항우울제와 paroxetine의 병용치료가 효과가 있음을 확인하였다. 2) 두 명의 환자에게서 심각한 약물독성이 발생하였다. 이중 한 명은 삼환계 항우울제의 높은 혈중농도로 인한 항콜린성 위기(anticholinergic crisis) 소견을 보였으며, 다른 한 명은 인지기능 및 의식수준은 명료하였으나 망상과 환각증상이 약화되는 소견을 보였다. 따라서 본 연구에서 시도된 복합적 약물치료의 경우, 삼환계 항우울제의 혈중농도의 측정을 포함한 세심한 임상적 추적이 필요하다고 생각된다. 3) 기저치의 amitriptyline과 그 대사물인 nortriptyline의 농도합. imipramine과 대사물인 desipramine의 농도합은 각각 47.8-226.5ng/㎖. 80.5-395.6ng/㎖였으며 일반적으로 이들 약물들의 단독사용시에 문헌에 보고된 혈중농도를 훨씬 상회하고 있었다. 이는 병용투여된 항정신병 약물 약시 강력한 CYP2D6 효소억제제로서 기저치의 삼환계 항우울제들의 혈장농도를 이미 상당히 증가시켰던 것으로 판단되며, 그러한 결과로 인해 본 연구에서는 paroxetine이 이전의 문헌보고들과는 달리 뚜렷하게 삼환계 항우울제들의 혈장농도를 증가시키지 못하였다. 본 연구는 SSRI와 삼환계 항우울제의 병합 투여가 우울증의 개선 효과를 빠르게 하고, 치료역을 넓히고, 약물상호작용의 결과 paroxetine이 삼환계 항우울제의 혈중농도를 증가시킨다는 기존의 연구결과를 이용하여 정신분열병 우울증상의 치료에 parotextine과 소량의 삼환계 항우울제를 병용하는 방법을 시도해 본 연구이다. 저자들은 이러한 약물치료가 일부의 환자들에게서 효과가 있음을 관찰하였으나, 항정신병약물과 삼환계 항우울제를 병용투여 할 경우는 물론 이에 paroxetine과 같은 선택적 세로토닌 재흡수 억제제를 병용할 경우 복합약물상호작용의 결과로 약물독성의 위험성이 크며 세심한 주의가 필요함을 경험하였다. Depression is well-known to comorbid with several psychiatric disorders. Many schizophrenics also suffer from depression in the course of their illness. Combined therapy of SSRI and tricyclic antidepressants were reported to have benefits in some depressed patients. Paroxetine, a potent CYP2D6 inhibitor, increases the blood levels of tricyclic antidepressant markedly. Using paroxetine, we tried this combined therapy in the treatment of depressive symptoms in 10 chronic schizophrenic inpatients and evaluated its efficacy and drug interactions between paroxetine and tricyclic antidepressants. The following results were obtained : 1) The mean score of Hamilton's Depression Rating Scale(HDRS) was reduced significantly after 6 weeks-trials of this combined therapy for the mild depressive symptoms in 10 chronic schizophrenics. In four patients, 50% or more reductions in the scores of HDRS were noticed at final evaluation. 2) Two among our 10 subjects experienced severe toxic behavioral problems. Anticholinergic crisis with toxic confusion due to high blood levels of tricyclics was found in one patient and the other showed rapid clinical deterioration in his psychotic symptoms such as delusion and hallucination without any consciousness alternation. 3) Baseline plasma levels of tricyclics before adding paroxetine were higher than expected in our chronic schizophrenic subjects maintained with their antipsychotic medications. Several antipsychotics were also known as a potent CYP2D6 inhibitors and to increase the blood levels of tricyclics. Because the blood levels of tricyclics had already increased significantly by the use of antipsychotics, adding paroxetine to antipsychotics and tricyclic antidepressant in our subjects could increase the blood levels of tricyclics not so much as previously reported in the literatures.

