수온에 따른 Norfloxacin의 잉어(Cyprinus carpio)와 뱀장어(Anguilla japonica)체내에서 약물동태학적 특성

김진우,정승희,이주석,최동림,조미라 한국어병학회 2002 한국어병학회지 Vol.15 No.2

양식어류의 세균성 질병 치료약제로서 사용량이 증가하고 있는 NFX의 정량분석 방법을 확립하고, 사육수온과 관련된 NFX의 어체내에서 흡수, 분포, 배설 등 NFX의 합목적적 사용 방법 설정에 필요한 약물동태학적 요인을 조사하였다. 수온에 따른 NFX의 어체 내에서의 혈중최대 농도는 뱀장어에서는 유의적인 차이는 없었으나 잉어에서는 혈중최대농도가 23℃에서 유의적으로 높게 (p〈0.05) 나타났을 뿐만 아니라 NFX의 흡수 및 배설속도정수, 최대혈중농도 도달시간 등 어종별, 수온별 약물동태학적 요인에 차이가 있었다. 이러한 결과로 NFX의 효과적인 사용방법과 휴약기간 설정을 위하여 어류의 사육환경과 관련된 임상 약물동력학적 특성을 충분히 고려하여 결정되어야 할 것으로 판단된다. Effects of Temperature on the pharmacokinetics of norfloxacin(NFX) were studied in the cultured carp, Cyprinus caripo, and cel, Angulla japonica, using high performance liquid chromatography(HPLC) originally developed for quinolone determination in livestocks. Pharmacokinetics of NFX was apparently affected by amibent water temperature. In a two-compartment model for carp after oral dosage of 20㎎/㎏, K01 at 13℃ and 23℃ were 2.60 and 5.20/hr, respectively. In carp the K_(w), T_(max) and C_(max) for carp at 13℃ were 13.30/hr, 17.44 ug/ml and 7.00 ug/ml, respectively. The corresponding values at 23℃ were 3.93/hr, 15.40㎍/㎖ and 9.44 ㎍/㎖, respectively. The AUC and T_(1/2) were 355.66 ㎍:hr/㎖ and 12.70 hr at 13℃ and 417.24 ㎍:hr/㎖ and 13.86 hrs at 23℃, respectively, Similar trends were revealed in the NFX pharmacokinetics of cel kept under the two water temperature regimes after oral NFX dosage of 20 mg/kg. These pharmacokinetical results have some implication in the optimal usage of recently introduced antibacterials in farmed fish, which were originally adapted for poultry and mammalian species.

골격성 Ⅲ 급 부정교합자의 두개안모 성장예측에 대한 평가

손우성,강은희,정미라,성지현 대한치과교정학회 2003 대한치과교정학회지 Vol.33 No.1

본 연구는 성장에 의한 변화를 예측하는 현재의 방법이 실제로 골격성 Ⅲ급 부정교합자의 진단과 치료계획에 적절히 사용될 수 있는 지를 판단해 보기 위해 초진 시 골격성 Ⅲ급 부정교합으로 진단받고 성장 종료 후 악교정 수술을 받기위해 재내원한 골격성 Ⅲ 급 부정교합자 25명(남자 13명, 여자 12명)을 대상으로 시행되었다. 초진시 채득된 측모 두부방사선 사진에서 Ricketts의 성장예측법을 통해 성장 종료 후의 상태를 예측한 후, 악교정 수술을 위해 재내원 했을 때 채득된 측모 두부방사선 사진에서 계측된 실제 성장량과 비교분석 함으로써 다음과 같은 결론을 얻었다. 1. 예측치와 관측치의 일치정도를 평가해본 결과 Porion Location, Ramus Position, Facial Depth, Facial Axis, Mandibular Plane angle, Maxillary Convexity에서의 예측치가 관측치와 차이를 보이고 있어 이 항목에 대한 Ricketts 성장예측법의 예측치가 실제 성장량을 잘 설명해주지 못함이 관찰되었다. 2. 하악골체의 성장량은 정상 성장량과 유사하였으나 Porion Location, Ramus Position이 정상적인 성장과정을 벗어나면서 하악골의 전방위치를 유도하였다. 3. 골격성 Ⅲ 급 부정교합자에서는 성장의 양과 방향이 비정상적인 성장변화를 나타내어 정상 성장에서라면 변화를 보이지 않을 하악지의 전방 위치, 하악이부의 전상방 회전 등이 일어난 하악 전돌의 경향이 악화될 수 있다. This study was performed to evaluate whether growth prediction method can be used to diagnose and make treatment plan in skeletal Class Ⅲ malocclusion patients or not. The sample was consisted of 25 patients(13 males, 12 females) who had been diagnosed with skeletal Class Ⅲ malocclusion at first visit and after that had returned to take orthognathic surgery. Growth prediction performed with Ricketts' growth prediction method from first cephalogram was compared with actual growth of the second cephalogram. The findings of this study were as follows ; 1. There was significant difference between actual growth and growth prediction in Porion Location, Ramus Position, Facial Depth, Facial Axis, Mandibular Plane angle, Maxillary Convexity. So, for these items Ricketts' growth prediction method is not proper to predict growth. 2. Although the growth amount of mandibular body was similar to normal growth amount, mandible was positioned anteriorly because of Porion Location and Ramus Position. 3. In skeletal Class Ⅲ malocclusion patients, the tendency of mandibular prognathism might be aggreviated because of anterior placement of ramus and anterosuperior rotation of pogonion.

