Investigation of surface pressures on CAARC tall building concerning effects of turbulence

Yong-gui Li,Jiahui Yan,Xinzhong Chen,Qiu-sheng Li,Yi Li 한국풍공학회 2020 Wind and Structures, An International Journal (WAS Vol.31 No.4

This paper presents an experimental investigation on the surface pressures on the CAARC standard tall building model concerning the effects of freestream turbulence. Two groups of incidence turbulence are generated in the wind tunnel experiment. The first group has an approximately constant turbulence intensity of 10.3% but different turbulence integral scale varying from 0.141 m to 0.599 m or from 0.93 to 5.88 in terms of scale ratio (turbulence integral scale to building dimension). The second group presents similar turbulence integral scale but different turbulence intensity ranging from 7.2% to 13.5%. The experimental results show that the mean pressure coefficients on about half of the axial length of the side faces near the leading edge slightly decrease as the turbulence integral scale ratio that is larger than 4.25 increases, but respond markedly to the changes in turbulence intensity. The root-mean-square (RMS) and peak pressure coefficients depend on both turbulence integral scale and intensity. The RMS pressure coefficients increase with turbulence integral scale and intensity. As the turbulence integral scale increases from 0.141 m to 0.599 m, the mean peak pressure coefficient increases by 7%, 20% and 32% at most on the windward, side faces and leeward of the building model, respectively. As the turbulence intensity increases from 7.2% to 13.5%, the mean value of peak pressure coefficient increases by 47%, 69% and 23% at most on windward, side faces and leeward, respectively. The values of cross-correlations of fluctuating pressures increase as the turbulence integral scale increases, but decrease as turbulence intensity increases in most cases.

Mixtures of Tea and Citrus maxima (pomelo) Alleviate Lipid Deposition in HepG2 Cells Through the AMPK/ACC Signaling Pathway

Ran An,Shuai Wen,Dong-Li Li,Qiu-Hua Li,Xing-Fei Lai,Wen-Ji Zhang,Ruo-Hong Chen,Jun-Xi Cao,Zhi-Gang Li,Qiu-Sheng Huang,Ling-Li Sun,Shi-Li Sun 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.9

Tea and citrus maxima are natural, medicinal homologous plants, typically used for making beverages, which have anticancer, antiobesity, and antioxidation properties. Green tea, yellow tea, and black tea were combined with citrus maxima to obtain green tea and Citrus maxima (GTCM), yellow tea and Citrus maxima (YTCM), and black tea and Citrus maxima (BTCM). The biochemical components of these mixtures were analyzed, and their possible effects and mechanisms on relieving liver lipid deposition were explored. The tea polyphenols, free amino acids, phenolamine ratio, and caffeine were comparable in YTCM and GTCM, being significantly higher than those in BTCM. In addition, the content of esterified catechins, nonesterified catechins, and total catechins in YTCM was significantly higher than those in GTCM and BTCM. All three mixtures of Citrus maxima tea significantly reduced lipid deposition in HepG2 cells, with GTCM and YTCM being slightly more effective than BTCM. Regarding the possible mechanism, Western blot analysis revealed that the three Citrus maxima tea mixtures could activate the AMPK/ACC signaling pathway, upregulate the expression of p-AMPK, p-ACC, and CPT-1 proteins, and downregulate the expression of SREBP1c and fatty acid synthase proteins to inhibit fat synthesis, thereby relieving lipid deposition in liver cells. In conclusion, as a novel and healthy beverage, Citrus maxima tea has the potential to alleviate liver lipid deposition, and further could be responsible for obesity treatment.

Brief introduction of geology in North Korea

Mingguo Zhai,Xiao-Hui Zhang,Yan-Bin Zhang,Peng Peng,Qiu-Li Li,Jinghui Guo,Tie-Sheng Li,Lei Zhao,Li-Gang Zhou,Xiyan Zhu 대한지질학회 2019 대한지질학회 학술대회 Vol.2019 No.10

Clinical Neuropathological Analysis of 10 Cases of Cerebral Amyloid Angiopathy-Related Cerebral Lobar Hemorrhage

Li, Xiao-Qiu,Su, Dong-Feng,Chen, Hui-Sheng,Fang, Qu The Korean Neurosurgical Society 2015 Journal of Korean neurosurgical society Vol.46 No.4

