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노창섭,최대균,우이형,최부병,Roh Chang-Sup,Choi Dae-Gyun,Woo Yi-Hyung,Choi Boo-Byung 대한치과보철학회 1992 대한치과보철학회지 Vol.30 No.3
This study was performed to investigate the phonetic alterations with upper anterior teeth were missing. To compare the changes of the phonations, before and after insertion of the temporary prosthesis, six subjects who lost their upper anterior teeth were selected (2-male, 4-female). Tested sounds (/ga(가), na(나), da(다), ra(라), sa(사), ja(자), cha(차), ta(타), pa(파), ha(하), gi(기), ni(니), di(디), ri(리), si(시), jl(지), chi(치), ti(티), pi(피), hi(히), seu(스), se(세), so(소), su(수)/were programmed into an IBM AT with and without temporary prosthesis. These experiments were analyzed by formants, consonants durations, and energy level changes with an LSI speech work station program. During the pronunciation of the tested sounds (with and without temporary prosthesis), mandibular movements were recorded to a Mandibular Kinesiogram and analyzed . The findings led to the following conclusions: 1. Objective differences could not be found. However, in every informant, subjective improvement could be noticed. 2. There were no persistant correlations of the formant's changes. And in every informant, phonetic changes were variable. 3. There were various changes of the consonant durations in every informant. By and large, those of /si(시), jl(지), chi(치), Pi(피), hi(히)/ were longer than other tested sounds. After insertion of the prosthesis, durations were shorter. Consonants with /i(ㅣ)/ were longer than with /a(ㅏ)/, with or without prosthesis. 4. With and without temporary prosthesis, mandibular movements were various in the frontal view. Mandibular movements showed lateral deviations, and mandibular positions with /si(시), ji(지), ti(티), seu(스), hi(히)/ were nearer to the mandibular rest position. 5. The kinds of temporary prosthesis and conditions of the missing teeth influenced every informant variously, so there were no correlation between informants. 6. Energy levels increased in all tested sounds with a fixed temporary prosthesis. And, there were no differences between before and after insertion of a removable temporary prosthesis. However, sibilant sounds, and consonants with /i(ㅣ)/ showed a little increased energy level.
포도상구균 초항원과 연관된 만성 비·부비동염의 병인에서 감마 인터페론 생산 T세포의 역할
김창수,조규섭,이현순,박희영,노환중 부산대학교 병원 암연구소 2008 부산대병원학술지 Vol.- No.24
Background and Objectives: The etiology and pathogenesis of chronic rhinosinusitis (CRS) is multifactorial and the role of infectious agents in CRS is not clear. S. aureus is the most frequent cultured pathogen in CRS and it expresses toxin, SEA, SEB and TSST-l, with superantigen (SAG) activity. Recently an importnat role of these staphylococcal toxins in CRS with nasal polyposis (CRSwNP) has been suggested. CRSwNP is a severe chronic inflammation characterized by massive infiltration of lymphocytes and eosinophils in the sinonasal mucosa and nasal polyp. However, there has been no further studies evaluating the properties of infiltrating T lymphocytes in CRSwNP and the cytokine profiles in activated T-Iymphocyte relating with SAGs. The aims of this study was to know what kind of T lymphocytes infiltrates in nasal mucosa and polyp tissue of CRSwNP, to analyze the cytokine profiles in infiltrating T cells, and to determine whether infiltrating T lymphocytes are specific for SAGs. Patients and Methods: Ethmoid sinus mucosa and polyp tissue samples were collected from 13 patients with CRSwNP and control sinus mucosa were obtained from 10 patient without CRS. Tissue infiltrating cells and T cells were isolated from tissue samples and flow cytometry, enzyme-linked immunosorbent assay, reverse transcriptase-polymerase chain reaction, in vitro T lymphocyte stimulation with S. aureus toxin were performed. Results: The mean total CD3+ T cell count was significantly higher in the mucosa and polyp tissue of patients with CRSwNP compared with control mucosa. Most infiltrating T cells in mucosa and polyp tissue were activated type, expressing CD45RO. CD8+ T cells were significantly increased in mucosa and polyp tissue of patients with CRSwNP compared with CD4+ cells IFN-γ was highly expressed in infiltrating T cells in both mucosa and polyp tissue, whereas IL-10 was expressed a small amount and IL-4 was not expressed. IFN-γ levels were significantly higher than IL-4 and IL-10 when isolated T cells were stimulated with SAGs in vitro. Conclusion: CD8+ T-cytotoxic and IFN-γ producing Th1 cells could paly an important role in the CRSwNP if sinonasal chronic inflammation is induced by SAGs.