저작습관에 따른 교합력과 안면골격형태의 비교연구

정미라,손우성 대한치과교정학회 1995 대한치과교정학회지 Vol.25 No.3

이상적 교합이란 치아의 교합이 저작계의 다른 부분과 기능적으로 조화를 이루고, 중심교합상태에서 양측으로 동시에 균일한 접촉을 이루는 것을 말한다. 악골의 양측을 이용한 균형된 저작은 양측의 균등한 견치유도와 기능적 능력에 의해 가능해지지만 교합간섭이나 저작계에 대한 기능적 요구의 감소로 좌우측중 어느 한쪽만을 선호하는 편측 저작양상이 유도되기도 한다. 편측저작은 악골의 발육, 교합 및 안면의 전체적인 형태에 이르기까지 악안면 전체에 형태적, 기능적인 부전을 초래할 잠재성을 가진 증상이나 이에 대한 연구가 많지 않다. 본 연구는 저작습관의 분포를 알아보고, 저작습관에 따른 교합력의 차이와 안면골격형태를 비교 연구할 복적으로 시도하였다. 부산대학교 치과대학 재학생 186명을 대상으로 설문지를 이용하여 저작습관에 따라 양측저작군과 편측저작군으로 나누어 저작습관의분포를 조사하였고, 이 중 두개안면부의 성장발육에 영향을 미칠만한 질병에 이환되지 않았고 측모가 양호하며 Angle 분류 Ⅰ급의 교합상태를 보이면서 교정치료와 보철치료를 받은 경험이 없고 악관절 질환이 없는자 중 양측저작자와 편측저작자 각각 25명을 선정하여 교합력계(MPM 3000)를 이용하여 최대교합력을 측정하고, 정모두부방사선규격사진을 촬영하여 안면골격형태를 비교연구하여 다음과 같은 결과를 얻었다. 1. 저작습관은 양측저작자(68%)가 많았으며, 편측저작자 중 68%는 우측을, 32%는 좌측의 저작을 선호하였다. 2. 양측저작군은 좌우측의 최대교합력이 비슷하였고, 편측저작군은 저작측이 비저작측보다 교합력이 컸으며 특히 여자에서 그 차가 뚜렷하였다. 편측저작군은 양측저작군에 비해 저작측은 교합력이 컸으며, 비저작측은 작았지만 유의성은 없었다. 저작습관에 상관없이 남자가 여자보다 교합력이 컸으며 남자는 여자의 교합력의 약 2배정도이었다. 남,녀를 합한 경우 편측저작군의 저작측은 양측저작군의 교합력과 비슷하였으나 비저작측은 그것보다 작았다. 3. 정모두부반사선규격사진을 이용하여 안면골격형태를 비교한 결과 양측저작군의 좌우측, 편측저작군의 저작측과 비저작측간에 차이가 없었다. This study was undertaken to investigate the distribution of the chewing side preference and variations in the maximum bite force and facial morphology according to chewing side preference since unilateral chewing may cause morphologic and functional anomalies. 50 dental students who had no signs or symptoms of masticatory system and Angle's Class Ⅰ relationship in posterior segments were selected, and divided into two groups, that is, 25 in bilateral chewing group(19 male and 6 female) and 25 in unilateral chewing group(10 male and 15 female). Maximum bite force was estimated and posteroanterior cephalogram were measured and statistically analyzed. The results were as follows : 1. There were more students with bilateral chewing side preference(68%) and unilateral chewing side group consisted of right side preference(68%) and left side preference(32%). 2. There was no significant difference in the strength of max. bite force between the right and left side in bilateral chewing group. The bite force of the chewing side was greater in the unilateral chewing group but less in the non-chewing side compared to those of bilateral chewing group with no significant difference. Max. bite force of chewing side was greater than that of non-chewing side in the unilateral chewing group(Female : p<0.05). Max. bite force of males was about twice in that of females in both groups(p<0.05). Max. bite force of chewing side of the unilateral chewing group was similar to that of the bilateral chewing group, but that of non-chewing side was less than that of the bilateral chewing group. 3. In comparision of the facial morphology, there was no statistically significant difference in the size between the right and left side of the bilateral chewing group and between chewing and non-chewing side of the unilateral chewing group.

소아에서의 악관절 기능장애 증례보고

이상호,이미라,우종윤 大韓小兒齒科學會 1990 大韓小兒齒科學會誌 Vol.17 No.2

Temporamandibular disorders have symptoms such as pain, muscular tenderness, clicking noise in the TMJ and restriction of mandibular movement. The diversity of problems and causes of pain among patients is so great that there is no particular method of treatment which can be applied without differentiation to a large group of patient. Temporamandibular disorder in children and adolescents have been studied since the beginning of the 1970s. A report of child who had been treated with occlusal splint due to TMJ disorder was presented.

