文化財 景觀 保存을 위한 移入要素 規制에 관한 硏究

박강철,김재웅,신웅주 朝鮮大學校 建設技術硏究所 2003 建設技術硏究 Vol.23 No.1

This study is to examine the degree of damages for the view of cultural properties, extract the validity of control methods of import elements and suggest the preservation method of view of cu1tural properties. For these, it evaluates and analyzes the views of cultural properties in Hwasun-gun, suggests the preservation methods through computer simulation and the conclusions are as follows. First, it is suggested that the degree of satisfaction is generally low and the need of control is high. Second, the highest correlations to traditionality are aesthetics and harmony and to keep the traditionality, control of import elements against harmony should be accompanied. Third, control methods of import elements are based on that unnecessary view should be removed and in case that it is difficult it should be moved to a place not to be found easily or concealed. In addition, it can be considered that materials of import elements should be changed into traditional materials or colors should be changed simply.

고효율 태양전지를 위한 p-Type CdTe막의 Cu Doping에 따른 광전기적 특성에 관한 연구

박성,이강렬,신웅선 明知大學校 産業技術硏究所 1995 産業技術硏究所論文集 Vol.14 No.-

p-type CdTe Films that contained CdCl₂and CuCl₂were prepared by coating and sintering. For the sintered CdTe films that contained 1wt% of CdCl₂befor sintering, the electrical resistivity decreases sharply with increasing sintering temperature, and the resistivity is dependent of the sintering temperature for the sintered CdTe films that contained 1wt%, 6wt% and 11wt% of CdCl₂. This fact conbined with the observed microstructures indicate that the CdCl₂acts as a sintering aid. For the specimens which contained various amounts of CdCl₂befor sintering and were sintered at a high temperature(such as at 700℃), the microstructures are improved and the electrical resistivity increases with the amounts of CdCl₂. Therefore it can be concluded that the CdCl₂acts not only as a sintering aid but also a dopant source of donor (Cl) during the sintering measurement, it can also be concluded that all the grains are depleted of dark conductivity and C-V measurement, it can also be concluded that all the grains are depleted of carrier by the trapping centered at grain boundaries. The electrical resistivity decreases with increasing amounts of CuCl₂up to 250ppm due to Cu-doping sintering.

광주·전남지역 재실의 건축적 특성에 관한 연구

박강철,이상선,신웅주 조선대학교 지역사회발전연구원 2003 地域發展硏究 Vol.8 No.1

This study is to examine the actual conditions of the houses built for ancestral rites in Jeonnam region with them located at Hwasun-gun, Jangseong-gun and Gwangsan-gu in Jeonnam through the process of literature survey, measurement and analysis. The results of this study are as follows. It is found that the location of the houses built for ancestral rites is mostly found at mountain in back of the village, followed by inside and back of the village. According to the period, it was built distant from the village earlier and it was difficult to approach them and was closed space for family, but it has been opened and generalized to the public people because it was built back or inside the village. The location of the houses built for ancestral was mostly 二-letter type, followed by 一-letter type. 一-letter type can be classified according to the number of rooms. The three rooms type has the basic type of "R1-F-R2〔WVF〕", extra type of "R1(Rs)-F-R2(Rs)〔WVF〕" and division type of "R1/Rs-F-R2/Rs〔WVF〕". the four rooms type has the basic type of "R1-F-F-R2〔WVF〕", extra type of "R1/Rs-F-F-R2/Rs〔WVF〕", division type of "R1(Rs)-F-F-R2〔WVF〕" and other type of "R1(Rs)-F-F-R2/Rs〔WVF〕". The five rooms type has four types such as the basic types of "R1-F-F-F-R2〔WVF〕", "S-R1-F-F-F-R2〔WVF, WVL〕", the extra type of "R1/Rs-R/FH-F-F-R2〔WVF〕" and the division type of "R1/Rs-R/R-F-F-R2〔WVF〕".