Objective : The clinical and pathological characteristics of 10 cases of cerebral amyloid angiopathy (CAA)-related cerebral lobar hemorrhage (CLH) that was diagnosed at autopsy were investigated to facilitate the diagnosis of this condition. Methods : The clinical characteristics of 10 cases of CAA-related CLH were retrospectively reviewed, and a neuropathological examination was performed on autopsy samples. Results : The 10 cases included two with a single lobar hemorrhage and eight with multifocal lobar hemorrhages. In all of the cases, the hemorrhage bled into the subarachnoid space. Pathological examinations of the 10 cases revealed microaneurysms in two, double barrel-like changes in four, multifocal arteriolar clusters in five, obliterative onion skin-like intimal changes in four, fibrinoid necrosis of the vessels in seven, neurofibrillary tangles in eight, and senile plaques in five cases. Conclusion : CAA-related CLHs were located primarily in the parietal, temporal, and occipital lobes. These hemorrhages normally consisted of multiple repeated CLHs that frequently bled into the subarachnoid space. CAA-associated microvascular lesions may be the pathological factor underlying CLH.

Across-wind dynamic loads on L-shaped tall buildings

Li, Yi,Li, Qiu-Sheng Techno-Press 2016 Wind and Structures, An International Journal (WAS Vol.23 No.5

The across-wind dynamic loads on L-shaped tall buildings with various geometric dimensions were investigated through a series of wind tunnel testing. The lift coefficients, power spectral densities and vertical correlation coefficients of the across-wind loads were analyzed and discussed in details. Taking the side ratio and terrain category as key variables, empirical formulas for estimating the across-wind dynamic loads on L-shaped tall buildings were proposed on the basis of the wind tunnel testing results. Comparisons between the predictions by the empirical formulas and the wind tunnel test results were made to verify the accuracy and applicability of the proposed formulas. Moreover, a simplified procedure to evaluate the across-wind dynamic loads on L-shaped tall buildings was derived from the proposed formulas. This study aims to provide a simple and reliable way for the estimation of across-wind dynamic loads on L-shaped tall buildings.

Parkinson’s Disease with Fatigue: Clinical Characteristics and Potential Mechanisms Relevant to α-Synuclein Oligomer

Li-Jun Zuo,Shu-Yang Yu,Fang Wang,Yanghui Xia,Ying-Shan Piao,Yang Du,Teng-Hong Lian,Rui-Dan Wang,Qiu-Jin Yu,Ya-Jie Wang,Xiao-Min Wang,Piu Chan,Sheng-Di Chen,Yongjun Wang,Wei Zhang 대한신경과학회 2016 Journal of Clinical Neurology Vol.12 No.2

Background and Purpose The aim of this study was to identify the clinical characteristics and potential mechanisms relevant to pathological proteins in Parkinson’s disease (PD) patients who experience fatigue. Methods PD patients (n=102) were evaluated using a fatigue severity scale and scales for motor and nonmotor symptoms. The levels of three pathological proteins—α-synuclein oligomer, β-amyloid (Aβ)1-42, and tau—were measured in 102 cerebrospinal fluid (CSF) samples from these PD patients. Linear regression analyses were performed between fatigue score and the CSF levels of the above-listed pathological proteins in PD patients. Results The frequency of fatigue in the PD patients was 62.75%. The fatigue group had worse motor symptoms and anxiety, depression, and autonomic dysfunction. The CSF level of α-synuclein oligomer was higher and that of Aβ1-42 was lower in the fatigue group than in the non-fatigue group. In multiple linear regression analyses, fatigue severity was significantly and positively correlated with the α-synuclein oligomer level in the CSF of PD patients, after adjusting for confounders. Conclusions PD patients experience a high frequency of fatigue. PD patients with fatigue have worse motor and part nonmotor symptoms. Fatigue in PD patients is associated with an increased α-synuclein oligomer level in the CSF

The Prognostic Value of Treatment-Related Lymphopenia in Nasopharyngeal Carcinoma Patients

Li-Ting Liu,Qiu-Yan Chen,Lin-Quan Tang,Shan-Shan Guo,Ling Guo,Hao-Yuan Mo,Ming-Yuan Chen,Chong Zhao,Xiang Guo,Chao-Nan Qian,Mu-Sheng Zeng,Jin-Xin Bei,Jing Tan,Shuai Chen,Ming-Huang Hong,Jian-Yong Shao 대한암학회 2018 Cancer Research and Treatment Vol.50 No.1