전국 10개 종합병원 중환자실 환자의 직장내 Vancomycin-resistant Enterococci(VRE) 보균율, 보균의 위험요인 및 유전적 다양성 조사

정희진,송준영,엄중식,김우주,최선주,최정현,이혁,정문현,이광미,신동현,손보라,최종성,우흥정,권정아,이경원,최강원,박승철 대한감염학회 2002 감염 Vol.34 No.5

Characterization of Entomopathogenic Fungi, Lecanicillium attenuatum Producing Secondary Metabolites with JHAN and Insecticidal Activity

Ra Mi Woo,Jong Hoon Kim,Jae Young Choi,Dong Hwan Park,Min Gu Park,Bo Ram Lee,Jae Su Kim,Soo Dong Woo,Yeon Ho Je 한국응용곤충학회 2018 한국응용곤충학회 학술대회논문집 Vol.2018 No.04

The development of entomopathogenic fungi has received increasing interest as part of integrated pest management strategies as biocontrol agents. It is reasonable to assume that entomopathogenic fungi might produce secondary metabolites modulating juvenile hormone for their survival against defense mechanisms of host insects. In this study, acetone extracts of 189 entomopathogenic fungi cultured on unpolished rice medium were screened for their juvenile hormone antagonist (JHAN) activities using the yeast-two hybrid system. Among 14 extracts showing JHAN activities, extract of the F-145 showed high level of insecticidal activities against both Plutella xylostella and Aedes albopictus. This isolate was identified as Lecanicillium attenuatum. These results suggested that the Lecanicillium attenuatum could be useful for development of eco-friendly insecticides.

Mosquitocidal and growth regulatory activities of secondary metabolites from entomopathogenic fungi

Ra Mi Woo,Min Gu Park,Jae Young Choi,Jong Hoon Kim,Seok-Hee Lee,Ying Fang,Dong Hwan Park,Bo Ram Lee,Woo Jin Kim,Jae Su Kim,Soo Dong Woo,Yeon Ho Je 한국응용곤충학회 2017 한국응용곤충학회 학술대회논문집 Vol.2017 No.10

Entomopathogenic fungi have been widely studied for their potential as the effective biological control agents. Theyproduce variety of secondary metabolites with insecticidal activities, and it is reasonable to assume that entomopathogenicfungi might produce secondary metabolites modulating juvenile hormone for their survival against defense mechanismsof host insect. In this study, Acetone extracts of 189 entomopathogenic fungi cultured on unpolished rice medium werescreened for their juvenile hormone antagonist (JHAN) activities using the yeast-two hybrid system. Among them, 14extracts showed high level of JHAN activities and their insecticidal activities against Aedes albopictus were investigated.

Antioxidant Activities of Water Extracts from The Flower buds of Inula britannica

Mi-Ra Han,Soo-Jung Seo,Mi-Ran Kong,Nam-Woo Kim 한국식품영양과학회 2011 한국식품영양과학회 학술대회발표집 Vol.2011 No.10

먹거리를 활용한 유아 수학교육 프로그램이 만 4세 유아의 수학능력에 미치는 효과

오미라(Mi Ra Oh),민하영(Ha Young Min),조우미(Woo Mi Cho) 한국보육지원학회 2019 한국보육지원학회지 Vol.15 No.3

Objective: The purpose of the study was to develop a mathematics education program utilizing food to improve the mathematical abilities of 4-year-olds and to analyze the effects of this program on 4-years-olds’ mathematical concepts (number and operation, algebra, geometry, measurement, data analysis, and probability). Methods: The study selected 30 4-year-olds from two daycare centers located in K city. The experimental group (N=15) participated in the mathematics education program utilizing food, 10 times for five weeks, while the comparative group (N=15) participated in the seasonal mathematics education program based on the Nuri Curriculum. The activities of this intervention program were designed to cover all domains of Mathematical Exploratory areas in the Nuri Curriculum. For data processing and analysis, pre-test and post-test score differences between the two groups were analyzed through MANCOVA. Results: The experimental group had significantly higher scores on five mathematical concepts compared with the control group. A mathematics education program utilizing food had the positive effect of improving 4-year-olds’ mathematical ability. Conclusion/Implications: Mathematic education programs utilizing food are recommended as necessary pedagogical data to develop the mathematical abilities of children in education centers, families, or relating to parenting education.

Development of a Rapid Detection Kit for H9 Specific Avian Influenza Virus

Ok Mi Jeong,Min Chul Kim,Hyun Mi Kang,Gun Woo Ha,Jin Sik Oh,Su Chul Lee,Kun Seok Na,Ji Sun Kwon,Mi Ra Pack,Jun Hun Kwon,Youn Jeong Lee 대한수의학회 2009 대한수의학회 학술대회발표집 Vol.2009 No.-