사람 말초혈액 림프구에서 FudR에 의해 유도되는 Fragile Sites

박경란,신웅기,박성국,김원식 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.1

Chromosomal abnormalities including fragile sites induced by 10 ㎍/ml and 20 ㎍/ml fluorodeoxyuridine (FudR) were studied in lymphocytes cultures of six healthy individuals. A significant decrease in mitotic indexes in respect to control cultures was observed with two FudR concentrations used. The cells showing chromosome aberrations and the total number of cytogenetic alterations were significantly increased both FudR treated cultures with respect to control cultures. Damaged cells showing chromosome aberrations and total number of chromosomal aberrations were not significantly increased in FudR 20 ㎍/ml treated groups compared to FudR lO㎍/ml treated groups. The most frequent type of chromosomal aberration is a gap. A site showing a gap or break was defind as fragile if it appeated in 1% of cells analyzed and in at least three of six individuals studied with the same culture tre atment. Using these criteria, fragile sites 3p14, 6p25, 3q32, 1Oq22, 12q21 and 13q21 were induced in different proportions by different concentration of FudR.

취약계층지역을 위한 건강증진센터 운영방안

신형철,박웅섭 關東大學校 醫科大學 醫科學硏究所 2004 關東醫大學術誌 Vol.8 No.2

The study is conducted to plan the health promotion center for the poor districts. We conducted the diagnosis of community for the health problems and set the priority of the needs for the health promotion by the basic priority rating(BPR), and developed the plan. Considering results of diagnosis of community and BPR, we selected the Jumunjin, and Seongdeok district for the subject of the health promotion programs. And we developed the details of health promotion programs for exercise, nutrition, smoking & alcohol, and stress.

스테로이드 주사를 이용한 이개혈종의 치료

박재율,신승헌,김광훈,이웅렬,박일동,박광헌,마도훈,전일훈 대한이비인후과학회 2000 대한이비인후과학회지 두경부외과학 Vol.43 No.2

자궁 무스카린 수용체의 확인 및 분류

이신웅,이정수,박영주 영남대학교 약품개발연구소 1992 영남대학교 약품개발연구소 연구업적집 Vol.2 No.-

The muscarinic acetylcholine receptors of the dog unpregant uterus were characterized using [³H]quinuclidinyl benzilate(QNB) as a radioligand and the binding of muscarinic receptor agonists and antagonists in the uterus was compared to that in the urinary bladder which contains almost exclusively the M₂ receptors in order to determine the receptor subtypes in the uterus. [³H]QNB binding to uterus and bladder was rapid, saturable and reversible. Scatchard analysis of the saturation data gave linear plots and the Hill coefficients were close to unit, which indicated that each preparation contained a single population of specific binding sites for [³H]QNB. The K_(D) values(120 pM) for QNB were almost identical in both organs, whereas the B_(MAX) value of 256 fmol/mg protein in the uterus was significantly different from that of 563 fmol/mg protein in the bladder. Muscarinic agonists and antagonists inhibited in a competitive manner the [³H]QNB binding to the same extent in both organs. The competition binding studies using antagonists(atropine and pirenzepine) exhibited a single binding site and this site had a low affinity for pirenzepine with the Ki value of about 330 nM. However, high and low affinity binding sites were observed with carbachol, methacholine and oxotremorine. These binding studies with agonists and antagonists did not show any differences in drug affinities between uterus and bladder. These results indicate that the muscarinic receptors in the uterus are M₂ receptors which have a low affinity for pirenzepine.

항 Histamine와 Muscarinic Receptor 와의 상호작용 (Ⅱ) : 대뇌 Muscarinic M1 Receptor 에 대한 작용 Action on the cerebral muscarinic M₁ Receptor