공황장애 환자의 성격요인과 방어기제의 특성에 관한 연구

심진현,백상빈,신영철,오강섭,노경선,이시형 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6

연구목적: 본 연구는 공황장애 환자들을 대상으로 성격요인과 방어기제 검사를 실시하였으며 우울 및 사회기능 정도를 측정하여 상관관계를 알아보았다. 방 법: 1997년 9월부터 1998년 8월까지 환자들중 공황장애로 진단된 35명을 대상으로 성격요인검사(Sixteen Personality Questionnaire 한국판) 및 방어기제검사(이화방어기제검사)를 시행하여 스텐점수(1-10)화 하였고, 우울증척도(Beck Depressive Inventory 한국판) 및 사회기능장애척도(Sheehan Disability 한국판)를 시행하였다. 결 과: 1) 개별항목 (1) 성격요인과 방어기제의 척도별 평균점수에서 정상보다 높거나(8점이상) 낮은(3점이하) 척도는 없었다. (2) 성격요인중 불안감이 높았고 자아강도, 신중성, 사변성은 낮은 점수를 보였다. (3) 방어기제중 신체화, 행동화의 점수가 높았고 유우머, 억제, 이타주의, 회피, 합리화는 낮은 점수를 보였다. (4) BDI의 평균점수는 18.25±9.97이었다. (5) SDS의 평균점수는 업무항목 4.88±3.11. 사회활동/오락활동항목 4.57±2.92였다. 2) 상관관계 (1) 성별간 비교에서 성격요인은 사변성, 죄책감을 방어기제는 허세, 부정, 수동공격, 투사를 남성 이 높게 보였다(p<0.05). (2) 연령증가는 성격요인중 낮은지능과 방어기제는 예견, 해리와 상관을 허세와 역상관을 보였다(p<0.05). (3) BDI 점수는 성격요인중 지능도, 자아강도, 도덕성, 죄책감, 통제력, 불안감등과 방어기 제중 해리, 신체화등과 유의미한 상관관계를 나타냈다(p<0.05). (4) 사회기능장애척도의 업무항목은 성격요인중 죄책감, 진보성, 불안감, 도덕성과 방어기제의 신 체화, 투사등과 유의미한 상관이 있었고, 사회/오락활동항목은 성격요인의 죄책감, 불안감과 방어기제중 허세, 투사 등과 유의미한 상관관계가 있는 것으로 나타났다(p<0.05). 3) BDI와 사회기능장애척도의 업무항목간에는 유의미한 상관관계가 있는 것으로 나타났다(p<0.05). 결 론: 공황장애 환자는 성격요인검사상 불안감이 높고 자아강도, 신중성, 사변성은 낮게 나타 났으며, 신체화 등의 신경증적 방어기제를 주로 사용하는 반면 유우머, 억제, 이타주의, 회피, 합리화의 방어기제는 적게 사용하는 것으로 나타났다. 증상의 강도와 관련이 있는 우울증상은 업무활동에 영향을 미쳐 이와 관련된 중등도의 사회기능의 장애를 초래하고 있는 것으로 보인다. Objectives : The purpose of this study was to evaluate the characteristics of personality factor and defense mechanism and relationship with depression and disability. Methods : Study subjects consisted of 35 panic disorder patients diagnosed with the criteria of DSM-Ⅳ. Data were collected through Sixteen Personality Factor Questionnaire, Ehwa Diagnostic Test of Defense Mechanism, Beck Depression Inventory and Sheehan Disability Scale. Statistics employed for the analyses were Pearson correlation and independent sample t-test. Results : In personality factors and defense mechanisms, there were no definitely abnormal range of scores. But, among personality factors, tension/anxiety factor scored high and unstableness/stableness, shyness/boldness and praxernia/atunia were in low range of score. In defense mechanism, somatization and acting-out scored high and humor, suppression, altruism, avoidance and rationalization scored low. The mean BDI score was 18.25±9.97. The mean score of SDS were 4.88±3.11 in work category and 4.57±2.92 in social/leasure category. Male patients were significantly correlated with guit-proneness and atuia in personality factor and passive-aggressiveness, projection, denial and show-off in defense mechanism, compared with female patients(p<0.05). The patients` age was correlated with low intelligence in persolity factor and dissociation and anticipation in defense mechanism. It was negatively correlated with show-off(p<0.05). The BDI score was correlated with low intelligence, superego, unstableness, self-conflict, high superego and atunia in personality factor and dissociation and somatization in defense mechanism(p<0.05). There was a significant relationship between BDI score and SDS work category(p<0.05). Conclusions: Panic disorder patients show high score of tension/anxiety factor and they frequently use neurotic defense style like somatization. The depressive symptom, which depends on symptom severity, appears to have influence on work category and to cause social disability.

구강으로 돌출한 선천성 두개내 기형종 -1 부검례-

김영실,이교영,강창석,심상민,김선무 대한병리학회 1990 Journal of Pathology and Translational Medicine Vol.24 No.3

주의력 결핍 과잉행동 장애 아동에서의 집단 프로그램의 치료 효과

심세훈,오창근,권자영,정유숙,홍성도 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.1

Background : The authors attempted to introduce group program for improving interpersonal relationship and evaluate the effects of that program. Material and Methods : This program had been held twice a week for 8 weeks for children and parents training had been for times on the treatment and continued from 2001 to 2002. Twenty-five ADHD children in school age were selected as subjects from child psychiatric clinic of a general hospital in Seoul. Treatment outcomes were evaluated by comparing at pre- and post- treatment using the various rating scale. Result : According to the results of statistical analysis, paired t-test, the score of total self-concept including popularity was increased and family environment and parenting stress were improved significantly. These results suggest that this program is useful for its orginal goal. The parents evaluated also that children's total problem behaviors were decreased. Conclusion : These results suggest that the designed and performed group program in this study would be effective in facilitating ADHD children's emotional and interpersonal growth, and decreasing their parents stress. Finally they would have healthy interpersonal reationship.

포-만트 VOCODER의 구성에 관한 연구

심장엽,안종영,김상범,허강인 東亞大學校 附設 情報通信硏究所 1995 情報通信硏究所論文誌 Vol.3 No.1

본 논문에서는 포-만트 vocoder를 구성하여 한국어 음성 합성을 연구하였다. 포-만트 vocoder의 구성에 필요한 합성파라메터로서는 스펙트럼 모멘트법에 의한 포-만트 주파수, 최적 Comb법에 의한 피치 주파수, 단시간 평균에너지와 단시간 평균진폭, 대역폭, 음원파형, 가우시안 백색잡음이다. 합성실험은 남성 화자가 발성한 음절, 단어, 문장 등의 음성데이터를 이용하였다. 청취결과, 유무성음에 대해 각각 Rosenberg의 음원파형과 삼각파를 음원으로 적용한 경우가 우수하였다. This paper studies on a method of Korean speech synthesis by composing formant VOCODER. The parameters of speech synthesis are formant frequencies by spectrum moment method, pitch frequencies by optimum Comb method, short time average energy, short time average amplitude, bandwidth, excitation wave and gaussian white noise. In this paper, synthesis is performed using speech data which are syllable, word and sentence spoken by man. Synthesis results are good in case of using Rosenberg & Triangle wave respectively as voice source.