Purpose This study was conducted to evaluate the prognostic value of treatment-related lymphopenia in patients with nasopharyngeal carcinoma (NPC). Materials and Methods A total of 413 consecutive stage II-IVb NPC patients treated with concurrent chemoradiotherapy (CCRT) were enrolled. The overall survival (OS), progression-free survival (PFS), and distant metastasis-free survival (DMFS) were calculated with the Kaplan-Meier method, and differences were compared using the log-rank test. Results A minimum (mini)–absolute lymphocyte counts (ALC) of < 390 cells/μL or ALC after 3 months of CCRT (post3m-ALC) < 705 cells/μL was significantly associated with worse outcome than mini-ALC ! 390 cells/μL (OS, p=0.002; PFS, p=0.005; DMFS, p=0.004) or post3m-ALC ! 705 cells/μL (OS, p < 0.001; PFS, p < 0.001; DMFS, p=0.001). Patients with lymphopenia (mini-ALC < 390 cells/μL and post3m-ALC < 705 cells/μL) had a worse prognosis than those without lymphopenia (mini-ALC ! 390 cells/μL and post3m-ALC ! 705 cells/μL) (OS, p < 0.001; PFS, p < 0.001; DMFS, p < 0.001). Multivariate analysis revealed that post3m-ALC was an independent prognostic factor for OS (hazard ratio [HR], 1.76; 95% confidence interval [CI], 1.12 to 2.78; p=0.015), PFS (HR, 1.86; 95% CI, 1.23 to 2.82; p=0.003), and DMFS (HR, 1.87; 95% CI, 1.13 to 3.08; p=0.014). Multivariate analysis also revealed that patients with lymphopenia had a high risk of death (HR, 3.79; 95% CI, 1.75 to 8.19; p=0.001), disease progression (HR, 2.93; 95% CI, 1.59 to 5.41; p=0.001), and distant metastasis (HR, 3.89; 95% CI, 1.67 to 9.10; p=0.002). Multivariate analysis performed with time dependent Cox regression demonstrated ALC was an independent prognostic factor for OS (HR, 0.995; 95% CI, 0.991 to 0.999; p=0.025) and PFS (HR, 0.993; 95% CI, 0.988 to 0.998; p=0.006). Conclusion Treatment-related lymphopenia was a poor prognostic factor in NPC patients.

Emergy analysis-based study of the sustainable development of Kunming’s urban eco-economic system

Li Hui,Cao Lei,Chen Youbin,Qiu Huiyi,Huang Xue,Guo Wanqi,Wang Shuntao,Sheng Weiguo,Zhou Yilu,Xu Qing 서울시립대학교 도시과학연구원 2023 도시과학국제저널 Vol.27 No.2

We studied Kunming’s urban eco-economic system’s evolution from 2009 to 2018, using the emergy theory and method; with the entropy evaluation method, we analyzed the system’s natural, social and economic subsystems to know its sustainable development capacity. The results show that the system’s emergy structure has clearly improved, and its renewable resources’ emergy has been rationally employed. The environment load ratio, after reaching its peak in 2011, has been decreasing, and the environment stress has becoming lower year by year, as is conducive to sustainable development. Its eco-economic system, however, is highly dependent on the internal resources; its emergy self-sufficiency ratio indicates that it does not see sufficient utilization of imported emergy and feels excessive stress on its internal resources. It witnesses relatively high emergy intensity. The current population is about twice of its renewable resources’ population carrying capacity, and its dramatically growing population is presenting even high pressure on its social subsystems. This indicates that the living standard per capita in Kunming is lower than the national average. All of these factors will hinder the sustainable development of Kunming’s urban eco-economic system. Our analysis of attribute classification shows that it is more appropriate to calculate the tourist revenue by taking into account export emergy. At the same time, the analysis results of sustainable development emergy indexes obtained by ESI, EISD, euehi, euehi’ and entropy method are compared, which shows that the entropy method is able to better reflect the dynamic changes of the sustainable development capacity of its urban eco-economic system because it introduces all indicators of social, economic and natural subsystems for evaluation. In a word, sustainable development capacity represents the outcome of tradeoff and coordination of the three subsystems of society, economy and nature, and we can formulate corresponding strategies based on the above research findings.