이신웅,박영주,박인숙,이정수 영남대학교 약품개발연구소 1991 영남대학교 약품개발연구소 연구업적집 Vol.1 No.-

A single uniform population of specific, saturable, high affinity binding site of [³H] guinuclidinyl benzilate(QNB) was identified in the rat cerebral microsomes. The Kd value(37.2 pM) for [³H]QNB calculated from the kinetically derived rate constants was in agreement with the Kd value(48.9 pM) determined by analysis of saturation isotherms at various receptor concentrations. Dimenhydrinate(DMH), histamine H₁-blocker, increased Kd value for [³H] QNB without affecting the binding site concentrations and this effect resulted from the ability of DMH to slow [³H]QNB-receptor association. Pirenzepine inhibition curve of [³H]QNB binding was shallow(nH = 0.52) indicating the presence of two receptor subtypes with high (M₁-site) and low(M₂-site) affinity for pirenzepine. Analysis of these inhibition curves yielded that 68% of the total receptor populations were of the M₁-subtype and the remaining 32% of the M₂-subtype. Ki values for the M₁- and M₂-subtypes were 2.42 nM and 629.3 nM, respectively. Ki values for H₁-blockers that inhibited [³H]QNB binding varied with a wide range (0.02-2.5μM). The Pseudo-Hill coefficients for inhibition of [³H]QNB binding by most of H₁-blockers examined except for oxomemazine inhibition of [³H]QNB binding were close to one. The inhibition curve for oxomemazine in competition with [³H]QNB was shallow(nH = 0.74) indicating the presence of two receptor populations with different affinities for this drug. The proportion of high and low affinity was 33:67. The Ki values for oxomemazine were 0.045±0.016 μM for high affinity and 1.145±0.232 μM for low affinity sites. These data indicate that muscarinic receptor blocking potency of H₁-blockers varies widely between different drugs and that most of H₁-blockers examined are nonselective antagonist for the muscarinic receptor subtypes, whereas oxomemazine might be capable of distinguishing between subclasses of muscarinic receptor.

항 히스타민제의 H₁ 수용체와 무스카린 수용체에 대한 상대적 역가

이신웅,박영주,이정수 영남대학교 약품개발연구소 1994 영남대학교 약품개발연구소 연구업적집 Vol.4 No.-

The muscarinic antagonist l-[benzilic-4, 4'-³H]quinuclidinyl benzilate([³H]QNB) bound to a single class of muscarinic receptor with high affinity in guinea pig ileal membranes. The K_(D) and B_(max) values for [³H]QNB calculated from analysis of saturation isotherms were 54 pM and 156 fmol/mg, respectively. H₁-blockers inhibited [³H]QNB binding to ileal membranes with K_(i) values ranged from 0.008 μM to 1.6 μM. The pseudo-Hill coefficients of H₁-blockers for inhibition of [³H]QNB binding to the ileal membranes were close to unit. The K_(i) values for H₁-blockers were similar to the K_(M) values calculated by Schild plot of functional data obtained from inhibition of the carbachol-induced contraction in guinea-pig ileum, suggesting that binding of H₁-blockers vs [³H]QNB in ileal membranes represents an interaction with a receptor of physiological relevance. The K_(H) values of H₁-blockers for H₁-receptor estimated from inhibition of the histamine-induced contraction were the range of 0.15 nM to 56.5 nM. The K_(M)/K_(H) ratio of H₁-blockers varied over a wide range of 3 to 2300. Thus, the antihistaminic potencies of H₁-blockers do not correlate with their antimuscarinic potencies, which suggest that antihistamines have different antimuscarinic potencies in therapeutic blood levels causing similar antiallergic effect. Among 13 traditional antihistaminics examined in this study, drug having the highest and the lowest K_(M)/K_(H) ratio is triprolidine and diphenidol, respectively. The present results demonstrate that the antimuscarinic property of antihistamines is not necessary for their antiallergic effect, and data on the affinity of antihistamines for muscarinic and H₁-receptors can be an important parameter in the selection and evaluation of these drugs.

쥐 大腦 Muscarinic Receptor에 미치는 카드뮴의 影響

李正秀,朴令珠,裵基哲,李神雄 嶺南大學校 環境問題硏究所 1991 環境硏究 Vol.10 No.2

The effect of cadmium ?? on the [³H] quinuclidinyl benzilate (QNB) binding of the muscarinic receptors in the cerebrum was examined. ?? Inhibited [³H]QNB binding in both dose-dependent and time-dependent manners and this inhibitory action was irreversible. The ?? Value of ?? to inhibit [³H]QNB binding in the presence of 100 pM [³H]QNB in the cerebral microsome pretreated with ?? at 37℃ for 15 min was about 50㎛. The inhibition of [³H]QNB binding by 50㎛ ?? followed biphasic kinetics ; there is a rapid inhibition phase during first 10 min incubation periods and a slow inhibition phase after a rapid phase. ?? decreased the binding site concentration for [³H]QNB binding without affecting the affinity of QNB. These results suggest that sulphydryl group plays an important role to maintain the muscarinic receptor conformation for [³H]QNB binding.