노성우,정상섭,박용구,임승철,이규창 대한신경외과학회 1987 Journal of Korean neurosurgical society Vol.16 No.4
To preserve function of the acoustic nerve and brainstem during posterior fossa surgery, the authors monitored (brainstem auditory evoked potentials) in 42 cases of posterior fossa surgery who were operated at the Department of Neurosurgery of Yonsei University College of Medicine from March, 1983 to February, 1987. The results were summarized as followings : 1) There were 28 cases of hemifacial spasm, 13 cases of trigeminal neuralgia and 1 case of cerebello-pontine angel tumor. 2) Among the 41 cases of neurovascular decompression, there were 10 cases(24%) with hearing impairment postoperatively. But there was no postoperative auditory dysfunction in 13 cases of hemifacial spasm in which caudal approach was utilized. 3) There was no postoperative auditory dysfunction in the patients who showed intraoperative BAEPs of Types Ⅰ, Ⅱ and Ⅲ which were characterized by no loss of waves, but 10 cases(77%) who showed BAEPs of Types Ⅳ, Ⅴ and Ⅵ which were characterized by loss of the waves showed auditory dysfunction postoperatively.
Lee, Chang-Kwon,Kim, Jung-Kwan,Won, Kyung-Jong,Lee, Hwan-Myung,Kim, Hyo-Jin,Roh, Hui-Yul,Park, Hyo-Jun,Shin, Hwa-Sup,Park, Tae-Kyu,Kim, Bo-Kyung,Lee, Sang-Mok The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.11
The role of mitogen-activated protein kinase (MAPK) in the decreased contractile response to phorbol ester in aortic smooth muscle strips from deoxycorticosterone acetate (DOCA)-salt hypertensive rats was examined. Norepinephrine (NE) evoked greater contractility in aortic strips from DOCA rats than in those of sham-operated rats. 12-Deoxyphorbol 13-isobutyrate (DPB) induced contraction in $Ca^{2+}-free$ medium, which was diminished in strips from DOCA rats compared to sham-operated rats. Vasoconstrictions induced by these stimulants were inhibited by SB203580 and PD098059, inhibitors of p38 MAPK and extracellular signal-regulated kinase (ERK) 1/2, respectively, in both strips. The phosphorylation of p38 MAPK and ERK1/2 induced by NE was greater in strips from DOCA rats compared to those from sham-operated rats, and this phosphorylation was inhibited by the kinase inhibitors. DPB increased the phosphorylation of p38 MAPK and ERK1/2 in strips from both animals, and the increment of p38 MAPK phosphorylation by the stimulant was diminished in strips from DOCA rats compared to sham-operated rats. These findings suggest that the $Ca^{2+}-independent$ contraction evoked by DPB results from the activation of MAPKs in rat aortic smooth muscle and that the attenuated contractility by DPB in DOCA rat appears to be associated with diminished p38 MAPK activity.
개체간의 제어 및 자료 종속성을 이용한 Ada 패키지의 재구성에 관한 연구
노영희(Young-hee Roh),윤창섭(Chang-sup Yoon),류성열(Sung-yul Rhew) 한국정보과학회 1992 한국정보과학회 학술발표논문집 Vol.19 No.1
Ada 프로그램에서 패키지는 재사용을 지원하는 프로그램 단위중 가장 중심이 되는 요소이다. 본 논문은 Ada 패키지에 대한 미참조 개체식별에 대한 연구[1]를 기반으로 재사용하고자 하는 패키지에서 사용이 확실한 개체들만을 가지고 패키지를 재구성하는 연구이다. 재구성에 앞서 식별된 개체간의 종속성 분석을 통해서 참조개체, 미참조 개체, 미참조개체지만 참조개체에 영향을 주는 개체들에 대한 처리가 필요하므로 본 논문은 이와같은 개체식별 처리모형을 제안하고 재구성시 기대효과를 제시한다.