Comparative effectiveness of Chinese herbal injections treating for rotavirus enteritis in children: A systematic review and Bayesian network meta-analysis

Li-Qing Niu,Lu Xiao,Qiu-Han Cai,Yu-Yi Wu,Si-Yuan Hu,Sheng-Xuan Guo,Yu-Ling Tian,Qiu-Rong Wang 한국한의학연구원 2023 Integrative Medicine Research Vol.12 No.2

Background: Rotavirus enteritis (RVE) accounts for 37% of all death in children (<5 years) with diarrhea. Chinese herbal injections (CHIs) have drawn more attention from practitioners because of the valid effects for RVE. However, the most beneficial one has not yet been determined. Methods: Eight databases were searched from their inception up to September 3, 2022. The primary outcome was clinical effective rate and the secondary outcomes were time for disappearance of diarrhea, time of defervescence, time for disappearance of vomiting, and adverse drug reactions or adverse drug events. OpenBUGS 3.2.3 and STATA 14.0 software were employed to carry out the NMA. Results: 58 randomized controlled trials (RCTs) with 6436 child patients were included in this Bayesian NMA. Four CHIs were investigated including Yanhuning injection (YHN), Xiyanping injection (XYP), Reduning injection (RDN), and Zedoary Turmeric Oil injection (ZTO). The results showed that YHN [OR=6.16, 95% CI (4.39, 8.77)] had a superior effect in improving clinical effective rate compared to Ribavirin based on Western medicine (WM). According to SUCRA values, YHN (84.1%) ranked highest. As for the secondary outcomes, XYP was the better intervention in shortening the time for disappearance of diarrhea. Regarding time for defervescence, RDN had obvious advantages and also performed well in time for disappearance of vomiting. Conclusions: CHIs combined with WM could be beneficial than Ribavirin in improving clinical effective rate, and YHN was the optimum treatment. From the comprehensive evaluations of both the clinical effective rate and other outcomes, YHN also indicated a favorable therapeutic effect in RVE. Study registration: This study was registered on PROSPERO (CRD42022357149).

Honokiol ameliorates endothelial dysfunction through suppression of PTX3 expression, a key mediator of IKK/IκB/NF-κB, in atherosclerotic cell model

Ling Qiu,Rong Xu,Siyang Wang,Shuijun Li,Hongguang Sheng,Jiaxi Wu,Yi Qu 생화학분자생물학회 2015 Experimental and molecular medicine Vol.47 No.-

Pentraxin 3 (PTX3) was identified as a marker of the inflammatory response and overexpressed in various tissues and cells related to cardiovascular disease. Honokiol, an active component isolated from the Chinese medicinal herb Magnolia officinalis, was shown to have a variety of pharmacological activities. In the present study, we aimed to investigate the effects of honokiol on palmitic acid (PA)-induced dysfunction of human umbilical vein endothelial cells (HUVECs) and to elucidate potential regulatory mechanisms in this atherosclerotic cell model. Our results showed that PA significantly accelerated the expression of PTX3 in HUVECs through the IκB kinase (IKK)/IκB/nuclear factor-κB (NF-κB) pathway, reduced cell viability, induced cell apoptosis and triggered the inflammatory response. Knockdown of PTX3 supported cell growth and prevented apoptosis by blocking PA-inducted nitric oxide (NO) overproduction. Honokiol significantly suppressed the overexpression of PTX3 in PA-inducted HUVECs by inhibiting IκB phosphorylation and the expression of two NF-κB subunits (p50 and p65) in the IKK/IκB/NF-κB signaling pathway. Furthermore, honokiol reduced endothelial cell injury and apoptosis by regulating the expression of inducible NO synthase and endothelial NO synthase, as well as the generation of NO. Honokiol showed an antiinflammatory effect in PA-inducted HUVECs by significantly inhibiting the generation of interleukin-6 (IL-6), IL-8 and monocyte chemoattractant protein-1. In summary, honokiol repaired endothelial dysfunction by suppressing PTX3 overexpression in an atherosclerotic cell model. PTX3 may be a potential therapeutic target for atherosclerosis.